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Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and associated symbionts

Objective

TASCMAR project aspires to develop new tools and strategies in order to overcome existing bottlenecks in the biodiscovery and industrial exploitation of novel marine derived biomolecules (secondary metabolites and enzymes) with applications in the pharmaceuticals, nutraceuticals, cosmeceuticals and fine chemicals industries. Exploitation of neglected and underutilized marine invertebrates and symbionts from mesophotic zone will be combined with innovative approaches for the cultivation and extraction of marine organisms from lab to pilot-scale, using the unique prototypes Platotex™ and Zippertex™, both reaching the Technology Readiness Level 7. Thus, marine dedicated cultivation and extraction equipment will be built and validated. These unique improvements will ensure sustainable supply of biomass and promote the production of high added value bioactive marine compounds. An integrated, holistic technological metabolomic approach will be applied, in conjunction with bioactivity profiling, as filtering and bio-prioritisation tools. Moreover, state-of-the-art analytical instrumentation and in-house databases will be employed for the dereplication and characterization of valuable compounds. A panel of libraries (marine organisms, extracts, pure metabolites and biocatalysts) will be constructed and exploited throughout the project. A focused panel of in-vitro, cell-based, in-ovo and in-vivo bioassays for discovering metabolites with anti-ageing and/or angiogenesis modulating activity will frame the entire work-flow and will reveal the lead compounds. In addition, the catalytic potential of mesophotic symbionts and deriving enzymes candidates will be evaluated in fine chemicals and bioremediation industries. The project activities will be constantly assessed via effective management for their societal, economical and environmental impact in order to find the best compromise between industrial development and sustainable growth.

Field of science

  • /social sciences/economics and business/economics/sustainable economy
  • /engineering and technology/environmental biotechnology/bioremediation
  • /natural sciences/biological sciences/zoology/invertebrate zoology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-BG-2014-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 442 248,76

Participants (12)

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 801 250
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 460 280
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
CHULALONGKORN UNIVERSITY
Thailand
EU contribution
€ 299 975
Address
Phyathai Road 254 Pathumwan
10330 Bangkok
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LA REUNION
France
EU contribution
€ 380 000
Address
Avenue Rene Cassin 15
97715 Saint Denis De La Reunion Cedex 9
Activity type
Higher or Secondary Education Establishments
CRELUX GMBH
Germany
EU contribution
€ 801 212,50
Address
Am Klopferspitz 19A
82152 Martinsried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BICT SRL
Italy
EU contribution
€ 311 000
Address
Via Einstein Casc Codazza Snc - Parco Tecnologico Padano
26900 Lodi Lo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PIERRE GUERIN SAS
France
EU contribution
€ 800 015
Address
179 Grande Rue
79210 Niort
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IMARE NATURAL SL
Spain
EU contribution
€ 324 956
Address
Avenida De La Habana 10
18600 Motril Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASTAREAL AB
Sweden
EU contribution
€ 187 690,49
Address
Idrottsvagen 4
134 40 Gustavsberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
APIVITA KALLYNTIKA DIAITITIKA FARMAKA ANONYMI EMPORIKI KAI VIOTECHNIKI ETAIREIA
Greece
EU contribution
€ 399 687,50
Address
Industrial Park Of Markopoulo
19003 Markopoulo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
T6 ECOSYSTEMS SRL
Italy
EU contribution
€ 208 000
Address
Via Aureliana 63
00187 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASSOCIATION ECO OCEAN
Israel
EU contribution
€ 339 635
Address
Hayarkon Street 113
63573 Tel Aviv Yaffo
Activity type
Research Organisations