Molecularly guided trials with specific treatment strategies in patients with advanced newly molecular defined subtypes of colorectal cancer (MoTriColor)

Deliverables

Submission of scientific paper for publication and thereby bringing trial results into the public domain CT3

After collection of all clinical data and data cleaning a scientific report will be delivered and submitted to a peer-reviewed journal to make all data available in the public domain.

Construction of a website portal

To be updated until the end of the project.

Communication plan and tools

A plan for dissemination that includes the communication objectives, target audiences, activities to be carried out and tools that will support their implementation, with connections among these components.

Submission of scientific paper for publication and thereby bringing trial results into the public domain CT2

After collection of all clinical data and data cleaning a scientific report will be delivered and submitted to a peer-reviewed journal to make all data available in the public domain.

Clinical Trial 1 EUDRA CT

Registry of the Clinical Trial 1 in the European Union Clinical Trials Register

Clinical Trial 2 EUDRA CT

Registry of the Clinical Trial 2 in the European Union Clinical Trials Register

Clinical Trial 3 EUDRA CT

Registry of the Clinical Trial 3 in the European Union Clinical Trials Register

Publications

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Author(s): Sabrina Arena, Giorgio Corti, Erika Durinikova, Monica Montone, Nicole M. Reilly, Mariangela Russo, Annalisa Lorenzato, Pamela Arcella, Luca Lazzari, Giuseppe Rospo, Massimiliano Pagani, Carlotta Cancelliere, Carola Negrino, Claudio Isella, Alice Bartolini, Andrea Cassingena, Alessio Amatu, Gianluca Mauri, Andrea Sartore-Bianchi, Gloria Mittica, Enzo Medico, Silvia Marsoni, Michael Linnebacher, Se
Published in: Clinical Cancer Research, Issue 26/6, 2020, Page(s) 1372-1384, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-2409

The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review

Author(s): Roberta Lombardo, Federica Tosi, Annunziata Nocerino, Katia Bencardino, Valentina Gambi, Riccardo Ricotta, Francesco Spina, Salvatore Siena, Andrea Sartore-Bianchi
Published in: Frontiers in Oncology, Issue 10, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00533

The liquid biopsy in the management of colorectal cancer patients: Current applications and future scenarios

Author(s): Nicola Normanno, Andres Cervantes, Fortunato Ciardiello, Antonella De Luca, Carmine Pinto
Published in: Cancer Treatment Reviews, Issue 70, 2018, Page(s) 1-8, ISSN 0305-7372
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2018.07.007

Entrectinib approval by EMA reinforces options for ROS1 and tumour agnostic NTRK targeted cancer therapies

Author(s): Elena Ardini, Salvatore Siena
Published in: ESMO Open, Issue 5/5, 2020, Page(s) e000867, ISSN 2059-7029
Publisher: Cancer Epidemiology
DOI: 10.1136/esmoopen-2020-000867

Adaptive mutability of colorectal cancers in response to targeted therapies

Author(s): Russo M.; Crisafulli G.; Sogari A.; Reilly N.M.; Arena S.; Lamba S.; Bartolini A.; Amodio V.; Magri A.; Novara L.; Sarotto I.; Nagel Z.D.; Piett C.G.; Amatu A.; Sartore-Bianchi A.; Siena S.; Bertotti A.; Trusolino L.; Corigliano M.; Gherardi M.; Lagomarsino M.C.; Nicolantonio F.D.; Bardelli A.
Published in: Science, 2019, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aav4474

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer

Author(s): Annalisa Lorenzato, Alessandro Magrì, Vittoria Matafora, Valentina Audrito, Pamela Arcella, Luca Lazzari, Monica Montone, Simona Lamba, Silvia Deaglio, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Angela Bachi, Federica Di Nicolantonio, Alberto Bardelli, Sabrina Arena
Published in: Cancers, Issue 12/3, 2020, Page(s) 685, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030685

Increased incidence of colon cancer among individuals younger than 50 years: A 17 years analysis from the cancer registry of the municipality of Milan, Italy

