Targeting Cartilage Regeneration in joint and intervertebral disc diseases

Project Information

TargetCaRe

Grant agreement ID: 642414

DOI 10.3030/642414

Project closed

EC signature date 5 December 2014

Start date 1 March 2015

End date 28 February 2019

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 971 459,88

EU contribution € 3 971 459,88

Coordinated by

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

Website

Website designed and accessable

Information for lay people, incl. patients via website
At least 40 presentations in international meetings

Documents, reports (2)

At least 30 publications in peer reviewed journals
At least 3 articles in general press in at least 3 countries

Other (2)

15 young multidisciplinary European researchers with excellent networks, at least half of them found a suitable position in the area
15 young European researchers trained in at least two disciplines, at least 90% (ready to be) graduated

Publications

Peer reviewed articles (43)

Gold Nanocluster Extracellular Vesicle Supraparticles: Self-Assembled Nanostructures for Three-Dimensional Uptake Visualization.

Author(s): Kauscher U, Penders J, Nagelkerke A, Holme MN, Nele V, Massi L, Gopal S, Whittaker TE, Stevens MM. r
Published in: Langmui, 2020, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.9b03479

Enhanced chondrogenic phenotype of primary bovine articular chondrocytes in Fibrin-Hyaluronan hydrogel by multi-axial mechanical loading and FGF18.

Author(s): Antunes BP, Vainieri ML, Alini M, Monsonego-Ornan E, Grad S, Yayon A
Published in: Acta Biomaterialia, 2020, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.01.032

Tuneable peptide cross-linked nanogels for enzyme-triggered protein delivery

Author(s): Lucia Massi; Adrian Najer; Robert Chapman; Christopher D. Spicer; Valeria Nele; Junyi Che; Marsilea A. Booth; James Doutch; Molly M. Stevens
Published in: 2050-750X, Issue 7, 2020, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tb01546f

Controlled Dendrimersome Nanoreactor System for Localized Hypochlorite-Induced Killing of Bacteria.

Author(s): Potter M, Najer A, Klöckner A, Zhang S, Holme MN, Nele V, Che J, Massi L, Penders J, Saunders C, Doutch JJ, Edwards AM, Ces O, Stevens MM
Published in: ACS Nano, 2021, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c07459

Hydrogel-based delivery of antimiR-221 enhances cartilage regeneration by endogenous cells

Author(s): Lolli, Andrea; Sivasubramaniyan, Kavitha; Vainieri, Maria Letizia; Oieni, J. (Jacopo); Kops, Nicole; Yayon, A. (A.); Osch, Gerjo
Published in: J Control Release, Issue 3, 2019, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.07.040

Nano-ghosts: Novel biomimetic nano-vesicles for the delivery of antisense oligonucleotides.

Author(s): Oieni J, Lolli A, D'Atri D, Kops N, Yayon A, van Osch GJVM, Machluf M
Published in: J control release, 2021, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.018

Emerging potential of gene silencing approaches targeting anti-chondrogenic factors for cell-based cartilage repair.

Author(s): Andrea Lolli; Letizia Penolazzi; Roberto Narcisi; Gerjo J.V.M. van Osch; Roberta Piva
Published in: STARTPAGE=1;ENDPAGE=15;ISSN=1420682X;TITLE=Cellular and Molecular Life Sciences, Issue 2, 2017, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-017-2531-z

Functional cell phenotype induction with TGF-β1 and collagen-polyurethane scaffold for annulus fibrosus rupture repair.

Author(s): J. Du; Rose G. Long; Tomoko Nakai; Daisuke Sakai; Lorin Michael Benneker; G. Zhou; B. Li; David Eglin; James C. Iatridis; M. Alini; Sibylle Grad; Zhen Li
Published in: eur Cells Materials, Issue 3, 2020, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v039a01

Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents

Author(s): Colella F, Garcia JP, Sorbona M, Lolli A, Antunes B, D'Atri D, Barré FPY, Oieni J, Vainieri ML, Zerrillo L, Capar S, Häckel S, Cai Y, Creemers LB
Published in: J Control Release, 2020, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2020.08.041

Evaluation of biomimetic hyaluronic-based hydrogels with enhanced endogenous cell recruitment and cartilage matrix formation.

