Molecularly guided trials with specific treatment strategies in patients with advanced newly molecular defined subtypes of colorectal cancer (MoTriColor)

Rezultaty

Submission of scientific paper for publication and thereby bringing trial results into the public domain CT3

After collection of all clinical data and data cleaning a scientific report will be delivered and submitted to a peer-reviewed journal to make all data available in the public domain.

Construction of a website portal

To be updated until the end of the project.

Communication plan and tools

A plan for dissemination that includes the communication objectives, target audiences, activities to be carried out and tools that will support their implementation, with connections among these components.

Submission of scientific paper for publication and thereby bringing trial results into the public domain CT2

After collection of all clinical data and data cleaning a scientific report will be delivered and submitted to a peer-reviewed journal to make all data available in the public domain.

Clinical Trial 1 EUDRA CT

Registry of the Clinical Trial 1 in the European Union Clinical Trials Register

Clinical Trial 2 EUDRA CT

Registry of the Clinical Trial 2 in the European Union Clinical Trials Register

Clinical Trial 3 EUDRA CT

Registry of the Clinical Trial 3 in the European Union Clinical Trials Register

Publikacje

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Autorzy: Sabrina Arena, Giorgio Corti, Erika Durinikova, Monica Montone, Nicole M. Reilly, Mariangela Russo, Annalisa Lorenzato, Pamela Arcella, Luca Lazzari, Giuseppe Rospo, Massimiliano Pagani, Carlotta Cancelliere, Carola Negrino, Claudio Isella, Alice Bartolini, Andrea Cassingena, Alessio Amatu, Gianluca Mauri, Andrea Sartore-Bianchi, Gloria Mittica, Enzo Medico, Silvia Marsoni, Michael Linnebacher, Se
Opublikowane w: Clinical Cancer Research, Numer 26/6, 2020, Strona(/y) 1372-1384, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-2409

The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review

Autorzy: Roberta Lombardo, Federica Tosi, Annunziata Nocerino, Katia Bencardino, Valentina Gambi, Riccardo Ricotta, Francesco Spina, Salvatore Siena, Andrea Sartore-Bianchi
Opublikowane w: Frontiers in Oncology, Numer 10, 2020, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00533

The liquid biopsy in the management of colorectal cancer patients: Current applications and future scenarios

Autorzy: Nicola Normanno, Andres Cervantes, Fortunato Ciardiello, Antonella De Luca, Carmine Pinto
Opublikowane w: Cancer Treatment Reviews, Numer 70, 2018, Strona(/y) 1-8, ISSN 0305-7372
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2018.07.007

Entrectinib approval by EMA reinforces options for ROS1 and tumour agnostic NTRK targeted cancer therapies

Autorzy: Elena Ardini, Salvatore Siena
Opublikowane w: ESMO Open, Numer 5/5, 2020, Strona(/y) e000867, ISSN 2059-7029
Wydawca: Cancer Epidemiology
DOI: 10.1136/esmoopen-2020-000867

Adaptive mutability of colorectal cancers in response to targeted therapies

Autorzy: Russo M.; Crisafulli G.; Sogari A.; Reilly N.M.; Arena S.; Lamba S.; Bartolini A.; Amodio V.; Magri A.; Novara L.; Sarotto I.; Nagel Z.D.; Piett C.G.; Amatu A.; Sartore-Bianchi A.; Siena S.; Bertotti A.; Trusolino L.; Corigliano M.; Gherardi M.; Lagomarsino M.C.; Nicolantonio F.D.; Bardelli A.
Opublikowane w: Science, 2019, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aav4474

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer

Autorzy: Annalisa Lorenzato, Alessandro Magrì, Vittoria Matafora, Valentina Audrito, Pamela Arcella, Luca Lazzari, Monica Montone, Simona Lamba, Silvia Deaglio, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Angela Bachi, Federica Di Nicolantonio, Alberto Bardelli, Sabrina Arena
Opublikowane w: Cancers, Numer 12/3, 2020, Strona(/y) 685, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030685

Increased incidence of colon cancer among individuals younger than 50 years: A 17 years analysis from the cancer registry of the municipality of Milan, Italy

