Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity

Project Information

IDEM

Grant agreement ID: 637647

DOI

10.3030/637647

Project closed

EC signature date 10 June 2015

Start date 1 September 2015

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 454 249,99

EU contribution

€ 1 454 249,99

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (34)

Opinion: Why science needs philosophy

Author(s): Lucie Laplane, Paolo Mantovani, Ralph Adolphs, Hasok Chang, Alberto Mantovani, Margaret McFall-Ngai, Carlo Rovelli, Elliott Sober, Thomas Pradeu
Published in: Proceedings of the National Academy of Sciences, Issue 116/10, 2019, Page(s) 3948-3952, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1900357116

The vaccinologist’s “dirty little secret”: a better understanding of structure-function relationships of viral immunogens might advance rational HIV vaccine design

Author(s): Gregor P. Greslehner
Published in: Archives of Virology, 2021, ISSN 0304-8608
Publisher: Springer Verlag
DOI: 10.1007/s00705-021-04982-7

Philosophy of CRISPR-Cas: Introduction to Eugene Koonin’s target paper and commentaries

Author(s): Thomas Pradeu
Published in: Biology & Philosophy, Issue 34/1, 2019, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-018-9664-9

The visibility of philosophy of science in the sciences, 1980–2018

Author(s): Mahdi Khelfaoui, Yves Gingras, Maël Lemoine, Thomas Pradeu
Published in: Synthese, 2021, ISSN 0039-7857
Publisher: D. Reidel Pub. Co.
DOI: 10.1007/s11229-021-03067-x

The Multiple Layers of the Tumor Environment

Author(s): Lucie Laplane, Dorothée Duluc, Nicolas Larmonier, Thomas Pradeu, Andreas Bikfalvi
Published in: Trends in Cancer, Issue 4/12, 2018, Page(s) 802-809, ISSN 2405-8033
Publisher: Cell Press
DOI: 10.1016/j.trecan.2018.10.002

Not by structures alone: Can the immune system recognize microbial functions?

Author(s): Gregor P.Greslehner
Published in: Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 2020, ISSN 1369-8486
Publisher: Elsevier BV
DOI: 10.1016/j.shpsc.2020.101336

Immunology and individuality

Author(s): Thomas Pradeu
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.47384

Beyond the tumour microenvironment

Author(s): Lucie Laplane, Dorothée Duluc, Andreas Bikfalvi, Nicolas Larmonier, Thomas Pradeu
Published in: International Journal of Cancer, Issue 145/10, 2019, Page(s) 2611-2618, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32343

A dual decomposition strategy of both microbial and phenotypic components for a better understanding of causal claims

Author(s): Gregor P. Greslehner, Maël Lemoine
Published in: Biology & Philosophy, Issue 35/1, 2020, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-019-9708-9

Microbiome Structure and Function: A New Framework for Interpreting Data

Author(s): Gregor P. Greslehner
Published in: BioEssays, Issue 42/7, 2020, Page(s) 1900255, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201900255

Protective Microbiota: From Localized to Long-Reaching Co-Immunity

Author(s): Lynn Chiu, Thomas Bazin, Marie-Elise Truchetet, Thierry Schaeverbeke, Laurence Delhaes, Thomas Pradeu
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2017.01678

Immune-Mediated Repair: A Matter of Plasticity

Author(s): Paôline Laurent, Valérie Jolivel, Pauline Manicki, Lynn Chiu, Cécile Contin-Bordes, Marie-Elise Truchetet, Thomas Pradeu
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: LFrontiers Research Foundation
DOI: 10.3389/fimmu.2017.00454

Right out of the box: how to situate metaphysics of science in relation to other metaphysical approaches

Author(s): Alexandre Guay, Thomas Pradeu
Published in: Synthese, 2018, ISSN 0039-7857
Publisher: D. Reidel Pub. Co.
DOI: 10.1007/s11229-017-1576-8

Holobionts and the ecology of organisms: Multi-species communities or integrated individuals?

Author(s): Derek Skillings
Published in: Biology & Philosophy, Issue 31/6, 2016, Page(s) 875-892, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-016-9544-0

Towards a General Theory of Immunity?

Author(s): Gérard Eberl, Thomas Pradeu
Published in: Trends in Immunology, Issue 39/4, 2018, Page(s) 261-263, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2017.11.004

Immunological memory: What's in a name?

Author(s): Thomas Pradeu, Louis Du Pasquier
Published in: Immunological Reviews, Issue 283/1, 2018, Page(s) 7-20, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12652

Ontologies of Living Beings: Introduction

Author(s): A. M. Ferner, Thomas Pradeu
Published in: Philosophy, Theory, and Practice in Biology, Issue 9/20171201, 2017, ISSN 2475-3025
Publisher: Michigan Publishing
DOI: 10.3998/ptb.6959004.0009.004

Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system

Author(s): Marie-Elise Truchetet, Thomas Pradeu
Published in: Seminars in Immunology, Issue 36, 2018, Page(s) 45-55, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2018.02.013

Mutualistic viruses and the heteronomy of life

Author(s): Thomas Pradeu
Published in: Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, Issue 59, 2016, Page(s) 80-88, ISSN 1369-8486
Publisher: Elsevier BV
DOI: 10.1016/j.shpsc.2016.02.007

Methodological Strategies in Microbiome Research and their Explanatory Implications

Author(s): Maureen A. O’Malley, Derek J. Skillings
Published in: Perspectives on Science, Issue 26/2, 2018, Page(s) 239-265, ISSN 1063-6145
Publisher: University of Chicago Press
DOI: 10.1162/POSC_a_00274

