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Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Training reports

Annual report on progress of the training program. Due in months:13, 25,37, 48.

Minutes of training events

Minutes of network-wide training events. Due in months: 7, 13, 19, 37

Progress, periodic, midterm and final reports

Progress, periodic, midterm and final reports. Due at months: 13, 18, 25, 37, 48

Agenda

Annual agenda of open local training activities. Due in months: 3, 13, 25, 37.

Annual agenda of outreach activities

Annual agenda of outreach activities. Due at months 6, 13, 25, 37.

Dissemination plan
Consortium quarterly newsletter

Consortium quarterly newsletter, due each 4 months.

Publications

Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives

Author(s): Lenny Zaffaroni, Francesco Peri
Published in: Future Medicinal Chemistry, 2018, ISSN 1756-8919
Publisher: Future Science Ltd.
DOI: 10.4155/fmc-2017-0172

Co-administration of Antimicrobial Peptides Enhances Toll-like Receptor 4 Antagonist Activity of a Synthetic Glycolipid

Author(s): Fabio A. Facchini, Helena Coelho, Stefania E. Sestito, Sandra Delgado, Alberto Minotti, David Andreu, Jesús Jiménez-Barbero, Francesco Peri
Published in: ChemMedChem, Issue 13/3, 2018, Page(s) 280-287, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201700694

The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling

Author(s): Florent Cochet, Francesco Peri
Published in: International Journal of Molecular Sciences, Issue 18/11, 2017, Page(s) 2318, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18112318

The Deep-Sea Polyextremophile Halobacteroides lacunaris TB21 Rough-Type LPS: Structure and Inhibitory Activity towards Toxic LPS

Author(s): Flaviana Di Lorenzo, Angelo Palmigiano, Ida Paciello, Mateusz Pallach, Domenico Garozzo, Maria-Lina Bernardini, Violetta La Cono, Michail M. Yakimov, Antonio Molinaro, Alba Silipo
Published in: Marine Drugs, Issue 15/12, 2017, Page(s) 201, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md15070201

Structure of the Lipopolysaccharide from the Bradyrhizobium sp. ORS285 rfaL Mutant Strain

Author(s): Flaviana Di Lorenzo, Angelo Palmigiano, Katarzyna A. Duda, Mateusz Pallach, Nicolas Busset, Luisa Sturiale, Eric Giraud, Domenico Garozzo, Antonio Molinaro, Alba Silipo
Published in: ChemistryOpen, Issue 6/4, 2017, Page(s) 541-553, ISSN 2191-1363
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/open.201700074

Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

Author(s): Fabio A. Facchini, Lenny Zaffaroni, Alberto Minotti, Silvia Rapisarda, Valentina Calabrese, Matilde Forcella, Paola Fusi, Cristina Airoldi, Carlotta Ciaramelli, Jean-Marc Billod, Andra B. Schromm, Harald Braun, Charys Palmer, Rudi Beyaert, Fabio Lapenta, Roman Jerala, Grisha Pirianov, Sonsoles Martin-Santamaria, Francesco Peri
Published in: Journal of Medicinal Chemistry, 2018, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01803

The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40T

Author(s): Clara Barrau, Flaviana Di Lorenzo, Rodolfo Menes, Rosa Lanzetta, Antonio Molinaro, Alba Silipo
Published in: Marine Drugs, Issue 16/4, 2018, Page(s) 124, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md16040124

Lipid A Structure and Immunoinhibitory Effect of the Marine Bacterium Cobetia pacifica KMM 3879 T

Author(s): Flaviana Di Lorenzo, Angelo Palmigiano, Sami Albitar-Nehme, Mateusz Pallach, Maxim Kokoulin, Nadezhda Komandrova, Lyudmila Romanenko, Maria Lina Bernardini, Domenico Garozzo, Antonio Molinaro, Alba Silipo
Published in: European Journal of Organic Chemistry, Issue 2018/20-21, 2018, Page(s) 2707-2716, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201800279

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo

Author(s): Ajasja Ljubetič, Fabio Lapenta, Helena Gradišar, Igor Drobnak, Jana Aupič, Žiga Strmšek, Duško Lainšček, Iva Hafner-Bratkovič, Andreja Majerle, Nuša Krivec, Mojca Benčina, Tomaž Pisanski, Tanja Ćirković Veličković, Adam Round, José María Carazo, Roberto Melero, Roman Jerala
Published in: Nature Biotechnology, 2017, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.3994

Coiled coil protein origami: from modular design principles towards biotechnological applications

Author(s): Fabio Lapenta, Jana Aupič, Žiga Strmšek, Roman Jerala
Published in: Chemical Society Reviews, Issue 47/10, 2018, Page(s) 3530-3542, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cs00822h

Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

Author(s): Luigi Lembo-Fazio, Jean-Marc Billod, Flaviana Di Lorenzo, Ida Paciello, Mateusz Pallach, Sara Vaz-Francisco, Aurora Holgado, Rudi Beyaert, Manuel Fresno, Atsushi Shimoyama, Rosa Lanzetta, Koichi Fukase, Djamel Gully, Eric Giraud, Sonsoles Martín-Santamaría, Maria-Lina Bernardini, Alba Silipo
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01888

Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1

Author(s): Giordano Traini, Ane Ruiz-de-Angulo, Juan Bautista Blanco-Canosa, Kepa Zamacola Bascarán, Antonio Molinaro, Alba Silipo, David Escors, Juan C. Mareque-Rivas
Published in: Small, Issue 15/4, 2019, Page(s) 1803993, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201803993

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

Author(s): Florent Cochet, Fabio A. Facchini, Lenny Zaffaroni, Jean-Marc Billod, Helena Coelho, Aurora Holgado, Harald Braun, Rudi Beyaert, Roman Jerala, Jesus Jimenez-Barbero, Sonsoles Martin-Santamaria, Francesco Peri
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-37421-w

Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108

Author(s): Mateusz Pallach, Flaviana Di Lorenzo, Fabio Alessandro Facchini, Djamel Gully, Eric Giraud, Francesco Peri, Katarzyna A. Duda, Antonio Molinaro, Alba Silipo
Published in: International Journal of Biological Macromolecules, Issue 119, 2018, Page(s) 1027-1035, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2018.08.035

Modulation of endothelial function by Toll like receptors

Author(s): Beatriz Salvador, Alicia Arranz, Sara Francisco, Laura Córdoba, Carmen Punzón, Miguel Ángel Llamas, Manuel Fresno
Published in: Pharmacological Research, Issue 108, 2016, Page(s) 46-56, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2016.03.038

Computational Approaches to Toll-Like Receptor 4 Modulation

Author(s): Jean-Marc Billod, Alessandra Lacetera, Joan Guzmán-Caldentey, Sonsoles Martín-Santamaría
Published in: Molecules, Issue 21/8, 2016, Page(s) 994, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules21080994

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