Autorzy: A.Grusso; A.Andreano, A.Sartore-Bianchi, G.Mauri, A.Decarli, S.Siena
Opublikowane w: Cancer Epidemiology, 2019, ISSN 1877-7821
Wydawca: Elsevier BV
DOI: 10.1016/j.canep.2019.03.015

High-dose vitamin C enhances cancer immunotherapy

Autorzy: Alessandro Magrì, Giovanni Germano, Annalisa Lorenzato, Simona Lamba, Rosaria Chilà, Monica Montone, Vito Amodio, Tommaso Ceruti, Francesco Sassi, Sabrina Arena, Sergio Abrignani, Maurizio D’Incalci, Massimo Zucchetti, Federica Di Nicolantonio, Alberto Bardelli
Opublikowane w: Science Translational Medicine, Numer 12/532, 2020, Strona(/y) eaay8707, ISSN 1946-6234
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aay8707

Breaking Barriers in HER2+ Cancers

Autorzy: Salvatore Siena, Silvia Marsoni, Andrea Sartore-Bianchi
Opublikowane w: Cancer Cell, Numer 38/3, 2020, Strona(/y) 317-319, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2020.07.012

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses

Autorzy: Clara Montagut, Guillem Argilés, Fortunato Ciardiello, Thomas T. Poulsen, Rodrigo Dienstmann, Michael Kragh, Scott Kopetz, Trine Lindsted, Cliff Ding, Joana Vidal, Jenifer Clausell-Tormos, Giulia Siravegna, Francisco J. Sánchez-Martín, Klaus Koefoed, Mikkel W. Pedersen, Michael M. Grandal, Mikhail Dvorkin, Lucjan Wyrwicz, Ana Rovira, Antonio Cubillo, Ramon Salazar, Françoise Desseigne, Cristin
Opublikowane w: JAMA Oncology, Numer 4/4, 2018, Strona(/y) e175245, ISSN 2374-2437
Wydawca: JAMA Oncol
DOI: 10.1001/jamaoncol.2017.5245

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Autorzy: Giovanni Germano, Simona Lamba, Giuseppe Rospo, Ludovic Barault, Alessandro Magrì, Federica Maione, Mariangela Russo, Giovanni Crisafulli, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Federica Morano, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio D’Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi
Opublikowane w: Nature, 2017, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature24673

BRAF mutant colorectal cancer: prognosis, treatment, and new perspectives

Autorzy: E Sanz-Garcia, G Argiles, E Elez, J Tabernero
Opublikowane w: Annals of Oncology, Numer 28/11, 2017, Strona(/y) 2648-2657, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdx401

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer

Autorzy: Filippo Pietrantonio, Federica Di Nicolantonio, Alexa B Schrock, Jeeyun Lee, Sabine Tejpar, Andrea Sartore-Bianchi, Jaclyn F Hechtman, Jason Christiansen, Luca Novara, Niall Tebbutt, Giovanni Fucà, Carlotta Antoniotti, Seung Tae Kim, Danielle Murphy, Rosa Berenato, Federica Morano, James Sun, Bosun Min, Philip J Stephens, Marissa Chen, Luca Lazzari, Vincent A Miller, Robert Shoemaker, Alessio Ama
Opublikowane w: JNCI: Journal of the National Cancer Institute, Numer 109/12, 2017, ISSN 0027-8874
Wydawca: Oxford University Press
DOI: 10.1093/jnci/djx089

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

Autorzy: Ludovic Barault, Alessio Amatu, Giulia Siravegna, Agostino Ponzetti, Sebastian Moran, Andrea Cassingena, Benedetta Mussolin, Chiara Falcomatà, Alexandra M Binder, Carmen Cristiano, Daniele Oddo, Simonetta Guarrera, Carlotta Cancelliere, Sara Bustreo, Katia Bencardino, Sean Maden, Alice Vanzati, Patrizia Zavattari, Giuseppe Matullo, Mauro Truini, William M Grady, Patrizia Racca, Karin B Michels, S
Opublikowane w: Gut, Numer 67/11, 2018, Strona(/y) 1995-2005, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-313372