Microorganisms as scaffolds of host individuality: an eco-immunity account of the holobiont

Author(s): Lynn Chiu, Gérard Eberl
Published in: Biology & Philosophy, Issue 31/6, 2016, Page(s) 819-837, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-016-9552-0

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

Author(s): Jean-Francois Moreau, Thomas Pradeu, Andrea Grignolio, Christine Nardini, Filippo Castiglione, Paolo Tieri, Miriam Capri, Stefano Salvioli, Jean-Luc Taupin, Paolo Garagnani, Claudio Franceschi
Published in: Ageing Research Reviews, Issue 35, 2017, Page(s) 322-335, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2016.11.005

Understanding viruses: Philosophical investigations

Author(s): Thomas Pradeu, Gladys Kostyrka, John Dupré
Published in: Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, Issue 59, 2016, Page(s) 57-63, ISSN 1369-8486
Publisher: Elsevier BV
DOI: 10.1016/j.shpsc.2016.02.008

Thirty years of Biology & Philosophy: philosophy of which biology?

Author(s): Thomas Pradeu
Published in: Biology & Philosophy, Issue 32/2, 2017, Page(s) 149-167, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-016-9558-7

Organisms or biological individuals? Combining physiological and evolutionary individuality

Author(s): Thomas Pradeu
Published in: Biology & Philosophy, Issue 31/6, 2016, Page(s) 797-817, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-016-9551-1

Is defining life pointless? Operational definitions at the frontiers of biology

Author(s): Leonardo Bich, Sara Green
Published in: Synthese, 2017, ISSN 0039-7857
Publisher: D. Reidel Pub. Co.
DOI: 10.1007/s11229-017-1397-9

The discontinuity theory of immunity

Author(s): Thomas Pradeu, Eric Vivier
Published in: Science Immunology, Issue 1/1, 2016, Page(s) aag0479-aag0479, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.aag0479

The many faces of biological individuality

Author(s): Thomas Pradeu
Published in: Biology & Philosophy, Issue 31/6, 2016, Page(s) 761-773, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-016-9553-z

“Microbiota, symbiosis and individuality summer school” meeting report

Author(s): Isobel Ronai, Gregor P. Greslehner, Federico Boem, Judith Carlisle, Adrian Stencel, Javier Suárez, Saliha Bayir, Wiebke Bretting, Joana Formosinho, Anna C. Guerrero, William H. Morgan, Cybèle Prigot-Maurice, Salome Rodeck, Marie Vasse, Jacqueline M. Wallis, Oryan Zacks
Published in: Microbiome, Issue 8/1, 2020, ISSN 2049-2618
Publisher: Microbiome
DOI: 10.1186/s40168-020-00898-7

Understanding Multicellularity: The Functional Organization of the Intercellular Space

Author(s): Leonardo Bich, Thomas Pradeu, Jean-François Moreau
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.01170

CRISPR-Cas immunity: beyond nonself and defence

Author(s): Pradeu, Thomas; Moreau, Jean-François
Published in: Biology and Philosophy, Issue 3, 2019, ISSN 0169-3867
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10539-018-9665-8

Characterizing causality in cancer

Author(s): Elena Rondeau, Nicolas Larmonier, Thomas Pradeu, Andreas Bikfalvi
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.53755

Dissecting the Meanings of “Physiology” to Assess the Vitality of the Discipline

Author(s): Maël Lemoine, Thomas Pradeu
Published in: Physiology, Issue 33/4, 2018, Page(s) 236-245, ISSN 1548-9213
Publisher: American Physiological Society
DOI: 10.1152/physiol.00015.2018

Constitutive immune mechanisms: mediators of host defence and immune regulation

Author(s): Søren R. Paludan, Thomas Pradeu, Seth L. Masters, Trine H. Mogensen
Published in: Nature Reviews Immunology, 2020, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-020-0391-5

Book chapters (3)

Robustness and Autonomy in Biological Systems: How Regulatory Mechanisms Enable Functional Integration, Complexity and Minimal Cognition Through the Action of Second-Order Control Constraints

Author(s): Leonardo Bich
Published in: Biological Robustness - Emerging Perspectives from within the Life Sciences, Issue 23, 2018, Page(s) 123-147, ISBN 978-3-030-01197-0
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-01198-7_6

Jean Gayon, l’histoire, la philosophie et la biologie : Une synthèse moderne

Author(s): Thomas Pradeu
Published in: Philosophie, histoire, biologie: Mélanges offerts à Jean Gayon, 2018, Page(s) 87-102, ISBN 978-2-37361-144-1
Publisher: Editions Matériologiques

Genidentity and Biological Processes

Author(s): Pradeu , Thomas
Published in: Dan Nicholson and John Dupré; Edited by Daniel J. Nicholson and John Dupré. Everything Flows: Towards a Processual Philosophy of Biology , 2018, Issue 4, 2018, ISBN 9780-198779636
Publisher: Oxford University Press
DOI: 10.1093/oso/9780198779636.001.0001

Other (1)

Life is not easily bounded

Author(s): Derek Skillings
Published in: Aeon (this magazine does not accept acknowledgments), 2017
Publisher: Aeon Media Group

Monographic books (1)

Philosophy of Immunology

Author(s): Thomas Pradeu
Published in: Elements in the Philosophy of Biology, 2019, ISBN 9781108616706
Publisher: Cambridge University Press
DOI: 10.1017/9781108616706