Author(s): Vainieri ML, Lolli A, Kops N, D'Atri D, Eglin D, Yayon A, Alini M, Grad S, Sivasubramaniyan K, van Osch GJVM
Published in: Acta Biomater, 2020, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.11.015

Modulation of Inflamed Synovium Improves Migration of Mesenchymal Stromal Cells in Vitro Through Anti-Inflammatory Macrophages.

Author(s): Wesdorp MA, Bastiaansen-Jenniskens YM, Capar S, Verhaar JAN, Narcisi R, Van Osch GJVM.
Published in: Cartilage, 2022, ISSN 1947-6035
Publisher: SAGE Publications Inc.
DOI: 10.1177/19476035221085136

Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients.

Author(s): J. Garcia; Lizette Utomo; Imke Rudnik-Jansen; Jie Du; Nicolaas P.A. Zuithoff; Anita Krouwels; Gerjo J.V.M. van Osch; Laura B. Creemers
Published in: Cells, Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10030508

pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis.

Author(s): Zerrillo, L.; Que, I.; Vepris, O.; Morgado, L.N.; Chan, A.; Bierau, K.; Li, Y.; Galli, F.; Bos, E.; Censi, R.; Di Martino, P.; van Osch, G.J.V.M.; Cruz, L.J.
Published in: VOLUME=309;STARTPAGE=265;ENDPAGE=276;TITLE=Journal of Controlled Release, Issue 8, 2019, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.07.031

Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus Pulposus Cells.

Author(s): Häckel, Sonja; Zolfaghar, Mona; Du, Jie; Hoppe, Sven; Benneker, Lorin M.; Garstka, Nathalie; Peroglio, Marianna; Alini, Mauro; Grad, Sibylle; Yayon, Avner; Li, Zhen
Published in: International Journal of Molecular Sciences, Vol 20, Iss 20, p 5036 (2019), Issue 1, 2019, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.7892/boris.134168

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

Author(s): Kania, Karolina; Colella, Fabio; Riemen, Anna H. K.; Wang, Hui; Howard, Kenneth A.; Aigner, Thomas; Dell’Accio, Francesco; Capellini, Terence D.; Roelofs, Anke J.; De Bari, Cosimo
Published in: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020), Issue 3, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-57011-8

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research.

Author(s): Barré, Florian P. Y.; Paine, Martin R. L.; Flinders, Bryn; Trevitt, Adam J.; Kelly, Patrick D.; Ait-Belkacem, Rima; Garcia, João P.; Creemers, Laura B.; Stauber, Jonathan; Vreeken, Rob J.; Cillero-Pastor, Berta; Ellis, Shane R.; Heeren, Ron M. A.
Published in: urn:issn:0003-2700, Issue 1, 2019, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b02495

Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling

Author(s): Conor C. Horgan; Anika Nagelkerke; Thomas E. Whittaker; Valeria Nele; Lucia Massi; Ulrike Kauscher; Jelle Penders; Mads Sylvest Bergholt; Steve R. Hood; Molly M. Stevens
Published in: J mater chem B, Issue 7, 2020, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tb00620c

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Author(s): Michael Lykke Hvam, Yunpeng Cai, Frederik Dagnæs-Hansen, Jesper Sejrup Nielsen, Jesper Wengel, Jørgen Kjems, Kenneth A. Howard
Published in: Molecular Therapy, Issue 25/7, 2017, Page(s) 1710-1717, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.05.009

Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging

Author(s): Florian P.Y. Barré, Britt S.R. Claes, Frédéric Dewez, Carine Peutz-Kootstra, Helga F. Munch-Petersen, Kirsten Grønbæk, Anders H. Lund, Ron M.A. Heeren, Christophe Côme, Berta Cillero-Pastor
Published in: Analytical Chemistry, Issue 90/24, 2018, Page(s) 14198-14206, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.8b02910

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Author(s): João Pedro Garcia, Jeroen Stein, Yunpeng Cai, Frank Riemers, Ezequiel Wexselblatt, Jesper Wengel, Marianna Tryfonidou, Avner Yayon, Kenneth A. Howard, Laura B. Creemers
Published in: Journal of Controlled Release, Issue 294, 2019, Page(s) 247-258, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2018.12.030

Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: A new paradigm in cartilage repair

Author(s): Andrea Lolli, Fabio Colella, Cosimo De Bari, Gerjo J. V. M. van Osch
Published in: Journal of Orthopaedic Research®, 2018, ISSN 0736-0266
Publisher: Elsevier BV
DOI: 10.1002/jor.24136