Author(s): A.Grusso; A.Andreano, A.Sartore-Bianchi, G.Mauri, A.Decarli, S.Siena
Published in: Cancer Epidemiology, 2019, ISSN 1877-7821
Publisher: Elsevier BV
DOI: 10.1016/j.canep.2019.03.015

High-dose vitamin C enhances cancer immunotherapy

Author(s): Alessandro Magrì, Giovanni Germano, Annalisa Lorenzato, Simona Lamba, Rosaria Chilà, Monica Montone, Vito Amodio, Tommaso Ceruti, Francesco Sassi, Sabrina Arena, Sergio Abrignani, Maurizio D’Incalci, Massimo Zucchetti, Federica Di Nicolantonio, Alberto Bardelli
Published in: Science Translational Medicine, Issue 12/532, 2020, Page(s) eaay8707, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aay8707

Breaking Barriers in HER2+ Cancers

Author(s): Salvatore Siena, Silvia Marsoni, Andrea Sartore-Bianchi
Published in: Cancer Cell, Issue 38/3, 2020, Page(s) 317-319, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2020.07.012

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses

Author(s): Clara Montagut, Guillem Argilés, Fortunato Ciardiello, Thomas T. Poulsen, Rodrigo Dienstmann, Michael Kragh, Scott Kopetz, Trine Lindsted, Cliff Ding, Joana Vidal, Jenifer Clausell-Tormos, Giulia Siravegna, Francisco J. Sánchez-Martín, Klaus Koefoed, Mikkel W. Pedersen, Michael M. Grandal, Mikhail Dvorkin, Lucjan Wyrwicz, Ana Rovira, Antonio Cubillo, Ramon Salazar, Françoise Desseigne, Cristin
Published in: JAMA Oncology, Issue 4/4, 2018, Page(s) e175245, ISSN 2374-2437
Publisher: JAMA Oncol
DOI: 10.1001/jamaoncol.2017.5245

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Author(s): Giovanni Germano, Simona Lamba, Giuseppe Rospo, Ludovic Barault, Alessandro Magrì, Federica Maione, Mariangela Russo, Giovanni Crisafulli, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Federica Morano, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio D’Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi
Published in: Nature, 2017, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature24673

BRAF mutant colorectal cancer: prognosis, treatment, and new perspectives

Author(s): E Sanz-Garcia, G Argiles, E Elez, J Tabernero
Published in: Annals of Oncology, Issue 28/11, 2017, Page(s) 2648-2657, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdx401

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer

Author(s): Filippo Pietrantonio, Federica Di Nicolantonio, Alexa B Schrock, Jeeyun Lee, Sabine Tejpar, Andrea Sartore-Bianchi, Jaclyn F Hechtman, Jason Christiansen, Luca Novara, Niall Tebbutt, Giovanni Fucà, Carlotta Antoniotti, Seung Tae Kim, Danielle Murphy, Rosa Berenato, Federica Morano, James Sun, Bosun Min, Philip J Stephens, Marissa Chen, Luca Lazzari, Vincent A Miller, Robert Shoemaker, Alessio Ama
Published in: JNCI: Journal of the National Cancer Institute, Issue 109/12, 2017, ISSN 0027-8874
Publisher: Oxford University Press
DOI: 10.1093/jnci/djx089

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

Author(s): Ludovic Barault, Alessio Amatu, Giulia Siravegna, Agostino Ponzetti, Sebastian Moran, Andrea Cassingena, Benedetta Mussolin, Chiara Falcomatà, Alexandra M Binder, Carmen Cristiano, Daniele Oddo, Simonetta Guarrera, Carlotta Cancelliere, Sara Bustreo, Katia Bencardino, Sean Maden, Alice Vanzati, Patrizia Zavattari, Giuseppe Matullo, Mauro Truini, William M Grady, Patrizia Racca, Karin B Michels, S
Published in: Gut, Issue 67/11, 2018, Page(s) 1995-2005, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-313372

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo

Author(s): Sara Mainardi, Antonio Mulero-Sánchez, Anirudh Prahallad, Giovanni Germano, Astrid Bosma, Paul Krimpenfort, Cor Lieftink, Jeffrey D. Steinberg, Niels de Wit, Samuel Gonçalves-Ribeiro, Ernest Nadal, Alberto Bardelli, Alberto Villanueva, Rene Bernards
Published in: Nature Medicine, Issue 24/7, 2018, Page(s) 961-967, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0023-9

