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Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach.

Objective

Based on an international team derived from the COST action BM1003 (www.cost-bm1003.info, 2011-2014) and thus relying on consolidated group interactions and synergies and on a unique combination of chemistry, biology, biophysics, biochemistry and pharmacology expertise, the TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signaling by using synthetic and natural compounds and nanoparticles that interact selectively with some components (mainly MD-2 and CD14) of the TRL4 recognition system.
TLR4 is an emerging molecular target related to an impressively broad spectrum of modern day disorders still lacking specific pharmacological treatment. These include autoimmune disorders, chronic inflammations, allergies, asthma, infectious and CNS diseases and cancer.
The short-term scientific objective is to develop novel, non-toxic, synthetic and natural TLR4 modulators (agonists or antagonists) and to assess their therapeutic potential on animal models of TLR4-related acute and chronic pathologies that still lack efficient pharmacological treatment. The long-term scientific objective is to develop a new generation of innovative, TLR4-based therapeutics, to be used as vaccine adjuvants, anti-sepsis agents, and anti-inflammatory agents to treat chronic inflammations (allergy, asthma). The training programme will provide Early Stage Researchers (ESR) with broad competences, experience and skills in the cutting-edge, inter-disciplinary research in the field of chemical biology related to the molecular mechanisms of innate immunity and inflammation. During the training, the young researchers will be supported by senior scientists to cultivate their scientific, entrepreneurial and inter-cultural mindset. The non-academic sector will be committed to provide ESRs with entrepreneurship and company management skills, in order to enhance their employability by the private sector or even to motivate them to create own start-up companies.

Field of science

  • /medical and health sciences/clinical medicine/allergology
  • /natural sciences/physical sciences/optics/microscopy
  • /medical and health sciences/basic medicine/medicinal chemistry
  • /medical and health sciences/clinical medicine/pneumology/asthma
  • /natural sciences/chemical sciences/nuclear chemistry/radiochemistry
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines
  • /natural sciences/biological sciences/microbiology/bacteriology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/health sciences/inflammatory diseases

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Address
Piazza Dell'ateneo Nuovo 1
20126 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 516 122,64

Participants (9)

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 247 872,96
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSITAET BIELEFELD
Germany
EU contribution
€ 249 216,48
Address
Universitaetsstrasse 25
33615 Bielefeld
Activity type
Higher or Secondary Education Establishments
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain
EU contribution
€ 247 872,96
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Activity type
Research Organisations
DIOMUNE SL
Spain
EU contribution
€ 247 872,96
Address
Cl Felix Boix 9 4 C
28036 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KEMIJSKI INSTITUT
Slovenia
EU contribution
€ 469 995,12
Address
Hajdrihova 19
1000 Ljubljana
Activity type
Research Organisations
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
EU contribution
€ 247 872,96
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Activity type
Research Organisations
VIB VZW
Belgium
EU contribution
€ 250 560
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
LOFARMA S.P.A.
Italy
EU contribution
€ 129 030,66
Address
Viale Cassala, 40
20143 Milan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 516 122,64
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments