Deliverables Other (7) PCDPs ESR supervisors selected and all PCDPs written Short course 2-day short course organized on antibacterial targets and validation SAB SAB board members appointed ESR recruitments Call for ESR applicants published and recruiting course organised INTEGRATE Outreach Conference Final conference and outreach event to promote findings of INTEGRATE Kick-off Meeting Kick off meeting organized and press announcement released. Supervisory Board will be organised at the same moment. Gender Equality in Science Course All ESRs and beneficiaries attend a Gender Equality in Science Course Websites, patent fillings, videos etc. (1) Website INTEGRATE website operational Publications Peer reviewed articles (16) Inhibition of O -acetylserine sulfhydrylase by fluoroalanine derivatives Author(s): Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons, Andrea Mozzarelli Published in: Journal of Enzyme Inhibition and Medicinal Chemistry, Issue 33/1, 2018, Page(s) 1343-1351, ISSN 1475-6366 Publisher: Taylor & Francis DOI: 10.1080/14756366.2018.1504040 Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design Author(s): Joana Magalhães, Nina Franko, Giannamaria Annunziato, Martin Welch, Stephen K. Dolan, Agostino Bruno, Andrea Mozzarelli, Stefano Armao, Aigars Jirgensons, Marco Pieroni, Gabriele Costantino, Barbara Campanini Published in: Journal of Enzyme Inhibition and Medicinal Chemistry, Issue 33/1, 2018, Page(s) 1444-1452, ISSN 1475-6366 Publisher: Taylor & Francis DOI: 10.1080/14756366.2018.1512596 Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms Author(s): Joana Magalhães, Nina Franko, Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Anna Nikitjuka, Andrea Mozzarelli, Stefano Bettati, Anna Karawajczyk, Aigars Jirgensons, Barbara Campanini, Gabriele Costantino Published in: Journal of Enzyme Inhibition and Medicinal Chemistry, Issue 34/1, 2018, Page(s) 31-43, ISSN 1475-6366 Publisher: Taylor & Francis DOI: 10.1080/14756366.2018.1518959 Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening Author(s): Silvia Stotani, Christoph Lorenz, Matthias Winkler, Federico Medda, Edwige Picazo, Raquel Ortega Martinez, Anna Karawajczyk, Jorge Sanchez-Quesada, Fabrizio Giordanetto Published in: ACS Combinatorial Science, Issue 18/6, 2016, Page(s) 330-336, ISSN 2156-8952 Publisher: American Chemical Society DOI: 10.1021/acscombsci.6b00005 A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing Author(s): Silvia Stotani, Viviana Gatta, Federico Medda, Mohan Padmanaban, Anna Karawajczyk, Päivi Tammela, Fabrizio Giordanetto, Dimitrios Tzalis, Simona Collina Published in: Molecules, Issue 23/10, 2018, Page(s) 2545, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules23102545 Structure-Based Virtual Screening of LsrK Kinase Inhibitors to Target Quorum Sensing Author(s): Prasanthi Medarametla, Viviana Gatta, Tommi Kajander, Tuomo Laitinen, Päivi Tammela, Antti Poso Published in: ChemMedChem, Issue 13/22, 2018, Page(s) 2400-2407, ISSN 1860-7179 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/cmdc.201800548 Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa Author(s): Alyssa C. McVey, Prasanthi Medarametla, Xavier Chee, Sean Bartlett, Antti Poso, David R. Spring, Taufiq Rahman, Martin Welch Published in: Biochemistry, Issue 56/41, 2017, Page(s) 5539-5549, ISSN 0006-2960 Publisher: American Chemical Society DOI: 10.1021/acs.biochem.7b00852 Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors Author(s): Tihomir Tomašič, Michaela Barančoková, Nace Zidar, Janez Ilaš, Päivi Tammela, Danijel Kikelj Published in: Archiv der Pharmazie, Issue 351/1, 2018, Page(s) 1700333, ISSN 0365-6233 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/ardp.201700333 Synthesis and Evaluation of N -Phenylpyrrolamides as DNA Gyrase B Inhibitors Author(s): Martina Durcik, Päivi Tammela, Michaela Barančoková, Tihomir Tomašič, Janez Ilaš, Danijel Kikelj, Nace Zidar Published in: ChemMedChem, Issue 13/2, 2018, Page(s) 186-198, ISSN 1860-7179 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/cmdc.201700549 Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors Author(s): Žiga Jakopin, Janez Ilaš, Michaela