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CORDIS - EU research results
CORDIS

UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Sporulation Mutants Isolated (opens in new window)

Directed random from Clostridium sp

Germination Mutants Isolated (opens in new window)

Directed random from Clostridium sp

Increased understanding of disease (opens in new window)

Improved epidemiology/ diagnostics

Characterised sporulation genes (opens in new window)

Role of sporulation genes determined

ESRs recruited (opens in new window)

Target date for all starters

First ESR scientific presentation (opens in new window)

Given at nationalinternational meeting

Appointment of Supervisory Board (opens in new window)

Supervisory Board committee members selected

Conditionally CDEPTsporulating strain (opens in new window)

Prototype strain for clinical trial

Decision-making at single cell level (opens in new window)

Understanding sporulationtoxigenesis

Ethics (opens in new window)

Delivery of ethics documents before commencement of the relevant part of the research

Exemplification of ACE technology (opens in new window)

Demonstrated in target Clostridium sp

Characterised germination genes (opens in new window)

Role of germination genes determined

Promotional material distributed (opens in new window)

Webdownloads and meeting flyers

Mid-term Conference (opens in new window)

Conference Proceedings at website

Submission of Doctorate Thesis (opens in new window)

Subject to National requirements

Universal transposon exemplified (opens in new window)

Exemplified in target Clostridium

Final Conference Proceedings (opens in new window)

Conference Proceedings at website

Spore regulators common to toxins (opens in new window)

Links to toxin/metabolite production

New sporulation/germination genes (opens in new window)

In pathogenic nonpathogenic clostridia

Asporogenous butanol producers (opens in new window)

In C acetobutylicum Clostridium sp

Final Report (opens in new window)

Final Project report submitted to commission

Publications

Hijacking CRISPR-Cas for high-throughput bacterial metabolic engineering: advances and prospects (opens in new window)

Author(s): Ioannis Mougiakos, Elleke F Bosma, Joyshree Ganguly, John van der Oost, Richard van Kranenburg
Published in: Current Opinion in Biotechnology, Issue 50, 2018, Page(s) 146-157, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2018.01.002

Investigating the Central Metabolism of Clostridium thermosuccinogenes (opens in new window)

Author(s): Jeroen Girwar Koendjbiharie, Kilian Wiersma, Richard van Kranenburg
Published in: Applied and Environmental Microbiology, Issue 84/13, 2018, Page(s) e00363-18, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/AEM.00363-18

L-Rhamnose metabolism in Clostridium beijerinckii DSM 6423 (opens in new window)

Author(s): M. Diallo, A. D. Simons, H. van der Wal, F. Collas, Bwee Houweling-Tan, S. W. M. Kengen, A. M. López-Contreras
Published in: Applied and Environmental Microbiology, 2018, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.02656-18

Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system (opens in new window)

Author(s): Patrick Ingle, Daphne Groothuis, Peter Rowe, He Huang, Alan Cockayne, Sarah A. Kuehne, Weihong Jiang, Yang Gu, Christopher M. Humphreys, Nigel P. Minton
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-44458-y

RiboCas: A Universal CRISPR-Based Editing Tool for Clostridium (opens in new window)

Author(s): Inés C. Cañadas, Daphne Groothuis, Maria Zygouropoulou, Raquel Rodrigues, Nigel P. Minton
Published in: ACS Synthetic Biology, 2019, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.9b00075

Intellectual Property Rights

PROCESSES INVOLVING CLOSTRIDIUM SACCHAROPERBUTYLACETONICUM

Application/Publication number: PCT/ GB2018/052937
Date: 2018-10-12
Applicant(s): BIOCLEAVE LIMITED

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