Tracking colorectal cancer evolution in time and space

Author(s): G. Rospo, G. Corti, G. Crisafulli, L. Novara, A. Bardelli
Published in: Annals of Oncology, Issue 28/6, 2017, Page(s) 1163-1165, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdx127

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Author(s): Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Andrea Sartore-Bianchi, Benedetta Mussolin, Andrea Cassingena, Cosimo Martino, Richard B. Lanman, Rebecca J. Nagy, Stephen Fairclough, Giuseppe Rospo, Giorgio Corti, Alice Bartolini, Pamela Arcella, Monica Montone, Francesca Lodi, Annalisa Lorenzato, Alice Vanzati, Emanuele Valtorta, Giovanni Cappello, Andrea Bertotti, Sara Lonardi, Vittorina Za
Published in: Cancer Cell, Issue 34/1, 2018, Page(s) 148-162.e7, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2018.06.004

Tumor Evolution as a Therapeutic Target

Author(s): Nabil Amirouchene-Angelozzi, Charles Swanton, Alberto Bardelli
Published in: Cancer Discovery, Issue 7/8, 2017, Page(s) 805-817, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.CD-17-0343

Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis

Author(s): Federica Tosi, Elena Magni, Alessio Amatu, Gianluca Mauri, Katia Bencardino, Mauro Truini, Silvio Veronese, Luciano De Carlis, Giovanni Ferrari, Michele Nichelatti, Andrea Sartore-Bianchi, Salvatore Siena
Published in: Clinical Colorectal Cancer, Issue 16/3, 2017, Page(s) e153-e163, ISSN 1533-0028
Publisher: Cancer Information Group
DOI: 10.1016/j.clcc.2017.01.004

Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case

Author(s): Erika Martinelli, Teresa Troiani, Vincenzo Sforza, Giulia Martini, Claudia Cardone, Pietro Paolo Vitiello, Davide Ciardiello, Anna Maria Rachiglio, Nicola Normanno, Andrea Sartore-Bianchi, Silvia Marsoni, Alberto Bardelli, Salvatore Siena, Fortunato Ciardiello
Published in: ESMO Open, Issue 3/1, 2018, Page(s) e000299, ISSN 2059-7029
Publisher: BJM
DOI: 10.1136/esmoopen-2017-000299

Genotyping tumour DNA in cerebrospinal fluid and plasma of a HER2-positive breast cancer patient with brain metastases

Author(s): Giulia Siravegna, Elena Geuna, Benedetta Mussolin, Giovanni Crisafulli, Alice Bartolini, Danilo Galizia, Laura Casorzo, Ivana Sarotto, Maurizio Scaltriti, Anna Sapino, Alberto Bardelli, Filippo Montemurro
Published in: ESMO Open, Issue 2/4, 2017, Page(s) e000253, ISSN 2059-7029
Publisher: BJM
DOI: 10.1136/esmoopen-2017-000253

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Author(s): Mariangela Russo, Simona Lamba, Annalisa Lorenzato, Alberto Sogari, Giorgio Corti, Giuseppe Rospo, Benedetta Mussolin, Monica Montone, Luca Lazzari, Sabrina Arena, Daniele Oddo, Michael Linnebacher, Andrea Sartore-Bianchi, Filippo Pietrantonio, Salvatore Siena, Federica Di Nicolantonio, Alberto Bardelli
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04506-z

Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer

Author(s): S Siena, A Sartore-Bianchi, S Marsoni, H I Hurwitz, S J McCall, F Penault-Llorca, S Srock, A Bardelli, L Trusolino
Published in: Annals of Oncology, Issue 29/5, 2018, Page(s) 1108-1119, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdy100

Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer

Author(s): S Siena, A Sartore-Bianchi, R Garcia-Carbonero, M Karthaus, D Smith, J Tabernero, E Van Cutsem, X Guan, M Boedigheimer, A Ang, B Twomey, B A Bach, A S Jung, A Bardelli
Published in: Annals of Oncology, Issue 29/1, 2017, Page(s) 119-126, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdx504

