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Novel marine biomolecules against biofilm. Application to medical devices.

Deliverables

Presentation of NOMORFILM webpage and leaflet

Design of the webpage and leaflet accepted by all partners.

Secondary scholars contest. M42

Report including the list of winners of this secondary school contest, involved laboratories, tasks, an report from the students.

Workshop on microalgae issues

Report about the Workshop focus on microalgae issues celebrated in Coimbra (number of assistants, poster presentations, etc).

Secondary scholars contest. M30

Report including the list of winners of this secondary school contest, involved laboratories, tasks, an report from the students.

At least one patent

Report explaining the patent(s) obtained along the project.

Presentation of the video clips. M51

Video 2 will be reported in month 51 and will be specifically delivered to medical doctors involved in prosthetic devices surgery and treatment of biofilm associated conditions. Clinical and industrial partners will describe, in English, their roles in the project and how the final objective has been tackled. Preclinical data from animal tests and economic feasibility data on this new technology will be also explained.

e-learning course

Report about the e-learning course offered by NOMORFILM project (lessons, speakers, number of participants, reports from participants, evaluation from participants, etc).

Workshop on antibiofilm issues

Report about the Workshop focus on antibiofilm therapeutic strategies celebrated in Barcelona (number of assistants, poster presentations, etc).

Secondary scholars contest. M9

Report including the list of winners of this secondary school contest, involved laboratories, tasks, an report from the students.

Secondary scholars contest. M18

Report including the list of winners of this secondary school contest, involved laboratories, tasks, an report from the students.

Presentation of the video clips. M6

Report on month 6 will include the video clip directed to EU citizens where different patients from biofilm infections in prosthetic devices or catheters will explain to the public in their native languages (with subtitles in Consortium languages) this important medical problem and how it affected their lives, and the convenience of getting solutions as the ones pursued in NOMORFILM. Video 2 will be reported in month 42 and will be specifically delivered to medical doctors involved in prosthetic devices surgery and treatment of biofilm associated conditions. Clinical and industrial partners will describe, in English, their roles in the project and how the final objective has been tackled. Preclinical data from animal tests and economic feasibility data on this new technology will be also explained.

European network database for project strains

Report about the generation of an European database on microalgae which includes information on cultivation conditions, cryopreservation protocols, product profile, taxonomy, genetics, physiology, origin and other characteristics.

Roadmap for EU marine biotechnology resources national policies. M36

Description of the roadmap developed by Consortium partners. List of the interested European countries.

Roadmap for EU marine biotechnology resources national policies. M12

Description of the roadmap developed by Consortium partners. List of the interested European countries.

At least 28 papers and 56 scientific communications

List of scientific papers and scientific communications to congresses and conferences obtained during NOMORFILM project.

Parity document

Description of the measures takes by the consortium to improve the equality between women and men in the science field.

Random transposon library for selected pathogens

A characterised random transpososn library for Escherichia coli, Pseudomonas aeruginosa, Candida and Enterobacter strains will be included in the report. This will be the base for the next studies on bacterial interference.

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Publications

The sea as a source of antibiotics

Author(s): Sara M. Soto
Published in: Clinical Microbiology: Open Access, Issue Volume 4, Issue 4, 1000e126, 2015, ISSN 2327-5073

Porcine Models of Biofilm Infections with Focus on Pathomorphology

Author(s): Louise K. Jensen, Anne S. B. Johansen, Henrik E. Jensen
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
DOI: 10.3389/fmicb.2017.01961

Combined Staining Techniques for Demonstration of Staphylococcus aureus Biofilm in Routine Histopathology

Author(s): Louise Kruse Jensen, Nicole Lind Henriksen, Thomas Bjarnsholt, Kasper Nørskov Kragh, Henrik Elvang Jensen
Published in: Journal of Bone and Joint Infection, Issue 3/1, 2018, Page(s) 27-36, ISSN 2206-3552
DOI: 10.7150/jbji.22799

Novel porcine model of implant-associated osteomyelitis: A comprehensive analysis of local, regional, and systemic response

Author(s): Louise Kruse Jensen, Janne Koch, Kirstine Dich-Jorgensen, Bent Aalbaek, Andreas Petersen, Kurt Fuursted, Thomas Bjarnsholt, Kasper Nørskov Kragh, Mikkel Tøtterup, Mats Bue, Pelle Hanberg, Kjeld Søballe, Peter M.H. Heegaard, Henrik Elvang Jensen
Published in: Journal of Orthopaedic Research, Issue 35/10, 2017, Page(s) 2211-2221, ISSN 0736-0266
DOI: 10.1002/jor.23505

Cyanobacterial diversity held in microbial biological resource centers as a biotechnological asset: the case study of the newly established LEGE culture collection