Mechanically stimulated osteochondral organ culture for evaluation of biomaterials in cartilage repair studies

Author(s): M.L. Vainieri, D. Wahl, M. Alini, G.J.V.M. van Osch, S. Grad
Published in: Acta Biomaterialia, Issue 81, 2018, Page(s) 256-266, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.09.058

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

Author(s): Yunpeng Cai, Anna-Marie Makarova, Jesper Wengel, Kenneth A. Howard
Published in: The Journal of Gene Medicine, Issue 20/7-8, 2018, Page(s) e3025, ISSN 1099-498X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jgm.3025

Hyaluronan-based hydrogel delivering antimiR-221 for the guidance of endogenous cartilage repair

Author(s): A. Lolli, K. Sivasubramaniyan, M.L. Vainieri, D. Eglin, E. Wexselblatt, A. Yayon, S. Grad, M. Alini, G.J. van Osch
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S163, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2018.02.355

Distribution, quantification and effects of triamcinolone acetonide in human osteoarthritic cartilage

Author(s): F.P. Barré, M. Paine, B. Flinders, M. Eveque-Mourroux, J. Garcia, S. Ellis, R.M. Heeren, L. Creemers, B. Cillero Pastor
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S284-S285, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2018.02.574

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis

Author(s): J. Garcia, J. Stein, Y. Cai, E. Wexselblatt, L. Creemers, J. Wengel, K. Howard, D. Saris, A. Yayon
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S145, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2018.02.313

YAP targeting in synovial MSCs as a novel therapeutic approach for osteoarthritis

Author(s): F. Colella, Y. Cai, K. Howard, A. Roelofs, C. De Bari
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S301, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2018.02.605

Inhibiting Stat Signaling Pathways as a Possible Therapy to Modulate Synovial Inflammation in Osteoarthritis

Author(s): M.A. Suijkerbuijk, S. Çapar, N. Kops, D.E. Meuffels, G.J. van Osch, Y.M. Bastiaansen-Jenniskens
Published in: Osteoarthritis and Cartilage, Issue 25, 2017, Page(s) S271-S272, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2017.02.457

Depletion of the anti-chondrogenic regulators MIR-221 and slug: a novel approach to induce chondrogenesis

Author(s): A. Lolli, R. Narcisi, E. Lambertini, L. Penolazzi, M. Angelozzi, G.J. van Osch, R. Piva
Published in: Osteoarthritis and Cartilage, Issue 24, 2016, Page(s) S39-S40, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2016.01.095

The Paradoxical Effects of Chronic Intra-Amniotic <b><i>Ureaplasma parvum</i></b> Exposure on Ovine Fetal Brain Development

Author(s): Ruth Gussenhoven, Daan R.M.G. Ophelders, Matthew W. Kemp, Matthew S. Payne, Owen B. Spiller, Michael L. Beeton, Sarah J. Stock, Bertha Cillero-Pastor, Florian P.Y. Barré, Ron M.A. Heeren, Lilian Kessels, Bas Stevens, Bart P. Rutten, Suhas G. Kallapur, Alan H. Jobe, Boris W. Kramer, Tim G.A.M. Wolfs
Published in: Developmental Neuroscience, Issue 39/6, 2017, Page(s) 472-486, ISSN 0378-5866
Publisher: S. Karger AG
DOI: 10.1159/000479021

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Author(s): Florian Barré, Beatriz Rocha, Frédéric Dewez, Mark Towers, Paul Murray, Emmanuelle Claude, Berta Cillero-Pastor, Ron Heeren, Tiffany Porta Siegel
Published in: International Journal of Mass Spectrometry, Issue 437, 2019, Page(s) 38-48, ISSN 1387-3806
Publisher: Elsevier BV
DOI: 10.1016/j.ijms.2018.09.015

Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic

Author(s): Lennart R.S. Huizing, Shane R. Ellis, Bart W.A.M.M. Beulen, Florian P.Y. Barré, Paul B. Kwant, Rob J. Vreeken, Ron M.A. Heeren
Published in: Clinical Mass Spectrometry, Issue 12, 2019, Page(s) 7-15, ISSN 2376-9998
Publisher: elsevier
DOI: 10.1016/j.clinms.2019.01.004

