Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications

Livrables

5 day Summer School to focus TP8: general skills (iv-x)

A Blogspot will be incorporated into the BIOGEL website to provide a place where ESRs can communicate and share their challenges and knowledge.

Workshop 4

3 day Workshop 4: TP3: Biomimetic hydrogels

Design BIOGEL Website

Communicate the projects and results to the public and the other participants

Workshop 1

2 day Workshop 1: TP8: general skills (i-iii)

Workshop 3

3 day Workshop 3: TP2: Mechanical characterization

Workshop 2

3 day Workshop 2: TP1: Synthesis

Ambassador Day

All ESRs will act as Marie Skłodowska-Curie Ambassadors and visit schools, universities, community organizations

International conference

3 day international conference organized by BIOGEL

Workshop 7

3 day Workshop 7: TP7: Imaging

Workshop 6

4 day Workshop 6: TP5-6: in vitro, ex vivo, and in vivo models

Workshop 5

3 day Workshop 5: TP4: Coatings and sensors

Open ITN day

All participants will open their door to inform the public one day

Newsletters

Bi-annual newsletters to announce training events and scientific results

14 (anticipated) PhD diplomas

Awarding (anticipated) doctoral degrees by all partners

Bicyclic peptides

Different improved biological bicyclic peptides with integrin binding domains and proteolytic cleavage sites

Optical characterization methods

Characterization of thin film hydrogels by optical waveguide spectroscopy (OWS) and surface plasmon resonance (SPR)

Completion of Recruitment

All individual projects will have started by month 12

Publications

Fibrous Hydrogels under Multi-Axial Deformation: Persistence Length as the Main Determinant of Compression Softening

Auteurs: Paula de Almeida, Paul A. Janmey, Paul H. J. Kouwer
Publié dans: Advanced Functional Materials, 2021, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202010527

Nanofibrillar Cellulose as an Enzymatically and Flow Driven Degradable Scaffold for Three-Dimensional Tissue Engineering

Auteurs: Melanie Krüger, Bart Spee, Andreas Walther, Laura De Laporte, Linda M. Kock
Publié dans: ASME. ASME J of Medical Diagnostics, 2019, ISSN 2572-7958
Éditeur: ASME
DOI: 10.1115/1.4044473

Biomimetic Cell-Laden MeHA Hydrogels for the Regeneration of Cartilage Tissue

Auteurs: Evgenia Tsanaktsidou, Olga Kammona, Norina Labude, Sabine Neuss, Melanie Krüger, Linda Kock, Costas Kiparissides
Publié dans: Polymers, 2020, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym12071598

Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids

Auteurs: Melanie Krüger, Loes A. Oosterhoff, Monique E. van Wolferen, Simon A. Schiele, Andreas Walther, Niels Geijsen, Laura De Laporte, Luc J. W. van der Laan, Linda M. Kock, Bart Spee
Publié dans: Advanced Healthcare Materials, 2020, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1002/adhm.201901658

Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical-Free Microfluidic System

Auteurs: Luis P. B. Guerzoni, Jonas C. Rose, David B. Gehlen, Alexander Jans, Tamàs Haraszti, Matthias Wessling, Alexander J. C. Kuehne, Laura De Laporte
Publié dans: Small, 2019, ISSN 1613-6829
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/smll.201900692

Hydrophobic Cholesteryl Moieties Trigger Substrate Cell−Membrane Interaction of Elastin−Mimetic Protein Coatings in Vitro

Auteurs: Leander Poocza, Filippo Cipriani, Matilde Alonso, José Carlos Rodríguez-Cabello
Publié dans: ACS Omega, 2019, ISSN 2470-1343
Éditeur: ACS Publications
DOI: 10.1021/acsomega.9b00548

Thin-Film Polyisocyanide-Based Hydrogels for Affinity Biosensors

Auteurs: Daria Kotlarek, Kaizheng Liu, Nestor G. Quilis, Dominik Bernhagen, Peter Timmerman, Paul Kouwer, Jakub Dostalek
Publié dans: The Journal of Physical Chemistry C, 2021, ISSN 1932-7447
Éditeur: American Chemical Society
DOI: 10.1021/acs.jpcc.1c02489

Actively Tunable Collective Localized Surface Plasmons by Responsive Hydrogel Membrane

Auteurs: Nestor Gisbert Quilis, Marcel van Dongen, Priyamvada Venugopalan, Daria Kotlarek, Christian Petri, Alberto Moreno Cencerrado, Sorin Stanescu, Jose Luis Toca Herrera, Ulrich Jonas, Martin Möller, Ahmed Mourran, Jakub Dostalek
Publié dans: Advanced Optical Materials, 2019, ISSN 2195-1071
Éditeur: WILEY VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/adom.201900342