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo

Autorzy: Sara Mainardi, Antonio Mulero-Sánchez, Anirudh Prahallad, Giovanni Germano, Astrid Bosma, Paul Krimpenfort, Cor Lieftink, Jeffrey D. Steinberg, Niels de Wit, Samuel Gonçalves-Ribeiro, Ernest Nadal, Alberto Bardelli, Alberto Villanueva, Rene Bernards
Opublikowane w: Nature Medicine, Numer 24/7, 2018, Strona(/y) 961-967, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-018-0023-9

Tracking colorectal cancer evolution in time and space

Autorzy: G. Rospo, G. Corti, G. Crisafulli, L. Novara, A. Bardelli
Opublikowane w: Annals of Oncology, Numer 28/6, 2017, Strona(/y) 1163-1165, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdx127

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Autorzy: Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Andrea Sartore-Bianchi, Benedetta Mussolin, Andrea Cassingena, Cosimo Martino, Richard B. Lanman, Rebecca J. Nagy, Stephen Fairclough, Giuseppe Rospo, Giorgio Corti, Alice Bartolini, Pamela Arcella, Monica Montone, Francesca Lodi, Annalisa Lorenzato, Alice Vanzati, Emanuele Valtorta, Giovanni Cappello, Andrea Bertotti, Sara Lonardi, Vittorina Za
Opublikowane w: Cancer Cell, Numer 34/1, 2018, Strona(/y) 148-162.e7, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2018.06.004

Tumor Evolution as a Therapeutic Target

Autorzy: Nabil Amirouchene-Angelozzi, Charles Swanton, Alberto Bardelli
Opublikowane w: Cancer Discovery, Numer 7/8, 2017, Strona(/y) 805-817, ISSN 2159-8274
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.CD-17-0343

Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis

Autorzy: Federica Tosi, Elena Magni, Alessio Amatu, Gianluca Mauri, Katia Bencardino, Mauro Truini, Silvio Veronese, Luciano De Carlis, Giovanni Ferrari, Michele Nichelatti, Andrea Sartore-Bianchi, Salvatore Siena
Opublikowane w: Clinical Colorectal Cancer, Numer 16/3, 2017, Strona(/y) e153-e163, ISSN 1533-0028
Wydawca: Cancer Information Group
DOI: 10.1016/j.clcc.2017.01.004

Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case

Autorzy: Erika Martinelli, Teresa Troiani, Vincenzo Sforza, Giulia Martini, Claudia Cardone, Pietro Paolo Vitiello, Davide Ciardiello, Anna Maria Rachiglio, Nicola Normanno, Andrea Sartore-Bianchi, Silvia Marsoni, Alberto Bardelli, Salvatore Siena, Fortunato Ciardiello
Opublikowane w: ESMO Open, Numer 3/1, 2018, Strona(/y) e000299, ISSN 2059-7029
Wydawca: BJM
DOI: 10.1136/esmoopen-2017-000299

Genotyping tumour DNA in cerebrospinal fluid and plasma of a HER2-positive breast cancer patient with brain metastases

Autorzy: Giulia Siravegna, Elena Geuna, Benedetta Mussolin, Giovanni Crisafulli, Alice Bartolini, Danilo Galizia, Laura Casorzo, Ivana Sarotto, Maurizio Scaltriti, Anna Sapino, Alberto Bardelli, Filippo Montemurro
Opublikowane w: ESMO Open, Numer 2/4, 2017, Strona(/y) e000253, ISSN 2059-7029
Wydawca: BJM
DOI: 10.1136/esmoopen-2017-000253

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Autorzy: Mariangela Russo, Simona Lamba, Annalisa Lorenzato, Alberto Sogari, Giorgio Corti, Giuseppe Rospo, Benedetta Mussolin, Monica Montone, Luca Lazzari, Sabrina Arena, Daniele Oddo, Michael Linnebacher, Andrea Sartore-Bianchi, Filippo Pietrantonio, Salvatore Siena, Federica Di Nicolantonio, Alberto Bardelli
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-04506-z

Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer

Autorzy: S Siena, A Sartore-Bianchi, S Marsoni, H I Hurwitz, S J McCall, F Penault-Llorca, S Srock, A Bardelli, L Trusolino
Opublikowane w: Annals of Oncology, Numer 29/5, 2018, Strona(/y) 1108-1119, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdy100

Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer

Autorzy: S Siena, A Sartore-Bianchi, R Garcia-Carbonero, M Karthaus, D Smith, J Tabernero, E Van Cutsem, X Guan, M Boedigheimer, A Ang, B Twomey, B A Bach, A S Jung, A Bardelli
Opublikowane w: Annals of Oncology, Numer 29/1, 2017, Strona(/y) 119-126, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdx504

Toxicity of oxaliplatin rechallenge in metastatic colorectal cancer

Autorzy: G Mauri, K Bencardino, A Sartore-Bianchi, S Siena
Opublikowane w: Annals of Oncology, Numer 29/10, 2018, Strona(/y) 2143-2144, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdy306

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers

Autorzy: Sjors In ’t Veld, Kim Duong, Mireille Snel, Anke Witteveen, Inès Beumer, Leonie Delahaye, Diederik Wehkamp, René Bernards, Annuska Glas, Sun Tian
Opublikowane w: High-Throughput, Numer 6/4, 2017, Strona(/y) 16, ISSN 2571-5135
Wydawca: MDPI
DOI: 10.3390/ht6040016

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

Autorzy: Giovanni Germano, Gianluca Mauri, Giulia Siravegna, Caroline Dive, Jackie Pierce, Federica Di Nicolantonio, Maurizio D'Incalci, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Opublikowane w: Clinical Colorectal Cancer, Numer 17/1, 2018, Strona(/y) 80-83, ISSN 1533-0028
Wydawca: Cancer Information Group
DOI: 10.1016/j.clcc.2017.10.017

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Autorzy: Daniele Oddo, Giulia Siravegna, Annunziata Gloghini, Claudio Vernieri, Benedetta Mussolin, Federica Morano, Giovanni Crisafulli, Rosa Berenato, Giorgio Corti, Chiara Costanza Volpi, Michela Buscarino, Monica Niger, Philip D Dunne, Giuseppe Rospo, Emanuele Valtorta, Alice Bartolini, Giovanni Fucà, Simona Lamba, Antonia Martinetti, Maria Di Bartolomeo, Filippo de Braud, Alberto Bardelli, Filippo Pi
Opublikowane w: British Journal of Cancer, Numer 117/3, 2017, Strona(/y) 347-352, ISSN 0007-0920
Wydawca: Nature Publishing Group
DOI: 10.1038/bjc.2017.196

Preclinical models for precision oncology

Autorzy: Maider Ibarrola-Villava, Andrés Cervantes, Alberto Bardelli
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Numer 1870/2, 2018, Strona(/y) 239-246, ISSN 0304-419X
Wydawca: Elsevier BV
DOI: 10.1016/j.bbcan.2018.06.004

Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience

Autorzy: Andrea Sartore-Bianchi, Alessio Amatu, Erica Bonazzina, Stefano Stabile, Laura Giannetta, Giulio Cerea, Ilaria Schiavetto, Katia Bencardino, Chiara Funaioli, Riccardo Ricotta, Tiziana Cipani, Michele Schirru, Valentina Gambi, Laura Palmeri, Giulia Carlo-Stella, Francesca Rusconi, Sara Di Bella, Giovanni Burrafato, Andrea Cassingena, Emanuele Valtorta, Calogero Lauricella, Federica Pazzi, Alessandr
Opublikowane w: Targeted Oncology, Numer 12/4, 2017, Strona(/y) 525-533, ISSN 1776-2596
Wydawca: Springer Verlag
DOI: 10.1007/s11523-017-0505-6

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study)

