Training Network for the Immunotherapy of Cancer

Resultado final

IMMUTRAIN position paper

Report on the IMMUTRAIN experience for future networks

Reports on conferences on the homepage

Publication for the non-scientific community, Rep month 21, 31 and 45

One manuscript on the combination of antibodies with therapeutic nucleic acids submitted for publication

Scientific article based on the ESR’s results in a major journal

One manuscript on the combination of antibodies with dendritic cell therapy submitted for publication

Scientific article based on the ESR’s results in a major journal

One manuscript on new formulations of antibodies to activate immune cells submitted for publication

Scientific article based on the ESR’s results in a major journal

One manuscript on the combination of antibodies with T cells submitted for publication

Scientific article based on the ESR’s results in a major journal

supervisory board

Supervisory Board committee members selected

Publicaciones

Cancer cells induce interleukin-22 production from memory CD4 + T cells via interleukin-1 to promote tumor growth

Autores: Cornelia Voigt, Peter May, Adrian Gottschlich, Anamarija Markota, Daniel Wenk, Inga Gerlach, Sebastian Voigt, Georgios T. Stathopoulos, Kristina A. M. Arendt, Constanze Heise, Felicitas Rataj, Klaus-Peter Janssen, Melanie Königshoff, Hauke Winter, Isabelle Himsl, Wolfgang E. Thasler, Max Schnurr, Simon Rothenfußer, Stefan Endres, Sebastian Kobold
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/49, 2017, Página(s) 12994-12999, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1705165114

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

Autores: David Olmeda, Daniela Cerezo-Wallis, Erica Riveiro-Falkenbach, Paula C. Pennacchi, Marta Contreras-Alcalde, Nuria Ibarz, Metehan Cifdaloz, Xavier Catena, Tonantzin G. Calvo, Estela Cañón, Direna Alonso-Curbelo, Javier Suarez, Lisa Osterloh, Osvaldo Graña, Francisca Mulero, Diego Megías, Marta Cañamero, Jorge L. Martínez-Torrecuadrada, Chandrani Mondal, Julie Di Martino, David Lora, Inés Mar
Publicado en: Nature, Edición 546/7660, 2017, Página(s) 676-680, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature22977

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Autores: Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P. M. Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P. Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein, Kristina Iribarren, Laura Mondragón, Nicolas Jacquelot, Bo Qu, Gladys Ferrere, Céline Clémenson, Laura Mezquita, Jordi Re
Publicado en: Science, Edición 359/6371, 2018, Página(s) 91-97, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aan3706

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Autores: Felicitas Rataj, Fabian B. T. Kraus, Michael Chaloupka, Simon Grassmann, Constanze Heise, Bruno L. Cadilha, Peter Duewell, Stefan Endres, Sebastian Kobold
Publicado en: Frontiers in Immunology, Edición 9, 2018, Página(s) 9: 1955, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01955

MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer

Autores: Jayakumar Vadakekolathu, Shaymaa Ismael Kadhim Al-Juboori, Catherine Johnson, Anne Schneider, Magdalena Elżbieta Buczek, Anna Di Biase, Alan Graham Pockley, Graham Roy Ball, Desmond George Powe, Tarik Regad
Publicado en: Cell Death & Disease, Edición 9/3, 2018, Página(s) 9(3):344, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-018-0364-9

Sialic acid blockade suppresses tumor growth by enhancing T cell-mediated tumor immunity

Autores: Christian Büll, Thomas J Boltje, Natasja Balneger, Sarah M Weischer, Melissa Wassink, Jasper J van Gemst, Victor R.L.J Bloemendal, Louis Boon, Johan van der Vlag, Torben Heise, Martijn H den Brok, Gosse J. Adema
Publicado en: Cancer Research, 2018, Página(s) canres.3376.2017, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-17-3376

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids

Autores: Torben Heise, Johan F. A. Pijnenborg, Christian Büll, Niek van Hilten, Esther D. Kers-Rebel, Natasja Balneger, Hidde Elferink, Gosse J. Adema, Thomas J. Boltje
Publicado en: Journal of Medicinal Chemistry, Edición 62/2, 2019, Página(s) 1014-1021, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b01757

Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

Autores: Xiao Liu, Junjian Li, Bruno Loureiro Cadilha, Anamarija Markota, Cornelia Voigt, Zhe Huang, Peter P. Lin, Daisy D. Wang, Juncheng Dai, Gisela Kranz, Anna Krandick, Darko Libl, Horst Zitzelsberger, Isabella Zagorski, Herbert Braselmann, Min Pan, Sibo Zhu, Yuanchi Huang, Sebastian Niedermeyer, Christoph A. Reichel, Bernd Uhl, Daria Briukhovetska, Javier Suárez, Sebastian Kobold, Olivier Gires, Hong
Publicado en: Science Advances, Edición 5/6, 2019, Página(s) eaav4275, ISSN 2375-2548
Editor: Science Advances
DOI: 10.1126/sciadv.aav4275

