Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications

Risultati finali

5 day Summer School to focus TP8: general skills (iv-x)

A Blogspot will be incorporated into the BIOGEL website to provide a place where ESRs can communicate and share their challenges and knowledge.

Workshop 4

3 day Workshop 4: TP3: Biomimetic hydrogels

Design BIOGEL Website

Communicate the projects and results to the public and the other participants

Workshop 1

2 day Workshop 1: TP8: general skills (i-iii)

Workshop 3

3 day Workshop 3: TP2: Mechanical characterization

Workshop 2

3 day Workshop 2: TP1: Synthesis

Ambassador Day

All ESRs will act as Marie Skłodowska-Curie Ambassadors and visit schools, universities, community organizations

International conference

3 day international conference organized by BIOGEL

Workshop 7

3 day Workshop 7: TP7: Imaging

Workshop 6

4 day Workshop 6: TP5-6: in vitro, ex vivo, and in vivo models

Workshop 5

3 day Workshop 5: TP4: Coatings and sensors

Open ITN day

All participants will open their door to inform the public one day

Newsletters

Bi-annual newsletters to announce training events and scientific results

14 (anticipated) PhD diplomas

Awarding (anticipated) doctoral degrees by all partners

Bicyclic peptides

Different improved biological bicyclic peptides with integrin binding domains and proteolytic cleavage sites

Optical characterization methods

Characterization of thin film hydrogels by optical waveguide spectroscopy (OWS) and surface plasmon resonance (SPR)

Completion of Recruitment

All individual projects will have started by month 12

Pubblicazioni

Fibrous Hydrogels under Multi-Axial Deformation: Persistence Length as the Main Determinant of Compression Softening

Autori: Paula de Almeida, Paul A. Janmey, Paul H. J. Kouwer
Pubblicato in: Advanced Functional Materials, 2021, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202010527

Nanofibrillar Cellulose as an Enzymatically and Flow Driven Degradable Scaffold for Three-Dimensional Tissue Engineering

Autori: Melanie Krüger, Bart Spee, Andreas Walther, Laura De Laporte, Linda M. Kock
Pubblicato in: ASME. ASME J of Medical Diagnostics, 2019, ISSN 2572-7958
Editore: ASME
DOI: 10.1115/1.4044473

Biomimetic Cell-Laden MeHA Hydrogels for the Regeneration of Cartilage Tissue

Autori: Evgenia Tsanaktsidou, Olga Kammona, Norina Labude, Sabine Neuss, Melanie Krüger, Linda Kock, Costas Kiparissides
Pubblicato in: Polymers, 2020, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym12071598

Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids

Autori: Melanie Krüger, Loes A. Oosterhoff, Monique E. van Wolferen, Simon A. Schiele, Andreas Walther, Niels Geijsen, Laura De Laporte, Luc J. W. van der Laan, Linda M. Kock, Bart Spee
Pubblicato in: Advanced Healthcare Materials, 2020, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.201901658

Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical-Free Microfluidic System

Autori: Luis P. B. Guerzoni, Jonas C. Rose, David B. Gehlen, Alexander Jans, Tamàs Haraszti, Matthias Wessling, Alexander J. C. Kuehne, Laura De Laporte
Pubblicato in: Small, 2019, ISSN 1613-6829
Editore: Wiley-VCH GmbH
DOI: 10.1002/smll.201900692

Hydrophobic Cholesteryl Moieties Trigger Substrate Cell−Membrane Interaction of Elastin−Mimetic Protein Coatings in Vitro

Autori: Leander Poocza, Filippo Cipriani, Matilde Alonso, José Carlos Rodríguez-Cabello
Pubblicato in: ACS Omega, 2019, ISSN 2470-1343
Editore: ACS Publications
DOI: 10.1021/acsomega.9b00548

Thin-Film Polyisocyanide-Based Hydrogels for Affinity Biosensors

Autori: Daria Kotlarek, Kaizheng Liu, Nestor G. Quilis, Dominik Bernhagen, Peter Timmerman, Paul Kouwer, Jakub Dostalek
Pubblicato in: The Journal of Physical Chemistry C, 2021, ISSN 1932-7447
Editore: American Chemical Society
DOI: 10.1021/acs.jpcc.1c02489

