Targeting Cartilage Regeneration in joint and intervertebral disc diseases

Deliverables

Websites, patent fillings, videos etc. (3)

Website

Website designed and accessable

Information for lay people, incl. patients via website

Information for lay people, incl. patients via website

At least 40 presentations in international meetings

At least 40 presentations in international meetings

Documents, reports (2)

At least 30 publications in peer reviewed journals

At least 30 publications in peer reviewed journals

At least 3 articles in general press in at least 3 countries

At least 3 articles in general press in at least 3 countries

Other (2)

15 young multidisciplinary European researchers with excellent networks, at least half of them found a suitable position in the area

15 young multidisciplinary European researchers with excellent networks, at least half of them found a suitable position in the area

15 young European researchers trained in at least two disciplines, at least 90% (ready to be) graduated

15 young European researchers trained in at least two disciplines, at least 90% (ready to be) graduated

Publications

Peer reviewed articles (19)

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Author(s): Michael Lykke Hvam, Yunpeng Cai, Frederik Dagnæs-Hansen, Jesper Sejrup Nielsen, Jesper Wengel, Jørgen Kjems, Kenneth A. Howard
Published in: Molecular Therapy, Issue 25/7, 2017, Page(s) 1710-1717, ISSN 1525-0016
DOI: 10.1016/j.ymthe.2017.05.009

Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging

Author(s): Florian P.Y. Barré, Britt S.R. Claes, Frédéric Dewez, Carine Peutz-Kootstra, Helga F. Munch-Petersen, Kirsten Grønbæk, Anders H. Lund, Ron M.A. Heeren, Christophe Côme, Berta Cillero-Pastor
Published in: Analytical Chemistry, Issue 90/24, 2018, Page(s) 14198-14206, ISSN 0003-2700
DOI: 10.1021/acs.analchem.8b02910

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Author(s): João Pedro Garcia, Jeroen Stein, Yunpeng Cai, Frank Riemers, Ezequiel Wexselblatt, Jesper Wengel, Marianna Tryfonidou, Avner Yayon, Kenneth A. Howard, Laura B. Creemers
Published in: Journal of Controlled Release, Issue 294, 2019, Page(s) 247-258, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2018.12.030

Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: A new paradigm in cartilage repair

Author(s): Andrea Lolli, Fabio Colella, Cosimo De Bari, Gerjo J. V. M. van Osch
Published in: Journal of Orthopaedic Research®, 2018, ISSN 0736-0266
DOI: 10.1002/jor.24136

Mechanically stimulated osteochondral organ culture for evaluation of biomaterials in cartilage repair studies

Author(s): M.L. Vainieri, D. Wahl, M. Alini, G.J.V.M. van Osch, S. Grad
Published in: Acta Biomaterialia, Issue 81, 2018, Page(s) 256-266, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.09.058

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

Author(s): Yunpeng Cai, Anna-Marie Makarova, Jesper Wengel, Kenneth A. Howard
Published in: The Journal of Gene Medicine, Issue 20/7-8, 2018, Page(s) e3025, ISSN 1099-498X
DOI: 10.1002/jgm.3025

Hyaluronan-based hydrogel delivering antimiR-221 for the guidance of endogenous cartilage repair

Author(s): A. Lolli, K. Sivasubramaniyan, M.L. Vainieri, D. Eglin, E. Wexselblatt, A. Yayon, S. Grad, M. Alini, G.J. van Osch
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S163, ISSN 1063-4584
DOI: 10.1016/j.joca.2018.02.355

Distribution, quantification and effects of triamcinolone acetonide in human osteoarthritic cartilage

Author(s): F.P. Barré, M. Paine, B. Flinders, M. Eveque-Mourroux, J. Garcia, S. Ellis, R.M. Heeren, L. Creemers, B. Cillero Pastor
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S284-S285, ISSN 1063-4584
DOI: 10.1016/j.joca.2018.02.574

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis

Author(s): J. Garcia, J. Stein, Y. Cai, E. Wexselblatt, L. Creemers, J. Wengel, K. Howard, D. Saris, A. Yayon
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S145, ISSN 1063-4584
DOI: 10.1016/j.joca.2018.02.313

