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Sustainable industrial processes based on a C-C bond-forming enzyme platform

Objective

C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project.
Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners.
CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-LEIT-BIO-2014-1
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

TECHNISCHE UNIVERSITAT DARMSTADT
Address
Karolinenplatz 5
64289 Darmstadt
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 469 606

Participants (14)

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 1 145 190
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 786 375
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET BRAUNSCHWEIG
Germany
EU contribution
€ 677 018
Address
Universitaetsplatz 2
38106 Braunschweig
Activity type
Higher or Secondary Education Establishments
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 726 452
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
SVEUCILISTE U ZAGREBU FAKULTET KEMIJSKOG INZENJERSTVA I TEHNOLOGIJE
Croatia
EU contribution
€ 544 260
Address
Marulicev Trg 19
10000 Zagreb
Activity type
Higher or Secondary Education Establishments
BIOCHEMIZE SL
Spain
EU contribution
€ 207 987
Address
Carrer Marie Curie 8
08042 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIO-PRODICT BV
Netherlands
EU contribution
€ 463 736
Address
Nieuwe Marktstraat 54
6511 AA Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SUSTAINABLE MOMENTUM SL
Spain
EU contribution
€ 109 200
Address
Avda Alcalde Jose Ramirez Bethencourt 17 Planta 6 Puerta B
35004 Las Palmas De Gran Canaria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT UNIV DE CIENCIA I TECNOLOGIA SA
Spain
EU contribution
€ 416 325
Address
Calle Alvarez De Castro 63
08100 Mollet Del Valles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENZYMICALS AG
Germany
EU contribution
€ 380 800
Address
Walther-rathenau-strasse 49A
17489 Greifswald
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 412 500
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
PROZOMIX LIMITED
United Kingdom
EU contribution
€ 384 892
Address
Station Court 3
NE49 9HN Haltwhistle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EVONIK INDUSTRIES AG

Participation ended

Germany
EU contribution
€ 0
Address
Rellinghauser Strasse 1-11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EVONIK CREAVIS GMBH
Germany
EU contribution
€ 478 625
Address
Rellinghauser Strasse 1-11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)