Deliverables
Directed random from Clostridium sp
Germination Mutants IsolatedDirected random from Clostridium sp
Increased understanding of diseaseImproved epidemiology/ diagnostics
Characterised sporulation genesRole of sporulation genes determined
ESRs recruitedTarget date for all starters
First ESR scientific presentationGiven at nationalinternational meeting
Appointment of Supervisory BoardSupervisory Board committee members selected
Conditionally CDEPTsporulating strainPrototype strain for clinical trial
Decision-making at single cell levelUnderstanding sporulationtoxigenesis
EthicsDelivery of ethics documents before commencement of the relevant part of the research
Exemplification of ACE technologyDemonstrated in target Clostridium sp
Characterised germination genesRole of germination genes determined
Promotional material distributedWebdownloads and meeting flyers
Mid-term ConferenceConference Proceedings at website
Submission of Doctorate ThesisSubject to National requirements
Universal transposon exemplifiedExemplified in target Clostridium
Final Conference ProceedingsConference Proceedings at website
Spore regulators common to toxinsLinks to toxin/metabolite production
New sporulation/germination genesIn pathogenic nonpathogenic clostridia
Asporogenous butanol producersIn C acetobutylicum Clostridium sp
Final Project report submitted to commission
Twitter account Facebook Page active
CLOSPORE websiteWebsite established at wwwclosporenet
Publications
Author(s):
Ioannis Mougiakos, Elleke F Bosma, Joyshree Ganguly, John van der Oost, Richard van Kranenburg
Published in:
Current Opinion in Biotechnology, Issue 50, 2018, Page(s) 146-157, ISSN 0958-1669
Publisher:
Elsevier BV
DOI:
10.1016/j.copbio.2018.01.002
Author(s):
Jeroen Girwar Koendjbiharie, Kilian Wiersma, Richard van Kranenburg
Published in:
Applied and Environmental Microbiology, Issue 84/13, 2018, Page(s) e00363-18, ISSN 0099-2240
Publisher:
American Society for Microbiology
DOI:
10.1128/AEM.00363-18
Author(s):
M. Diallo, A. D. Simons, H. van der Wal, F. Collas, Bwee Houweling-Tan, S. W. M. Kengen, A. M. López-Contreras
Published in:
Applied and Environmental Microbiology, 2018, ISSN 0099-2240
Publisher:
American Society for Microbiology
DOI:
10.1128/aem.02656-18
Author(s):
Patrick Ingle, Daphne Groothuis, Peter Rowe, He Huang, Alan Cockayne, Sarah A. Kuehne, Weihong Jiang, Yang Gu, Christopher M. Humphreys, Nigel P. Minton
Published in:
Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-019-44458-y
Author(s):
Inés C. Cañadas, Daphne Groothuis, Maria Zygouropoulou, Raquel Rodrigues, Nigel P. Minton
Published in:
ACS Synthetic Biology, 2019, ISSN 2161-5063
Publisher:
American Chemical Society
DOI:
10.1021/acssynbio.9b00075
Intellectual Property Rights
Application/Publication number:
PCT/
GB2018/052937
Date:
2018-10-12
Applicant(s):
BIOCLEAVE LIMITED
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