Objective
TASCMAR project aspires to develop new tools and strategies in order to overcome existing bottlenecks in the biodiscovery and industrial exploitation of novel marine derived biomolecules (secondary metabolites and enzymes) with applications in the pharmaceuticals, nutraceuticals, cosmeceuticals and fine chemicals industries. Exploitation of neglected and underutilized marine invertebrates and symbionts from mesophotic zone will be combined with innovative approaches for the cultivation and extraction of marine organisms from lab to pilot-scale, using the unique prototypes Platotex™ and Zippertex™, both reaching the Technology Readiness Level 7. Thus, marine dedicated cultivation and extraction equipment will be built and validated. These unique improvements will ensure sustainable supply of biomass and promote the production of high added value bioactive marine compounds. An integrated, holistic technological metabolomic approach will be applied, in conjunction with bioactivity profiling, as filtering and bio-prioritisation tools. Moreover, state-of-the-art analytical instrumentation and in-house databases will be employed for the dereplication and characterization of valuable compounds. A panel of libraries (marine organisms, extracts, pure metabolites and biocatalysts) will be constructed and exploited throughout the project. A focused panel of in-vitro, cell-based, in-ovo and in-vivo bioassays for discovering metabolites with anti-ageing and/or angiogenesis modulating activity will frame the entire work-flow and will reveal the lead compounds. In addition, the catalytic potential of mesophotic symbionts and deriving enzymes candidates will be evaluated in fine chemicals and bioremediation industries. The project activities will be constantly assessed via effective management for their societal, economical and environmental impact in order to find the best compromise between industrial development and sustainable growth.
Fields of science
- natural scienceschemical sciencesorganic chemistryaromatic compounds
- natural scienceschemical sciencescatalysisbiocatalysis
- natural sciencesbiological sciencesmicrobiology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
- natural sciencesbiological scienceszoologyinvertebrate zoology
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
75794 Paris
France
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Participants (12)
10561 Athina
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69978 Tel Aviv
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10330 Bangkok
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97715 Saint Denis De La Reunion Cedex 9
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82152 Martinsried
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
26818 Villanova Del Sillaro
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
79210 Niort
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18600 Motril Granada
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
134 40 Gustavsberg
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19003 Markopoulo
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
00187 Roma
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
63573 Tel Aviv Yaffo
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