Optical imaging of ocular pathology in Alzheimer’s disease

Advanced methods for tissue scattering characterization with optical coherence tomography

Author(s): Pablo Eugui
Published in: 2020
Publisher: Medical University of Vienna

High resolution polarization sensitive optical coherence tomography for ocular imaging in small animals

Author(s): Stanislava Fialová
Published in: 2016
Publisher: Medical University of Vienna

Multi-Functional Optical Coherence Tomography for Preclinical Retinal Imaging

Author(s): Marco Augustin
Published in: 2018
Publisher: Medical University of Vienna

Multimodal visible light optical coherence microscopy for ex vivo brain imaging

Author(s): Antonia Lichtenegger
Published in: 2020
Publisher: Medical University of Vienna

Depth-resolved multi-contrast retinal imaging with high axial resolution

Author(s): Danielle J. Harper
Published in: 2020
Publisher: Medical University of Vienna

Three-dimensional visualization of opacifications in the murine crystalline lens by in vivo optical coherence tomography

Author(s): Pablo Eugui, Danielle J. Harper, Stefan Kummer, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Marco Augustin, Conrad W. Merkle, Martin Glösmann, Bernhard Baumann
Published in: Biomedical Optics Express, Issue 11/4, 2020, Page(s) 2085, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.387335

Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice

Author(s): Marco Augustin, Danielle J. Harper, Conrad W. Merkle, Martin Glösmann, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Translational Vision Science & Technology, Issue 9/4, 2020, Page(s) 15, ISSN 2164-2591
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/tvst.9.4.15

Ex-vivo Alzheimer’s disease brain tissue investigation: a multiscale approach using 1060-nm swept source optical coherence tomography for a direct correlation to histology

Author(s): Antonia Lichtenegger, Johanna Gesperger, Michael Niederleithner, Laurin Ginner, Adelheid Woehrer, Wolfgang Drexler, Bernhard Baumann, Rainer A. Leitgeb, Matthias Salas
Published in: Neurophotonics, Issue 7/03, 2020, ISSN 2329-423X
Publisher: SPIE
DOI: 10.1117/1.nph.7.3.035004

Indocyanine green provides absorption and spectral contrast for optical coherence tomography at 840 nm in vivo

Author(s): Conrad W. Merkle, Marco Augustin, Danielle J. Harper, Bernhard Baumann
Published in: Optics Letters, Issue 45/8, 2020, Page(s) 2359, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.380051

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

Author(s): Bernhard Baumann
Published in: Applied Sciences, Issue 7/5, 2017, Page(s) 474, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app7050474

Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

Author(s): Antonia Lichtenegger, Danielle J. Harper, Marco Augustin, Pablo Eugui, Martina Muck, Johanna Gesperger, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Published in: Biomedical Optics Express, Issue 8/9, 2017, Page(s) 4007, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.8.004007

In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography

Author(s): Marco Augustin, Matthias Wechdorn, Ulrike Pfeiffenberger, Tanja Himmel, Stanislava Fialová, René M. Werkmeister, Christoph K. Hitzenberger, Martin Glösmann, Bernhard Baumann
Published in: Investigative Opthalmology & Visual Science, Issue 59/5, 2018, Page(s) 2054, ISSN 1552-5783
Publisher: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.17-23208

White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina

Author(s): Danielle J. Harper, Marco Augustin, Antonia Lichtenegger, Pablo Eugui, Carlos Reyes, Martin Glösmann, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Biomedical Optics Express, Issue 9/5, 2018, Page(s) 2115, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.9.002115

Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure

Author(s): Marco Augustin, Stanislava Fialová, Corinna Fischak, Leopold Schmetterer, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-09310-1

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

Author(s): Johanna Klughammer, Barbara Kiesel, Thomas Roetzer, Nikolaus Fortelny, Amelie Nemc, Karl-Heinz Nenning, Julia Furtner, Nathan C. Sheffield, Paul Datlinger, Nadine Peter, Martha Nowosielski, Marco Augustin, Mario Mischkulnig, Thomas Ströbel, Donat Alpar, Bekir Ergüner, Martin Senekowitsch, Patrizia Moser, Christian F. Freyschlag, Johannes Kerschbaumer, Claudius Thomé, Astrid E. Grams, Günther S
Published in: Nature Medicine, Issue 24/10, 2018, Page(s) 1611-1624, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0156-x

Polarization-sensitive optical coherence tomography imaging of the anterior mouse eye

Author(s): Bernhard Baumann, Marco Augustin, Antonia Lichtenegger, Danielle J. Harper, Martina Muck, Pablo Eugui, Andreas Wartak, Michael Pircher, Christoph K. Hitzenberger
Published in: Journal of Biomedical Optics, Issue 23/08, 2018, Page(s) 1, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.JBO.23.8.086005

Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

Author(s): Antonia Lichtenegger, Martina Muck, Pablo Eugui, Danielle J. Harper, Marco Augustin, Konrad Leskovar, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Published in: Neurophotonics, Issue 5/03, 2018, Page(s) 1, ISSN 2329-423X
Publisher: SPIE
DOI: 10.1117/1.NPh.5.3.035002

Beyond backscattering: optical neuroimaging by BRAD

Author(s): Pablo Eugui, Antonia Lichtenegger, Marco Augustin, Danielle J. Harper, Martina Muck, Thomas Roetzer, Andreas Wartak, Thomas Konegger, Georg Widhalm, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Published in: Biomedical Optics Express, Issue 9/6, 2018, Page(s) 2476, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.9.002476

Multimodal Optical Medical Imaging Concepts Based on Optical Coherence Tomography

Author(s): Rainer A. Leitgeb, Bernhard Baumann
Published in: Frontiers in Physics, Issue 6, 2018, Page(s) 114, ISSN 2296-424X
Publisher: Frontiers Media SA
DOI: 10.3389/fphy.2018.00114

Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model

Author(s): Marco Augustin, Stanislava Fialová, Tanja Himmel, Martin Glösmann, Theresia Lengheimer, Danielle J. Harper, Roberto Plasenzotti, Michael Pircher, Christoph K. Hitzenberger, Bernhard Baumann
Published in: PLOS one, Issue 11(10), 2016, Page(s) 0164419, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0164419

Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

Author(s): Bernhard Baumann, Adelheid Woehrer, Gerda Ricken, Marco Augustin, Christian Mitter, Michael Pircher, Gabor G. Kovacs, Christoph K. Hitzenberger
Published in: Scientific Reports, Issue 7, 2017, Page(s) 43477, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep43477

Posterior rat eye during acute intraocular pressure elevation studied using polarization sensitive optical coherence tomography

Author(s): Stanislava Fialová, Marco Augustin, Corinna Fischak, Leopold Schmetterer, Stephan Handschuh, Martin Glösmann, Michael Pircher, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Biomedical Optics Express, Issue 8, 2017, Page(s) 298-314, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.8.000298

Evaluating cellularity and structural connectivity on whole brain slides using a custom-made digital pathology pipeline

Author(s): Thomas Roetzer, Konrad Leskovar, Nadine Peter, Julia Furtner, Martina Muck, Marco Augustin, Antonia Lichtenegger, Martha Nowosielski, Johannes A. Hainfellner, Bernhard Baumann, Adelheid Woehrer
Published in: Journal of Neuroscience Methods, Issue 311, 2019, Page(s) 215-221, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2018.10.029

Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging

Author(s): Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Martina Muck, Pablo Eugui, Danielle J. Harper, Matthias Salas, Marco Augustin, Conrad W. Merkle, Christoph K. Hitzenberger, Georg Widhalm, Adelheid Woehrer, Bernhard Baumann
Published in: Journal of Biomedical Optics, Issue 24/06, 2019, Page(s) 1, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.24.6.066010

Signal averaging improves signal-to-noise in OCT images: But which approach works best, and when?

Author(s): Bernhard Baumann, Conrad W. Merkle, Rainer A. Leitgeb, Marco Augustin, Andreas Wartak, Michael Pircher, Christoph K. Hitzenberger
Published in: Biomedical Optics Express, Issue 10/11, 2019, Page(s) 5755, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.10.005755

Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography

Author(s): Danielle J. Harper, Marco Augustin, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Martina Muck, Conrad W. Merkle, Pablo Eugui, Stefan Kummer, Adelheid Woehrer, Martin Glösmann, Bernhard Baumann
Published in: Neurophotonics, Issue 7/01, 2020, Page(s) 1, ISSN 2329-423X
Publisher: SPIE
DOI: 10.1117/1.nph.7.1.015006

Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium

Author(s): Danielle J. Harper, Thomas Konegger, Marco Augustin, Kornelia Schützenberger, Pablo Eugui, Antonia Lichtenegger, Conrad W. Merkle, Christoph K. Hitzenberger, Martin Glösmann, Bernhard Baumann
Published in: Journal of Biophotonics, Issue 12/12, 2019, Page(s) 14, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201900153

Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography

Author(s): Pablo Eugui, Danielle J. Harper, Antonia Lichtenegger, Marco Augustin, Conrad W. Merkle, Adelheid Woehrer, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Optics Letters, Issue 44/16, 2019, Page(s) 4040, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.44.004040

Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

Author(s): Johanna Gesperger, Antonia Lichtenegger, Thomas Roetzer, Marco Augustin, Danielle J. Harper, Pablo Eugui, Conrad W. Merkle, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Published in: Applied Sciences, Issue 9/10, 2019, Page(s) 2100, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app9102100

Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning

Author(s): Johanna Gesperger, Antonia Lichtenegger, Thomas Roetzer, Matthias Salas, Pablo Eugui, Danielle J. Harper, Conrad W. Merkle, Marco Augustin, Barbara Kiesel, Petra A. Mercea, Georg Widhalm, Bernhard Baumann, Adelheid Woehrer
Published in: Cancers, Issue 12/7, 2020, Page(s) 1806, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12071806

Visible light spectral domain optical coherence microscopy system for ex vivo imaging

Author(s): Antonia Lichtenegger, Danielle J. Harper, Marco Augustin, Pablo Eugui, Stanislava Fialová, Adelheid Woehrer, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Neural Imaging and Sensing, 2017, Page(s) 1005103
Publisher: SPIE
DOI: 10.1117/12.2250158

Multi-functional optical coherence tomography imaging of spontaneous neovascularization in the mouse retina

Author(s): Marco Augustin, Matthias Wechdorn, Ulrike Pfeiffenberger, Stanislava Fialová, René M. Werkmeister, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Optical Coherence Imaging Techniques and Imaging in Scattering Media II, 2017, Page(s) 23, ISBN 9781-510612914
Publisher: SPIE
DOI: 10.1117/12.2286128

Polarization-sensitive optical coherence microscopy of human brain samples

Author(s): Bernhard Baumann, Adelheid Woehrer, Christian Mitter, Gerda Ricken, Marco Augustin, Martina Muck, Michael Pircher, Christoph K. Hitzenberger
Published in: Optics in the Life Sciences Congress, 2017, Page(s) BrW4B.3, ISBN 978-1-943580-25-5
Publisher: OSA
DOI: 10.1364/brain.2017.brw4b.3

Visible light spectral domain optical coherence microscopy system for ex vivo brain imaging

Author(s): Antonia Lichtenegger, Danielle J. Harper, Marco Augustin, Pablo Eugui, Stanislava Fialová, Adelheid Woehrer, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Optics in the Life Sciences Congress, 2017, Page(s) JTu4A.16, ISBN 978-1-943580-25-5
Publisher: OSA
DOI: 10.1364/boda.2017.jtu4a.16

Few-mode fiber detection for tissue characterization in optical coherence tomography

Author(s): Antonia Lichtenegger, Danielle J. Harper, Marco Augustin, Stanislava Fialová, Andreas Wartak, Christoph K. Hitzenberger, Bernhard Baumann, Pablo Eugui
Published in: Optical Coherence Imaging Techniques and Imaging in Scattering Media II, 2017, Page(s) 34, ISBN 9781-510612914
Publisher: SPIE
DOI: 10.1117/12.2287667

Simultaneous Bright and Dark Field Optical Coherence Tomography Using Few-Mode Fiber Detection for Neuropathology Imaging

Author(s): Pablo Eugui, Antonia Lichtenegger, Marco Augustin, Danielle Harper, Martina Muck, Thomas Roetzer, andreas wartak, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) OTh2D.3, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/ots.2018.oth2d.3

Investigating Pathological Features of Alzheimer’s Disease in Human and Mouse Brain Tissue with Visible Light Optical Coherence Microscopy

Author(s): Antonia Lichtenegger, Martina Muck, Pablo Eugui, Danielle Harper, Marco Augustin, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) BF4C.3, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/brain.2018.bf4c.3

Multimode fiber for angle-resolved optical coherence tomography

Author(s): Pablo Eugui, Danielle J. Harper, Antonia Lichtenegger, Marco Augustin, Stanislava Fialová, Andreas Wartak, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Optics in the Life Sciences Congress, 2017, Page(s) BoM4A.3, ISBN 978-1-943580-25-5
Publisher: OSA
DOI: 10.1364/boda.2017.bom4a.3

Polarization-sensitive optical coherence tomography in the anterior mouse eye (Conference Presentation)

Author(s): Marco Augustin, Danielle J. Harper, Antonia Lichtenegger, Martina Muck, Pablo Eugui, Michael Pircher, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Ophthalmic Technologies XXVIII, 2018, Page(s) 7, ISBN 9781-510614345
Publisher: SPIE
DOI: 10.1117/12.2287334

Segmentation of Retinal Layers in OCT Images of the Mouse Eye Utilizing Polarization Contrast

Author(s): Marco Augustin, Danielle J. Harper, Conrad W. Merkle, Christoph K. Hitzenberger, Bernhard Baumann
Published in: 2018, Page(s) 310-318
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-00949-6_37

Combined visible light optical coherence microscopy and fluorescence imaging setup to investigate 5-aminolevulinic acid postive glioma samples

Author(s): Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Danielle J. Harper, Pablo Eugui, Matthias Salas, Marco Augustin, Thomas Roetzer, Christoph K. Hitzenberger, Georg Widhalm, Adelheid Woehrer, Bernhard Baumann
Published in: Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 2019, Page(s) 44, ISBN 9781-510628502
Publisher: SPIE
DOI: 10.1117/12.2526618