Autorzy: Riccardo Ricotta, Antonella Verrioli, Silvia Ghezzi, Luca Porcu, A Grothey, Alfredo Falcone, Eric Van Cutsem, Guillem Argilés, Antoine Adenis, Marc Ychou, Carlo Barone, Olivier Bouché, Marc Peeters, Yves Humblet, Laurent Mineur, Alberto F Sobrero, Joleen M Hubbard, Chiara Cremolini, Hans Prenen, Josep Tabernero, Hajer Jarraya, Thibault Mazard, Sophie Deguelte-Lardiere, Konstantinos Papadimitriou
Opublikowane w: ESMO Open, Numer 1/6, 2017, Strona(/y) e000111, ISSN 2059-7029
Wydawca: BMJ
DOI: 10.1136/esmoopen-2016-000111

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib

Autorzy: Alessio Amatu, Marta Schirripa, Federica Tosi, Sara Lonardi, Katia Bencardino, Erica Bonazzina, Laura Palmeri, Damiano Alfio Patanè, Elio Gregory Pizzutilo, Benedetta Mussolin, Francesca Bergamo, Giulia Alberti, Rossana Intini, Letizia Procaccio, Marco Arese, Silvia Marsoni, Michele Nichelatti, Vittorina Zagonel, Salvatore Siena, Alberto Bardelli, Fotios Loupakis, Federica Di Nicolantonio, Andrea
Opublikowane w: Frontiers in Oncology, Numer 9, 2019, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00622

Plasma HER2 ( ERBB2 ) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

Autorzy: Giulia Siravegna, Andrea Sartore-Bianchi, Rebecca J. Nagy, Kanwal Raghav, Justin I. Odegaard, Richard B. Lanman, Livio Trusolino, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
Opublikowane w: Clinical Cancer Research, Numer 25/10, 2019, Strona(/y) 3046-3053, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3389

Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases

Autorzy: J Seoane, L De Mattos-Arruda, E Le Rhun, A Bardelli, M Weller
Opublikowane w: Annals of Oncology, Numer 30/2, 2018, Strona(/y) 211-218, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdy544

Failure is not final: ctDNA-guided rechallenge therapy in colorectal cancer

Autorzy: G Siravegna, A Bardelli
Opublikowane w: Annals of Oncology, Numer 30/2, 2018, Strona(/y) 157-159, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdy525

How liquid biopsies can change clinical practice in oncology

Autorzy: G Siravegna, B Mussolin, T Venesio, S Marsoni, J Seoane, C Dive, N Papadopoulos, S Kopetz, R B Corcoran, L L Siu, A Bardelli
Opublikowane w: Annals of Oncology, 2019, ISSN 0923-7534
Wydawca: Oxford University Press
DOI: 10.1093/annonc/mdz227

New clinical trial designs in the era of precision medicine

Autorzy: Elena Garralda, Rodrigo Dienstmann, Alejandro Piris-Giménez, Irene Braña, Jordi Rodon, Josep Tabernero
Opublikowane w: Molecular Oncology, Numer 13/3, 2019, Strona(/y) 549-557, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.1002/1878-0261.12465

Early-onset colorectal cancer in young individuals

Autorzy: Gianluca Mauri, Andrea Sartore-Bianchi, Antonio-Giampiero Russo, Silvia Marsoni, Alberto Bardelli, Salvatore Siena
Opublikowane w: Molecular Oncology, Numer 13/2, 2019, Strona(/y) 109-131, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.1002/1878-0261.12417

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

Autorzy: Aparna R. Parikh, Ignaty Leshchiner, Liudmila Elagina, Lipika Goyal, Chaya Levovitz, Giulia Siravegna, Dimitri Livitz, Kahn Rhrissorrakrai, Elizabeth E. Martin, Emily E. Van Seventer, Megan Hanna, Kara Slowik, Filippo Utro, Christopher J. Pinto, Alicia Wong, Brian P. Danysh, Ferran Fece de la Cruz, Isobel J. Fetter, Brandon Nadres, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffr
Opublikowane w: Nature Medicine, Numer 25/9, 2019, Strona(/y) 1415-1421, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-019-0561-9

The Clinical Impact of the Genomic Landscape of Mismatch Repair–Deficient Cancers

Autorzy: Giovanni Germano, Nabil Amirouchene-Angelozzi, Giuseppe Rospo, Alberto Bardelli
Opublikowane w: Cancer Discovery, Numer 8/12, 2018, Strona(/y) 1518-1528, ISSN 2159-8274
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-18-0150

