Antibody-Mediated Therapy of HIV-1 Infection

Pubblicazioni

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

Autori: Schoofs T, Klein F, Braunschweig M, Kreider EF, Feldmann A, Nogueira L, Oliveira T, Lorenzi JC, Parrish EH, Learn GH, West AP Jr, Bjorkman PJ, Schlesinger SJ, Seaman MS, Czartoski J, McElrath MJ, Pfeifer N, Hahn BH, Caskey M, Nussenzweig MC.
Pubblicato in: Science, Numero May 20;352(6288):997-1001, 2016, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aaf0972

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

Autori: Gristick HB, von Boehmer L, West AP Jr, Schamber M, Gazumyan A, Golijanin J, Seaman MS, Fätkenheuer G, Klein F, Nussenzweig MC, Bjorkman PJ
Pubblicato in: Nat Struct Mol Biol, Numero Oct;23(10):906-915, 2016, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/nsmb.3291

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.

Autori: Theobald SJ, Kreer C, Khailaie S, Bonifacius A, Eiz-Vesper B, Figueiredo C, Mach M, Backovic M, Ballmaier M, Koenig J, Olbrich H, Schneider A, Volk V, Danisch S, Gieselmann L, Ercanoglu MS, Messerle M, Kaisenberg CV, Witte T, Klawonn F, Meyer-Hermann M, Klein F, Stripecke R.
Pubblicato in: PLoS Pathog, Numero 16(7): e1008560, 2020, ISSN 1553-7374
Editore: Pubic Library Science
DOI: 10.1371/journal.ppat.1008560

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

Autori: Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Münn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Łuksza M, Lässig M, Bjorkman PJ, Klein F.
Pubblicato in: Cell Host Microbe, Numero 30(1): 69-82.e10., 2022, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2021.12.010

Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG.

Autori: Eberhardt KA, Dewald F, Heger E, Gieselmann L, Vanshylla K, Wirtz M, Kleipass F, Johannis W, Schommers P, Gruell H, Brensing KA, Müller RU, Augustin M, Lehmann C, Koch M, Klein F, Di Cristanziano V.
Pubblicato in: Microorganisms, Numero 31;9(4):733, 2021, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms9040733

Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption

Autori: Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, Barton J, Lorenzi JCC, Cohen YZ, Cohn LB, Klein F, Caskey M, Nussenzweig MC, Jankovic M.
Pubblicato in: Acad Sci U S A, Numero 115(48): E11341-e8, 2018, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1813512115

Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV

Autori: Ehrhardt SA, Zehner M, Krahling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F.
Pubblicato in: Nat Med, Numero 25(10):1589-1600., 2019, ISSN 1546-170X
Editore: Nature Publishing Group
DOI: 10.1038/s41591-019-0602-4

Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans.

Autori: Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
Pubblicato in: Cell Host Microbe, Numero 29(6): 917-29.e4, 2021, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2021.04.015

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Autori: Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP, Jr., Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger
Pubblicato in: Nat Med, Numero 23(2): 185-91, 2017, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/nm.4268

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

Autori: Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP, Jr., Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ.
Pubblicato in: Immunity, Numero 50(6): 1513-29 e9, 2019, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2019.04.014

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Autori: Caskey M, Klein F, Nussenzweig MC
Pubblicato in: Nat Med, Numero 25(4): 547-53, 2019, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-019-0412-8

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies

Autori: Kreer C, Gruell H, Mora T, Walczak A.M. and Klein F.
Pubblicato in: Vaccines, Numero 1;8(1):13, 2020, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8010013

Antibody-mediated prevention and treatment of HIV-1 infection.

Autori: Gruell H, Klein F.
Pubblicato in: Retrovirology, Numero 15(1): 73, 2018, ISSN 1742-4690
Editore: BioMed Central
DOI: 10.1186/s12977-018-0455-9

OpenPrimeR for multiplex amplification of highly diverse templates

Autori: Kreer C, Döring M, Lehnen N, Ercanoglu MS, Gieselmann L, Luca D, Jain K, Schommers P, Pfeifer N, Klein F.
Pubblicato in: J Immunol Methods, Numero May;480:112752, 2020, ISSN 1872-7905
Editore: Elsevier
DOI: 10.1016/j.jim.2020.112752

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Autori: Schommers P, Gruell H, Abernathy ME, Tran M-K, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MV, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman J, Klein F.
Pubblicato in: Cell, Numero Feb 6;180(3):471-489.e22, 2020, ISSN 1097-4172
Editore: Cell press
DOI: 10.1016/j.cell.2020.01.010

Effective high-throughput isolation of fully human antibodies targeting infectious pathogens

Autori: Gieselmann L, Kreer C, Ercanoglu MS, Lehnen N, Zehner M, Schommers P, Potthoff J, Gruell H, Klein F.
Pubblicato in: Nat Protoc, Numero 16(7): 3639-71, 2021, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-021-00554-w

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Autori: Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC.
Pubblicato in: Nat Med, Numero 24(11): 1701-7, 2018, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-018-0186-4

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Autori: Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP, Jr., Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M,
Pubblicato in: Nature, Numero 561(7724): 479-84, 2018, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0531-2

CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention

Autori: Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Münch J, Grüttner B, Geldmacher C, Klein F. . 2021; 9(3).
Pubblicato in: Vaccines (Basel), Numero Feb 27;9(3):198, 2021, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9030198

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