Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds

Livrables

Project guideline document
3rd Report from the Scientific Advisory Board meeting

Report from the SAB regarding the project's progress during the third year.

Report on critical EDC mixtures for the three health domains in the SELMA and the Life Child study modelled with covariates and potential confounders (mixtures I).

Report on doses and exposure regiments for experimental studies with mixtures 0

Report on doses and exposure regiments for experimental studies with mixtures 0. Mixture 0 is based on a Bio-statistical model (pre-study on existing data) including prenatal EDC exposure for a subset of EDCs (10 phthalate metabolites, 2 phenols and 8 PFCs) and health outcomes at 2.5 years of age in the three health domains.

1st Report from Scientific Advisory Board meeting

Report from the SAB regarding the project's progress during the first year.

Report on inclusive strategies for the regulatory implementation of risk assessment tools for EDC mixtures
2nd Dissemination activity and quality report

Report on the activity and quality of dissemination during the second half of the project.

Report EDC mixtures III

Report on final biostatistical models for identifying critical EDC mixtures including covariates and potential confounders, new biomarkers, genetic/epigenetic analyses and new biomarkers (mixtures III).

1st Dissemination activity and quality report

Report on the activity and quality of dissemination during the first half of the project.

Report on how to ensure workability of the IPCS definition of EDCs

Report on how to ensure workability of the IPCS definition of EDCs.

Report on chemical levels in SELMA and Life Child.

Report on measured levels of chemicals in serumplasma and urine of mothers in SELMA and Life Child

Report on a novel framework for risk assessment of mixtures
Dissemination guideline

Guideline on the dissemination of information and results generated within EDC-MixRisk.

Meeting report of the WHO Chemical Risk Assessment Network
Whitepaper on EDCs and health risks
4th Report from the Scientific Advisory Board meeting

Report from the SAB regarding the project's progress during the fourth year.

Internal communication plan document

Document about the internal communication plan

Report on doses and exposure regiments for experimental studies with mixtures I

Report on doses and exposure regiments for experimental studies with mixtures I. Mixture I on a Bio-statistical model including prenatal EDC exposure (full data set), and health outcome data at 7 years of age, and potential confounders in SELMA and LIFE Child.

2nd Report from the Scientific Advisory Board meeting

Report from the SAB regarding the project's progress during the second year.

Comprehensive information about ECD-MixRisk in EN, SE, FR, DE, FI, GR, IT
Launch of webpage

Launch of project webpage.

Data management plan document

Document about the data management plan

Publications

Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals

Auteurs: Miriam N. Jacobs, Emma L. Marczylo, Carlos Guerrero-Bosagna, Joëlle Rüegg
Publié dans: Annual Review of Environment and Resources, Numéro 42/1, 2017, Page(s) 105-160, ISSN 1543-5938
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-environ-102016-061111

Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods

Auteurs: Ali Alavian-Ghavanini, Joëlle Rüegg
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 122/1, 2018, Page(s) 38-45, ISSN 1742-7835
Éditeur: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12878

Endokrine Modulatoren

Auteurs: M. Hoffmann, S. Gebauer, M. Nüchter, R. Baber, J. Ried, M. von Bergen, W. Kiess
Publié dans: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Numéro 60/6, 2017, Page(s) 640-648, ISSN 1436-9990
Éditeur: Springer Verlag
DOI: 10.1007/s00103-017-2551-8

Androgenic potential of human fetal adrenals at the end of the first trimester

Auteurs: I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder, K Svechnikov
Publié dans: Endocrine Connections, Numéro 6/6, 2017, Page(s) 348-359, ISSN 2049-3614
Éditeur: BioScientifica Ltd.
DOI: 10.1530/EC-17-0085

Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos

Auteurs: Jean-Baptiste Fini, Bilal B. Mughal, Sébastien Le Mével, Michelle Leemans, Mélodie Lettmann, Petra Spirhanzlova, Pierre Affaticati, Arnim Jenett, Barbara A. Demeneix
Publié dans: Scientific Reports, Numéro 7, 2017, Page(s) 43786, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep43786

Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic

Auteurs: Lars Lind, P. Monica Lind, Margareta H. Lejonklou, Linda Dunder, Åke Bergman, Carlos Guerrero-Bosagna, Erik Lampa, Hong Kyu Lee, Juliette Legler, Angel Nadal, Youngmi Kim Pak, Richard P. Phipps, Laura N. Vandenberg, Daniel Zalko, Marlene Ågerstrand, Mattias Öberg, Bruce Blumberg, Jerrold J. Heindel, Linda S. Birnbaum
Publié dans: Environmental Health Perspectives, Numéro 124/5, 2016, ISSN 0091-6765
Éditeur: US Department of Health and Human Services
DOI: 10.1289/ehp.1511115

Effects of pre- and post-natal exposure to bisphenol A on the stress system

Auteurs: E. Kitraki, I. Nalvarte, A. Alavian-Ghavanini, J. Rüegg
Publié dans: Endocrine Disruptors, Numéro 4/1, 2016, Page(s) e1184775, ISSN 2327-3747
Éditeur: Taylor & Francis
DOI: 10.1080/23273747.2016.1184775

Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement

Auteurs: Roland Solecki, Andreas Kortenkamp, Åke Bergman, Ibrahim Chahoud, Gisela H. Degen, Daniel Dietrich, Helmut Greim, Helen Håkansson, Ulla Hass, Trine Husoy, Miriam Jacobs, Susan Jobling, Alberto Mantovani, Philip Marx-Stoelting, Aldert Piersma, Vera Ritz, Remy Slama, Ralf Stahlmann, Martin van den Berg, R. Thomas Zoeller, Alan R. Boobis
Publié dans: Archives of Toxicology, 2016, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-016-1866-9

Thyroid-disrupting chemicals and brain development: an update

Auteurs: Bilal B Mughal, Jean-Baptiste Fini, Barbara A Demeneix
Publié dans: Endocrine Connections, Numéro 7/4, 2018, Page(s) R160-R186, ISSN 2049-3614
Éditeur: BioScientifica Ltd.
DOI: 10.1530/EC-18-0029

Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans

Auteurs: Ali Alavian-Ghavanini, Ping-I Lin, P. Monica Lind, Sabina Risén Rimfors, Margareta Halin Lejonklou, Linda Dunder, Mandy Tang, Christian Lindh, Carl-Gustaf Bornehag, Joëlle Rüegg
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-29732-9

Current EU research activities on combined exposure to multiple chemicals

Auteurs: Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Publié dans: Environment International, Numéro 120, 2018, Page(s) 544-562, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2018.07.037

Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes

Auteurs: Anastasia Repouskou, Emily Panagiotidou, Lydia Panagopoulou, Pernilla Larsdotter Bisting, Astrud R. Tuck, Marcus O. D. Sjödin, Johan Lindberg, Evangelos Bozas, Joëlle Rüegg, Chris Gennings, Carl-Gustaf Bornehag, Pauliina Damdimopoulou, Antonios Stamatakis, Efthymia Kitraki
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-42377-6

A Novel Approach to Chemical Mixture Risk Assessment—Linking Data from Population‐Based Epidemiology and Experimental Animal Tests

Auteurs: Carl‐Gustaf Bornehag, Efthymia Kitraki, Antonios Stamatakis, Emily Panagiotidou, Christina Rudén, Huan Shu, Christian Lindh, Joelle Ruegg, Chris Gennings
Publié dans: Risk Analysis, 2019, ISSN 0272-4332
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/risa.13323

Following Endocrine-Disrupting Effects on Gene Expression in Xenopus laevis

Auteurs: Petra Spirhanzlova, Michelle Leemans, Barbara A. Demeneix, Jean-Baptiste Fini
Publié dans: Cold Spring Harbor Protocols, Numéro 2019/7, 2019, Page(s) pdb.prot098301, ISSN 1559-6095
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/pdb.prot098301

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