Toxicity of oxaliplatin rechallenge in metastatic colorectal cancer

Author(s): G Mauri, K Bencardino, A Sartore-Bianchi, S Siena
Published in: Annals of Oncology, Issue 29/10, 2018, Page(s) 2143-2144, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdy306

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers

Author(s): Sjors In ’t Veld, Kim Duong, Mireille Snel, Anke Witteveen, Inès Beumer, Leonie Delahaye, Diederik Wehkamp, René Bernards, Annuska Glas, Sun Tian
Published in: High-Throughput, Issue 6/4, 2017, Page(s) 16, ISSN 2571-5135
Publisher: MDPI
DOI: 10.3390/ht6040016

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

Author(s): Giovanni Germano, Gianluca Mauri, Giulia Siravegna, Caroline Dive, Jackie Pierce, Federica Di Nicolantonio, Maurizio D'Incalci, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Published in: Clinical Colorectal Cancer, Issue 17/1, 2018, Page(s) 80-83, ISSN 1533-0028
Publisher: Cancer Information Group
DOI: 10.1016/j.clcc.2017.10.017

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Author(s): Daniele Oddo, Giulia Siravegna, Annunziata Gloghini, Claudio Vernieri, Benedetta Mussolin, Federica Morano, Giovanni Crisafulli, Rosa Berenato, Giorgio Corti, Chiara Costanza Volpi, Michela Buscarino, Monica Niger, Philip D Dunne, Giuseppe Rospo, Emanuele Valtorta, Alice Bartolini, Giovanni Fucà, Simona Lamba, Antonia Martinetti, Maria Di Bartolomeo, Filippo de Braud, Alberto Bardelli, Filippo Pi
Published in: British Journal of Cancer, Issue 117/3, 2017, Page(s) 347-352, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/bjc.2017.196

Preclinical models for precision oncology

Author(s): Maider Ibarrola-Villava, Andrés Cervantes, Alberto Bardelli
Published in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Issue 1870/2, 2018, Page(s) 239-246, ISSN 0304-419X
Publisher: Elsevier BV
DOI: 10.1016/j.bbcan.2018.06.004

Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience

Author(s): Andrea Sartore-Bianchi, Alessio Amatu, Erica Bonazzina, Stefano Stabile, Laura Giannetta, Giulio Cerea, Ilaria Schiavetto, Katia Bencardino, Chiara Funaioli, Riccardo Ricotta, Tiziana Cipani, Michele Schirru, Valentina Gambi, Laura Palmeri, Giulia Carlo-Stella, Francesca Rusconi, Sara Di Bella, Giovanni Burrafato, Andrea Cassingena, Emanuele Valtorta, Calogero Lauricella, Federica Pazzi, Alessandr
Published in: Targeted Oncology, Issue 12/4, 2017, Page(s) 525-533, ISSN 1776-2596
Publisher: Springer Verlag
DOI: 10.1007/s11523-017-0505-6

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study)

Author(s): Riccardo Ricotta, Antonella Verrioli, Silvia Ghezzi, Luca Porcu, A Grothey, Alfredo Falcone, Eric Van Cutsem, Guillem Argilés, Antoine Adenis, Marc Ychou, Carlo Barone, Olivier Bouché, Marc Peeters, Yves Humblet, Laurent Mineur, Alberto F Sobrero, Joleen M Hubbard, Chiara Cremolini, Hans Prenen, Josep Tabernero, Hajer Jarraya, Thibault Mazard, Sophie Deguelte-Lardiere, Konstantinos Papadimitriou
Published in: ESMO Open, Issue 1/6, 2017, Page(s) e000111, ISSN 2059-7029
Publisher: BMJ
DOI: 10.1136/esmoopen-2016-000111

