Training Network for the Immunotherapy of Cancer

Rezultaty

IMMUTRAIN position paper

Report on the IMMUTRAIN experience for future networks

Reports on conferences on the homepage

Publication for the non-scientific community, Rep month 21, 31 and 45

One manuscript on the combination of antibodies with therapeutic nucleic acids submitted for publication

Scientific article based on the ESR’s results in a major journal

One manuscript on the combination of antibodies with dendritic cell therapy submitted for publication

Scientific article based on the ESR’s results in a major journal

One manuscript on new formulations of antibodies to activate immune cells submitted for publication

Scientific article based on the ESR’s results in a major journal

One manuscript on the combination of antibodies with T cells submitted for publication

Scientific article based on the ESR’s results in a major journal

supervisory board

Supervisory Board committee members selected

Publikacje

Cancer cells induce interleukin-22 production from memory CD4 + T cells via interleukin-1 to promote tumor growth

Autorzy: Cornelia Voigt, Peter May, Adrian Gottschlich, Anamarija Markota, Daniel Wenk, Inga Gerlach, Sebastian Voigt, Georgios T. Stathopoulos, Kristina A. M. Arendt, Constanze Heise, Felicitas Rataj, Klaus-Peter Janssen, Melanie Königshoff, Hauke Winter, Isabelle Himsl, Wolfgang E. Thasler, Max Schnurr, Simon Rothenfußer, Stefan Endres, Sebastian Kobold
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 114/49, 2017, Strona(/y) 12994-12999, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1705165114

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

Autorzy: David Olmeda, Daniela Cerezo-Wallis, Erica Riveiro-Falkenbach, Paula C. Pennacchi, Marta Contreras-Alcalde, Nuria Ibarz, Metehan Cifdaloz, Xavier Catena, Tonantzin G. Calvo, Estela Cañón, Direna Alonso-Curbelo, Javier Suarez, Lisa Osterloh, Osvaldo Graña, Francisca Mulero, Diego Megías, Marta Cañamero, Jorge L. Martínez-Torrecuadrada, Chandrani Mondal, Julie Di Martino, David Lora, Inés Mar
Opublikowane w: Nature, Numer 546/7660, 2017, Strona(/y) 676-680, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature22977

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Autorzy: Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P. M. Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P. Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein, Kristina Iribarren, Laura Mondragón, Nicolas Jacquelot, Bo Qu, Gladys Ferrere, Céline Clémenson, Laura Mezquita, Jordi Re
Opublikowane w: Science, Numer 359/6371, 2018, Strona(/y) 91-97, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aan3706

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Autorzy: Felicitas Rataj, Fabian B. T. Kraus, Michael Chaloupka, Simon Grassmann, Constanze Heise, Bruno L. Cadilha, Peter Duewell, Stefan Endres, Sebastian Kobold
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, Strona(/y) 9: 1955, ISSN 1664-3224
Wydawca: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01955

MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer

Autorzy: Jayakumar Vadakekolathu, Shaymaa Ismael Kadhim Al-Juboori, Catherine Johnson, Anne Schneider, Magdalena Elżbieta Buczek, Anna Di Biase, Alan Graham Pockley, Graham Roy Ball, Desmond George Powe, Tarik Regad
Opublikowane w: Cell Death & Disease, Numer 9/3, 2018, Strona(/y) 9(3):344, ISSN 2041-4889
Wydawca: Nature Publishing Group
DOI: 10.1038/s41419-018-0364-9

Sialic acid blockade suppresses tumor growth by enhancing T cell-mediated tumor immunity

Autorzy: Christian Büll, Thomas J Boltje, Natasja Balneger, Sarah M Weischer, Melissa Wassink, Jasper J van Gemst, Victor R.L.J Bloemendal, Louis Boon, Johan van der Vlag, Torben Heise, Martijn H den Brok, Gosse J. Adema
Opublikowane w: Cancer Research, 2018, Strona(/y) canres.3376.2017, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-17-3376

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids

Autorzy: Torben Heise, Johan F. A. Pijnenborg, Christian Büll, Niek van Hilten, Esther D. Kers-Rebel, Natasja Balneger, Hidde Elferink, Gosse J. Adema, Thomas J. Boltje
Opublikowane w: Journal of Medicinal Chemistry, Numer 62/2, 2019, Strona(/y) 1014-1021, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b01757

Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

Autorzy: Xiao Liu, Junjian Li, Bruno Loureiro Cadilha, Anamarija Markota, Cornelia Voigt, Zhe Huang, Peter P. Lin, Daisy D. Wang, Juncheng Dai, Gisela Kranz, Anna Krandick, Darko Libl, Horst Zitzelsberger, Isabella Zagorski, Herbert Braselmann, Min Pan, Sibo Zhu, Yuanchi Huang, Sebastian Niedermeyer, Christoph A. Reichel, Bernd Uhl, Daria Briukhovetska, Javier Suárez, Sebastian Kobold, Olivier Gires, Hong
Opublikowane w: Science Advances, Numer 5/6, 2019, Strona(/y) eaav4275, ISSN 2375-2548
Wydawca: Science Advances
DOI: 10.1126/sciadv.aav4275