Author(s): Vitor Ramos, João Morais, Raquel Castelo-Branco, Ângela Pinheiro, Joana Martins, Ana Regueiras, Ana L. Pereira, Viviana R. Lopes, Bárbara Frazão, Dina Gomes, Cristiana Moreira, Maria Sofia Costa, Sébastien Brûle, Silvia Faustino, Rosário Martins, Martin Saker, Joana Osswald, Pedro N. Leão, Vitor M. Vasconcelos
Published in: Journal of Applied Phycology, 2017, ISSN 0921-8971
DOI: 10.1007/s10811-017-1369-y

Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells

Author(s): Cristina Brunati, Thomas T Thomsen, Eleonora Gaspari, Sonia Maffioli, Margherita Sosio, Daniela Jabes, Anders Løbner-Olesen, Stefano Donadio
Published in: Journal of Antimicrobial Chemotherapy, Issue 73/2, 2017, Page(s) 414-424, ISSN 0305-7453
DOI: 10.1093/jac/dkx395

Comparative study of structure and properties of thermal spray coatings using conventional and nanostructured hydroxyapatite powder, for applications in medical implants

Author(s): P. Gkomoza, M. Vardavoulias, D.I. Pantelis, Ch. Sarafoglou
Published in: Surface and Coatings Technology, Issue 357, 2019, Page(s) 748-758, ISSN 0257-8972
DOI: 10.1016/j.surfcoat.2018.10.044

Microstructural investigation of porous titanium coatings, produced by thermal spraying techniques, using plasma atomization and hydride-dehydride powders, for orthopedic implants

Author(s): P. Gkomoza, G.S. Lampropoulos, M. Vardavoulias, D.I. Pantelis, P.N. Karakizis, Ch. Sarafoglou
Published in: Surface and Coatings Technology, Issue 357, 2019, Page(s) 947-956, ISSN 0257-8972
DOI: 10.1016/j.surfcoat.2018.10.072

Biofilms in the Food Industry: Health Aspects and Control Methods

Author(s): Serena Galié, Coral García-Gutiérrez, Elisa M. Miguélez, Claudio J. Villar, Felipe Lombó
Published in: Frontiers in Microbiology, Issue 9, 2018, ISSN 1664-302X
DOI: 10.3389/fmicb.2018.00898

Pigs are useful for the molecular study of bone inflammation and regeneration in humans

Author(s): Freja Lea Lüthje, Kerstin Skovgaard, Henrik Elvang Jensen, Louise Kruse Jensen
Published in: Laboratory Animals, Issue 52/6, 2018, Page(s) 630-640, ISSN 0023-6772
DOI: 10.1177/0023677218766391

In Vivo Gentamicin Susceptibility Test for Prevention of Bacterial Biofilms in Bone Tissue and on Implants

Author(s): Louise Kruse Jensen, Thomas Bjarnsholt, Kasper N. Kragh, Bent Aalbæk, Nicole Lind Henriksen, Sophie Amalie Blirup, Karen Pankoke, Andreas Petersen, Henrik Elvang Jensen
Published in: Antimicrobial Agents and Chemotherapy, Issue 63/2, 2019, Page(s) e01889-18, ISSN 0066-4804
DOI: 10.1128/aac.01889-18

Chlorosphaerolactylates A-D: the natural chlorinated lactylates isolated from the Portuguese cyanobacterium Sphaerospermopsis sp. LEGE 00249

Author(s): Ignacio Gutiérrez-del-Río Nelly B. de Fraissinette Raquel Castelo-Branco Flavio Oliveira João Morais Saúl Redondo-Blanco Claudio J. Villar María José Iglesias Raquel G. Soengas Virginio Cepas Yuly López Cubillos Giacomo Sampietro Liliana Rodolfi Felipe Lombó Sara M. Soto González Fernando López Ortiz Vitor M. Vasconcelos Mariana Reis
Published in: ChemRxiv, Issue 20.01.2020, 2020, ISSN 0000-0000
DOI: 10.26434/chemrxiv.11619873.v1

Chemotaxonomic profiling through NMR

Author(s): María José Iglesias, Raquel Soengas, Clara B Martins, Maria João Correia, Joana D Ferreira, Lilia M.A. Santos, Fernando López Ortiz
Published in: Journal of Phycology, 2019, ISSN 0022-3646
DOI: 10.1111/jpy.12959

Biopelículas y su relación con las infecciones protésicas


Published in: ISSN 2444-1171

Impact of manganese on biofilm formation and cell morphology of Candida parapsilosis clinical isolates with different biofilm forming abilities

Author(s): Sulman Shafeeq, Srisuda Pannanusorn, Youssef Elsharabasy, Bernardo Ramírez-Zavala, Joachim Morschhäuser, Ute Römling
Published in: FEMS Yeast Research, Issue 19/6, 2019, ISSN 1567-1364
DOI: 10.1093/femsyr/foz057