YAP targeting in synovial MSCs as a novel therapeutic approach for osteoarthritis

Author(s): F. Colella, Y. Cai, K. Howard, A. Roelofs, C. De Bari
Published in: Osteoarthritis and Cartilage, Issue 26, 2018, Page(s) S301, ISSN 1063-4584
DOI: 10.1016/j.joca.2018.02.605

Inhibiting Stat Signaling Pathways as a Possible Therapy to Modulate Synovial Inflammation in Osteoarthritis

Author(s): M.A. Suijkerbuijk, S. Çapar, N. Kops, D.E. Meuffels, G.J. van Osch, Y.M. Bastiaansen-Jenniskens
Published in: Osteoarthritis and Cartilage, Issue 25, 2017, Page(s) S271-S272, ISSN 1063-4584
DOI: 10.1016/j.joca.2017.02.457

Depletion of the anti-chondrogenic regulators MIR-221 and slug: a novel approach to induce chondrogenesis

Author(s): A. Lolli, R. Narcisi, E. Lambertini, L. Penolazzi, M. Angelozzi, G.J. van Osch, R. Piva
Published in: Osteoarthritis and Cartilage, Issue 24, 2016, Page(s) S39-S40, ISSN 1063-4584
DOI: 10.1016/j.joca.2016.01.095

The Paradoxical Effects of Chronic Intra-Amniotic <b><i>Ureaplasma parvum</i></b> Exposure on Ovine Fetal Brain Development

Author(s): Ruth Gussenhoven, Daan R.M.G. Ophelders, Matthew W. Kemp, Matthew S. Payne, Owen B. Spiller, Michael L. Beeton, Sarah J. Stock, Bertha Cillero-Pastor, Florian P.Y. Barré, Ron M.A. Heeren, Lilian Kessels, Bas Stevens, Bart P. Rutten, Suhas G. Kallapur, Alan H. Jobe, Boris W. Kramer, Tim G.A.M. Wolfs
Published in: Developmental Neuroscience, Issue 39/6, 2017, Page(s) 472-486, ISSN 0378-5866
DOI: 10.1159/000479021

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Author(s): Florian Barré, Beatriz Rocha, Frédéric Dewez, Mark Towers, Paul Murray, Emmanuelle Claude, Berta Cillero-Pastor, Ron Heeren, Tiffany Porta Siegel
Published in: International Journal of Mass Spectrometry, Issue 437, 2019, Page(s) 38-48, ISSN 1387-3806
DOI: 10.1016/j.ijms.2018.09.015

Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic

Author(s): Lennart R.S. Huizing, Shane R. Ellis, Bart W.A.M.M. Beulen, Florian P.Y. Barré, Paul B. Kwant, Rob J. Vreeken, Ron M.A. Heeren
Published in: Clinical Mass Spectrometry, Issue 12, 2019, Page(s) 7-15, ISSN 2376-9998
DOI: 10.1016/j.clinms.2019.01.004

Mass spectrometry imaging in nanomedicine: unravelling the potential of MSI for detection of nanoparticles in neuroscience

Author(s): Florian P.Y. Barré, Ron M. A. Heeren, Nina Ogrinc Potočnik
Published in: Current Pharmaceutical Design, Issue 23, 2017, ISSN 1381-6128

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

Author(s): Yunpeng Cai, Elena López-Ruiz, Jesper Wengel, Laura B. Creemers, Kenneth A. Howard
Published in: Journal of Controlled Release, Issue 253, 2017, Page(s) 153-159, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2017.03.004

Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Author(s): Florian P. Y. Barré, Bryn Flinders, João P. Garcia, Imke Jansen, Lennart R. S. Huizing, Tiffany Porta, Laura B. Creemers, Ron M. A. Heeren, Berta Cillero-Pastor
Published in: Analytical Chemistry, Issue 88/24, 2016, Page(s) 12051-12059, ISSN 0003-2700
DOI: 10.1021/acs.analchem.6b02491

Emerging potential of gene silencing approaches targeting anti-chondrogenic factors for cell-based cartilage repair

