Next Generation Label-free Chemical Nanoscopy for Biomedical Applications

Project Information

NanoChemBioVision

Grant agreement ID: 638258

DOI 10.3030/638258

Project closed

EC signature date 9 March 2015

Start date 1 April 2015

End date 31 March 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 916 076,00

EU contribution € 1 916 076,00

Coordinated by

UNIVERSITY OF SOUTHAMPTON
United Kingdom

Publications

Peer reviewed articles (14)

Multimodal spectral focusing CARS and SFG microscopy with a tailored coherent continuum from a microstructured fiber

Author(s): Krzysztof P. Herdzik, Konstantinos N. Bourdakos, Peter B. Johnson, Adam P. Lister, Aleksandra P. Pitera, Chun-yu Guo, Peter Horak, David J. Richardson, Jonathan H. V. Price, Sumeet Mahajan
Published in: Applied Physics B, Issue 126/5, 2020, ISSN 0946-2171
Publisher: Springer Verlag
DOI: 10.1007/s00340-020-7406-6

Serum Raman spectroscopy as a diagnostic tool in patients with Huntington's disease

Author(s): Anna Huefner, Wei-Li Kuan, Sarah L. Mason, Sumeet Mahajan, Roger A. Barker
Published in: Chemical Science, Issue 11/2, 2020, Page(s) 525-533, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc03711j

Live-imaging of Bioengineered Cartilage Tissue using Multimodal Non-linear Molecular Imaging

Author(s): Catarina Costa Moura, Konstantinos N. Bourdakos, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-41466-w

Conformational Evolution of Molecular Signatures during Amyloidogenic Protein Aggregation

Author(s): George Devitt, William Rice, Anna Crisford, Iris Nandhakumar, Amrit Mudher, Sumeet Mahajan
Published in: ACS Chemical Neuroscience, Issue 10/11, 2019, Page(s) 4593-4611, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.9b00451

Tracking adipogenic differentiation of skeletal stem cells by label-free chemically selective imaging

Author(s): Justyna P. Smus, Catarina Costa Moura, Emma McMorrow, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Published in: Chemical Science, Issue 6/12, 2015, Page(s) 7089-7096, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C5SC02168E

Raman spectroscopy and coherent anti-Stokes Raman scattering imaging: prospective tools for monitoring skeletal cells and skeletal regeneration

Author(s): Catarina Costa Moura, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Published in: Journal of The Royal Society Interface, Issue 13/118, 2016, Page(s) 20160182, ISSN 1742-5689
Publisher: The Royal Society
DOI: 10.1098/rsif.2016.0182

Characterization and Visualization of Vesicles in the Endo-Lysosomal Pathway with Surface-Enhanced Raman Spectroscopy and Chemometrics

Author(s): Anna Huefner, Wei-Li Kuan, Karin H. Müller, Jeremy N. Skepper, Roger A. Barker, Sumeet Mahajan
Published in: ACS Nano, Issue 10/1, 2015, Page(s) 307-316, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.5b04456

Tuning plasmons layer-by-layer for quantitative colloidal sensing with surface-enhanced Raman spectroscopy

Author(s): William J. Anderson, Kamila Nowinska, Tanya Hutter, Sumeet Mahajan, Martin Fischlechner
Published in: Nanoscale, Issue 10/15, 2018, Page(s) 7138-7146, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7nr06656b

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

Author(s): Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauld
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.36354

Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis

Author(s): George Devitt, Kelly Howard, Amrit Mudher, Sumeet Mahajan
Published in: ACS Chemical Neuroscience, Issue 9/3, 2018, Page(s) 404-420, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.7b00413

Optimising superoscillatory spots for far-field super-resolution imaging

Author(s): Katrine S. Rogers, Konstantinos N. Bourdakos, Guang Hui Yuan, Sumeet Mahajan, Edward T. F. Rogers
Published in: Optics Express, Issue 26/7, 2018, Page(s) 8095, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.26.008095

Quantitative temporal interrogation in 3D of bioengineered human cartilage using multimodal label-free imaging

Author(s): Catarina Costa Moura, Stuart A. Lanham, Tual Monfort, Konstantinos N. Bourdakos, Rahul S. Tare, Richard O. C. Oreffo, Sumeet Mahajan
Published in: Integrative Biology, Issue 10/10, 2018, Page(s) 635-645, ISSN 1757-9694
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ib00050f

Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis

Author(s): Alan N. Hunt, Anagha Malur, Tual Monfort, Pavlos Lagoudakis, Sumeet Mahajan, Anthony D. Postle, Mary Jane Thomassen
Published in: American Journal of Respiratory Cell and Molecular Biology, Issue 57/4, 2017, Page(s) 448-458, ISSN 1044-1549
Publisher: American Lung Association
DOI: 10.1165/rcmb.2016-0242oc

Nanoparticles and intracellular applications of surface-enhanced Raman spectroscopy

Author(s): Jack Taylor, Anna Huefner, Li Li, Jonathan Wingfield, Sumeet Mahajan
Published in: The Analyst, Issue 141/17, 2016, Page(s) 5037-5055, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6an01003b

Other (2)

Super-resolved polarisation-enhanced second harmonic generation for direct imaging of nanoscale changes in collagen architecture

Author(s): Peter Johnson, Artemis Karvounis, H. Johnson Singh, Christopher J. Brereton, Konstantinos Bourdakos, Kerry Lunn, James JW Roberts, Donna E Davies, Otto L. Muskens, Mark G Jones, Sumeet Mahajan
Published in: 2020
Publisher: Cold spring harbor laboratory
DOI: 10.1101/2020.02.07.934000

Label-free and Multimodal Second Harmonic Generation Light Sheet Microscopy

Author(s): Niall Hanrahan, Simon I. R. Lane, Peter Johnson, Konstantinos Bourdakos, Christopher Brereton, Robert A. Ridley, Elizabeth R. Davies, Neveen A. Hosny, Gunnar Spickermann, Robert Forster, Graeme Malcolm, Donna Davies, Mark G. Jones, Sumeet Mahajan
Published in: 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.09.07.284703