MERTK Acts as a Costimulatory Receptor on Human CD8 + T Cells

Autorzy: Marlies J.W. Peeters, Donata Dulkeviciute, Arianna Draghi, Cathrin Ritter, Anne Rahbech, Signe K. Skadborg, Tina Seremet, Ana Micaela Carnaz Simões, Evelina Martinenaite, Hólmfridur R. Halldórsdóttir, Mads Hald Andersen, Gitte Holmen Olofsson, Inge Marie Svane, Lene Juel Rasmussen, Özcan Met, Jürgen C. Becker, Marco Donia, Claus Desler, Per thor Straten
Opublikowane w: Cancer Immunology Research, Numer 7/9, 2019, Strona(/y) 1472-1484, ISSN 2326-6066
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-18-0841

Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy

Autorzy: Clara H. Karches, Mohamed-Reda Benmebarek, Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus, Martina Geiger, Felicitas Rataj, Bruno L. Cadilha, Stefanie Lesch, Constanze Heise, Ramona Murr, Johannes vom Berg, Martin Jastroch, Daniel Lamp, Jian Ding, Peter Duewell, Gerhard Niederfellner, Claudio Sustmann, Stefan Endres, Christian Klein, Sebastian Kobold
Opublikowane w: Clinical Cancer Research, Numer 25/19, 2019, Strona(/y) 5890-5900, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3927

A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model

Autorzy: Lydia Bellmann, Giuseppe Cappellano, Johanna F. Schachtl‐Riess, Anastasia Prokopi, Athanasios Seretis, Daniela Ortner, Christoph H. Tripp, Constance E. Brinckerhoff, David W. Mullins, Patrizia Stoitzner
Opublikowane w: International Journal of Cancer, Numer 146/5, 2019, Strona(/y) 1409-1420, ISSN 0020-7136
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32777

P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation

Autorzy: Diana Darowski, Christian Jost, Kay Stubenrauch, Uwe Wessels, Jörg Benz, Andreas Ehler, Anne Freimoser-Grundschober, Peter Brünker, Ekkehard Mössner, Pablo Umaña, Sebastian Kobold, Christian Klein
Opublikowane w: Protein Engineering, Design and Selection, 2019, ISSN 1741-0126
Wydawca: Oxford University Press
DOI: 10.1093/protein/gzz027

Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

Autorzy: Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. Koenig, Christine Hörth, Carlotta A. Rambuscheck, Daniel Böhmer, Julia Ahlfeld, Sebastian Kobold, Caroline C. Friedel, Stefan Endres, Max Schnurr, Peter Duewell
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 7/1, 2019, Strona(/y) 7:288, ISSN 2051-1426
Wydawca: Journal for Immunotherapy of Cancer
DOI: 10.1186/s40425-019-0778-7

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

Autorzy: Michael Ruzicka, Lars M. Koenig, Simone Formisano, Daniel F. R. Boehmer, Binje Vick, Eva-M. Heuer, Hanna Meinl, Lorenz Kocheise, Marcus Zeitlhöfler, Julia Ahlfeld, Sebastian Kobold, Stefan Endres, Marion Subklewe, Peter Duewell, Max Schnurr, Irmela Jeremias, Felix S. Lichtenegger, Simon Rothenfusser
Opublikowane w: Leukemia, 2019, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/s41375-019-0639-x

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy

Autorzy: Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes vom Berg
Opublikowane w: Frontiers in Oncology, Numer 8, 2018, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00285

Can we use interleukin-1β blockade for lung cancer treatment?

Autorzy: Adrian Gottschlich, Stefan Endres, Sebastian Kobold
Opublikowane w: Translational Lung Cancer Research, Numer 7/S2, 2018, Strona(/y) S160-S164, ISSN 2218-6751
Wydawca: AME Publishing Company
DOI: 10.21037/tlcr.2018.03.15

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Autorzy: Mohamed-Reda Benmebarek, Clara Karches, Bruno Cadilha, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Opublikowane w: International Journal of Molecular Sciences, Numer 20/6, 2019, Strona(/y) 1283, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20061283

Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

Autorzy: Stefan Stoiber, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Opublikowane w: Cells, Numer 8/5, 2019, Strona(/y) 472, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells8050472

Cancer Stem Cells and Targeting Strategies

Autorzy: Luisa Barbato, Marco Bocchetti, Anna Di Biase, Tarik Regad
Opublikowane w: Cells, Numer 8/8, 2019, Strona(/y) 926, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells8080926

Rezultaty

Publikacje

Udostępnij tę stronę

Pobierz