MERTK Acts as a Costimulatory Receptor on Human CD8 + T Cells

Autores: Marlies J.W. Peeters, Donata Dulkeviciute, Arianna Draghi, Cathrin Ritter, Anne Rahbech, Signe K. Skadborg, Tina Seremet, Ana Micaela Carnaz Simões, Evelina Martinenaite, Hólmfridur R. Halldórsdóttir, Mads Hald Andersen, Gitte Holmen Olofsson, Inge Marie Svane, Lene Juel Rasmussen, Özcan Met, Jürgen C. Becker, Marco Donia, Claus Desler, Per thor Straten
Publicado en: Cancer Immunology Research, Edición 7/9, 2019, Página(s) 1472-1484, ISSN 2326-6066
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-18-0841

Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy

Autores: Clara H. Karches, Mohamed-Reda Benmebarek, Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus, Martina Geiger, Felicitas Rataj, Bruno L. Cadilha, Stefanie Lesch, Constanze Heise, Ramona Murr, Johannes vom Berg, Martin Jastroch, Daniel Lamp, Jian Ding, Peter Duewell, Gerhard Niederfellner, Claudio Sustmann, Stefan Endres, Christian Klein, Sebastian Kobold
Publicado en: Clinical Cancer Research, Edición 25/19, 2019, Página(s) 5890-5900, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3927

A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model

Autores: Lydia Bellmann, Giuseppe Cappellano, Johanna F. Schachtl‐Riess, Anastasia Prokopi, Athanasios Seretis, Daniela Ortner, Christoph H. Tripp, Constance E. Brinckerhoff, David W. Mullins, Patrizia Stoitzner
Publicado en: International Journal of Cancer, Edición 146/5, 2019, Página(s) 1409-1420, ISSN 0020-7136
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32777

P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation

Autores: Diana Darowski, Christian Jost, Kay Stubenrauch, Uwe Wessels, Jörg Benz, Andreas Ehler, Anne Freimoser-Grundschober, Peter Brünker, Ekkehard Mössner, Pablo Umaña, Sebastian Kobold, Christian Klein
Publicado en: Protein Engineering, Design and Selection, 2019, ISSN 1741-0126
Editor: Oxford University Press
DOI: 10.1093/protein/gzz027

Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

Autores: Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. Koenig, Christine Hörth, Carlotta A. Rambuscheck, Daniel Böhmer, Julia Ahlfeld, Sebastian Kobold, Caroline C. Friedel, Stefan Endres, Max Schnurr, Peter Duewell
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 7/1, 2019, Página(s) 7:288, ISSN 2051-1426
Editor: Journal for Immunotherapy of Cancer
DOI: 10.1186/s40425-019-0778-7

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

Autores: Michael Ruzicka, Lars M. Koenig, Simone Formisano, Daniel F. R. Boehmer, Binje Vick, Eva-M. Heuer, Hanna Meinl, Lorenz Kocheise, Marcus Zeitlhöfler, Julia Ahlfeld, Sebastian Kobold, Stefan Endres, Marion Subklewe, Peter Duewell, Max Schnurr, Irmela Jeremias, Felix S. Lichtenegger, Simon Rothenfusser
Publicado en: Leukemia, 2019, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-019-0639-x

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy

Autores: Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes vom Berg
Publicado en: Frontiers in Oncology, Edición 8, 2018, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00285

Can we use interleukin-1β blockade for lung cancer treatment?

Autores: Adrian Gottschlich, Stefan Endres, Sebastian Kobold
Publicado en: Translational Lung Cancer Research, Edición 7/S2, 2018, Página(s) S160-S164, ISSN 2218-6751
Editor: AME Publishing Company
DOI: 10.21037/tlcr.2018.03.15

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Autores: Mohamed-Reda Benmebarek, Clara Karches, Bruno Cadilha, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Publicado en: International Journal of Molecular Sciences, Edición 20/6, 2019, Página(s) 1283, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20061283

Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

Autores: Stefan Stoiber, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Publicado en: Cells, Edición 8/5, 2019, Página(s) 472, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells8050472

Cancer Stem Cells and Targeting Strategies

Autores: Luisa Barbato, Marco Bocchetti, Anna Di Biase, Tarik Regad
Publicado en: Cells, Edición 8/8, 2019, Página(s) 926, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells8080926

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