Actively Tunable Collective Localized Surface Plasmons by Responsive Hydrogel Membrane

Autori: Nestor Gisbert Quilis, Marcel van Dongen, Priyamvada Venugopalan, Daria Kotlarek, Christian Petri, Alberto Moreno Cencerrado, Sorin Stanescu, Jose Luis Toca Herrera, Ulrich Jonas, Martin Möller, Ahmed Mourran, Jakub Dostalek
Pubblicato in: Advanced Optical Materials, 2019, ISSN 2195-1071
Editore: WILEY VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/adom.201900342

Bicyclic RGD Peptides with Exquisite Selectivity for the Integrin α v β 3 Receptor Using a “Random Design” Approach

Autori: Dominik Bernhagen, Vanessa Jungbluth, Nestor Gisbert Quilis, Jakub Dostalek, Paul B. White, Kees Jalink, Peter Timmerman
Pubblicato in: ACS Combinatorial Science, 2019, ISSN 2156-8952
Editore: American Chemical Society
DOI: 10.1021/acscombsci.8b00144

Cytoskeletal stiffening in synthetic hydrogels

Autori: Paula de Almeida, Maarten Jaspers, Sarah Vaessen, Oya Tagit, Giuseppe Portale, Alan E. Rowan, Paul H. J. Kouwer
Pubblicato in: Nature Communications, Numero 10/1, 2019, Pagina/e 609, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-08569-4

Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization

Autori: Kaizheng Liu, Silvia M. Mihaila, Alan Rowan, Egbert Oosterwijk, Paul H. J. Kouwer
Pubblicato in: Biomacromolecules, Numero 20/2, 2019, Pagina/e 826-834, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b01445

Controlling the gelation temperature of biomimetic polyisocyanides

Autori: Paul H.J. Kouwer, Paula de Almeida, Onno ven den Boomen, Zaskia H. Eksteen-Akeroyd, Roel Hammink, Maarten Jaspers, Stijn Kragt, Mathijs F.J. Mabesoone, Roeland J.M. Nolte, Alan E. Rowan, Martin G.T.A. Rutten, Vincent A.A. Le Sage, Daniël C. Schoenmakers, Chengfen Xing, Jialiang Xu
Pubblicato in: Chinese Chemical Letters, Numero 29/2, 2018, Pagina/e 281-284, ISSN 1001-8417
Editore: Institute of Materia Medica
DOI: 10.1016/j.cclet.2017.11.002

Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings

Autori: Irene Buzzacchera, Mariia Vorobii, Nina Yu. Kostina, Andres de los Santos Pereira, Tomáš Riedel, Michael Bruns, Wojciech Ogieglo, Martin Möller, Christopher J. Wilson, Cesar Rodriguez-Emmenegger
Pubblicato in: Biomacromolecules, Numero 18/6, 2017, Pagina/e 1983-1992, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.7b00516

Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes

Autori: Irene Buzzacchera, Qi Xiao, Hong Han, Khosrow Rahimi, Shangda Li, Nina Yu. Kostina, B. Jelle Toebes, Samantha E. Wilner, Martin Möller, Cesar Rodriguez-Emmenegger, Tobias Baumgart, Daniela A. Wilson, Christopher J. Wilson, Michael L. Klein, Virgil Percec
Pubblicato in: Biomacromolecules, Numero 20/2, 2019, Pagina/e 712-727, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b01405

Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules

Autori: Luis P. B. Guerzoni, Jan Bohl, Alexander Jans, Jonas C. Rose, Jens Koehler, Alexander J. C. Kuehne, Laura De Laporte
Pubblicato in: Biomaterials Science, Numero 5/8, 2017, Pagina/e 1549-1557, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/c7bm00322f

Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating

Autori: Alicja E. Kownacka, Dovile Vegelyte, Maurits Joosse, Nicoleta Anton, B. Jelle Toebes, Jan Lauko, Irene Buzzacchera, Katarzyna Lipinska, Daniela A. Wilson, Nel Geelhoed-Duijvestijn, Christopher J. Wilson
Pubblicato in: Biomacromolecules, Numero 19/11, 2018, Pagina/e 4504-4511, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b01429