Author(s): Andrea Lolli, Letizia Penolazzi, Roberto Narcisi, Gerjo J.V.M. van Osch, Roberta Piva
Published in: Cellular and Molecular Life Sciences, 2017, ISSN 1420-682X

Conference proceedings (10)

Nanoghosts targeted delivery of RNA interference therapy for the treatment of Osteoarthritis

Author(s): Jacopo Oieni, Marcelle Machluf
Published in: 2017

Effects of FGF18 on OA human articular chondrocytes embedded in a novel FBG:HA hydrogel

Author(s): Bernardo Antunes1,2, João Pedro Garcia3, Efrat Monsonego-Ornan2, Laura Creemers3, Avner Yayon1
Published in: 2017

Nano-ghosts delivery system and Link-N peptide, enhanced anti-inflammatory activity: a new approaches for the treatment of osteoarthritis

Author(s): Domenico D'Atri, Marcelle Machluf
Published in: 2017

Establishment of a hydrogel-based antimiR-221 delivery system for in situ guidance of cartilage repair

Author(s): Andrea Lolli1, Kavitha Sivasubramaniyan1, Gerjo van Osch1,2
Published in: 2017

Inhibiting STAT signaling pathways in macrophages to improve tissue regeneration

Author(s): Mathijs Suijkerbuijk, Serdar Çapar, Nicole Kops, Duncan Meuffels, Gerjo van Osch, Yvonne Bastiaansen-Jenniskens
Published in: 2017

Novel ex-vivo osteochondral model for cartilage repair in mechanical stimulated joint bioreactor

Author(s): ML Vainieri1,2, D Wahl 1, G Van Osch2, M Alini1, S Grad1
Published in: 2018, Page(s) 50

Novel ex-vivo osteochondral defect model in a joint bioreactor system for articular cartilage repair studies

Author(s): M.Letizia Vainieri, Dieter Whal, Patrick Leuzo, Gerjo van Osch, Mauro Alini, Sibylle Grad
Published in: 2017

3D non-invasive bioimaging of cartilage tissue engineered constructs using contrast enhanced computed tomography

Author(s): J.P. Garcia1, A. Longoni2, L.B. Creemers1, M.W. Grinstaff3, J. Töyräs4, H. Weinans1,5, B. Pouran1,5
Published in: 2018, Page(s) 44

A novel nano-ghosts based system for targeted delivery of antimir-221 and stimulation of cartilage repair

Author(s): J Oieni1, A Lolli2, GJVM van Osch2, M Machluf1
Published in: 2018, Page(s) 43

Effects of mechanical stimulation combined with FGF18 on bovine chondrocytes embedded in a novel Fibrin:HA hydrogel

Author(s): BP Antunes1, 2, ML Vainieri3, E Monsonego-Ornan2, M Alini3, S Grad3, A Yayon1
Published in: 2018, Page(s) 2

Other (3)

P268 - Antimir-221 Loaded Fibrin/Hyaluronic Acid Hydrogel For The Guidance Of Endogenous Cartilage Repair

Author(s): A. Lolli (Rotterdam, Netherlands), K. Sivasubramaniyan (Rotterdam, Netherlands), M. Vainieri (Davos Platz, Switzerland), A. Yayon (Nes Ziona, Israel), G. Van Osch (Rotterdam, Netherlands)
Published in: 2018

P75 - Hyaluronic acid-based hydrogels promote mesenchymal stem cell ingrowth and cartilage production in vitro and in vivo.

Author(s): M. Vainieri, K. Sivasubramaniyan, A. Lolli , D. Eglid , A. Yayon, E. Wexselblatt, M. Alini S. Grad , G. van Osch
Published in: 2018

Uniek onderzoek behandeling artroseL Slimme Medicijnen

Author(s): Gerben Stolk
Published in: Monitor, Issue nummer 4, jaargang 46 (4x per year), 2017, Page(s) 34-35

Thesis dissertations (2)

. Enzyme and temperature dual-responsive polymer nanostructures towards the treatment of osteoarthritis

Author(s): Massi L
Published in: 2019

Local and systemic delivery of gapmer antisense oligonucleotides for arthritis treatment

Author(s): Cai Y
Published in: 2018