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Stem Cells for Cardiac Arrhythmia Risk Assessment

Pubblicazioni

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Autori: J. Pei, M. Schuldt, E. Nagyova, Z. Gu, S. el Bouhaddani, L. Yiangou, M. Jansen, J. J. A. Calis, L. M. Dorsch, C. Snijders Blok, N. A. M. van den Dungen, N. Lansu, B. J. Boukens, I. R. Efimov, M. Michels, M. C. Verhaar, R. de Weger, A. Vink, F. G. van Steenbeek, A. F. Baas, R. P. Davis, H. W. Uh, D. W. D. Kuster, C. Cheng, M. Mokry, J. van der Velden, F. W. Asselbergs, M. Harakalova
Pubblicato in: Clinical Epigenetics, Issue 13/1, 2021, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-021-01043-3

Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart Fails

Autori: Loukia Yiangou, Richard P. Davis, Christine L. Mummery
Pubblicato in: Stem Cell Reports, Issue 16/3, 2021, Page(s) 385-397, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2020.11.003

Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells

Autori: Giulia Campostrini, Viviana Meraviglia, Elisa Giacomelli, Ruben W. J. van Helden, Loukia Yiangou, Richard P. Davis, Milena Bellin, Valeria V. Orlova, Christine L. Mummery
Pubblicato in: Nature Protocols, Issue 16/4, 2021, Page(s) 2213-2256, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-021-00497-2

Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies

Autori: Karina O. Brandão, Viola A. Tabel, Douwe E. Atsma, Christine L. Mummery, Richard P. Davis
Pubblicato in: Disease Models & Mechanisms, Issue 10/9, 2017, Page(s) 1039-1059, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.030320

MUSCLEMOTIONNovelty and Significance

Autori: Luca Sala, Berend J. van Meer, Leon G.J. Tertoolen, Jeroen Bakkers, Milena Bellin, Richard P. Davis, Chris Denning, Michel A.E. Dieben, Thomas Eschenhagen, Elisa Giacomelli, Catarina Grandela, Arne Hansen, Eduard R. Holman, Monique R.M. Jongbloed, Sarah M. Kamel, Charlotte D. Koopman, Quentin Lachaud, Ingra Mannhardt, Mervyn P.H. Mol, Diogo Mosqueira, Valeria V. Orlova, Robert Passier, Marcelo C.
Pubblicato in: Circulation Research, Issue 122/3, 2018, Page(s) e5-e16, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.312067

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Autori: David J. Anderson, David I. Kaplan, Katrina M. Bell, Katerina Koutsis, John M. Haynes, Richard J. Mills, Dean G. Phelan, Elizabeth L. Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S. Ng, Richard P. Davis, Simona Casini, Robert Passier, James E. Hudson, Enzo R. Porrello, Mauro W. Costa, Arash Rafii, Clare L. Curl, Lea M. Delbridge, Richard P. Harvey, Alicia Oshlack, Mich
Pubblicato in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-03714-x

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes

Autori: Verena Schwach, Arie O. Verkerk, Mervyn Mol, Jantine J. Monshouwer-Kloots, Harsha D. Devalla, Valeria V. Orlova, Konstantinos Anastassiadis, Christine L. Mummery, Richard P. Davis, Robert Passier
Pubblicato in: Stem Cell Reports, Issue 9/6, 2017, Page(s) 1765-1779, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2017.10.024

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Autori: Berend J. van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G. J. Tertoolen, Christine L. Mummery
Pubblicato in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-12354-8

Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries

Autori: Talip E Eroglu, Grimur H Mohr, Marieke T Blom, Arie O Verkerk, Patrick C Souverein, Christian Torp-Pedersen, Fredrik Folke, Mads Wissenberg, Lettine van den Brink, Richard P Davis, Anthonius de Boer, Gunnar H Gislason, Hanno L Tan
Pubblicato in: European Heart Journal - Cardiovascular Pharmacotherapy, 2019, ISSN 2055-6837
Editore: Oxford University Press
DOI: 10.1093/ehjcvp/pvz038

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties

Autori: Lettine van den Brink, Karina O. Brandão, Loukia Yiangou, Mervyn P.H. Mol, Catarina Grandela, Christine L. Mummery, Arie O. Verkerk, Richard P. Davis
Pubblicato in: Stem Cell Research, Issue 43, 2020, Page(s) 101698, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2019.101698

Concise review: Inherited cardiac diseases, pluripotent stem cells, and genome editing combined-the past, present, and future

Autori: Lettine van den Brink, Catarina Grandela, Christine L. Mummery, Richard P. Davis
Pubblicato in: STEM CELLS, 2020, ISSN 1066-5099
Editore: AlphaMed Press Inc
DOI: 10.1002/stem.3110

Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias

Autori: Karina O. Brandão, Lettine van den Brink, Duncan C. Miller, Catarina Grandela, Berend J. van Meer, Mervyn P.H. Mol, Tessa de Korte, Leon G.J. Tertoolen, Christine L. Mummery, Luca Sala, Arie O. Verkerk, Richard P. Davis
Pubblicato in: Stem Cell Reports, Issue 15/5, 2020, Page(s) 1127-1139, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2020.10.005

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Autori: Elisa Giacomelli, Viviana Meraviglia, Giulia Campostrini, Amy Cochrane, Xu Cao, Ruben W.J. van Helden, Ana Krotenberg Garcia, Maria Mircea, Sarantos Kostidis, Richard P. Davis, Berend J. van Meer, Carolina R. Jost, Abraham J. Koster, Hailiang Mei, David G. Míguez, Aat A. Mulder, Mario Ledesma-Terrón, Giulio Pompilio, Luca Sala, Daniela C.F. Salvatori, Roderick C. Slieker, Elena Sommariva, Antoin
Pubblicato in: Cell Stem Cell, Issue 26/6, 2020, Page(s) 862-879.e11, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2020.05.004

CRISPR/Cas9-Mediated Introduction of Specific Heterozygous Mutations in Human Induced Pluripotent Stem Cells

Autori: Karina O. Brandão, Catarina Grandela, Loukia Yiangou, Christine L. Mummery, Richard P. Davis
Pubblicato in: Methods in Molecular Biology, 2021
Editore: Springer US
DOI: 10.1007/7651_2021_368

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