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Autorzy: Luca Lazzari, Giorgio Corti, Gabriele Picco, Claudio Isella, Monica Montone, Pamela Arcella, Erika Durinikova, Eugenia R. Zanella, Luca Novara, Fabiane Barbosa, Andrea Cassingena, Carlotta Cancelliere, Enzo Medico, Andrea Sartore-Bianchi, Salvatore Siena, Mathew J. Garnett, Andrea Bertotti, Livio Trusolino, Federica Di Nicolantonio, Michael Linnebacher, Alberto Bardelli, Sabrina Arena
Opublikowane w: Clinical Cancer Research, Numer 25/20, 2019, Strona(/y) 6243-6259, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3440

Exploiting DNA repair defects in colorectal cancer

Autorzy: Nicole M. Reilly, Luca Novara, Federica Di Nicolantonio, Alberto Bardelli
Opublikowane w: Molecular Oncology, Numer 13/4, 2019, Strona(/y) 681-700, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.1002/1878-0261.12467

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

Autorzy: Giorgio Corti, Alice Bartolini, Giovanni Crisafulli, Luca Novara, Giuseppe Rospo, Monica Montone, Carola Negrino, Benedetta Mussolin, Michela Buscarino, Claudio Isella, Ludovic Barault, Giulia Siravegna, Salvatore Siena, Silvia Marsoni, Federica Di Nicolantonio, Enzo Medico, Alberto Bardelli
Opublikowane w: Clinical Colorectal Cancer, Numer 18/2, 2019, Strona(/y) 91-101.e3, ISSN 1533-0028
Wydawca: Cancer Information Group
DOI: 10.1016/j.clcc.2019.02.008

Inactivation of DNA repair—prospects for boosting cancer immune surveillance

Autorzy: Anna Truini, Giovanni Germano, Alberto Bardelli
Opublikowane w: Genome Medicine, Numer 10/1, 2018, Strona(/y) 91, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-018-0603-9

HER2 Positivity Predicts Unresponsiveness to EGFR‐Targeted Treatment in Metastatic Colorectal Cancer

Autorzy: Andrea Sartore‐Bianchi, Alessio Amatu, Luca Porcu, Silvia Ghezzi, Sara Lonardi, Francesco Leone, Francesca Bergamo, Elisabetta Fenocchio, Erika Martinelli, Beatrice Borelli, Federica Tosi, Patrizia Racca, Emanuele Valtorta, Emanuela Bonoldi, Cosimo Martino, Caterina Vaghi, Giovanna Marrapese, Fortunato Ciardiello, Vittorina Zagonel, Alberto Bardelli, Livio Trusolino, Valter Torri, Silvia Marsoni
Opublikowane w: The Oncologist, Numer 24/10, 2019, Strona(/y) 1395-1402, ISSN 1083-7159
Wydawca: AlphaMed Press Inc
DOI: 10.1634/theoncologist.2018-0785

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Autorzy: Giuseppe Rospo, Annalisa Lorenzato, Nabil Amirouchene-Angelozzi, Alessandro Magrì, Carlotta Cancelliere, Giorgio Corti, Carola Negrino, Vito Amodio, Monica Montone, Alice Bartolini, Ludovic Barault, Luca Novara, Claudio Isella, Enzo Medico, Andrea Bertotti, Livio Trusolino, Giovanni Germano, Federica Di Nicolantonio, Alberto Bardelli
Opublikowane w: Genome Medicine, Numer 11/1, 2019, Strona(/y) 42, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-019-0654-6

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

Autorzy: S. Arena, G. Siravegna, B. Mussolin, J. D. Kearns, B. B. Wolf, S. Misale, L. Lazzari, A. Bertotti, L. Trusolino, A. A. Adjei, C. Montagut, F. Di Nicolantonio, R. Nering, A. Bardelli
Opublikowane w: Science Translational Medicine, Numer 8/324, 2016, Strona(/y) 324ra14-324ra14, ISSN 1946-6234
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