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Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets

Objective

Antimicrobial resistance is posing a continuously-rising threat to global health. Indeed, one key recommendation from the recent “Action plan against the rising threats from Antimicrobial Resistance” report (submitted by the Commission to the European Parliament and Council (15.11.2011)) is the development of effective antimicrobials or alternatives for treatment of human and animal infections. The INTEGRATE project is a direct response to this. We have assembled a team of 10 beneficiaries from eight EU member states, encompassing both academic and non-academic sectors and different disciplines, to form a consortium committed to training Early Stage Researchers (ESRs) in the discovery and preclinical validation of novel Gram-negative antibacterial agents and antibacterial targets. The principle aim of the consortium is to provide a training platform where students are exposed to every aspect of the antimicrobial discovery process, ranging from target identification and validation, through organic synthesis, in silico design and compound screening, to mode-of-action and possible resistance mechanisms. This exposure will be accomplished through a concrete secondment plan, coupled with a series of high-level consortium-wide training events and networking programmes. Our intention is to reverse the current fragmentation of approaches towards antibacterial discovery through mutual cooperation. The INTEGRATE training framework is built on an innovative research project aimed at targeting important but non-essential gene products as an effective means of reducing bacterial fitness, thereby facilitating clearance of the pathogen by the host immune system. To achieve this, the individual work programmes have been designed to seamlessly inter-mesh contributions from the fields of in silico design, organic synthesis, molecular biology and biochemistry, and the very latest in vitro and in vivo screening technologies.

Field of science

  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/basic medicine/immunology
  • /natural sciences/biological sciences/biochemistry
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITA DEGLI STUDI DI PARMA
Address
Via Universita 12
43100 Parma
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 516 122,64

Participants (9)

HELSINGIN YLIOPISTO
Finland
EU contribution
€ 269 145,36
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 269 145,36
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Latvia
EU contribution
€ 223 577,64
Address
Aizkraukles 21
1006 Riga
Activity type
Research Organisations
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 273 287,88
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 234 997,56
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
TAROS CHEMICALS GMBH & CO KG
Germany
EU contribution
€ 249 216,48
Address
Emil-figge-str. 76A
44227 Dortmund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 250 560
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
APTUIT (VERONA) SRL
Italy
EU contribution
€ 258 061,32
Address
Via Alessandro Fleming 4
37135 Verona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 249 216,48
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations

Partners (4)

CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY
Finland
Address
Keilaranta 14
02101 Espoo
Activity type
Other
Matera, Lda
Portugal
Address
Parque Tecnologico De Cantanhede
3060-197 Cantanhede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Finnish Patent Office and Registration
Finland
Address
Arkadiankatu 6 A
00101 Helsinki
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
TTY-SAATIO
Finland
Address
Korkeakoulunkatu 10
33720 Tampere
Activity type
Higher or Secondary Education Establishments