Mass spectrometry imaging in nanomedicine: unravelling the potential of MSI for detection of nanoparticles in neuroscience

Author(s): Florian P.Y. Barré, Ron M. A. Heeren, Nina Ogrinc Potočnik
Published in: Current Pharmaceutical Design, Issue 23, 2017, ISSN 1381-6128
Publisher: Bentham Science Publishers

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

Author(s): Yunpeng Cai, Elena López-Ruiz, Jesper Wengel, Laura B. Creemers, Kenneth A. Howard
Published in: Journal of Controlled Release, Issue 253, 2017, Page(s) 153-159, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2017.03.004

Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Author(s): Florian P. Y. Barré, Bryn Flinders, João P. Garcia, Imke Jansen, Lennart R. S. Huizing, Tiffany Porta, Laura B. Creemers, Ron M. A. Heeren, Berta Cillero-Pastor
Published in: Analytical Chemistry, Issue 88/24, 2016, Page(s) 12051-12059, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.6b02491

Emerging potential of gene silencing approaches targeting anti-chondrogenic factors for cell-based cartilage repair

Author(s): Andrea Lolli, Letizia Penolazzi, Roberto Narcisi, Gerjo J.V.M. van Osch, Roberta Piva
Published in: Cellular and Molecular Life Sciences, 2017, ISSN 1420-682X
Publisher: Birkhauser Verlag

Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha.

Author(s): Jie Du; Judith‐J. Pfannkuche; Gernot Lang; Sonja Häckel; Laura B. Creemers; Mauro Alini; Sibylle Grad; Zhen Li
Published in: JOR Spine, Vol 3, Iss 3, Pp n/a-n/a (2020), Issue 2, 2020, ISSN 2572-1143
Publisher: Wiley
DOI: 10.48350/149054

Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.

Author(s): Rebecca A Symons; Fabio Colella; Fraser L. Collins; Alexandra J Rafipay; Karolina Kania; Jessica J McClure; Nathan White; Iain Cunningham; Sadaf Ashraf; Elizabeth A. Hay; Kevin Mackenzie; Kenneth A. Howard; Anna H. K. Riemen; Antonio Manzo; Susan Clark; Anke J. Roelofs; Cosimo De Bari
Published in: Annals of the Rheumatic Diseases, Issue 1, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220875

Novel Fluorinated Poly (Lactic-Co-Glycolic acid) (PLGA) and Polyethylene Glycol (PEG) Nanoparticles for Monitoring and Imaging in Osteoarthritis.

Author(s): Zerrillo L, Gupta KBSS, Lefeber FAWM, Da Silva CG, Galli F, Chan A, Veltien A, Dou W, Censi R, Di Martino P, Srinivas M, Cruz L
Published in: Pharmaceutics, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020235

Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: A new paradigm in cartilage repair.

Author(s): Andrea Lolli; Fabio Colella; Cosimo De Bari; Gerjo J.V.M. van Osch
Published in: Journal of Orthopaedic Research: a journal for musculoskeletal investigation, Issue 1, 2018, ISSN 1554-527X
Publisher: Wiley
DOI: 10.1002/jor.24136

Mechanical Stress Inhibits Early Stages of Endogenous Cell Migration: A Pilot Study in an Ex Vivo Osteochondral Model.

Author(s): Vainieri ML, Alini M, Yayon A, van Osch GJVM, Grad S
Published in: Polymers, 2020, ISSN 2073-4360
Publisher: MPDI
DOI: 10.3390/polym12081754

Intra-articular Administration of Triamcinolone Acetonide in a Murine Cartilage Defect Model Reduces Inflammation but Inhibits Endogenous Cartilage Repair

Author(s): Wesdorp MA, Capar S, Bastiaansen-Jenniskens YM, Kops N, Creemers LB, Verhaar JAN, Van Osch GJVM, Wei W
Published in: Am J Sports Med, 2022, ISSN 0363-5465
Publisher: SAGE Publications
DOI: 10.1177/03635465221083693

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Author(s): Garcia, João P.; Longoni, Alessia; Gawlitta, Debby; J.W.P. Rosenberg, Antoine; Grinstaff, Mark W.; Töyräs, Juha; Weinans, Harrie; Creemers, Laura B.; Pouran, Behdad
Published in: urn:issn:1742-7061, Issue 1, 2019, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2019.09.014

Conference proceedings (10)