Barančoková, Matjaž Brvar, Päivi Tammela, Marija Sollner Dolenc, Tihomir Tomašič, Danijel Kikelj Published in: European Journal of Medicinal Chemistry, Issue 130, 2017, Page(s) 171-184, ISSN 0223-5234 Publisher: Elsevier BV DOI: 10.1016/j.ejmech.2017.02.046 Recent progress in the discovery and development of DNA gyrase B inhibitors Author(s): Michaela Barančoková, Danijel Kikelj, Janez Ilaš Published in: Future Medicinal Chemistry, Issue 10/10, 2018, Page(s) 1207-1227, ISSN 1756-8919 Publisher: Future Science Ltd. DOI: 10.4155/fmc-2017-0257 Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O -acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR Author(s): Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Barbara Campanini, Thelma A. Pertinhez, Chiara Pecchini, Agostino Bruno, Joana Magalhães, Stefano Bettati, Nina Franko, Andrea Mozzarelli, Gabriele Costantino Published in: Journal of Enzyme Inhibition and Medicinal Chemistry, Issue 31/sup4, 2016, Page(s) 78-87, ISSN 1475-6366 Publisher: Taylor & Francis DOI: 10.1080/14756366.2016.1218486 Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors. Author(s): Tomašič T1, Mirt M2, Barančoková M2, Ilaš J2, Zidar N2, Tammela P3, Kikelj D2 Published in: Bioorganic & Medicinal Chemistry, Issue Vol. 25, Iss. 1 (2017), 2017, Page(s) 338-349, ISSN 0968-0896 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.bmc.2016.10.038 Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors Author(s): Gjorgjieva M1, Tomašič T1, Barančokova M1, Katsamakas S1,2, Ilaš J1, Tammela P3, Peterlin Mašič L1, Kikelj D1. Published in: Journal of Medicinal Chemistry, Issue Vol. 59, iss. 19 (2016), 2016, Page(s) 8941-8954, ISSN 0022-2623 Publisher: American Chemical Society DOI: 10.1021/acs.jmedchem.6b00864 α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease Author(s): Carlos Moreno-Cinos, Elisa Sassetti, Irene G. Salado, Gesa Witt, Siham Benramdane, Laura Reinhardt, Cristina D. Cruz, Jurgen Joossens, Pieter Van der Veken, Heike Brötz-Oesterhelt, Päivi Tammela, Mathias Winterhalter, Philip Gribbon, Björn Windshügel, Koen Augustyns Published in: Journal of Medicinal Chemistry, Issue 62/2, 2019, Page(s) 774-797, ISSN 0022-2623 Publisher: American Chemical Society DOI: 10.1021/acs.jmedchem.8b01466 Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets Author(s): Joana Magalhães, Giannamaria Annunziato, Nina Franko, Marco Pieroni, Barbara Campanini, Agostino Bruno, Gabriele Costantino Published in: Journal of Chemical Information and Modeling, Issue 58/3, 2018, Page(s) 710-723, ISSN 1549-9596 Publisher: American Chemical Society DOI: 10.1021/acs.jcim.7b00733 Conference proceedings (5) Structural and functional characterisation of the glyoxylate shunt enzymes from Pseudomonas aeruginosa - ORAL CONFERENCE TALK Author(s): Alyssa McVey, Sean Bartlett, Martin Welch Published in: 2017 Publisher: Microbiology Society Meeting Targeting the glyoxylate shunt for antibacterial intervention in Pseudomonas aeruginosa Author(s): Alyssa McVey, Sean Bartlett and Martin Welch Published in: 2017 Publisher: Pseudomonas conference 2017 Enzyme inhibition as a new strategy to overcome Multidrug Resistant Bacteria Author(s): Joana Magalhães, Giannamaria Annunziato, Marco Pieroni, Nina Franko, Barbara Campanini, Andrea Mozzarelli, Vanesa Estevez, Antonio Felici, and Gabriele Costantino Published in: 2016 Publisher: XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2016) Discovery of novel Gyrase B and GyraseB/Topoisomerase IV (ParE) dual Inhibitors with in vitro antibacterial activity Author(s): Michaela Barančoková, Janez Ilaš, Marina Gjorgjieva, Tihomir Tomašič, Päivi Tammela, Vanesa Garrido, Antonio Felici, and Danijel Kikelj Published in: 2016 Publisher: 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Budapest, Hungary - 18-20 November 2016 Design, synthesis and in vitro profiling of novel inhibitors of Pseudomonas aeruginosa MvfR Author(s): A Felici, M Antolini, M. Negri, V. Garrido Estevez, R Zahler, L Rahme, M Pucci, Aldo Feriani, and Daniele Andreotti Published in: 2017 Publisher: European Clinical Microbiology Society Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
