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Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and associated symbionts

Obiettivo

TASCMAR project aspires to develop new tools and strategies in order to overcome existing bottlenecks in the biodiscovery and industrial exploitation of novel marine derived biomolecules (secondary metabolites and enzymes) with applications in the pharmaceuticals, nutraceuticals, cosmeceuticals and fine chemicals industries. Exploitation of neglected and underutilized marine invertebrates and symbionts from mesophotic zone will be combined with innovative approaches for the cultivation and extraction of marine organisms from lab to pilot-scale, using the unique prototypes Platotex™ and Zippertex™, both reaching the Technology Readiness Level 7. Thus, marine dedicated cultivation and extraction equipment will be built and validated. These unique improvements will ensure sustainable supply of biomass and promote the production of high added value bioactive marine compounds. An integrated, holistic technological metabolomic approach will be applied, in conjunction with bioactivity profiling, as filtering and bio-prioritisation tools. Moreover, state-of-the-art analytical instrumentation and in-house databases will be employed for the dereplication and characterization of valuable compounds. A panel of libraries (marine organisms, extracts, pure metabolites and biocatalysts) will be constructed and exploited throughout the project. A focused panel of in-vitro, cell-based, in-ovo and in-vivo bioassays for discovering metabolites with anti-ageing and/or angiogenesis modulating activity will frame the entire work-flow and will reveal the lead compounds. In addition, the catalytic potential of mesophotic symbionts and deriving enzymes candidates will be evaluated in fine chemicals and bioremediation industries. The project activities will be constantly assessed via effective management for their societal, economical and environmental impact in order to find the best compromise between industrial development and sustainable growth.

Invito a presentare proposte

H2020-BG-2014-2
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Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Indirizzo
Rue Michel Ange 3
75794 Paris
Francia
Tipo di attività
Other
Contributo UE
€ 1 442 248,76

Partecipanti (12)

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
Contributo UE
€ 801 250
Indirizzo
6 Christou Lada Str
10561 Athina
Tipo di attività
Higher or Secondary Education Establishments
TEL AVIV UNIVERSITY
Israele
Contributo UE
€ 460 280
Indirizzo
Ramat Aviv
69978 Tel Aviv
Tipo di attività
Higher or Secondary Education Establishments
CHULALONGKORN UNIVERSITY
Thailandia
Contributo UE
€ 299 975
Indirizzo
Phyathai Road 254 Pathumwan
10330 Bangkok
Tipo di attività
Higher or Secondary Education Establishments
UNIVERSITE DE LA REUNION
Francia
Contributo UE
€ 380 000
Indirizzo
Avenue Rene Cassin 15
97715 Saint Denis De La Reunion Cedex 9
Tipo di attività
Higher or Secondary Education Establishments
CRELUX GMBH
Germania
Contributo UE
€ 801 212,50
Indirizzo
Am Klopferspitz 19A
82152 Martinsried
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BICT SRL
Italia
Contributo UE
€ 311 000
Indirizzo
Via Fratelli Sommariva 3
26818 Villanova Del Sillaro
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PIERRE GUERIN SAS
Francia
Contributo UE
€ 800 015
Indirizzo
179 Grande Rue
79210 Niort
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IMARE NATURAL SL
Spagna
Contributo UE
€ 324 956
Indirizzo
Avenida De La Habana 10
18600 Motril Granada
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASTAREAL AB
Svezia
Contributo UE
€ 187 690,49
Indirizzo
Idrottsvagen 4
134 40 Gustavsberg
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
APIVITA KALLYNTIKA DIAITITIKA FARMAKA ANONYMI EMPORIKI KAI VIOTECHNIKI ETAIREIA
Greece
Contributo UE
€ 399 687,50
Indirizzo
Industrial Park Of Markopoulo
19003 Markopoulo
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
T6 ECOSYSTEMS SRL
Italia
Contributo UE
€ 208 000
Indirizzo
Via Aureliana 63
00187 Roma
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASSOCIATION ECO OCEAN
Israele
Contributo UE
€ 339 635
Indirizzo
Hayarkon Street 113
63573 Tel Aviv Yaffo
Tipo di attività
Research Organisations