Nanoghosts targeted delivery of RNA interference therapy for the treatment of Osteoarthritis

Author(s): Jacopo Oieni, Marcelle Machluf
Published in: 2017
Publisher: ecmconferences

Effects of FGF18 on OA human articular chondrocytes embedded in a novel FBG:HA hydrogel

Author(s): Bernardo Antunes1,2, João Pedro Garcia3, Efrat Monsonego-Ornan2, Laura Creemers3, Avner Yayon1
Published in: 2017
Publisher: ecmconferences

Nano-ghosts delivery system and Link-N peptide, enhanced anti-inflammatory activity: a new approaches for the treatment of osteoarthritis

Author(s): Domenico D'Atri, Marcelle Machluf
Published in: 2017
Publisher: ecmconferences

Establishment of a hydrogel-based antimiR-221 delivery system for in situ guidance of cartilage repair

Author(s): Andrea Lolli1, Kavitha Sivasubramaniyan1, Gerjo van Osch1,2
Published in: 2017
Publisher: ecmconferences

Inhibiting STAT signaling pathways in macrophages to improve tissue regeneration

Author(s): Mathijs Suijkerbuijk, Serdar Çapar, Nicole Kops, Duncan Meuffels, Gerjo van Osch, Yvonne Bastiaansen-Jenniskens
Published in: 2017
Publisher: ecmconferences

Novel ex-vivo osteochondral model for cartilage repair in mechanical stimulated joint bioreactor

Author(s): ML Vainieri1,2, D Wahl 1, G Van Osch2, M Alini1, S Grad1
Published in: 2018, Page(s) 50
Publisher: ecmconferences

Novel ex-vivo osteochondral defect model in a joint bioreactor system for articular cartilage repair studies

Author(s): M.Letizia Vainieri, Dieter Whal, Patrick Leuzo, Gerjo van Osch, Mauro Alini, Sibylle Grad
Published in: 2017
Publisher: ecmconferences

3D non-invasive bioimaging of cartilage tissue engineered constructs using contrast enhanced computed tomography

Author(s): J.P. Garcia1, A. Longoni2, L.B. Creemers1, M.W. Grinstaff3, J. Töyräs4, H. Weinans1,5, B. Pouran1,5
Published in: 2018, Page(s) 44
Publisher: ecmconferences

A novel nano-ghosts based system for targeted delivery of antimir-221 and stimulation of cartilage repair

Author(s): J Oieni1, A Lolli2, GJVM van Osch2, M Machluf1
Published in: 2018, Page(s) 43
Publisher: ecmconferences

Effects of mechanical stimulation combined with FGF18 on bovine chondrocytes embedded in a novel Fibrin:HA hydrogel

Author(s): BP Antunes1, 2, ML Vainieri3, E Monsonego-Ornan2, M Alini3, S Grad3, A Yayon1
Published in: 2018, Page(s) 2
Publisher: ecmconferences

Other (3)

P268 - Antimir-221 Loaded Fibrin/Hyaluronic Acid Hydrogel For The Guidance Of Endogenous Cartilage Repair

Author(s): A. Lolli (Rotterdam, Netherlands), K. Sivasubramaniyan (Rotterdam, Netherlands), M. Vainieri (Davos Platz, Switzerland), A. Yayon (Nes Ziona, Israel), G. Van Osch (Rotterdam, Netherlands)
Published in: 2018
Publisher: ICRS

P75 - Hyaluronic acid-based hydrogels promote mesenchymal stem cell ingrowth and cartilage production in vitro and in vivo.

Author(s): M. Vainieri, K. Sivasubramaniyan, A. Lolli , D. Eglid , A. Yayon, E. Wexselblatt, M. Alini S. Grad , G. van Osch
Published in: 2018
Publisher: ICRS

Uniek onderzoek behandeling artroseL Slimme Medicijnen

Author(s): Gerben Stolk
Published in: Monitor, Issue nummer 4, jaargang 46 (4x per year), 2017, Page(s) 34-35
Publisher: Erasmus MC

Thesis and dissertations (2)

. Enzyme and temperature dual-responsive polymer nanostructures towards the treatment of osteoarthritis

Author(s): Massi L
Published in: 2019
Publisher: n.a.

Local and systemic delivery of gapmer antisense oligonucleotides for arthritis treatment

Author(s): Cai Y
Published in: 2018
Publisher: n.a.