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib

Author(s): Alessio Amatu, Marta Schirripa, Federica Tosi, Sara Lonardi, Katia Bencardino, Erica Bonazzina, Laura Palmeri, Damiano Alfio Patanè, Elio Gregory Pizzutilo, Benedetta Mussolin, Francesca Bergamo, Giulia Alberti, Rossana Intini, Letizia Procaccio, Marco Arese, Silvia Marsoni, Michele Nichelatti, Vittorina Zagonel, Salvatore Siena, Alberto Bardelli, Fotios Loupakis, Federica Di Nicolantonio, Andrea
Published in: Frontiers in Oncology, Issue 9, 2019, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00622

Plasma HER2 ( ERBB2 ) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

Author(s): Giulia Siravegna, Andrea Sartore-Bianchi, Rebecca J. Nagy, Kanwal Raghav, Justin I. Odegaard, Richard B. Lanman, Livio Trusolino, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
Published in: Clinical Cancer Research, Issue 25/10, 2019, Page(s) 3046-3053, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3389

Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases

Author(s): J Seoane, L De Mattos-Arruda, E Le Rhun, A Bardelli, M Weller
Published in: Annals of Oncology, Issue 30/2, 2018, Page(s) 211-218, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdy544

Failure is not final: ctDNA-guided rechallenge therapy in colorectal cancer

Author(s): G Siravegna, A Bardelli
Published in: Annals of Oncology, Issue 30/2, 2018, Page(s) 157-159, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdy525

How liquid biopsies can change clinical practice in oncology

Author(s): G Siravegna, B Mussolin, T Venesio, S Marsoni, J Seoane, C Dive, N Papadopoulos, S Kopetz, R B Corcoran, L L Siu, A Bardelli
Published in: Annals of Oncology, 2019, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdz227

New clinical trial designs in the era of precision medicine

Author(s): Elena Garralda, Rodrigo Dienstmann, Alejandro Piris-Giménez, Irene Braña, Jordi Rodon, Josep Tabernero
Published in: Molecular Oncology, Issue 13/3, 2019, Page(s) 549-557, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12465

Early-onset colorectal cancer in young individuals

Author(s): Gianluca Mauri, Andrea Sartore-Bianchi, Antonio-Giampiero Russo, Silvia Marsoni, Alberto Bardelli, Salvatore Siena
Published in: Molecular Oncology, Issue 13/2, 2019, Page(s) 109-131, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12417

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

Author(s): Aparna R. Parikh, Ignaty Leshchiner, Liudmila Elagina, Lipika Goyal, Chaya Levovitz, Giulia Siravegna, Dimitri Livitz, Kahn Rhrissorrakrai, Elizabeth E. Martin, Emily E. Van Seventer, Megan Hanna, Kara Slowik, Filippo Utro, Christopher J. Pinto, Alicia Wong, Brian P. Danysh, Ferran Fece de la Cruz, Isobel J. Fetter, Brandon Nadres, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffr
Published in: Nature Medicine, Issue 25/9, 2019, Page(s) 1415-1421, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0561-9

The Clinical Impact of the Genomic Landscape of Mismatch Repair–Deficient Cancers

Author(s): Giovanni Germano, Nabil Amirouchene-Angelozzi, Giuseppe Rospo, Alberto Bardelli
Published in: Cancer Discovery, Issue 8/12, 2018, Page(s) 1518-1528, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-18-0150

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Author(s): Luca Lazzari, Giorgio Corti, Gabriele Picco, Claudio Isella, Monica Montone, Pamela Arcella, Erika Durinikova, Eugenia R. Zanella, Luca Novara, Fabiane Barbosa, Andrea Cassingena, Carlotta Cancelliere, Enzo Medico, Andrea Sartore-Bianchi, Salvatore Siena, Mathew J. Garnett, Andrea Bertotti, Livio Trusolino, Federica Di Nicolantonio, Michael Linnebacher, Alberto Bardelli, Sabrina Arena
Published in: Clinical Cancer Research, Issue 25/20, 2019, Page(s) 6243-6259, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3440

Exploiting DNA repair defects in colorectal cancer

Author(s): Nicole M. Reilly, Luca Novara, Federica Di Nicolantonio, Alberto Bardelli
Published in: Molecular Oncology, Issue 13/4, 2019, Page(s) 681-700, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12467

