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Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications


Summer School

5 day Summer School to focus TP8: general skills (iv-x)

A Blogspot into the BIOGEL website

A Blogspot will be incorporated into the BIOGEL website to provide a place where ESRs can communicate and share their challenges and knowledge.

Workshop 4

3 day Workshop 4: TP3: Biomimetic hydrogels

Design BIOGEL Website

Communicate the projects and results to the public and the other participants

Workshop 1

2 day Workshop 1: TP8: general skills (i-iii)

Workshop 3

3 day Workshop 3: TP2: Mechanical characterization

Workshop 2

3 day Workshop 2: TP1: Synthesis

Ambassador Day

All ESRs will act as Marie Skłodowska-Curie Ambassadors and visit schools, universities, community organizations

International conference

3 day international conference organized by BIOGEL

Workshop 7

3 day Workshop 7: TP7: Imaging

Workshop 6

4 day Workshop 6: TP5-6: in vitro, ex vivo, and in vivo models

Workshop 5

3 day Workshop 5: TP4: Coatings and sensors

Open ITN day

All participants will open their door to inform the public one day


Bi-annual newsletters to announce training events and scientific results

14 (anticipated) PhD diplomas

Awarding (anticipated) doctoral degrees by all partners

Bicyclic peptides

Different improved biological bicyclic peptides with integrin binding domains and proteolytic cleavage sites

Optical characterization methods

Characterization of thin film hydrogels by optical waveguide spectroscopy (OWS) and surface plasmon resonance (SPR)

Completion of Recruitment

All individual projects will have started by month 12

Searching for OpenAIRE data...


Bicyclic RGD Peptides with Exquisite Selectivity for the Integrin α v β 3 Receptor Using a “Random Design” Approach

Author(s): Dominik Bernhagen, Vanessa Jungbluth, Nestor Gisbert Quilis, Jakub Dostalek, Paul B. White, Kees Jalink, Peter Timmerman
Published in: ACS Combinatorial Science, 2019, ISSN 2156-8952
DOI: 10.1021/acscombsci.8b00144

Cytoskeletal stiffening in synthetic hydrogels

Author(s): Paula de Almeida, Maarten Jaspers, Sarah Vaessen, Oya Tagit, Giuseppe Portale, Alan E. Rowan, Paul H. J. Kouwer
Published in: Nature Communications, Issue 10/1, 2019, Page(s) 609, ISSN 2041-1723
DOI: 10.1038/s41467-019-08569-4

Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization

Author(s): Kaizheng Liu, Silvia M. Mihaila, Alan Rowan, Egbert Oosterwijk, Paul H. J. Kouwer
Published in: Biomacromolecules, Issue 20/2, 2019, Page(s) 826-834, ISSN 1525-7797
DOI: 10.1021/acs.biomac.8b01445

Controlling the gelation temperature of biomimetic polyisocyanides

Author(s): Paul H.J. Kouwer, Paula de Almeida, Onno ven den Boomen, Zaskia H. Eksteen-Akeroyd, Roel Hammink, Maarten Jaspers, Stijn Kragt, Mathijs F.J. Mabesoone, Roeland J.M. Nolte, Alan E. Rowan, Martin G.T.A. Rutten, Vincent A.A. Le Sage, Daniël C. Schoenmakers, Chengfen Xing, Jialiang Xu
Published in: Chinese Chemical Letters, Issue 29/2, 2018, Page(s) 281-284, ISSN 1001-8417
DOI: 10.1016/j.cclet.2017.11.002

Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings

Author(s): Irene Buzzacchera, Mariia Vorobii, Nina Yu. Kostina, Andres de los Santos Pereira, Tomáš Riedel, Michael Bruns, Wojciech Ogieglo, Martin Möller, Christopher J. Wilson, Cesar Rodriguez-Emmenegger
Published in: Biomacromolecules, Issue 18/6, 2017, Page(s) 1983-1992, ISSN 1525-7797
DOI: 10.1021/acs.biomac.7b00516

Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes

Author(s): Irene Buzzacchera, Qi Xiao, Hong Han, Khosrow Rahimi, Shangda Li, Nina Yu. Kostina, B. Jelle Toebes, Samantha E. Wilner, Martin Möller, Cesar Rodriguez-Emmenegger, Tobias Baumgart, Daniela A. Wilson, Christopher J. Wilson, Michael L. Klein, Virgil Percec
Published in: Biomacromolecules, Issue 20/2, 2019, Page(s) 712-727, ISSN 1525-7797
DOI: 10.1021/acs.biomac.8b01405

Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules

Author(s): Luis P. B. Guerzoni, Jan Bohl, Alexander Jans, Jonas C. Rose, Jens Koehler, Alexander J. C. Kuehne, Laura De Laporte
Published in: Biomaterials Science, Issue 5/8, 2017, Page(s) 1549-1557, ISSN 2047-4830
DOI: 10.1039/c7bm00322f

Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating

Author(s): Alicja E. Kownacka, Dovile Vegelyte, Maurits Joosse, Nicoleta Anton, B. Jelle Toebes, Jan Lauko, Irene Buzzacchera, Katarzyna Lipinska, Daniela A. Wilson, Nel Geelhoed-Duijvestijn, Christopher J. Wilson
Published in: Biomacromolecules, Issue 19/11, 2018, Page(s) 4504-4511, ISSN 1525-7797
DOI: 10.1021/acs.biomac.8b01429

On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions

Author(s): Evgenia Tsanaktsidou, Olga Kammona, Costas Kiparissides
Published in: European Polymer Journal, Issue 114, 2019, Page(s) 47-56, ISSN 0014-3057
DOI: 10.1016/j.eurpolymj.2019.02.024

Tunable laser interference lithography preparation of plasmonic nanoparticle arrays tailored for SERS

Author(s): Nestor Gisbert Quilis, Médéric Lequeux, Priyamvada Venugopalan, Imran Khan, Wolfgang Knoll, Souhir Boujday, Marc Lamy de la Chapelle, Jakub Dostalek
Published in: Nanoscale, Issue 10/21, 2018, Page(s) 10268-10276, ISSN 2040-3364
DOI: 10.1039/c7nr08905h

Encoding biological recognition in a bicomponent cell-membrane mimic

Author(s): Cesar Rodriguez-Emmenegger, Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benjamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin Möller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec
Published in: Proceedings of the National Academy of Sciences, 2017, Page(s) 201821924, ISSN 0027-8424
DOI: 10.1073/pnas.1821924116

High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to α v β 3 , α v β 5 , and α 5 β 1 Integrin Receptors

Author(s): Dominik Bernhagen, Laura De Laporte, Peter Timmerman
Published in: Analytical Chemistry, Issue 89/11, 2017, Page(s) 5991-5997, ISSN 0003-2700
DOI: 10.1021/acs.analchem.7b00554

SET-LRP in biphasic mixtures of fluorinated alcohols with water

Author(s): Adrian Moreno, Tong Liu, Liang Ding, Irene Buzzacchera, Marina Galià, Martin Möller, Christopher J. Wilson, Gerard Lligadas, Virgil Percec
Published in: Polymer Chemistry, Issue 9/17, 2018, Page(s) 2313-2327, ISSN 1759-9954
DOI: 10.1039/c8py00062j

Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes

Author(s): Qi Xiao, Anna-Kristin Ludwig, Cecilia Romanò, Irene Buzzacchera, Samuel E. Sherman, Maria Vetro, Sabine Vértesy, Herbert Kaltner, Ellen H. Reed, Martin Möller, Christopher J. Wilson, Daniel A. Hammer, Stefan Oscarson, Michael L. Klein, Hans-Joachim Gabius, Virgil Percec
Published in: Proceedings of the National Academy of Sciences, Issue 115/11, 2018, Page(s) E2509-E2518, ISSN 0027-8424
DOI: 10.1073/pnas.1720055115

Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform

Author(s): Filippo Cipriani, Melanie Krüger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, José Carlos Rodriguez-Cabello
Published in: Biomacromolecules, Issue 19/11, 2018, Page(s) 4333-4347, ISSN 1525-7797
DOI: 10.1021/acs.biomac.8b01211

Bicyclic RGD peptides with high integrin α<sub>v</sub>β<sub>3</sub> and α<sub>5</sub>β<sub>1</sub> affinity promote cell adhesion on elastin-like recombinamers

Author(s): Filippo Cipriani, Dominik Bernhagen, Carmen Garcia-Arévalo, Israel González de Torre, Peter Timmerman, Jose Carlos Rodriguez-Cabello
Published in: Biomedical Materials, 2019, ISSN 1748-6041
DOI: 10.1088/1748-605x/aafd83

Sensor Devices Inspired by the Five Senses: A Review

Published in: ISSN 1040-0397
DOI: 10.1002/elan.201600047