Stem Cells for Cardiac Arrhythmia Risk Assessment

Project Information

STEMCARDIORISK

Grant agreement ID: 638030

DOI 10.3030/638030

Project closed

EC signature date 1 October 2015

Start date 1 November 2015

End date 30 April 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

Publications

Peer reviewed articles (13)

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author(s): J. Pei, M. Schuldt, E. Nagyova, Z. Gu, S. el Bouhaddani, L. Yiangou, M. Jansen, J. J. A. Calis, L. M. Dorsch, C. Snijders Blok, N. A. M. van den Dungen, N. Lansu, B. J. Boukens, I. R. Efimov, M. Michels, M. C. Verhaar, R. de Weger, A. Vink, F. G. van Steenbeek, A. F. Baas, R. P. Davis, H. W. Uh, D. W. D. Kuster, C. Cheng, M. Mokry, J. van der Velden, F. W. Asselbergs, M. Harakalova
Published in: Clinical Epigenetics, Issue 13/1, 2021, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-021-01043-3

Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart Fails

Author(s): Loukia Yiangou, Richard P. Davis, Christine L. Mummery
Published in: Stem Cell Reports, Issue 16/3, 2021, Page(s) 385-397, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.11.003

Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells

Author(s): Giulia Campostrini, Viviana Meraviglia, Elisa Giacomelli, Ruben W. J. van Helden, Loukia Yiangou, Richard P. Davis, Milena Bellin, Valeria V. Orlova, Christine L. Mummery
Published in: Nature Protocols, Issue 16/4, 2021, Page(s) 2213-2256, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00497-2

Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies

Author(s): Karina O. Brandão, Viola A. Tabel, Douwe E. Atsma, Christine L. Mummery, Richard P. Davis
Published in: Disease Models & Mechanisms, Issue 10/9, 2017, Page(s) 1039-1059, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.030320

MUSCLEMOTIONNovelty and Significance

Author(s): Luca Sala, Berend J. van Meer, Leon G.J. Tertoolen, Jeroen Bakkers, Milena Bellin, Richard P. Davis, Chris Denning, Michel A.E. Dieben, Thomas Eschenhagen, Elisa Giacomelli, Catarina Grandela, Arne Hansen, Eduard R. Holman, Monique R.M. Jongbloed, Sarah M. Kamel, Charlotte D. Koopman, Quentin Lachaud, Ingra Mannhardt, Mervyn P.H. Mol, Diogo Mosqueira, Valeria V. Orlova, Robert Passier, Marcelo C.
Published in: Circulation Research, Issue 122/3, 2018, Page(s) e5-e16, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.312067

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Author(s): David J. Anderson, David I. Kaplan, Katrina M. Bell, Katerina Koutsis, John M. Haynes, Richard J. Mills, Dean G. Phelan, Elizabeth L. Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S. Ng, Richard P. Davis, Simona Casini, Robert Passier, James E. Hudson, Enzo R. Porrello, Mauro W. Costa, Arash Rafii, Clare L. Curl, Lea M. Delbridge, Richard P. Harvey, Alicia Oshlack, Mich
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03714-x

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes

Author(s): Verena Schwach, Arie O. Verkerk, Mervyn Mol, Jantine J. Monshouwer-Kloots, Harsha D. Devalla, Valeria V. Orlova, Konstantinos Anastassiadis, Christine L. Mummery, Richard P. Davis, Robert Passier
Published in: Stem Cell Reports, Issue 9/6, 2017, Page(s) 1765-1779, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2017.10.024

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Author(s): Berend J. van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G. J. Tertoolen, Christine L. Mummery
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12354-8

Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries

Author(s): Talip E Eroglu, Grimur H Mohr, Marieke T Blom, Arie O Verkerk, Patrick C Souverein, Christian Torp-Pedersen, Fredrik Folke, Mads Wissenberg, Lettine van den Brink, Richard P Davis, Anthonius de Boer, Gunnar H Gislason, Hanno L Tan
Published in: European Heart Journal - Cardiovascular Pharmacotherapy, 2019, ISSN 2055-6837
Publisher: Oxford University Press
DOI: 10.1093/ehjcvp/pvz038

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties

Author(s): Lettine van den Brink, Karina O. Brandão, Loukia Yiangou, Mervyn P.H. Mol, Catarina Grandela, Christine L. Mummery, Arie O. Verkerk, Richard P. Davis
Published in: Stem Cell Research, Issue 43, 2020, Page(s) 101698, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2019.101698

Concise review: Inherited cardiac diseases, pluripotent stem cells, and genome editing combined-the past, present, and future

Author(s): Lettine van den Brink, Catarina Grandela, Christine L. Mummery, Richard P. Davis
Published in: STEM CELLS, 2020, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3110

Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias

Author(s): Karina O. Brandão, Lettine van den Brink, Duncan C. Miller, Catarina Grandela, Berend J. van Meer, Mervyn P.H. Mol, Tessa de Korte, Leon G.J. Tertoolen, Christine L. Mummery, Luca Sala, Arie O. Verkerk, Richard P. Davis
Published in: Stem Cell Reports, Issue 15/5, 2020, Page(s) 1127-1139, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.10.005

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Author(s): Elisa Giacomelli, Viviana Meraviglia, Giulia Campostrini, Amy Cochrane, Xu Cao, Ruben W.J. van Helden, Ana Krotenberg Garcia, Maria Mircea, Sarantos Kostidis, Richard P. Davis, Berend J. van Meer, Carolina R. Jost, Abraham J. Koster, Hailiang Mei, David G. Míguez, Aat A. Mulder, Mario Ledesma-Terrón, Giulio Pompilio, Luca Sala, Daniela C.F. Salvatori, Roderick C. Slieker, Elena Sommariva, Antoin
Published in: Cell Stem Cell, Issue 26/6, 2020, Page(s) 862-879.e11, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.05.004

Book chapters (1)

CRISPR/Cas9-Mediated Introduction of Specific Heterozygous Mutations in Human Induced Pluripotent Stem Cells

Author(s): Karina O. Brandão, Catarina Grandela, Loukia Yiangou, Christine L. Mummery, Richard P. Davis
Published in: Methods in Molecular Biology, 2021
Publisher: Springer US
DOI: 10.1007/7651_2021_368