Objectif Ageing is the major risk factor for idiopathic PARKINSON'S DISEASE (PD), the first motor neurodegenerative disorder (in EU 1% in 65+; about 4% in 80+). The most recent conceptualizations of ageing and PD indicate that they share basic mechanisms, e.g. accumulation of senescent cells and propagation phenomena such as inflammaging mirrored in PD by neuro-inflammaging in brain that foster a prion-like spreading of neuronal damage. Thus, to fully understand PD pathogenesis and set up innovative neuro-protective therapies it is mandatory to posit PD within the framework of ageing process. The main goal of PROPAG-AGEING is to identify specific cellular and molecular perturbations deviating from healthy ageing trajectories towards PD. To this aim the project will exploit four large, very informative EXISTING COHORTS where biomaterials are available: i) de novo PD patients (before any therapy) followed longitudinally, including the largest repository of PD patients, i.e. PPMI; ii) centenarians and their offspring (CO) who never showed clinical signs of motor disability; iii) old twins of the Swedish Twin Registry (STR) followed longitudinally for >45 years, assessed for lifestyle and exposure to toxicants, and where incident and prevalent cases of PD discordant twins have been collected, including brains. The most informative sample from these cohorts will be studied in a DISCOVERY PHASE by an integrated set of omics to identify molecular signatures whose results will enter in a VALIDATION PHASE exploiting the four large cohorts, and performing functional in in vitro studies using dopaminergic neurons obtained by PD somatic cells from PD patients and centenarians via iPSC protocol. An added value is that omic data in centenarians and CO are available, and will represent the gold standard of healthy ageing. This approach will allow to identify new molecular profiles for early diagnosis and therapy (identification of druggable targets) of PD and signatures of healthy ageing. Champ scientifique natural sciencescomputer and information sciencesdatabasesengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingmedical and health sciencesbasic medicineneurologyparkinsonengineering and technologyindustrial biotechnologybiomaterials Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Thème(s) PHC-01-2014 - Understanding health, ageing and disease: determinants, risk factors and pathways Appel à propositions H2020-PHC-2014-2015 Voir d’autres projets de cet appel Sous appel H2020-PHC-2014-two-stage Régime de financement RIA - Research and Innovation action Coordinateur AZIENDA UNITA' SANITARIA LOCALE DI BOLOGNA Contribution nette de l'UE € 745 437,50 Adresse VIA CASTIGLIONE 29 40124 Bologna Italie Voir sur la carte Région Nord-Est Emilia-Romagna Bologna Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 745 437,50 Participants (8) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire UNIVERSITY COLLEGE LONDON Royaume-Uni Contribution nette de l'UE € 997 057,50 Adresse GOWER STREET WC1E 6BT London Voir sur la carte Région London Inner London — West Camden and City of London Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 997 057,50 UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Allemagne Contribution nette de l'UE € 720 968,75 Adresse Robert-Koch-Strasse 40 37075 Goettingen Voir sur la carte Région Niedersachsen Braunschweig Göttingen Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 720 968,75 SERVICIO ANDALUZ DE SALUD Espagne Contribution nette de l'UE € 671 167,50 Adresse AVENIDA DE LA CONSTITUCION 18 41071 Sevilla Voir sur la carte Région Sur Andalucía Sevilla Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 671 167,50 PERSONAL GENOMICS SRL Italie Contribution nette de l'UE € 635 875,00 Adresse VIA ROVEGGIA 43 37136 Verona Voir sur la carte Région Nord-Est Veneto Verona Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 635 875,00 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Royaume-Uni Contribution nette de l'UE € 308 123,75 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 308 123,75 CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE Italie Contribution nette de l'UE € 721 261,25 Adresse PIAZZA DI SAN MARCO 4 50121 FIRENZE Voir sur la carte Région Centro (IT) Toscana Firenze Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 721 261,25 KAROLINSKA INSTITUTET Suède Contribution nette de l'UE € 901 232,50 Adresse Nobels Vag 5 17177 Stockholm Voir sur la carte Région Östra Sverige Stockholm Stockholms län Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 901 232,50 ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Italie Contribution nette de l'UE € 292 252,25 Adresse VIA ZAMBONI 33 40126 Bologna Voir sur la carte Région Nord-Est Emilia-Romagna Bologna Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 292 252,25