Objectif Mycoplasmas are the smallest cell wall less, free-living microorganisms. The lack of a cell wall makes them resistant to many of the common antibiotics. Every year, infections caused by Mycoplasmas in poultry, cows, and pigs, result in multimillion euros losses in USA and Europe. Currently, there are vaccines against M hyopneumoniae in pigs and M gallisepticum and M synoviae in poultry. However, there is no vaccination against many Mycoplasma species infecting pets, humans and farm animals (ie M bovis cow infection). Mycoplasma species in many cases are difficult to grown in axenic culture and those that grow need a complex media with animal serum. In large scale production of Mycoplasma species for vaccination aside from the high cost of animal serum, more important is the high irreproducibility in the production process and the possible contamination with animal viruses. All this together highlights what European industry needs:i) a defined cheap reproducible medium that is animal serum free and ii) an universal Mycoplasma chassis that could be used in a pipeline to vaccinate against Mycoplasma species, as well as any pathogen. M pneumoniae is an ideal starting point for designing such a vaccine chassis. It has a small genome (860 kb) and it is probably the organism with the most comprehensive systems biology data acquired so far. By genome comparison, metabolic modeling and rationally engineering its genome, we will create a vaccine chassis that will be introduced into an industrial pipeline. The process will be guided by the second world largest industry on animal vaccination (MSD), as well as a SME specialized on peptide display and screening. This will ensure the exploitation and commercialization of our work contributing to maintain Europe privileged position in this field. Our ultimate goal is to meet the needs of the livestock industry,taking care of ethical issues, foreseeable risks, and prepare effective dissemination and training material for the public. Champ scientifique natural sciencesbiological sciencessynthetic biologynatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesgeneticsgenomesmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Mots‑clés mycoplasma vaccination synthetic biology gene circuit design Programme(s) H2020-EU.2.1.4. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology Main Programme Thème(s) BIOTEC-1-2014 - Synthetic biology – construction of organisms for new products and processes Appel à propositions H2020-BIOTEC-2014-2015 Voir d’autres projets de cet appel Sous appel H2020-LEIT-BIO-2014-1 Régime de financement RIA - Research and Innovation action Coordinateur FUNDACIO CENTRE DE REGULACIO GENOMICA Contribution nette de l'UE € 2 128 507,00 Adresse CARRER DOCTOR AIGUADER 88 08003 Barcelona Espagne Voir sur la carte Région Este Cataluña Barcelona Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 2 128 507,00 Participants (7) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire INTERVET INTERNATIONAL BV Pays-Bas Contribution nette de l'UE € 1 476 250,00 Adresse WIM DE KORVERSTRAAT 35 5831 AN Boxmeer Voir sur la carte Région Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 476 250,00 INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Contribution nette de l'UE € 850 300,00 Adresse 147 RUE DE L'UNIVERSITE 75007 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 850 300,00 WAGENINGEN UNIVERSITY Pays-Bas Contribution nette de l'UE € 860 008,00 Adresse DROEVENDAALSESTEEG 4 6708 PB Wageningen Voir sur la carte Région Oost-Nederland Gelderland Veluwe Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 860 008,00 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Royaume-Uni Contribution nette de l'UE € 699 977,00 Adresse SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 699 977,00 ATG:BIOSYNTHETICS GMBH Allemagne Contribution nette de l'UE € 897 493,00 Adresse WEBERSTRASSE 40 79249 Merzhausen Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Baden-Württemberg Freiburg Breisgau-Hochschwarzwald Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 897 493,00 KOBENHAVNS UNIVERSITET Danemark Contribution nette de l'UE € 591 750,00 Adresse NORREGADE 10 1165 Kobenhavn Voir sur la carte Région Danmark Hovedstaden Byen København Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 591 750,00 BIOFACTION KG Autriche Contribution nette de l'UE € 552 392,00 Adresse KUNDMANNGASSE 39/12 1030 Wien Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Ostösterreich Wien Wien Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 552 392,00
