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UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION

Objective

Bacterial endospores are the most resistant life-forms on earth and the most important single feature of the genus Clostridium. Thus, whilst the pathogenesis of its notorious pathogens (C. botulinum, C. perfringens and C. difficile) is ascribed to the devastating toxins produced (neurotoxins, endotoxins and cytotoxins), it is their capacity to produce spores that lies at the heart of the diseases they cause. This is because spores play the pivotal role in the spread of infection (eg, C. difficile) and in foodstuff contamination and food poisoning (eg, C. botulinum and C. perfringens). The processes of spore formation (sporulation) and germination (return of the dormant spore to toxin-producing, vegetative cells), therefore, represent key intervention points. On the other hand, the majority of clostridia are entirely benign and can sustainably produce all manner of useful chemicals and fuels. Crucially, the regulation of chemical production is intimately linked to that of sporulation. Spores of benign species may also be used as a delivery system for treating cancer. Yet, despite the spore’s importance, little is known of the developmental processes of sporulation and germination. This is because research and training efforts on Clostridium spores are fragmented and there is no coherence between researchers working on pathogenic and industrially important species. CLOSPORE will address this deficiency by pooling the resources of Europe’s leading universities, research organisations and companies, to create an intersectorial Research and Training Programme that is multi-facetted, interdisciplinary and focused on clostridial spores. Accordingly, CLOSPORE will produce the innovative, applied research leaders of the future, able to tackle the big societal challenges facing Europe and the world.

Coordinator

THE UNIVERSITY OF NOTTINGHAM
Net EU contribution
€ 819 863,64
Address
University Park
NG7 2RD Nottingham
United Kingdom

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Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (7)

HELSINGIN YLIOPISTO
Finland
Net EU contribution
€ 538 290,72
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NIZO FOOD RESEARCH BV
Netherlands
Net EU contribution
€ 510 748,56
Address
Kernhemseweg 2
6718 ZB Ede Gld

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Gelderland Veluwe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSIDADE NOVA DE LISBOA
Portugal
Net EU contribution
€ 476 712,72
Address
Campus De Campolide
1099 085 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PURAC BIOCHEM BV
Netherlands
Net EU contribution
€ 510 748,56
Address
Arkelsedijk 46
4206AC Gorinchem

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Region
West-Nederland Zuid-Holland Zuidoost-Zuid-Holland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSTITUT PASTEUR
France
Net EU contribution
€ 525 751,20
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
BIOCLEAVE LIMITED
United Kingdom
Net EU contribution
€ 273 287,88
Address
154ah Brook Drive
OX14 4SD Abingdon

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
STICHTING WAGENINGEN RESEARCH
Netherlands
Net EU contribution
€ 255 374,28
Address
Droevendaalsesteeg 4
6708 PB Wageningen

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (9)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ASTELLAS PHARMA EUROPE LTD
United Kingdom
Net EU contribution
€ 0,00
Address
2000 Hillswood Drive
KT16 0RS Chertsey

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Region
South East (England) Surrey, East and West Sussex West Surrey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

LANZATECH UK LTD
United Kingdom
Net EU contribution
€ 0,00
Address
Horndean Road Forest House 3 5
RG12 0XQ Bracknell

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

METABOLIC EXPLORER SA
France
Net EU contribution
€ 0,00
Address
Biopole Clermont Limagne
63360 Saint Beauzire

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Auvergne-Rhône-Alpes Auvergne Puy-de-Dôme
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BIOMERIEUX SA
France
Net EU contribution
€ 0,00
Address
Chemin De L'orme
69280 Marcy L'etoile

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Ipsen Pharmaceuticals
United Kingdom
Net EU contribution
€ 0,00
Address

Oxford

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Atria Suomi Oy
Finland
Net EU contribution
€ 0,00
Address
Atriantie 1
60060 ATRIA Kuopio

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Region
Manner-Suomi Länsi-Suomi Etelä-Pohjanmaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

SaarioinenOy
Finland
Net EU contribution
€ 0,00
Address
Järvensivuntie 1
FI-33101 Tampere

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Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Snellmanin Lihanjalostus Oy
Finland
Net EU contribution
€ 0,00
Address

Pietarsaari

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

HKScan Ltd
Finland
Net EU contribution
€ 0,00
Address

Turku

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00