4D imaging of vascular leakage by contrast-enhanced OCT (Conference Presentation)

Author(s): Conrad W. Merkle, Marco Augustin, Vivek J. Srinivasan, Gerhard Garhofer, Bernhard Baumann
Published in: Ophthalmic Technologies XXIX, 2019, Page(s) 9, ISBN 9781-510623590
Publisher: SPIE
DOI: 10.1117/12.2510344

Indocyanine green provides absorption and spectral contrast for optical coherence tomography at 840 nm in vivo (Conference Presentation)

Author(s): Conrad W. Merkle, Marco Augustin, Danielle J. Harper, Bernhard Baumann
Published in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 2020, Page(s) 82, ISBN 9781-510632202
Publisher: SPIE
DOI: 10.1117/12.2548999

Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)

Author(s): Bernhard Baumann, Danielle J. Harper, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Martina Muck, Conrad W. Merkle, Pablo Eugui, Stefan Kummer, Adelheid Woehrer, Martin Glösmann, Marco Augustin
Published in: Ophthalmic Technologies XXX, 2020, Page(s) 47, ISBN 9781-510632004
Publisher: SPIE
DOI: 10.1117/12.2548412

Intra-tumor heterogeneity of glioblastoma samples revealed by visible light optical coherence microscopy (Conference Presentation)

Author(s): Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Pablo Eugui, Danielle J. Harper, Matthias Salas, Marco Augustin, Conrad W. Merkle, Christoph K. F. Hitzenberger, Georg Widhalm, Adelheid Wöhrer, Bernhard Baumann
Published in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 2020, Page(s) 64, ISBN 9781-510632202
Publisher: SPIE
DOI: 10.1117/12.2544612

Combined visible light optical coherence microscopy and fluorescence imaging system (Conference Presentation)

Author(s): Antonia Lichtenegger, Martina Muck, Danielle J. Harper, Marco Augustin, Pablo Eugui, Matthias Salas, Zoe Neuburger, Christoph K. Hitzenberger, Adelheid Wöhrer, Bernhard Baumann
Published in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 2019, Page(s) 31, ISBN 9781-510623774
Publisher: SPIE
DOI: 10.1117/12.2507445

Discrimination of brain tumor regional samples using combined visible light optical coherence microscopy and fluorescence imaging (Conference Presentation)

Author(s): Johanna Gesperger, Antonia Lichtenegger, Thomas Roetzer, Pablo Eugui Arrizabalaga, Barbara Kiesel, Danielle Jade Harper, Conrad Wiliam Merkle, Marco Augustin, Georg Widhalm, Adelheid Woehrer, Bernhard Baumann
Published in: Neural Imaging and Sensing 2020, 2020, Page(s) 49, ISBN 9781-510632165
Publisher: SPIE
DOI: 10.1117/12.2544652

Hyperspectral optical coherence tomography: a tool for in vivo visualization of melanin in the retinal pigment epithelium

Author(s): Danielle J. Harper, Thomas Konegger, Kornelia Schützenberger, Marco Augustin, Martin Glösmann, Antonia Lichtenegger, Pablo Eugui, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 2019, Page(s) 19, ISBN 9781-510628502
Publisher: SPIE
DOI: 10.1117/12.2526059

Simultaneous bright and dark field OCT with a polarization sensitive detection (Conference Presentation)

Author(s): Pablo Eugui, Conrad W. Merkle, Danielle J. Harper, Antonia Lichtenegger, Marco Augustin, Martina Muck, Adelheid Wöhrer, Christoph K. Hitzenberger, Bernhard Baumann
Published in: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 2019, Page(s) 64, ISBN 9781-510623774
Publisher: SPIE
DOI: 10.1117/12.2511454

Multi-scale investigation of Alzheimer’s disease brain tissue using 1060 nm swept source optical coherence tomography (Conference Presentation)

Author(s): Matthias Salas, Johanna Gesperger, Antonia Lichtenegger, Michael Niederleithner, Laurin Ginner, Adelheid Woehrer, Bernhard Baumann, Tilman Schmoll, Wolfgang Drexler, Rainer A. Leitgeb
Published in: Neural Imaging and Sensing 2020, 2020, Page(s) 27, ISBN 9781-510632165
Publisher: SPIE
DOI: 10.1117/12.2544765

Optical Coherence Tomography for Brain Imaging

Author(s): Bernhard Baumann
Published in: Advanced Optical Methods for Brain Imaging. Progress in Optical Science and Photonics, vol 5., 2018, Page(s) 49-68, ISBN 978-981-10-9019-6
Publisher: Springer Singapore
DOI: 10.1007/978-981-10-9020-2_2

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