NMR characterization and evaluation of antibacterial and antiobiofilm activity of organic extracts from stationary phase batch cultures of five marine microalgae (Dunaliella sp., D. salina, Chaetoceros calcitrans, C. gracilis and Tisochrysis lutea)

Author(s): Ma José Iglesias, Raquel Soengas, Ian Probert, Emilie Guilloud, Priscillia Gourvil, Mohamed Mehiri, Yuly López, Virginio Cepas, Ignacio Gutiérrez-del-Río, Saúl Redondo-Blanco, Claudio J. Villar, Felipe Lombó, Sara Soto, Fernando López Ortiz
Published in: Phytochemistry, Issue 164, 2019, Page(s) 192-205, ISSN 0031-9422
DOI: 10.1016/j.phytochem.2019.05.001

Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones

Author(s): Giampiero Pietrocola, Giulia Nobile, Mariangela J. Alfeo, Timothy J. Foster, Joan A. Geoghegan, Vincenzo De Filippis, Pietro Speziale
Published in: Journal of Biological Chemistry, Issue 294/10, 2019, Page(s) 3588-3602, ISSN 0021-9258
DOI: 10.1074/jbc.ra118.005707

Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria

Author(s): Virginio Cepas, Yuly López, Yaiza Gabasa, Clara B. Martins, Joana D. Ferreira, Maria J. Correia, Lília M.A. Santos, Flávio Oliveira, Vitor Ramos, Mariana Reis, Raquel Castelo-Branco, João Morais, Vitor Vasconcelos, Ian Probert, Emilie Guilloud, Mohamed Mehiri, Sara M. Soto
Published in: Antibiotics, Issue 8/2, 2019, Page(s) 77, ISSN 2079-6382
DOI: 10.3390/antibiotics8020077

JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia

Author(s): Avinash Khandagale, Beatrice Lazzaretto, Göran Carlsson, Mikael Sundin, Sulman Shafeeq, Ute Römling, Bengt Fadeel
Published in: Journal of Leukocyte Biology, Issue 104/6, 2018, Page(s) 1199-1213, ISSN 0741-5400
DOI: 10.1002/jlb.4a0118-030rr

Guideline for Preclinical Studies of Bone Infections in Large Animals Based on a Systematic Review of 316 Non-Rodent Models

Author(s): L.K. Jensen, N.L. Henriksen, S.A. Blirup, H.E. Jensen
Published in: The Journal of Bone and Joint Surgery, Issue 101/21, 2019, Page(s) 1894-1903, ISSN 0021-9355
DOI: 10.2106/jbjs.18.01369

The Usefulness of Microalgae Compounds for Preventing Biofilm Infections

Author(s): Yuly López, Sara M. Soto
Published in: Antibiotics, Issue 9/1, 2020, Page(s) 9, ISSN 2079-6382
DOI: 10.3390/antibiotics9010009

Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine

Author(s): Paolo Monciardini, Alice Bernasconi, Marianna Iorio, Cristina Brunati, Margherita Sosio, Laura Campochiaro, Paolo Landini, Sonia I. Maffioli, Stefano Donadio
Published in: Journal of Natural Products, Issue 82/1, 2019, Page(s) 35-44, ISSN 0163-3864
DOI: 10.1021/acs.jnatprod.8b00354

The inflammatory response to bone infection – a review based on animal models and human patients

Author(s): Freja Lea Lüthje, Louise Kruse Jensen, Henrik Elvang Jensen, Kerstin Skovgaard
Published in: APMIS, 2020, ISSN 0903-4641
DOI: 10.1111/apm.13027

The host response to bacterial bone infection involves a local upregulation of several acute phase proteins

Author(s): Freja Lea Lüthje, Sophie Amalie Blirup-Plum, Nadia Sara Møller, Peter M.H. Heegaard, Henrik Elvang Jensen, Klaus Kirketerp-Møller, Hans Gottlieb, Kerstin Skovgaard, Louise Kruse Jensen
Published in: Immunobiology, 2020, Page(s) 151914, ISSN 0171-2985
DOI: 10.1016/j.imbio.2020.151914

Molecular interactions of human plasminogen with FnBPB, a fibrinogen/fibronectin-binding protein from Staphylococcus aureus.

Author(s): Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P.
Published in: J Biol Chem., 2016, ISSN 1083-351X

Chapter 1: The Marine Ecosystem as a Source of Antibiotics

Author(s): Yuly López, Virginio Cepas, Sara M. Soto
Published in: Grand Challenges in Marine Biotechnology, 2018, Page(s) 3-48
DOI: 10.1007/978-3-319-69075-9_1