Objective
The purpose of the proposed project is to investigate the commercialisation potential of an innovative technology that has been developed in my lab with ERC funding. For over 15 years, our laboratory at the Ecole Normale Supérieure of the Centre Nationale de la Recherche Scientifique (CNRS) has been developing an instrument called a ‘magnetic trap’. Initially developed in order to study the mechanisms of DNA replication and repair, we have discovered in the past few years that this instrument can also be used to extract both genetic and epigenetic information from single molecules of DNA. The highly novel approach we have developed is called SIMDEQTM (short for ‘SIngle-molecule Magnetic DEtection and Quantification’). We have shown that it can be used to rapidly identify, map, quantify, and fully sequence DNA fragments present in a genetic sample. In addition, a unique feature of the technology is that it can detect and locate the naturally-occurring biochemical modifications to DNA’s four bases (e.g. methylation). There is substantial commercial interest in reading these ‘epigenetic’ modifications as they are important in areas such as developmental biology, cancer, and microbial virulence.
The SIMDEQTM approach to genetic analysis is simple, elegant, and combines the DNA mapping and sequencing abilities of current instruments with the revolutionary ability to directly detect a wide range of DNA modifications at single base resolution. We believe SIMDEQTM could be a disruptive technology across a wide range of research and diagnostics sectors, but recognize that this is a dynamic field with many competitors and specialized niches. We therefore hope to investigate the market potential of this technology and identify the most promising applications through the work described in this proposal.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2014-PoC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.