UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION

Rezultaty

Sporulation Mutants Isolated

Directed random from Clostridium sp

Germination Mutants Isolated

Directed random from Clostridium sp

Increased understanding of disease

Improved epidemiology/ diagnostics

Characterised sporulation genes

Role of sporulation genes determined

ESRs recruited

Target date for all starters

First ESR scientific presentation

Given at nationalinternational meeting

Appointment of Supervisory Board

Supervisory Board committee members selected

Conditionally CDEPTsporulating strain

Prototype strain for clinical trial

Decision-making at single cell level

Understanding sporulationtoxigenesis

Ethics

Delivery of ethics documents before commencement of the relevant part of the research

Exemplification of ACE technology

Demonstrated in target Clostridium sp

Characterised germination genes

Role of germination genes determined

Promotional material distributed

Webdownloads and meeting flyers

Mid-term Conference

Conference Proceedings at website

Submission of Doctorate Thesis

Subject to National requirements

Universal transposon exemplified

Exemplified in target Clostridium

Final Conference Proceedings

Conference Proceedings at website

Spore regulators common to toxins

Links to toxin/metabolite production

New sporulation/germination genes

In pathogenic nonpathogenic clostridia

Asporogenous butanol producers

In C acetobutylicum Clostridium sp

Final Report

Final Project report submitted to commission

Social Media Established

Twitter account Facebook Page active

CLOSPORE website

Website established at wwwclosporenet

Publikacje

Hijacking CRISPR-Cas for high-throughput bacterial metabolic engineering: advances and prospects

Autorzy: Ioannis Mougiakos, Elleke F Bosma, Joyshree Ganguly, John van der Oost, Richard van Kranenburg
Opublikowane w: Current Opinion in Biotechnology, Numer 50, 2018, Strona(/y) 146-157, ISSN 0958-1669
Wydawca: Elsevier BV
DOI: 10.1016/j.copbio.2018.01.002

Investigating the Central Metabolism of Clostridium thermosuccinogenes

Autorzy: Jeroen Girwar Koendjbiharie, Kilian Wiersma, Richard van Kranenburg
Opublikowane w: Applied and Environmental Microbiology, Numer 84/13, 2018, Strona(/y) e00363-18, ISSN 0099-2240
Wydawca: American Society for Microbiology
DOI: 10.1128/AEM.00363-18

L-Rhamnose metabolism in Clostridium beijerinckii DSM 6423

Autorzy: M. Diallo, A. D. Simons, H. van der Wal, F. Collas, Bwee Houweling-Tan, S. W. M. Kengen, A. M. López-Contreras
Opublikowane w: Applied and Environmental Microbiology, 2018, ISSN 0099-2240
Wydawca: American Society for Microbiology
DOI: 10.1128/aem.02656-18

Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system

Autorzy: Patrick Ingle, Daphne Groothuis, Peter Rowe, He Huang, Alan Cockayne, Sarah A. Kuehne, Weihong Jiang, Yang Gu, Christopher M. Humphreys, Nigel P. Minton
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-44458-y

RiboCas: A Universal CRISPR-Based Editing Tool for Clostridium

Autorzy: Inés C. Cañadas, Daphne Groothuis, Maria Zygouropoulou, Raquel Rodrigues, Nigel P. Minton
Opublikowane w: ACS Synthetic Biology, 2019, ISSN 2161-5063
Wydawca: American Chemical Society
DOI: 10.1021/acssynbio.9b00075

Prawa własności intelektualnej

PROCESSES INVOLVING CLOSTRIDIUM SACCHAROPERBUTYLACETONICUM

Numer wniosku/publikacji: PCT/ GB2018/052937
Data: 2018-10-12
Wnioskodawca/wnioskodawcy: BIOCLEAVE LIMITED

Rezultaty

Publikacje

Prawa własności intelektualnej

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