Bicyclic RGD Peptides with Exquisite Selectivity for the Integrin α v β 3 Receptor Using a “Random Design” Approach

Auteurs: Dominik Bernhagen, Vanessa Jungbluth, Nestor Gisbert Quilis, Jakub Dostalek, Paul B. White, Kees Jalink, Peter Timmerman
Publié dans: ACS Combinatorial Science, 2019, ISSN 2156-8952
Éditeur: American Chemical Society
DOI: 10.1021/acscombsci.8b00144

Cytoskeletal stiffening in synthetic hydrogels

Auteurs: Paula de Almeida, Maarten Jaspers, Sarah Vaessen, Oya Tagit, Giuseppe Portale, Alan E. Rowan, Paul H. J. Kouwer
Publié dans: Nature Communications, Numéro 10/1, 2019, Page(s) 609, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-08569-4

Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization

Auteurs: Kaizheng Liu, Silvia M. Mihaila, Alan Rowan, Egbert Oosterwijk, Paul H. J. Kouwer
Publié dans: Biomacromolecules, Numéro 20/2, 2019, Page(s) 826-834, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.8b01445

Controlling the gelation temperature of biomimetic polyisocyanides

Auteurs: Paul H.J. Kouwer, Paula de Almeida, Onno ven den Boomen, Zaskia H. Eksteen-Akeroyd, Roel Hammink, Maarten Jaspers, Stijn Kragt, Mathijs F.J. Mabesoone, Roeland J.M. Nolte, Alan E. Rowan, Martin G.T.A. Rutten, Vincent A.A. Le Sage, Daniël C. Schoenmakers, Chengfen Xing, Jialiang Xu
Publié dans: Chinese Chemical Letters, Numéro 29/2, 2018, Page(s) 281-284, ISSN 1001-8417
Éditeur: Institute of Materia Medica
DOI: 10.1016/j.cclet.2017.11.002

Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings

Auteurs: Irene Buzzacchera, Mariia Vorobii, Nina Yu. Kostina, Andres de los Santos Pereira, Tomáš Riedel, Michael Bruns, Wojciech Ogieglo, Martin Möller, Christopher J. Wilson, Cesar Rodriguez-Emmenegger
Publié dans: Biomacromolecules, Numéro 18/6, 2017, Page(s) 1983-1992, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.7b00516

Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes

Auteurs: Irene Buzzacchera, Qi Xiao, Hong Han, Khosrow Rahimi, Shangda Li, Nina Yu. Kostina, B. Jelle Toebes, Samantha E. Wilner, Martin Möller, Cesar Rodriguez-Emmenegger, Tobias Baumgart, Daniela A. Wilson, Christopher J. Wilson, Michael L. Klein, Virgil Percec
Publié dans: Biomacromolecules, Numéro 20/2, 2019, Page(s) 712-727, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.8b01405

Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules

Auteurs: Luis P. B. Guerzoni, Jan Bohl, Alexander Jans, Jonas C. Rose, Jens Koehler, Alexander J. C. Kuehne, Laura De Laporte
Publié dans: Biomaterials Science, Numéro 5/8, 2017, Page(s) 1549-1557, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c7bm00322f

Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating

Auteurs: Alicja E. Kownacka, Dovile Vegelyte, Maurits Joosse, Nicoleta Anton, B. Jelle Toebes, Jan Lauko, Irene Buzzacchera, Katarzyna Lipinska, Daniela A. Wilson, Nel Geelhoed-Duijvestijn, Christopher J. Wilson
Publié dans: Biomacromolecules, Numéro 19/11, 2018, Page(s) 4504-4511, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.8b01429

On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions

Auteurs: Evgenia Tsanaktsidou, Olga Kammona, Costas Kiparissides
Publié dans: European Polymer Journal, Numéro 114, 2019, Page(s) 47-56, ISSN 0014-3057
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.eurpolymj.2019.02.024

Tunable laser interference lithography preparation of plasmonic nanoparticle arrays tailored for SERS

Auteurs: Nestor Gisbert Quilis, Médéric Lequeux, Priyamvada Venugopalan, Imran Khan, Wolfgang Knoll, Souhir Boujday, Marc Lamy de la Chapelle, Jakub Dostalek
Publié dans: Nanoscale, Numéro 10/21, 2018, Page(s) 10268-10276, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c7nr08905h

Encoding biological recognition in a bicomponent cell-membrane mimic

Auteurs: Cesar Rodriguez-Emmenegger, Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benjamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin Möller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec
Publié dans: Proceedings of the National Academy of Sciences, 2017, Page(s) 201821924, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1821924116

High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to α v β 3 , α v β 5 , and α 5 β 1 Integrin Receptors

Auteurs: Dominik Bernhagen, Laura De Laporte, Peter Timmerman
Publié dans: Analytical Chemistry, Numéro 89/11, 2017, Page(s) 5991-5997, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.7b00554

