Objective C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project.Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners.CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints. Fields of science engineering and technologymechanical engineeringmanufacturing engineeringengineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords C-C bond forming enzymes lyases aldolases halohydrin dehalogenases enzyme engineering enzyme panels thermostabilization microreactor technical scale cascade reactions APIs bulk chemicals Programme(s) H2020-EU.2.1.4. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology Main Programme Topic(s) BIOTEC-3-2014 - Widening industrial application of enzymatic processes Call for proposal H2020-BIOTEC-2014-2015 See other projects for this call Sub call H2020-LEIT-BIO-2014-1 Funding Scheme IA - Innovation action Coordinator TECHNISCHE UNIVERSITAT DARMSTADT Net EU contribution € 1 469 606,00 Address KAROLINENPLATZ 5 64289 Darmstadt Germany See on map Region Hessen Darmstadt Darmstadt, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 469 606,25 Participants (14) Sort alphabetically Sort by Net EU contribution Expand all Collapse all AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain Net EU contribution € 1 145 190,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 145 190,00 UNIVERSIDAD AUTONOMA DE MADRID Spain Net EU contribution € 786 375,00 Address CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO 28049 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 786 375,00 TECHNISCHE UNIVERSITAET BRAUNSCHWEIG Germany Net EU contribution € 677 018,00 Address UNIVERSITAETSPLATZ 2 38106 Braunschweig See on map Region Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 677 018,75 RIJKSUNIVERSITEIT GRONINGEN Netherlands Net EU contribution € 726 452,00 Address Broerstraat 5 9712CP Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 726 452,50 SVEUCILISTE U ZAGREBU FAKULTET KEMIJSKOG INZENJERSTVA I TEHNOLOGIJE Croatia Net EU contribution € 544 260,00 Address MARULICEV TRG 19 10000 Zagreb See on map Region Hrvatska Grad Zagreb Grad Zagreb Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 544 260,00 BIOCHEMIZE SL Spain Net EU contribution € 207 987,00 Address CARRER MARIE CURIE 8 08005 Barcelona See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 297 125,00 BIO-PRODICT BV Netherlands Net EU contribution € 463 736,00 Address NIEUWE MARKTSTRAAT 54 6511 AA Nijmegen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 662 481,25 SUSTAINABLE MOMENTUM SL Spain Net EU contribution € 109 200,00 Address AVDA ALCALDE JOSE RAMIREZ BETHENCOURT 17 PLANTA 6 PUERTA B 35004 Las Palmas De Gran Canaria See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Canarias Canarias Gran Canaria Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 156 000,00 INSTITUT UNIV DE CIENCIA I TECNOLOGIA SA Spain Net EU contribution € 416 325,00 Address CALLE ALVAREZ DE CASTRO 63 08100 Mollet Del Valles See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 596 750,00 ENZYMICALS AG Germany Net EU contribution € 380 800,00 Address WALTHER-RATHENAU-STRASSE 49A 17489 Greifswald See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 544 000,00 ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germany Net EU contribution € 412 500,00 Address FAHNENBERGPLATZ 79098 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 412 500,00 PROZOMIX LIMITED United Kingdom Net EU contribution € 384 892,00 Address STATION COURT 3 NE49 9HN Haltwhistle See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region North East (England) Northumberland and Tyne and Wear Northumberland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 549 846,25 EVONIK INDUSTRIES AG Participation ended Germany Net EU contribution € 0,00 Address RELLINGHAUSER STRASSE 1-11 45128 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data EVONIK OPERATIONS GMBH Germany Net EU contribution € 478 625,00 Address RELLINGHAUSER STRASSE 1-11 45128 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 683 750,00
