Antibody-Mediated Therapy of HIV-1 Infection

Publicaciones

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

Autores: Schoofs T, Klein F, Braunschweig M, Kreider EF, Feldmann A, Nogueira L, Oliveira T, Lorenzi JC, Parrish EH, Learn GH, West AP Jr, Bjorkman PJ, Schlesinger SJ, Seaman MS, Czartoski J, McElrath MJ, Pfeifer N, Hahn BH, Caskey M, Nussenzweig MC.
Publicado en: Science, Edición May 20;352(6288):997-1001, 2016, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aaf0972

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

Autores: Gristick HB, von Boehmer L, West AP Jr, Schamber M, Gazumyan A, Golijanin J, Seaman MS, Fätkenheuer G, Klein F, Nussenzweig MC, Bjorkman PJ
Publicado en: Nat Struct Mol Biol, Edición Oct;23(10):906-915, 2016, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/nsmb.3291

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.

Autores: Theobald SJ, Kreer C, Khailaie S, Bonifacius A, Eiz-Vesper B, Figueiredo C, Mach M, Backovic M, Ballmaier M, Koenig J, Olbrich H, Schneider A, Volk V, Danisch S, Gieselmann L, Ercanoglu MS, Messerle M, Kaisenberg CV, Witte T, Klawonn F, Meyer-Hermann M, Klein F, Stripecke R.
Publicado en: PLoS Pathog, Edición 16(7): e1008560, 2020, ISSN 1553-7374
Editor: Pubic Library Science
DOI: 10.1371/journal.ppat.1008560

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

Autores: Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Münn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Łuksza M, Lässig M, Bjorkman PJ, Klein F.
Publicado en: Cell Host Microbe, Edición 30(1): 69-82.e10., 2022, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2021.12.010

Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG.

Autores: Eberhardt KA, Dewald F, Heger E, Gieselmann L, Vanshylla K, Wirtz M, Kleipass F, Johannis W, Schommers P, Gruell H, Brensing KA, Müller RU, Augustin M, Lehmann C, Koch M, Klein F, Di Cristanziano V.
Publicado en: Microorganisms, Edición 31;9(4):733, 2021, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms9040733

Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption

Autores: Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, Barton J, Lorenzi JCC, Cohen YZ, Cohn LB, Klein F, Caskey M, Nussenzweig MC, Jankovic M.
Publicado en: Acad Sci U S A, Edición 115(48): E11341-e8, 2018, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1813512115

Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV

Autores: Ehrhardt SA, Zehner M, Krahling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F.
Publicado en: Nat Med, Edición 25(10):1589-1600., 2019, ISSN 1546-170X
Editor: Nature Publishing Group
DOI: 10.1038/s41591-019-0602-4

Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans.

Autores: Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
Publicado en: Cell Host Microbe, Edición 29(6): 917-29.e4, 2021, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2021.04.015

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Autores: Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP, Jr., Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger
Publicado en: Nat Med, Edición 23(2): 185-91, 2017, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/nm.4268

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

Autores: Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP, Jr., Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ.
Publicado en: Immunity, Edición 50(6): 1513-29 e9, 2019, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2019.04.014

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Autores: Caskey M, Klein F, Nussenzweig MC
Publicado en: Nat Med, Edición 25(4): 547-53, 2019, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-019-0412-8

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies

Autores: Kreer C, Gruell H, Mora T, Walczak A.M. and Klein F.
Publicado en: Vaccines, Edición 1;8(1):13, 2020, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010013

Antibody-mediated prevention and treatment of HIV-1 infection.

Autores: Gruell H, Klein F.
Publicado en: Retrovirology, Edición 15(1): 73, 2018, ISSN 1742-4690
Editor: BioMed Central
DOI: 10.1186/s12977-018-0455-9

OpenPrimeR for multiplex amplification of highly diverse templates

Autores: Kreer C, Döring M, Lehnen N, Ercanoglu MS, Gieselmann L, Luca D, Jain K, Schommers P, Pfeifer N, Klein F.
Publicado en: J Immunol Methods, Edición May;480:112752, 2020, ISSN 1872-7905
Editor: Elsevier
DOI: 10.1016/j.jim.2020.112752

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Autores: Schommers P, Gruell H, Abernathy ME, Tran M-K, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MV, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman J, Klein F.
Publicado en: Cell, Edición Feb 6;180(3):471-489.e22, 2020, ISSN 1097-4172
Editor: Cell press
DOI: 10.1016/j.cell.2020.01.010

Effective high-throughput isolation of fully human antibodies targeting infectious pathogens

Autores: Gieselmann L, Kreer C, Ercanoglu MS, Lehnen N, Zehner M, Schommers P, Potthoff J, Gruell H, Klein F.
Publicado en: Nat Protoc, Edición 16(7): 3639-71, 2021, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-021-00554-w

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Autores: Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC.
Publicado en: Nat Med, Edición 24(11): 1701-7, 2018, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-018-0186-4

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Autores: Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP, Jr., Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M,
Publicado en: Nature, Edición 561(7724): 479-84, 2018, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0531-2

CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention

Autores: Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Münch J, Grüttner B, Geldmacher C, Klein F. . 2021; 9(3).
Publicado en: Vaccines (Basel), Edición Feb 27;9(3):198, 2021, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030198

Buscando datos de OpenAIRE...

Publicaciones

Compartir esta página

Descargar