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

Author(s): Giorgio Corti, Alice Bartolini, Giovanni Crisafulli, Luca Novara, Giuseppe Rospo, Monica Montone, Carola Negrino, Benedetta Mussolin, Michela Buscarino, Claudio Isella, Ludovic Barault, Giulia Siravegna, Salvatore Siena, Silvia Marsoni, Federica Di Nicolantonio, Enzo Medico, Alberto Bardelli
Published in: Clinical Colorectal Cancer, Issue 18/2, 2019, Page(s) 91-101.e3, ISSN 1533-0028
Publisher: Cancer Information Group
DOI: 10.1016/j.clcc.2019.02.008

Inactivation of DNA repair—prospects for boosting cancer immune surveillance

Author(s): Anna Truini, Giovanni Germano, Alberto Bardelli
Published in: Genome Medicine, Issue 10/1, 2018, Page(s) 91, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-018-0603-9

HER2 Positivity Predicts Unresponsiveness to EGFR‐Targeted Treatment in Metastatic Colorectal Cancer

Author(s): Andrea Sartore‐Bianchi, Alessio Amatu, Luca Porcu, Silvia Ghezzi, Sara Lonardi, Francesco Leone, Francesca Bergamo, Elisabetta Fenocchio, Erika Martinelli, Beatrice Borelli, Federica Tosi, Patrizia Racca, Emanuele Valtorta, Emanuela Bonoldi, Cosimo Martino, Caterina Vaghi, Giovanna Marrapese, Fortunato Ciardiello, Vittorina Zagonel, Alberto Bardelli, Livio Trusolino, Valter Torri, Silvia Marsoni
Published in: The Oncologist, Issue 24/10, 2019, Page(s) 1395-1402, ISSN 1083-7159
Publisher: AlphaMed Press Inc
DOI: 10.1634/theoncologist.2018-0785

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Author(s): Giuseppe Rospo, Annalisa Lorenzato, Nabil Amirouchene-Angelozzi, Alessandro Magrì, Carlotta Cancelliere, Giorgio Corti, Carola Negrino, Vito Amodio, Monica Montone, Alice Bartolini, Ludovic Barault, Luca Novara, Claudio Isella, Enzo Medico, Andrea Bertotti, Livio Trusolino, Giovanni Germano, Federica Di Nicolantonio, Alberto Bardelli
Published in: Genome Medicine, Issue 11/1, 2019, Page(s) 42, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-019-0654-6

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

Author(s): S. Arena, G. Siravegna, B. Mussolin, J. D. Kearns, B. B. Wolf, S. Misale, L. Lazzari, A. Bertotti, L. Trusolino, A. A. Adjei, C. Montagut, F. Di Nicolantonio, R. Nering, A. Bardelli
Published in: Science Translational Medicine, Issue 8/324, 2016, Page(s) 324ra14-324ra14, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aad5640

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

Author(s): D. Oddo, E. M. Sennott, L. Barault, E. Valtorta, S. Arena, A. Cassingena, G. Filiciotto, G. Marzolla, E. Elez, R. M. J. M. van Geel, A. Bartolini, G. Crisafulli, V. Boscaro, J. T. Godfrey, M. Buscarino, C. Cancelliere, M. Linnebacher, G. Corti, M. Truini, G. Siravegna, J. Grasselli, M. Gallicchio, R. Bernards, J. H. M. Schellens, J. Tabernero, J. A. Engelman, A. Sartore-Bianchi, A. Bardelli, S. Si
Published in: Cancer Research, Issue 76/15, 2016, Page(s) 4504-4515, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-16-0396

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer

Author(s): Filippo Pietrantonio, Claudio Vernieri, Giulia Siravegna, Alessia Mennitto, Rosa Berenato, Federica Perrone, Annunziata Gloghini, Elena Tamborini, Sara Lonardi, Federica Morano, Benedetta Picciani, Adele Busico, Chiara Costanza Volpi, Antonia Martinetti, Francesca Battaglin, Ilaria Bossi, Alessio Pellegrinelli, Massimo Milione, Chiara Cremolini, Maria Di Bartolomeo, Alberto Bardelli, Filippo de Br
Published in: Clinical Cancer Research, Issue 23/10, 2017, Page(s) 2414-2422, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-16-1863

Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer

Author(s): A. Amatu, L. Barault, C. Moutinho, A. Cassingena, K. Bencardino, S. Ghezzi, L. Palmeri, E. Bonazzina, F. Tosi, R. Ricotta, T. Cipani, P. Crivori, R. Gatto, G. Chirico, G. Marrapese, M. Truini, A. Bardelli, M. Esteller, F. Di Nicolantonio, A. Sartore-Bianchi, S. Siena
Published in: Annals of Oncology, Issue 27/6, 2016, Page(s) 1062-1067, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdw071

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers

Author(s): Takeo Fujii, Afsaneh Barzi, Andrea Sartore-Bianchi, Andrea Cassingena, Giulia Siravegna, Daniel D. Karp, Sarina A. Piha-Paul, Vivek Subbiah, Apostolia M. Tsimberidou, Helen J. Huang, Silvio Veronese, Federica Di Nicolantonio, Sandeep Pingle, Cecile Rose T. Vibat, Saege Hancock, David Berz, Vladislava O. Melnikova, Mark G. Erlander, Rajyalakshmi Luthra, E. Scott Kopetz, Funda Meric-Bernstam, Salvat
Published in: Clinical Cancer Research, 2017, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-16-2592

Liquid Biopsies, What We Do Not Know (Yet)

Author(s): Alberto Bardelli, Klaus Pantel
Published in: Cancer Cell, Issue 31/2, 2017, Page(s) 172-179, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2017.01.002

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Author(s): Beth O. Van Emburgh, Sabrina Arena, Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Giorgio Corti, Benedetta Mussolin, Federica Baldi, Michela Buscarino, Alice Bartolini, Emanuele Valtorta, Joana Vidal, Beatriz Bellosillo, Giovanni Germano, Filippo Pietrantonio, Agostino Ponzetti, Joan Albanell, Salvatore Siena, Andrea Sartore-Bianchi, Federica Di Nicolantonio, Clara Montagut, Alberto Bardell
Published in: Nature Communications, Issue 7, 2016, Page(s) 13665, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13665

Integrating liquid biopsies into the management of cancer

Author(s): Giulia Siravegna, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
Published in: Nature Reviews Clinical Oncology, 2017, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/nrclinonc.2017.14

Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies

Author(s): Mariangela Russo, Alberto Bardelli
Published in: Cold Spring Harbor Perspectives in Medicine, Issue 7/2, 2017, Page(s) a029587, ISSN 2157-1422
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a029587

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

Author(s): Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar, Josep Tabernero
Published in: Nature Reviews Cancer, Issue 17/2, 2017, Page(s) 79-92, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/nrc.2016.126

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor

Author(s): G. Siravegna, A. Sartore-Bianchi, B. Mussolin, A. Cassingena, A. Amatu, L. Novara, M. Buscarino, G. Corti, G. Crisafulli, A. Bartolini, F. Tosi, M. Erlander, F. Di Nicolantonio, S. Siena, A. Bardelli
Published in: Annals of Oncology, 2017, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdx095

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

Author(s): Gabriele Picco, Consalvo Petti, Alessia Centonze, Erica Torchiaro, Giovanni Crisafulli, Luca Novara, Andrea Acquaviva, Alberto Bardelli, Enzo Medico
Published in: EMBO Molecular Medicine, Issue 9/3, 2017, Page(s) 293-303, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201606773

Liquid biopsy for rectal cancer: A systematic review

Author(s): Daniela Massihnia, Elio Gregory Pizzutilo, Alessio Amatu, Federica Tosi, Silvia Ghezzi, Katia Bencardino, Pietro Di Masi, Elena Righetti, Giorgio Patelli, Francesco Scaglione, Angelo Vanzulli, Salvatore Siena, Andrea Sartore-Bianchi
Published in: Cancer Treatment Reviews, Issue 79, 2019, Page(s) 101893, ISSN 0305-7372
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2019.101893

Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients

Author(s): Giovanni Crisafulli, Benedetta Mussolin, Andrea Cassingena, Monica Montone,Alice Bartolini,Ludovic Barault, Antonia Martinetti,Federica Morano , Filippo Pietrantonio, Andrea Sartore-Bianchi, Salvatore Siena , Federica Di Nicolantonio, Silvia Marsoni, Alberto Bardelli, Giulia Siravegna
Published in: ESMO Open, 2019, ISSN 2059-7029
Publisher: BMJ Publishing Group
DOI: 10.1136/esmoopen-2019-000572

TRKA expression and NTRK1 gene copy number across solid tumours

Author(s): Gianluca Mauri, Emanuele Valtorta, Giulio Cerea, Alessio Amatu, Michele Schirru, Giovanna Marrapese, Vincenzo Fiorillo, Patrizia Recchimuzzo, Ivana Stella Cavenago, Erica Francesca Bonazzina, Valentina Motta, Calogero Lauricella, Silvio Veronese, Federica Tosi, Martina Maiolani, Giuseppe Rospo, Mauro Truini, Emanuela Bonoldi, Jason Christiansen, Steven J Potts, Salvatore Siena, Andrea Sartore-Bian
Published in: Journal of Clinical Pathology, Issue 71/10, 2018, Page(s) 926-931, ISSN 0021-9746
Publisher: BMJ Publishing Group
DOI: 10.1136/jclinpath-2018-205124

Low miR200c expression in tumor budding of invasive front predicts worse survival in patients with localized colon cancer and is related to PD-L1 overexpression

Author(s): Carolina Martinez-Ciarpaglini, Sara Oltra, Susana Roselló, Desamparados Roda, Cristina Mongort, Francisca Carrasco, José Gonzalez, Francisco Santonja, Noelia Tarazona, Marisol Huerta, Alejandro Espí, Gloria Ribas, Antonio Ferrández, Samuel Navarro, Andres Cervantes
Published in: Modern Pathology, Issue 32/2, 2019, Page(s) 306-313, ISSN 0893-3952
Publisher: Nature Publishing Group
DOI: 10.1038/s41379-018-0124-5

Molecular Subtypes and the Evolution of Treatment Decisions in Metastatic Colorectal Cancer

Author(s): Rodrigo Dienstmann, Ramon Salazar, Josep Tabernero
Published in: American Society of Clinical Oncology Educational Book, Issue 38, 2018, Page(s) 231-238, ISSN 1548-8748
Publisher: US
DOI: 10.1200/edbk_200929

Long-term Clinical Outcome of Trastuzumab and Lapatinib for HER2-positive Metastatic Colorectal Cancer

Author(s): Federica Tosi, Andrea Sartore-Bianchi, Sara Lonardi, Alessio Amatu, Francesco Leone, Silvia Ghezzi, Cosimo Martino, Katia Bencardino, Erica Bonazzina, Francesca Bergamo, Elisabetta Fenocchio, Erika Martinelli, Teresa Troiani, Giulia Siravegna, Gianluca Mauri, Valter Torri, Giovanna Marrapese, Emanuele Valtorta, Andrea Cassingena, Giovanni Cappello, Emanuela Bonoldi, Angelo Vanzulli, Daniele Regge,
Published in: Clinical Colorectal Cancer, Issue 19/4, 2020, Page(s) 256-262.e2, ISSN 1533-0028
Publisher: Cancer Information Group
DOI: 10.1016/j.clcc.2020.06.009

Combined Low Densities of FoxP3 + and CD3 + Tumor-Infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression

Author(s): Tommaso Cavalleri, Paolo Bianchi, Gianluca Basso, Giuseppe Celesti, Fabio Grizzi, Paola Bossi, Luana Greco, Calogero Pitrone, Emanuele Valtorta, Gianluca Mauri, Mauro Truini, Filippo Gustavo Dall'Olio, Giovanni Brandi, Andrea Sartore-Bianchi, Luigi Ricciardiello, Valter Torri, Lorenza Rimassa, Salvatore Siena, Alberto Mantovani, Alberto Malesci, Luigi Laghi
Published in: Cancer Immunology Research, Issue 7/5, 2019, Page(s) 751-758, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-18-0661

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