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Antibody-Mediated Therapy of HIV-1 Infection

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Publications

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

Author(s): Schoofs T, Klein F, Braunschweig M, Kreider EF, Feldmann A, Nogueira L, Oliveira T, Lorenzi JC, Parrish EH, Learn GH, West AP Jr, Bjorkman PJ, Schlesinger SJ, Seaman MS, Czartoski J, McElrath MJ, Pfeifer N, Hahn BH, Caskey M, Nussenzweig MC.
Published in: Science, May 20;352(6288):997-1001, 2016, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaf0972

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

Author(s): Gristick HB, von Boehmer L, West AP Jr, Schamber M, Gazumyan A, Golijanin J, Seaman MS, Fätkenheuer G, Klein F, Nussenzweig MC, Bjorkman PJ
Published in: Nat Struct Mol Biol, Oct;23(10):906-915, 2016, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3291

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.

Author(s): Theobald SJ, Kreer C, Khailaie S, Bonifacius A, Eiz-Vesper B, Figueiredo C, Mach M, Backovic M, Ballmaier M, Koenig J, Olbrich H, Schneider A, Volk V, Danisch S, Gieselmann L, Ercanoglu MS, Messerle M, Kaisenberg CV, Witte T, Klawonn F, Meyer-Hermann M, Klein F, Stripecke R.
Published in: PLoS Pathog, 16(7): e1008560, 2020, ISSN 1553-7374
Publisher: Pubic Library Science
DOI: 10.1371/journal.ppat.1008560

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

Author(s): Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Münn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Łuksza M, Lässig M, Bjorkman PJ, Klein F.
Published in: Cell Host Microbe, 30(1): 69-82.e10., 2022, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.12.010

Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG.

Author(s): Eberhardt KA, Dewald F, Heger E, Gieselmann L, Vanshylla K, Wirtz M, Kleipass F, Johannis W, Schommers P, Gruell H, Brensing KA, Müller RU, Augustin M, Lehmann C, Koch M, Klein F, Di Cristanziano V.
Published in: Microorganisms, 31;9(4):733, 2021, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9040733

Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption

Author(s): Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, Barton J, Lorenzi JCC, Cohen YZ, Cohn LB, Klein F, Caskey M, Nussenzweig MC, Jankovic M.
Published in: Acad Sci U S A, 115(48): E11341-e8, 2018, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1813512115

Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV

Author(s): Ehrhardt SA, Zehner M, Krahling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F.
Published in: Nat Med, 25(10):1589-1600., 2019, ISSN 1546-170X
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0602-4

Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans.

Author(s): Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
Published in: Cell Host Microbe, 29(6): 917-29.e4, 2021, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.04.015

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Author(s): Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP, Jr., Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger
Published in: Nat Med, 23(2): 185-91, 2017, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4268

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

Author(s): Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP, Jr., Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ.
Published in: Immunity, 50(6): 1513-29 e9, 2019, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2019.04.014

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Author(s): Caskey M, Klein F, Nussenzweig MC
Published in: Nat Med, 25(4): 547-53, 2019, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0412-8

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies

Author(s): Kreer C, Gruell H, Mora T, Walczak A.M. and Klein F.
Published in: Vaccines, 1;8(1):13, 2020, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010013

Antibody-mediated prevention and treatment of HIV-1 infection.

Author(s): Gruell H, Klein F.
Published in: Retrovirology, 15(1): 73, 2018, ISSN 1742-4690
Publisher: BioMed Central
DOI: 10.1186/s12977-018-0455-9

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Author(s): Pilar Mendoza, Henning Gruell, Lilian Nogueira, Joy A. Pai, Allison L. Butler, Katrina Millard, Clara Lehmann, Isabelle Suárez, Thiago Y. Oliveira, Julio C. C. Lorenzi, Yehuda Z. Cohen, Christoph Wyen, Tim Kümmerle, Theodora Karagounis, Ching-Lan Lu, Lisa Handl, Cecilia Unson-O’Brien, Roshni Patel, Carola Ruping, Maike Schlotz, Maggi Witmer-Pack, Irina Shimeliovich, Gisela Kremer, Eleonore Tho
Published in: Nature, 561/7724, 2018, Page(s) 479-484, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0531-2

