Skip to main content

UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION

Objective

Bacterial endospores are the most resistant life-forms on earth and the most important single feature of the genus Clostridium. Thus, whilst the pathogenesis of its notorious pathogens (C. botulinum, C. perfringens and C. difficile) is ascribed to the devastating toxins produced (neurotoxins, endotoxins and cytotoxins), it is their capacity to produce spores that lies at the heart of the diseases they cause. This is because spores play the pivotal role in the spread of infection (eg, C. difficile) and in foodstuff contamination and food poisoning (eg, C. botulinum and C. perfringens). The processes of spore formation (sporulation) and germination (return of the dormant spore to toxin-producing, vegetative cells), therefore, represent key intervention points. On the other hand, the majority of clostridia are entirely benign and can sustainably produce all manner of useful chemicals and fuels. Crucially, the regulation of chemical production is intimately linked to that of sporulation. Spores of benign species may also be used as a delivery system for treating cancer. Yet, despite the spore’s importance, little is known of the developmental processes of sporulation and germination. This is because research and training efforts on Clostridium spores are fragmented and there is no coherence between researchers working on pathogenic and industrially important species. CLOSPORE will address this deficiency by pooling the resources of Europe’s leading universities, research organisations and companies, to create an intersectorial Research and Training Programme that is multi-facetted, interdisciplinary and focused on clostridial spores. Accordingly, CLOSPORE will produce the innovative, applied research leaders of the future, able to tackle the big societal challenges facing Europe and the world.

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

THE UNIVERSITY OF NOTTINGHAM
Address
University Park
NG7 2RD Nottingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 819 863,64

Participants (7)

HELSINGIN YLIOPISTO
Finland
EU contribution
€ 538 290,72
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
NIZO FOOD RESEARCH BV
Netherlands
EU contribution
€ 510 748,56
Address
Kernhemseweg 2
6718 ZB Ede Gld
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDADE NOVA DE LISBOA
Portugal
EU contribution
€ 476 712,72
Address
Campus De Campolide
1099 085 Lisboa
Activity type
Higher or Secondary Education Establishments
PURAC BIOCHEM BV
Netherlands
EU contribution
€ 510 748,56
Address
Arkelsedijk 46
4206AC Gorinchem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT PASTEUR
France
EU contribution
€ 525 751,20
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Green Biologics Ltd.
United Kingdom
EU contribution
€ 273 287,88
Address
45A Western Avenue, Milton Park
OX144RU Abingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 255 374,28
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations

Partners (9)

ASTELLAS PHARMA EUROPE LTD
United Kingdom
Address
2000 Hillswood Drive
KT16 0RS Chertsey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LANZATECH UK LTD
United Kingdom
Address
Horndean Road Forest House 3 5
RG12 0XQ Bracknell
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
METABOLIC EXPLORER SA
France
Address
Biopole Clermont Limagne
63360 Saint Beauzire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOMERIEUX SA
France
Address
Chemin De L'orme
69280 Marcy L'etoile
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Ipsen Pharmaceuticals
United Kingdom
Address

Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Atria Suomi Oy
Finland
Address
Atriantie 1
60060 ATRIA Kuopio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SaarioinenOy
Finland
Address
Järvensivuntie 1
FI-33101 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Snellmanin Lihanjalostus Oy
Finland
Address

Pietarsaari
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HKScan Ltd
Finland
Address

Turku
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)