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Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets

Deliverables

PCDPs

ESR supervisors selected and all PCDPs written

Short course

2-day short course organized on antibacterial targets and validation

SAB

SAB board members appointed

ESR recruitments

Call for ESR applicants published and recruiting course organised

Kick-off Meeting

Kick off meeting organized and press announcement released. Supervisory Board will be organised at the same moment.

Gender Equality in Science Course

All ESRs and beneficiaries attend a Gender Equality in Science Course

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Publications

Inhibition of O -acetylserine sulfhydrylase by fluoroalanine derivatives


Published in: ISSN 1475-6366
DOI: 10.1080/14756366.2018.1504040

Design and Synthesis of Fsp 3 -Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

Author(s): Silvia Stotani, Christoph Lorenz, Matthias Winkler, Federico Medda, Edwige Picazo, Raquel Ortega Martinez, Anna Karawajczyk, Jorge Sanchez-Quesada, Fabrizio Giordanetto
Published in: ACS Combinatorial Science, Issue 18/6, 2016, Page(s) 330-336, ISSN 2156-8952
DOI: 10.1021/acscombsci.6b00005

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Author(s): Silvia Stotani, Viviana Gatta, Federico Medda, Mohan Padmanaban, Anna Karawajczyk, Päivi Tammela, Fabrizio Giordanetto, Dimitrios Tzalis, Simona Collina
Published in: Molecules, Issue 23/10, 2018, Page(s) 2545, ISSN 1420-3049
DOI: 10.3390/molecules23102545

Structure-Based Virtual Screening of LsrK Kinase Inhibitors to Target Quorum Sensing


Published in: ISSN 1860-7179
DOI: 10.1002/cmdc.201800548

Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa

Author(s): Alyssa C. McVey, Prasanthi Medarametla, Xavier Chee, Sean Bartlett, Antti Poso, David R. Spring, Taufiq Rahman, Martin Welch
Published in: Biochemistry, Issue 56/41, 2017, Page(s) 5539-5549, ISSN 0006-2960
DOI: 10.1021/acs.biochem.7b00852

Synthesis and Evaluation of N -Phenylpyrrolamides as DNA Gyrase B Inhibitors


Published in: ISSN 1860-7179
DOI: 10.1002/cmdc.201700549

Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

Author(s): Žiga Jakopin, Janez Ilaš, Michaela Barančoková, Matjaž Brvar, Päivi Tammela, Marija Sollner Dolenc, Tihomir Tomašič, Danijel Kikelj
Published in: European Journal of Medicinal Chemistry, Issue 130, 2017, Page(s) 171-184, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2017.02.046

Recent progress in the discovery and development of DNA gyrase B inhibitors

Author(s): Michaela Barančoková, Danijel Kikelj, Janez Ilaš
Published in: Future Medicinal Chemistry, Issue 10/10, 2018, Page(s) 1207-1227, ISSN 1756-8919
DOI: 10.4155/fmc-2017-0257

Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors

Author(s): Gjorgjieva M1, Tomašič T1, Barančokova M1, Katsamakas S1,2, Ilaš J1, Tammela P3, Peterlin Mašič L1, Kikelj D1.
Published in: Journal of Medicinal Chemistry, Issue Vol. 59, iss. 19 (2016), 2016, Page(s) 8941-8954, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.6b00864

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

Author(s): Carlos Moreno-Cinos, Elisa Sassetti, Irene G. Salado, Gesa Witt, Siham Benramdane, Laura Reinhardt, Cristina D. Cruz, Jurgen Joossens, Pieter Van der Veken, Heike Brötz-Oesterhelt, Päivi Tammela, Mathias Winterhalter, Philip Gribbon, Björn Windshügel, Koen Augustyns
Published in: Journal of Medicinal Chemistry, Issue 62/2, 2019, Page(s) 774-797, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.8b01466

Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets

Author(s): Joana Magalhães, Giannamaria Annunziato, Nina Franko, Marco Pieroni, Barbara Campanini, Agostino Bruno, Gabriele Costantino
Published in: Journal of Chemical Information and Modeling, Issue 58/3, 2018, Page(s) 710-723, ISSN 1549-9596
DOI: 10.1021/acs.jcim.7b00733

Structural and functional characterisation of the glyoxylate shunt enzymes from Pseudomonas aeruginosa - ORAL CONFERENCE TALK

Author(s): Alyssa McVey, Sean Bartlett, Martin Welch
Published in: 2017

Targeting the glyoxylate shunt for antibacterial intervention in Pseudomonas aeruginosa

Author(s): Alyssa McVey, Sean Bartlett and Martin Welch
Published in: 2017

Enzyme inhibition as a new strategy to overcome Multidrug Resistant Bacteria

Author(s): Joana Magalhães, Giannamaria Annunziato, Marco Pieroni, Nina Franko, Barbara Campanini, Andrea Mozzarelli, Vanesa Estevez, Antonio Felici, and Gabriele Costantino
Published in: 2016

Discovery of novel Gyrase B and GyraseB/Topoisomerase IV (ParE) dual Inhibitors with in vitro antibacterial activity

Author(s): Michaela Barančoková, Janez Ilaš, Marina Gjorgjieva, Tihomir Tomašič, Päivi Tammela, Vanesa Garrido, Antonio Felici, and Danijel Kikelj
Published in: 2016

Design, synthesis and in vitro profiling of novel inhibitors of Pseudomonas aeruginosa MvfR

Author(s): A Felici, M Antolini, M. Negri, V. Garrido Estevez, R Zahler, L Rahme, M Pucci, Aldo Feriani, and Daniele Andreotti
Published in: 2017