Antibody-mediated prevention and treatment of HIV-1 infection

Author(s): Henning Gruell, Florian Klein
Published in: Retrovirology, 15/1, 2018, ISSN 1742-4690
Publisher: BioMed Central
DOI: 10.1186/s12977-018-0455-9

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Author(s): Yotam Bar-On, Henning Gruell, Till Schoofs, Joy A. Pai, Lilian Nogueira, Allison L. Butler, Katrina Millard, Clara Lehmann, Isabelle Suárez, Thiago Y. Oliveira, Theodora Karagounis, Yehuda Z. Cohen, Christoph Wyen, Stefan Scholten, Lisa Handl, Shiraz Belblidia, Juan P. Dizon, Jörg J. Vehreschild, Maggi Witmer-Pack, Irina Shimeliovich, Kanika Jain, Kerstin Fiddike, Kelly E. Seaton, Nicole L. Yate
Published in: Nature Medicine, 24/11, 2018, Page(s) 1701-1707, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0186-4

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Author(s): Marina Caskey, Florian Klein, Michel C. Nussenzweig
Published in: Nature Medicine, 25/4, 2019, Page(s) 547-553, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0412-8

Relationship between intact HIV-1 proviruses in circulating CD4 + T cells and rebound viruses emerging during treatment interruption

Author(s): Ching-Lan Lu, Joy A. Pai, Lilian Nogueira, Pilar Mendoza, Henning Gruell, Thiago Y. Oliveira, John Barton, Julio C. C. Lorenzi, Yehuda Z. Cohen, Lillian B. Cohn, Florian Klein, Marina Caskey, Michel C. Nussenzweig, Mila Jankovic
Published in: Proceedings of the National Academy of Sciences, 115/48, 2018, Page(s) E11341-E11348, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1813512115

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

Author(s): T. Schoofs, F. Klein, M. Braunschweig, E. F. Kreider, A. Feldmann, L. Nogueira, T. Oliveira, J. C. C. Lorenzi, E. H. Parrish, G. H. Learn, A. P. West, P. J. Bjorkman, S. J. Schlesinger, M. S. Seaman, J. Czartoski, M. J. McElrath, N. Pfeifer, B. H. Hahn, M. Caskey, M. C. Nussenzweig
Published in: Science, 352/6288, 2016, Page(s) 997-1001, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaf0972

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Author(s): Marina Caskey, Till Schoofs, Henning Gruell, Allison Settler, Theodora Karagounis, Edward F Kreider, Ben Murrell, Nico Pfeifer, Lilian Nogueira, Thiago Y Oliveira, Gerald H Learn, Yehuda Z Cohen, Clara Lehmann, Daniel Gillor, Irina Shimeliovich, Cecilia Unson-O'Brien, Daniela Weiland, Alexander Robles, Tim Kümmerle, Christoph Wyen, Rebeka Levin, Maggi Witmer-Pack, Kemal Eren, Caroline Ignacio, Sz
Published in: Nature Medicine, 23/2, 2017, Page(s) 185-191, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4268

OpenPrimeR for multiplex amplification of highly diverse templates

Author(s): Kreer C, Döring M, Lehnen N, Ercanoglu MS, Gieselmann L, Luca D, Jain K, Schommers P, Pfeifer N, Klein F.
Published in: J Immunol Methods, May;480:112752, 2020, ISSN 1872-7905
Publisher: Elsevier
DOI: 10.1016/j.jim.2020.112752

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Author(s): Schommers P, Gruell H, Abernathy ME, Tran M-K, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MV, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman J, Klein F.
Published in: Cell, Feb 6;180(3):471-489.e22, 2020, ISSN 1097-4172
Publisher: Cell press
DOI: 10.1016/j.cell.2020.01.010

Effective high-throughput isolation of fully human antibodies targeting infectious pathogens

Author(s): Gieselmann L, Kreer C, Ercanoglu MS, Lehnen N, Zehner M, Schommers P, Potthoff J, Gruell H, Klein F.
Published in: Nat Protoc, 16(7): 3639-71, 2021, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00554-w

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Author(s): Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC.
Published in: Nat Med, 24(11): 1701-7, 2018, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0186-4

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Author(s): Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP, Jr., Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M,
Published in: Nature, 561(7724): 479-84, 2018, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0531-2

CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention

Author(s): Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Münch J, Grüttner B, Geldmacher C, Klein F. . 2021; 9(3).
Published in: Vaccines (Basel), Feb 27;9(3):198, 2021, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030198