New Catalytic Asymmetric Strategies for N-Heterocycle Synthesis

Informazioni relative al progetto

CatHet

ID dell’accordo di sovvenzione: 639594

DOI 10.3030/639594

Progetto chiuso

Data della firma CE 23 Marzo 2015

Data di avvio 1 Aprile 2015

Data di completamento 31 Marzo 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 548 738,00

Contributo UE € 1 548 738,00

Coordinato da

UNIVERSITY OF BRISTOL
United Kingdom

Pubblicazioni

Peer reviewed articles (19)

Modular Access to Substituted Azocanes via a Rhodium-Catalyzed Cycloaddition–Fragmentation Strategy

Autori: Megan H. Shaw, Rosemary A. Croft, William G. Whittingham, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 137/25, 2015, Pagina/e 8054-8057, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.5b05215

Transition Metal Free C–N Bond Forming Dearomatizations and Aryl C–H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent

Autori: Joshua J. Farndon, Xiaofeng Ma, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 139/40, 2017, Pagina/e 14005-14008, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b07830

A Simple and Broadly Applicable C−N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents

Autori: Xiaofeng Ma, Joshua J. Farndon, Tom A. Young, Natalie Fey, John F. Bower
Pubblicato in: Angewandte Chemie International Edition, Numero 56/46, 2017, Pagina/e 14531-14535, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708176

Reductive Coupling of Acrylates with Ketones and Ketimines by a Nickel-Catalyzed Transfer-Hydrogenative Strategy

Autori: Craig S. Buxton, David C. Blakemore, John F. Bower
Pubblicato in: Angewandte Chemie International Edition, Numero 56/44, 2017, Pagina/e 13824-13828, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201707531

Capture–Collapse Heterocyclization: 1,3-Diazepanes by C–N Reductive Elimination from Rhodacyclopentanones

Autori: Niall G. McCreanor, Steven Stanton, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 138/36, 2016, Pagina/e 11465-11468, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.6b07046

New Initiation Modes for Directed Carbonylative C–C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes

Autori: Gang-Wei Wang, Niall G. McCreanor, Megan H. Shaw, William G. Whittingham, John F. Bower
Pubblicato in: Journal of the American Chemical Society, 2016, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.6b08608

Diverse N -Heterocyclic Ring Systems via Aza-Heck Cyclizations of N -(Pentafluorobenzoyloxy)sulfonamides

Autori: Ian R. Hazelden, Xiaofeng Ma, Thomas Langer, John F. Bower
Pubblicato in: Angewandte Chemie International Edition, Numero 55/37, 2016, Pagina/e 11198-11202, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201605152

Synthesis and applications of rhodacyclopentanones derived from C–C bond activation

Autori: Megan H. Shaw, John F. Bower
Pubblicato in: Chem. Commun., Numero 52/72, 2016, Pagina/e 10817-10829, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/C6CC04359C

Modular Access to Azepines by Directed Carbonylative C–C Bond Activation of Aminocyclopropanes

Autori: Gang-Wei Wang, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 140/8, 2018, Pagina/e 2743-2747, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b13087

Carbonylative C−C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides

Autori: Andrew G. Dalling, Takayuki Yamauchi, Niall G. McCreanor, Lydia Cox, John F. Bower
Pubblicato in: Angewandte Chemie International Edition, Numero 58/1, 2019, Pagina/e 221-225, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811460

Modular Access to Eight-Membered N-Heterocycles by Directed Carbonylative C-C Bond Activation of Aminocyclopropanes

Autori: Olivia Boyd, Gangwei Wang, Olga Sokolova, Adam Calow, Sophie Bertrand, John Bower
Pubblicato in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201910276

Recent Methodologies That Exploit C−C Single-Bond Cleavage of Strained Ring Systems by Transition Metal Complexes

Autori: Gabriele Fumagalli, Steven Stanton, and John F. Bower
Pubblicato in: Chemical Reviews, 2017, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.6b00599

Synthesis of Nitrogen Heterocycles via Directed Carbonylative C–C Bond Activation of Cyclopropanes

Autori: Andrew G. Dalling, John F. Bower
Pubblicato in: CHIMIA International Journal for Chemistry, Numero 72/9, 2018, Pagina/e 595-600, ISSN 0009-4293
Editore: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2018.595

Enantioselective Aza-Heck Cyclizations of N -(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines

Autori: Xiaofeng Ma, Ian R. Hazelden, Thomas Langer, Rachel H. Munday, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 141/8, 2019, Pagina/e 3356-3360, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b12689

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates

Autori: Ian R. Hazelden, Rafaela C. Carmona, Thomas Langer, Paul G. Pringle, and John F. Bower
Pubblicato in: Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201801109

Stereospecific Alkene Aziridination Using a Bifunctional Amino-Reagent: An Aza-Prilezhaev Reaction

Autori: Joshua J. Farndon, Tom A. Young, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 140/51, 2018, Pagina/e 17846-17850, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b10485

Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

Autori: Simon Grélaud, Phillippa Cooper, Lyman J. Feron, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 140/30, 2018, Pagina/e 9351-9356, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b04627

Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles

Autori: Gang-Wei Wang, Olivia Boyd, Tom A. Young, Sophie M. Bertrand, John F. Bower
Pubblicato in: Journal of the American Chemical Society, Numero 142/4, 2019, Pagina/e 1740-1745, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b12421

Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters

Autori: Nicholas J. Race, Adele Faulkner, Gabriele Fumagalli, Takayuki Yamauchi, James S. Scott, Marie Rydén-Landergren, Hazel A. Sparkes, John F. Bower
Pubblicato in: Chem. Sci., Numero 8/3, 2017, Pagina/e 1981-1985, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c6sc04466b