Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.

Información del proyecto

TOLLerant

Identificador del acuerdo de subvención: 642157

DOI

10.3030/642157

Proyecto cerrado

Fecha de la firma de la CE 10 Diciembre 2014

Fecha de inicio 1 Enero 2015

Fecha de finalización 31 Diciembre 2018

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 122 539,38

Aportación de la UE

€ 3 122 539,38

Coordinado por

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (1)

Protocols for molecular modelling

Documents, reports (7)

Training reports

Annual report on progress of the training program. Due in months:13, 25,37, 48.

Minutes of training events

Minutes of network-wide training events. Due in months: 7, 13, 19, 37

Progress, periodic, midterm and final reports

Progress, periodic, midterm and final reports. Due at months: 13, 18, 25, 37, 48

Agenda

Annual agenda of open local training activities. Due in months: 3, 13, 25, 37.

Annual agenda of outreach activities

Annual agenda of outreach activities. Due at months 6, 13, 25, 37.

Dissemination plan
Consortium quarterly newsletter

Consortium quarterly newsletter, due each 4 months.

Websites, patent fillings, videos etc. (2)

TOLLerant website
TOLLerant linkedIn group

Publicaciones

Peer reviewed articles (16)

Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives

Autores: Lenny Zaffaroni, Francesco Peri
Publicado en: Future Medicinal Chemistry, 2018, ISSN 1756-8919
Editor: Future Science Ltd.
DOI: 10.4155/fmc-2017-0172

Co-administration of Antimicrobial Peptides Enhances Toll-like Receptor 4 Antagonist Activity of a Synthetic Glycolipid

Autores: Fabio A. Facchini, Helena Coelho, Stefania E. Sestito, Sandra Delgado, Alberto Minotti, David Andreu, Jesús Jiménez-Barbero, Francesco Peri
Publicado en: ChemMedChem, Edición 13/3, 2018, Página(s) 280-287, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201700694

The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling

Autores: Florent Cochet, Francesco Peri
Publicado en: International Journal of Molecular Sciences, Edición 18/11, 2017, Página(s) 2318, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18112318

The Deep-Sea Polyextremophile Halobacteroides lacunaris TB21 Rough-Type LPS: Structure and Inhibitory Activity towards Toxic LPS

Autores: Flaviana Di Lorenzo, Angelo Palmigiano, Ida Paciello, Mateusz Pallach, Domenico Garozzo, Maria-Lina Bernardini, Violetta La Cono, Michail M. Yakimov, Antonio Molinaro, Alba Silipo
Publicado en: Marine Drugs, Edición 15/12, 2017, Página(s) 201, ISSN 1660-3397
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md15070201

Structure of the Lipopolysaccharide from the Bradyrhizobium sp. ORS285 rfaL Mutant Strain

Autores: Flaviana Di Lorenzo, Angelo Palmigiano, Katarzyna A. Duda, Mateusz Pallach, Nicolas Busset, Luisa Sturiale, Eric Giraud, Domenico Garozzo, Antonio Molinaro, Alba Silipo
Publicado en: ChemistryOpen, Edición 6/4, 2017, Página(s) 541-553, ISSN 2191-1363
Editor: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/open.201700074

Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

Autores: Fabio A. Facchini, Lenny Zaffaroni, Alberto Minotti, Silvia Rapisarda, Valentina Calabrese, Matilde Forcella, Paola Fusi, Cristina Airoldi, Carlotta Ciaramelli, Jean-Marc Billod, Andra B. Schromm, Harald Braun, Charys Palmer, Rudi Beyaert, Fabio Lapenta, Roman Jerala, Grisha Pirianov, Sonsoles Martin-Santamaria, Francesco Peri
Publicado en: Journal of Medicinal Chemistry, 2018, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01803

The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40T

Autores: Clara Barrau, Flaviana Di Lorenzo, Rodolfo Menes, Rosa Lanzetta, Antonio Molinaro, Alba Silipo
Publicado en: Marine Drugs, Edición 16/4, 2018, Página(s) 124, ISSN 1660-3397
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md16040124

