Antibody-Mediated Therapy of HIV-1 Infection

Project Information

HIV1ABTHERAPY

Grant agreement ID: 639961

DOI

10.3030/639961

Project closed

EC signature date 15 December 2015

Start date 1 January 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

KLINIKUM DER UNIVERSITAET ZU KOELN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

Author(s): Schoofs T, Klein F, Braunschweig M, Kreider EF, Feldmann A, Nogueira L, Oliveira T, Lorenzi JC, Parrish EH, Learn GH, West AP Jr, Bjorkman PJ, Schlesinger SJ, Seaman MS, Czartoski J, McElrath MJ, Pfeifer N, Hahn BH, Caskey M, Nussenzweig MC.
Published in: Science, Issue May 20;352(6288):997-1001, 2016, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaf0972

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

Author(s): Gristick HB, von Boehmer L, West AP Jr, Schamber M, Gazumyan A, Golijanin J, Seaman MS, Fätkenheuer G, Klein F, Nussenzweig MC, Bjorkman PJ
Published in: Nat Struct Mol Biol, Issue Oct;23(10):906-915, 2016, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3291

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.

Author(s): Theobald SJ, Kreer C, Khailaie S, Bonifacius A, Eiz-Vesper B, Figueiredo C, Mach M, Backovic M, Ballmaier M, Koenig J, Olbrich H, Schneider A, Volk V, Danisch S, Gieselmann L, Ercanoglu MS, Messerle M, Kaisenberg CV, Witte T, Klawonn F, Meyer-Hermann M, Klein F, Stripecke R.
Published in: PLoS Pathog, Issue 16(7): e1008560, 2020, ISSN 1553-7374
Publisher: Pubic Library Science
DOI: 10.1371/journal.ppat.1008560

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

Author(s): Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Münn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Łuksza M, Lässig M, Bjorkman PJ, Klein F.
Published in: Cell Host Microbe, Issue 30(1): 69-82.e10., 2022, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.12.010

Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG.

Author(s): Eberhardt KA, Dewald F, Heger E, Gieselmann L, Vanshylla K, Wirtz M, Kleipass F, Johannis W, Schommers P, Gruell H, Brensing KA, Müller RU, Augustin M, Lehmann C, Koch M, Klein F, Di Cristanziano V.
Published in: Microorganisms, Issue 31;9(4):733, 2021, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9040733

Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption

Author(s): Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, Barton J, Lorenzi JCC, Cohen YZ, Cohn LB, Klein F, Caskey M, Nussenzweig MC, Jankovic M.
Published in: Acad Sci U S A, Issue 115(48): E11341-e8, 2018, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1813512115

Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV

Author(s): Ehrhardt SA, Zehner M, Krahling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F.
Published in: Nat Med, Issue 25(10):1589-1600., 2019, ISSN 1546-170X
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0602-4

Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans.

Author(s): Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
Published in: Cell Host Microbe, Issue 29(6): 917-29.e4, 2021, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.04.015

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Author(s): Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP, Jr., Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger
Published in: Nat Med, Issue 23(2): 185-91, 2017, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4268

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

Author(s): Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP, Jr., Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ.
Published in: Immunity, Issue 50(6): 1513-29 e9, 2019, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2019.04.014

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Author(s): Caskey M, Klein F, Nussenzweig MC
Published in: Nat Med, Issue 25(4): 547-53, 2019, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0412-8

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies

Author(s): Kreer C, Gruell H, Mora T, Walczak A.M. and Klein F.
Published in: Vaccines, Issue 1;8(1):13, 2020, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010013

Antibody-mediated prevention and treatment of HIV-1 infection.

Author(s): Gruell H, Klein F.
Published in: Retrovirology, Issue 15(1): 73, 2018, ISSN 1742-4690
Publisher: BioMed Central
DOI: 10.1186/s12977-018-0455-9

OpenPrimeR for multiplex amplification of highly diverse templates

Author(s): Kreer C, Döring M, Lehnen N, Ercanoglu MS, Gieselmann L, Luca D, Jain K, Schommers P, Pfeifer N, Klein F.
Published in: J Immunol Methods, Issue May;480:112752, 2020, ISSN 1872-7905
Publisher: Elsevier
DOI: 10.1016/j.jim.2020.112752

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Author(s): Schommers P, Gruell H, Abernathy ME, Tran M-K, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MV, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman J, Klein F.
Published in: Cell, Issue Feb 6;180(3):471-489.e22, 2020, ISSN 1097-4172
Publisher: Cell press
DOI: 10.1016/j.cell.2020.01.010

Effective high-throughput isolation of fully human antibodies targeting infectious pathogens

Author(s): Gieselmann L, Kreer C, Ercanoglu MS, Lehnen N, Zehner M, Schommers P, Potthoff J, Gruell H, Klein F.
Published in: Nat Protoc, Issue 16(7): 3639-71, 2021, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00554-w

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Author(s): Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC.
Published in: Nat Med, Issue 24(11): 1701-7, 2018, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0186-4

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Author(s): Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP, Jr., Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M,
Published in: Nature, Issue 561(7724): 479-84, 2018, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0531-2

CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention

Author(s): Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Münch J, Grüttner B, Geldmacher C, Klein F. . 2021; 9(3).
Published in: Vaccines (Basel), Issue Feb 27;9(3):198, 2021, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030198