New Catalytic Asymmetric Strategies for N-Heterocycle Synthesis

Project Information

CatHet

Grant agreement ID: 639594

DOI

10.3030/639594

Project closed

EC signature date 23 March 2015

Start date 1 April 2015

End date 31 March 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 548 738,00

EU contribution

€ 1 548 738,00

Coordinated by

UNIVERSITY OF BRISTOL
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

Modular Access to Substituted Azocanes via a Rhodium-Catalyzed Cycloaddition–Fragmentation Strategy

Author(s): Megan H. Shaw, Rosemary A. Croft, William G. Whittingham, John F. Bower
Published in: Journal of the American Chemical Society, Issue 137/25, 2015, Page(s) 8054-8057, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5b05215

Transition Metal Free C–N Bond Forming Dearomatizations and Aryl C–H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent

Author(s): Joshua J. Farndon, Xiaofeng Ma, John F. Bower
Published in: Journal of the American Chemical Society, Issue 139/40, 2017, Page(s) 14005-14008, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b07830

A Simple and Broadly Applicable C−N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents

Author(s): Xiaofeng Ma, Joshua J. Farndon, Tom A. Young, Natalie Fey, John F. Bower
Published in: Angewandte Chemie International Edition, Issue 56/46, 2017, Page(s) 14531-14535, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708176

Reductive Coupling of Acrylates with Ketones and Ketimines by a Nickel-Catalyzed Transfer-Hydrogenative Strategy

Author(s): Craig S. Buxton, David C. Blakemore, John F. Bower
Published in: Angewandte Chemie International Edition, Issue 56/44, 2017, Page(s) 13824-13828, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201707531

Capture–Collapse Heterocyclization: 1,3-Diazepanes by C–N Reductive Elimination from Rhodacyclopentanones

Author(s): Niall G. McCreanor, Steven Stanton, John F. Bower
Published in: Journal of the American Chemical Society, Issue 138/36, 2016, Page(s) 11465-11468, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.6b07046

New Initiation Modes for Directed Carbonylative C–C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes

Author(s): Gang-Wei Wang, Niall G. McCreanor, Megan H. Shaw, William G. Whittingham, John F. Bower
Published in: Journal of the American Chemical Society, 2016, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.6b08608

Diverse N -Heterocyclic Ring Systems via Aza-Heck Cyclizations of N -(Pentafluorobenzoyloxy)sulfonamides

Author(s): Ian R. Hazelden, Xiaofeng Ma, Thomas Langer, John F. Bower
Published in: Angewandte Chemie International Edition, Issue 55/37, 2016, Page(s) 11198-11202, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201605152

Synthesis and applications of rhodacyclopentanones derived from C–C bond activation

Author(s): Megan H. Shaw, John F. Bower
Published in: Chem. Commun., Issue 52/72, 2016, Page(s) 10817-10829, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6CC04359C

Modular Access to Azepines by Directed Carbonylative C–C Bond Activation of Aminocyclopropanes

Author(s): Gang-Wei Wang, John F. Bower
Published in: Journal of the American Chemical Society, Issue 140/8, 2018, Page(s) 2743-2747, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b13087

Carbonylative C−C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides

Author(s): Andrew G. Dalling, Takayuki Yamauchi, Niall G. McCreanor, Lydia Cox, John F. Bower
Published in: Angewandte Chemie International Edition, Issue 58/1, 2019, Page(s) 221-225, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811460

Modular Access to Eight-Membered N-Heterocycles by Directed Carbonylative C-C Bond Activation of Aminocyclopropanes

Author(s): Olivia Boyd, Gangwei Wang, Olga Sokolova, Adam Calow, Sophie Bertrand, John Bower
Published in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201910276

Recent Methodologies That Exploit C−C Single-Bond Cleavage of Strained Ring Systems by Transition Metal Complexes

Author(s): Gabriele Fumagalli, Steven Stanton, and John F. Bower
Published in: Chemical Reviews, 2017, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.6b00599

Synthesis of Nitrogen Heterocycles via Directed Carbonylative C–C Bond Activation of Cyclopropanes

Author(s): Andrew G. Dalling, John F. Bower
Published in: CHIMIA International Journal for Chemistry, Issue 72/9, 2018, Page(s) 595-600, ISSN 0009-4293
Publisher: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2018.595

Enantioselective Aza-Heck Cyclizations of N -(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines

Author(s): Xiaofeng Ma, Ian R. Hazelden, Thomas Langer, Rachel H. Munday, John F. Bower
Published in: Journal of the American Chemical Society, Issue 141/8, 2019, Page(s) 3356-3360, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b12689

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates

Author(s): Ian R. Hazelden, Rafaela C. Carmona, Thomas Langer, Paul G. Pringle, and John F. Bower
Published in: Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201801109

Stereospecific Alkene Aziridination Using a Bifunctional Amino-Reagent: An Aza-Prilezhaev Reaction

Author(s): Joshua J. Farndon, Tom A. Young, John F. Bower
Published in: Journal of the American Chemical Society, Issue 140/51, 2018, Page(s) 17846-17850, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b10485

Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

Author(s): Simon Grélaud, Phillippa Cooper, Lyman J. Feron, John F. Bower
Published in: Journal of the American Chemical Society, Issue 140/30, 2018, Page(s) 9351-9356, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b04627

Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles

Author(s): Gang-Wei Wang, Olivia Boyd, Tom A. Young, Sophie M. Bertrand, John F. Bower
Published in: Journal of the American Chemical Society, Issue 142/4, 2019, Page(s) 1740-1745, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b12421

Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters

Author(s): Nicholas J. Race, Adele Faulkner, Gabriele Fumagalli, Takayuki Yamauchi, James S. Scott, Marie Rydén-Landergren, Hazel A. Sparkes, John F. Bower
Published in: Chem. Sci., Issue 8/3, 2017, Page(s) 1981-1985, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6sc04466b