On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions

Autori: Evgenia Tsanaktsidou, Olga Kammona, Costas Kiparissides
Pubblicato in: European Polymer Journal, Numero 114, 2019, Pagina/e 47-56, ISSN 0014-3057
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.eurpolymj.2019.02.024

Tunable laser interference lithography preparation of plasmonic nanoparticle arrays tailored for SERS

Autori: Nestor Gisbert Quilis, Médéric Lequeux, Priyamvada Venugopalan, Imran Khan, Wolfgang Knoll, Souhir Boujday, Marc Lamy de la Chapelle, Jakub Dostalek
Pubblicato in: Nanoscale, Numero 10/21, 2018, Pagina/e 10268-10276, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c7nr08905h

Encoding biological recognition in a bicomponent cell-membrane mimic

Autori: Cesar Rodriguez-Emmenegger, Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benjamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin Möller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec
Pubblicato in: Proceedings of the National Academy of Sciences, 2017, Pagina/e 201821924, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1821924116

High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to α v β 3 , α v β 5 , and α 5 β 1 Integrin Receptors

Autori: Dominik Bernhagen, Laura De Laporte, Peter Timmerman
Pubblicato in: Analytical Chemistry, Numero 89/11, 2017, Pagina/e 5991-5997, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.7b00554

SET-LRP in biphasic mixtures of fluorinated alcohols with water

Autori: Adrian Moreno, Tong Liu, Liang Ding, Irene Buzzacchera, Marina Galià, Martin Möller, Christopher J. Wilson, Gerard Lligadas, Virgil Percec
Pubblicato in: Polymer Chemistry, Numero 9/17, 2018, Pagina/e 2313-2327, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/c8py00062j

Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes

Autori: Qi Xiao, Anna-Kristin Ludwig, Cecilia Romanò, Irene Buzzacchera, Samuel E. Sherman, Maria Vetro, Sabine Vértesy, Herbert Kaltner, Ellen H. Reed, Martin Möller, Christopher J. Wilson, Daniel A. Hammer, Stefan Oscarson, Michael L. Klein, Hans-Joachim Gabius, Virgil Percec
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 115/11, 2018, Pagina/e E2509-E2518, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1720055115

Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform

Autori: Filippo Cipriani, Melanie Krüger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, José Carlos Rodriguez-Cabello
Pubblicato in: Biomacromolecules, Numero 19/11, 2018, Pagina/e 4333-4347, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b01211

Bicyclic RGD peptides with high integrin αvβ3 and α5β1 affinity promote cell adhesion on elastin-like recombinamers

Autori: Filippo Cipriani, Dominik Bernhagen, Carmen Garcia-Arévalo, Israel González de Torre, Peter Timmerman, Jose Carlos Rodriguez-Cabello
Pubblicato in: Biomedical Materials, 2019, ISSN 1748-6041
Editore: Institute of Physics Publishing
DOI: 10.1088/1748-605x/aafd83

Sensor Devices Inspired by the Five Senses: A Review

Autori: Mila I. Svechtarova, Irene Buzzacchera, B. Jelle Toebes, Jan Lauko, Nicoleta Anton, Christopher J. Wilson
Pubblicato in: Electroanalysis, 2016, ISSN 1040-0397
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/elan.201600047

Charge Density as a Molecular Modulator of Nanostructuration in Intrinsically Disordered Protein Polymers

Autori: Sergio Acosta, Leander Poocza, Luis Quintanilla-Sierra, José Carlos Rodríguez-Cabello
Pubblicato in: Biomacromolecules, 2021, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.0c00934

A Layer-by-Layer Single-Cell Coating Technique To Produce Injectable Beating Mini Heart Tissues via Microfluidics

Autori: Luis P. B. Guerzoni, Yoshinari Tsukamoto, David B. Gehlen, Dirk Rommel, Tamás Haraszti, Mitsuru Akashi, Laura De Laporte
Pubblicato in: Biomacromolecules, 2019, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b00786

