Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.

Project Information

TOLLerant

Grant agreement ID: 642157

DOI 10.3030/642157

Project closed

EC signature date 10 December 2014

Start date 1 January 2015

End date 31 December 2018

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 122 539,38

EU contribution € 3 122 539,38

Coordinated by

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

Deliverables

Demonstrators, pilots, prototypes (1)

Protocols for molecular modelling

Documents, reports (7)

Training reports

Annual report on progress of the training program. Due in months:13, 25,37, 48.

Minutes of training events

Minutes of network-wide training events. Due in months: 7, 13, 19, 37

Progress, periodic, midterm and final reports

Progress, periodic, midterm and final reports. Due at months: 13, 18, 25, 37, 48

Agenda

Annual agenda of open local training activities. Due in months: 3, 13, 25, 37.

Annual agenda of outreach activities

Annual agenda of outreach activities. Due at months 6, 13, 25, 37.

Dissemination plan
Consortium quarterly newsletter

Consortium quarterly newsletter, due each 4 months.

Websites, patent fillings, videos etc. (2)

TOLLerant website
TOLLerant linkedIn group

Publications

Peer reviewed articles (16)

Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives

Author(s): Lenny Zaffaroni, Francesco Peri
Published in: Future Medicinal Chemistry, 2018, ISSN 1756-8919
Publisher: Future Science Ltd.
DOI: 10.4155/fmc-2017-0172

Co-administration of Antimicrobial Peptides Enhances Toll-like Receptor 4 Antagonist Activity of a Synthetic Glycolipid

Author(s): Fabio A. Facchini, Helena Coelho, Stefania E. Sestito, Sandra Delgado, Alberto Minotti, David Andreu, Jesús Jiménez-Barbero, Francesco Peri
Published in: ChemMedChem, Issue 13/3, 2018, Page(s) 280-287, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201700694

The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling

Author(s): Florent Cochet, Francesco Peri
Published in: International Journal of Molecular Sciences, Issue 18/11, 2017, Page(s) 2318, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18112318

The Deep-Sea Polyextremophile Halobacteroides lacunaris TB21 Rough-Type LPS: Structure and Inhibitory Activity towards Toxic LPS

Author(s): Flaviana Di Lorenzo, Angelo Palmigiano, Ida Paciello, Mateusz Pallach, Domenico Garozzo, Maria-Lina Bernardini, Violetta La Cono, Michail M. Yakimov, Antonio Molinaro, Alba Silipo
Published in: Marine Drugs, Issue 15/12, 2017, Page(s) 201, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md15070201

Structure of the Lipopolysaccharide from the Bradyrhizobium sp. ORS285 rfaL Mutant Strain

Author(s): Flaviana Di Lorenzo, Angelo Palmigiano, Katarzyna A. Duda, Mateusz Pallach, Nicolas Busset, Luisa Sturiale, Eric Giraud, Domenico Garozzo, Antonio Molinaro, Alba Silipo
Published in: ChemistryOpen, Issue 6/4, 2017, Page(s) 541-553, ISSN 2191-1363
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/open.201700074

Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

Author(s): Fabio A. Facchini, Lenny Zaffaroni, Alberto Minotti, Silvia Rapisarda, Valentina Calabrese, Matilde Forcella, Paola Fusi, Cristina Airoldi, Carlotta Ciaramelli, Jean-Marc Billod, Andra B. Schromm, Harald Braun, Charys Palmer, Rudi Beyaert, Fabio Lapenta, Roman Jerala, Grisha Pirianov, Sonsoles Martin-Santamaria, Francesco Peri
Published in: Journal of Medicinal Chemistry, 2018, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01803

The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40T

Author(s): Clara Barrau, Flaviana Di Lorenzo, Rodolfo Menes, Rosa Lanzetta, Antonio Molinaro, Alba Silipo
Published in: Marine Drugs, Issue 16/4, 2018, Page(s) 124, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md16040124

Lipid A Structure and Immunoinhibitory Effect of the Marine Bacterium Cobetia pacifica KMM 3879 T

Author(s): Flaviana Di Lorenzo, Angelo Palmigiano, Sami Albitar-Nehme, Mateusz Pallach, Maxim Kokoulin, Nadezhda Komandrova, Lyudmila Romanenko, Maria Lina Bernardini, Domenico Garozzo, Antonio Molinaro, Alba Silipo
Published in: European Journal of Organic Chemistry, Issue 2018/20-21, 2018, Page(s) 2707-2716, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201800279

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo

Author(s): Ajasja Ljubetič, Fabio Lapenta, Helena Gradišar, Igor Drobnak, Jana Aupič, Žiga Strmšek, Duško Lainšček, Iva Hafner-Bratkovič, Andreja Majerle, Nuša Krivec, Mojca Benčina, Tomaž Pisanski, Tanja Ćirković Veličković, Adam Round, José María Carazo, Roberto Melero, Roman Jerala
Published in: Nature Biotechnology, 2017, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.3994

Coiled coil protein origami: from modular design principles towards biotechnological applications

Author(s): Fabio Lapenta, Jana Aupič, Žiga Strmšek, Roman Jerala
Published in: Chemical Society Reviews, Issue 47/10, 2018, Page(s) 3530-3542, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cs00822h

Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

Author(s): Luigi Lembo-Fazio, Jean-Marc Billod, Flaviana Di Lorenzo, Ida Paciello, Mateusz Pallach, Sara Vaz-Francisco, Aurora Holgado, Rudi Beyaert, Manuel Fresno, Atsushi Shimoyama, Rosa Lanzetta, Koichi Fukase, Djamel Gully, Eric Giraud, Sonsoles Martín-Santamaría, Maria-Lina Bernardini, Alba Silipo
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01888

Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1

Author(s): Giordano Traini, Ane Ruiz-de-Angulo, Juan Bautista Blanco-Canosa, Kepa Zamacola Bascarán, Antonio Molinaro, Alba Silipo, David Escors, Juan C. Mareque-Rivas
Published in: Small, Issue 15/4, 2019, Page(s) 1803993, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201803993

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

Author(s): Florent Cochet, Fabio A. Facchini, Lenny Zaffaroni, Jean-Marc Billod, Helena Coelho, Aurora Holgado, Harald Braun, Rudi Beyaert, Roman Jerala, Jesus Jimenez-Barbero, Sonsoles Martin-Santamaria, Francesco Peri
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-37421-w

Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108

Author(s): Mateusz Pallach, Flaviana Di Lorenzo, Fabio Alessandro Facchini, Djamel Gully, Eric Giraud, Francesco Peri, Katarzyna A. Duda, Antonio Molinaro, Alba Silipo
Published in: International Journal of Biological Macromolecules, Issue 119, 2018, Page(s) 1027-1035, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2018.08.035

Modulation of endothelial function by Toll like receptors

Author(s): Beatriz Salvador, Alicia Arranz, Sara Francisco, Laura Córdoba, Carmen Punzón, Miguel Ángel Llamas, Manuel Fresno
Published in: Pharmacological Research, Issue 108, 2016, Page(s) 46-56, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2016.03.038

Computational Approaches to Toll-Like Receptor 4 Modulation

Author(s): Jean-Marc Billod, Alessandra Lacetera, Joan Guzmán-Caldentey, Sonsoles Martín-Santamaría
Published in: Molecules, Issue 21/8, 2016, Page(s) 994, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules21080994