Skip to main content

Targeting Cartilage Regeneration in joint and intervertebral disc diseases

Objective

Mobility, important for well-being, is seriously impaired by chronic low back pain and osteoarthritis in many people due to degeneration of cartilaginous tissue of the intervertebral disc and joint. To develop a treatment for these diseases this ETN aims to combine expertise in novel highly advanced drug delivery carriers with dedicated targeting tools, state of the art imaging techniques and expertise in stem cell and joint biology by training 15 young scientists in 12 partner institutes located in 5 different countries.
We aim to achieve regeneration of damaged and degenerated tissues by employing targeting strategies tailored both to the pathology and the tissues involved. Regeneration of diseased tissues will be achieved by loading biologically active agents in state-of-the-art nanocarriers. The biologically active agents will stimulate the body’s own capacity to regenerate by attracting local stem cells or inhibit degeneration. Targeting will be achieved by A] injection with synthetic or natural hydrogels loaded with the nanocarriers or B] coupling diseased tissue-specific antibodies and specific hyaluronic acid moieties to the nanocarriers. Delivery and retention will be monitored by advanced in vivo and molecular imaging techniques to monitor distribution of the delivered compounds at the tissue level, as well as detect biological markers of regeneration.

Major objectives:
1] To establish a network of scientists skilled in the use of smart nanocarriers, unique approach of targeting by disease-specific molecules and application of innovative imaging tools. Supported by generic scientific and training in economical and clinical valorisation, these researchers can further implement these technologies in the musculoskeletal or other areas, both in academia and industry.
2] To develop strategies exclusively targeting diseased tissues with controlled doses of bio-actives, circumventing the disadvantages of the current shotgun approaches in regenerative medicine.

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Net EU contribution
€ 510 748,56
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands

See on map

Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 546 575,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

See on map

Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PERCUROS BV
Netherlands
Net EU contribution
€ 255 374,28
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITY OF ABERDEEN
United Kingdom
Net EU contribution
€ 273 287,88
Address
King's College Regent Walk
AB24 3FX Aberdeen

See on map

Region
North Eastern Scotland Aberdeen City and Aberdeenshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Net EU contribution
€ 520 601,04
Address
Senate Building Technion City
32000 Haifa

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CARDIFF UNIVERSITY
United Kingdom
Net EU contribution
€ 273 287,88
Address
Newport Road 30 36
CF24 0DE Cardiff

See on map

Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 255 374,28
Address
Heidelberglaan 100
3584 CX Utrecht

See on map

Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
Net EU contribution
€ 530 453,52
Address
Clavadelerstrasse 8
7270 Davos Platz

See on map

Region
Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 290 081,88
Address
Nordre Ringgade 1
8000 Aarhus C

See on map

Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PROCORE LTD
Israel
Net EU contribution
€ 260 300,52
Address
Golda Meir 7 Weizmann Science Park 7
70400 Nes Ziona

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 255 374,28
Address
Minderbroedersberg 4
6200 MD Maastricht

See on map

Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (2)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Omics2Image B.V.
Netherlands
Net EU contribution
€ 0,00
Address
Science Park 105
1098 XG Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Stichting ReumaNederland
Netherlands
Net EU contribution
€ 0,00
Address
Dr J Van Breemenstraat 4
1056 AB Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Non-EU contribution
€ 0,00