Lipid A Structure and Immunoinhibitory Effect of the Marine Bacterium Cobetia pacifica KMM 3879 T

Autores: Flaviana Di Lorenzo, Angelo Palmigiano, Sami Albitar-Nehme, Mateusz Pallach, Maxim Kokoulin, Nadezhda Komandrova, Lyudmila Romanenko, Maria Lina Bernardini, Domenico Garozzo, Antonio Molinaro, Alba Silipo
Publicado en: European Journal of Organic Chemistry, Edición 2018/20-21, 2018, Página(s) 2707-2716, ISSN 1434-193X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201800279

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo

Autores: Ajasja Ljubetič, Fabio Lapenta, Helena Gradišar, Igor Drobnak, Jana Aupič, Žiga Strmšek, Duško Lainšček, Iva Hafner-Bratkovič, Andreja Majerle, Nuša Krivec, Mojca Benčina, Tomaž Pisanski, Tanja Ćirković Veličković, Adam Round, José María Carazo, Roberto Melero, Roman Jerala
Publicado en: Nature Biotechnology, 2017, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/nbt.3994

Coiled coil protein origami: from modular design principles towards biotechnological applications

Autores: Fabio Lapenta, Jana Aupič, Žiga Strmšek, Roman Jerala
Publicado en: Chemical Society Reviews, Edición 47/10, 2018, Página(s) 3530-3542, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/c7cs00822h

Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

Autores: Luigi Lembo-Fazio, Jean-Marc Billod, Flaviana Di Lorenzo, Ida Paciello, Mateusz Pallach, Sara Vaz-Francisco, Aurora Holgado, Rudi Beyaert, Manuel Fresno, Atsushi Shimoyama, Rosa Lanzetta, Koichi Fukase, Djamel Gully, Eric Giraud, Sonsoles Martín-Santamaría, Maria-Lina Bernardini, Alba Silipo
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2018.01888

Cancer Immunotherapy of TLR4 Agonist-Antigen Constructs Enhanced with Pathogen-Mimicking Magnetite Nanoparticles and Checkpoint Blockade of PD-L1

Autores: Giordano Traini, Ane Ruiz-de-Angulo, Juan Bautista Blanco-Canosa, Kepa Zamacola Bascarán, Antonio Molinaro, Alba Silipo, David Escors, Juan C. Mareque-Rivas
Publicado en: Small, Edición 15/4, 2019, Página(s) 1803993, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201803993

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

Autores: Florent Cochet, Fabio A. Facchini, Lenny Zaffaroni, Jean-Marc Billod, Helena Coelho, Aurora Holgado, Harald Braun, Rudi Beyaert, Roman Jerala, Jesus Jimenez-Barbero, Sonsoles Martin-Santamaria, Francesco Peri
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-37421-w

Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108

Autores: Mateusz Pallach, Flaviana Di Lorenzo, Fabio Alessandro Facchini, Djamel Gully, Eric Giraud, Francesco Peri, Katarzyna A. Duda, Antonio Molinaro, Alba Silipo
Publicado en: International Journal of Biological Macromolecules, Edición 119, 2018, Página(s) 1027-1035, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/j.ijbiomac.2018.08.035

Modulation of endothelial function by Toll like receptors

Autores: Beatriz Salvador, Alicia Arranz, Sara Francisco, Laura Córdoba, Carmen Punzón, Miguel Ángel Llamas, Manuel Fresno
Publicado en: Pharmacological Research, Edición 108, 2016, Página(s) 46-56, ISSN 1043-6618
Editor: Academic Press
DOI: 10.1016/j.phrs.2016.03.038

Computational Approaches to Toll-Like Receptor 4 Modulation

Autores: Jean-Marc Billod, Alessandra Lacetera, Joan Guzmán-Caldentey, Sonsoles Martín-Santamaría
Publicado en: Molecules, Edición 21/8, 2016, Página(s) 994, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules21080994