Cell-matrix reciprocity in 3D culture models with nonlinear elasticity

Autori: Kaizheng Liu, Maury Wiendels, Hongbo Yuan, Changshun Ruan, Paul H.J. Kouwer
Pubblicato in: Bioactive Materials, 2022, ISSN 2452-199X
Editore: Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
DOI: 10.1016/j.bioactmat.2021.08.002

Structural characterization of fibrous synthetic hydrogels using fluorescence microscopy

Autori: Johannes Vandaele, Boris Louis, Kaizheng Liu, Rafael Camacho, Paul H. J. Kouwer, Susana Rocha
Pubblicato in: Soft Matter, 2020, ISSN 1744-683X
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sm01828j

Actuated plasmonic nanohole arrays for sensing and optical spectroscopy applications

Autori: Daria Kotlarek, Stefan Fossati,Priyamvada Venugopalan, Nestor Gisbert Quilis, Jiří Slabý, Jiří Homola, Médéric Lequeux, Frédéric Amiard,Marc Lamy de la Chapelle, Ulrich Jonas, Jakub Dostálek
Pubblicato in: Nanoscale, 2020, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d0nr00761g

Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels

Autori: Sitara Vedaraman, Dominik Bernhagen, Tamas Haraszti, Christopher Licht, Arturo Castro Nava, Abdolrahman Omidinia Anarkoli, Peter Timmerman, Laura De Laporte
Pubblicato in: Biomaterials Science, 2021, ISSN 2397-1401
Editore: Royal Society of Chemistry
DOI: 10.1039/d0bm02051f

Compact Grating-Coupled Biosensor for the Analysis of Thrombin

Autori: Daria Kotlarek, Mariia Vorobii, Wojciech Ogieglo, Wolfgang Knoll, Cesar Rodriguez-Emmenegger, Jakub Dostálek
Pubblicato in: ACS Sensors, 2019, ISSN 2379-3694
Editore: American Chemical Society
DOI: 10.1021/acssensors.9b00827

Cellular responses to beating hydrogels to investigate mechanotransduction

Autori: Yashoda Chandorkar, Arturo Castro Nava, Sjören Schweizerhof, Marcel Van Dongen, Tamás Haraszti, Jens Köhler, Hang Zhang, Reinhard Windoffer, Ahmed Mourran, Martin Möller, Laura De Laporte
Pubblicato in: Nature Communications, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11475-4

Synthetic Extracellular Matrices as a Toolbox to Tune Stem CellSecretome

Autori: Kaizheng Liu, Tomas Veenendaal, Maury Wiendels, Alejandra M. Ruiz-Zapata, Justin van Laar, Rafail Kyranas, Hilde Enting, Bram van Cranenbroek, Hans J. P. M. Koenen, Silvia M. Mihaila, Egbert Oosterwijk, Paul H. J. Kouwer
Pubblicato in: ACS Applied Materials and Interfaces, 2020, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.0c16208

Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment

Autori: Sitara Vedaraman, Amaury Perez-Tirado, Tamas Haraszti, Jose Gerardo-Nava, Akihiro Nishiguchi, Laura De Laporte
Pubblicato in: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202100874

Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids

Autori: Paola Torre, Qi Xiao, Irene Buzzacchera, Samuel E. Sherman, Khosrow Rahimi, Nina Yu. Kostina, Cesar Rodriguez-Emmenegger, Martin Möller, Christopher J. Wilson, Michael L. Klein, Matthew C. Good, Virgil Percec
Pubblicato in: Proceedings of the National Academy of Sciences (PNAS), 2019, ISSN 1091-6490
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1904868116

Responsive polymer networks and brushes for active plasmonics

Autori: N. G. Quilis, N. Sharma, S. Fossati, W. Knoll, J. Dostalek
Pubblicato in: in Polymer and Biopolymer Brushes: Fundamentals and Applications in Materials Science and Biotechnology, 2018, ISBN 1118928903
Editore: John Wiley & Sons, Ltd.
DOI: 10.1002/9781119455042.ch24

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