SET-LRP in biphasic mixtures of fluorinated alcohols with water

Auteurs: Adrian Moreno, Tong Liu, Liang Ding, Irene Buzzacchera, Marina Galià, Martin Möller, Christopher J. Wilson, Gerard Lligadas, Virgil Percec
Publié dans: Polymer Chemistry, Numéro 9/17, 2018, Page(s) 2313-2327, ISSN 1759-9954
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8py00062j

Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes

Auteurs: Qi Xiao, Anna-Kristin Ludwig, Cecilia Romanò, Irene Buzzacchera, Samuel E. Sherman, Maria Vetro, Sabine Vértesy, Herbert Kaltner, Ellen H. Reed, Martin Möller, Christopher J. Wilson, Daniel A. Hammer, Stefan Oscarson, Michael L. Klein, Hans-Joachim Gabius, Virgil Percec
Publié dans: Proceedings of the National Academy of Sciences, Numéro 115/11, 2018, Page(s) E2509-E2518, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1720055115

Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform

Auteurs: Filippo Cipriani, Melanie Krüger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, José Carlos Rodriguez-Cabello
Publié dans: Biomacromolecules, Numéro 19/11, 2018, Page(s) 4333-4347, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.8b01211

Bicyclic RGD peptides with high integrin αvβ3 and α5β1 affinity promote cell adhesion on elastin-like recombinamers

Auteurs: Filippo Cipriani, Dominik Bernhagen, Carmen Garcia-Arévalo, Israel González de Torre, Peter Timmerman, Jose Carlos Rodriguez-Cabello
Publié dans: Biomedical Materials, 2019, ISSN 1748-6041
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1748-605x/aafd83

Sensor Devices Inspired by the Five Senses: A Review

Auteurs: Mila I. Svechtarova, Irene Buzzacchera, B. Jelle Toebes, Jan Lauko, Nicoleta Anton, Christopher J. Wilson
Publié dans: Electroanalysis, 2016, ISSN 1040-0397
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/elan.201600047

Charge Density as a Molecular Modulator of Nanostructuration in Intrinsically Disordered Protein Polymers

Auteurs: Sergio Acosta, Leander Poocza, Luis Quintanilla-Sierra, José Carlos Rodríguez-Cabello
Publié dans: Biomacromolecules, 2021, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.0c00934

A Layer-by-Layer Single-Cell Coating Technique To Produce Injectable Beating Mini Heart Tissues via Microfluidics

Auteurs: Luis P. B. Guerzoni, Yoshinari Tsukamoto, David B. Gehlen, Dirk Rommel, Tamás Haraszti, Mitsuru Akashi, Laura De Laporte
Publié dans: Biomacromolecules, 2019, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.9b00786

Cell-matrix reciprocity in 3D culture models with nonlinear elasticity

Auteurs: Kaizheng Liu, Maury Wiendels, Hongbo Yuan, Changshun Ruan, Paul H.J. Kouwer
Publié dans: Bioactive Materials, 2022, ISSN 2452-199X
Éditeur: Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
DOI: 10.1016/j.bioactmat.2021.08.002

Structural characterization of fibrous synthetic hydrogels using fluorescence microscopy

Auteurs: Johannes Vandaele, Boris Louis, Kaizheng Liu, Rafael Camacho, Paul H. J. Kouwer, Susana Rocha
Publié dans: Soft Matter, 2020, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9sm01828j

Actuated plasmonic nanohole arrays for sensing and optical spectroscopy applications

Auteurs: Daria Kotlarek, Stefan Fossati,Priyamvada Venugopalan, Nestor Gisbert Quilis, Jiří Slabý, Jiří Homola, Médéric Lequeux, Frédéric Amiard,Marc Lamy de la Chapelle, Ulrich Jonas, Jakub Dostálek
Publié dans: Nanoscale, 2020, ISSN 2040-3372
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0nr00761g

Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels

Auteurs: Sitara Vedaraman, Dominik Bernhagen, Tamas Haraszti, Christopher Licht, Arturo Castro Nava, Abdolrahman Omidinia Anarkoli, Peter Timmerman, Laura De Laporte
Publié dans: Biomaterials Science, 2021, ISSN 2397-1401
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0bm02051f

Compact Grating-Coupled Biosensor for the Analysis of Thrombin

Auteurs: Daria Kotlarek, Mariia Vorobii, Wojciech Ogieglo, Wolfgang Knoll, Cesar Rodriguez-Emmenegger, Jakub Dostálek
Publié dans: ACS Sensors, 2019, ISSN 2379-3694
Éditeur: American Chemical Society
DOI: 10.1021/acssensors.9b00827

Cellular responses to beating hydrogels to investigate mechanotransduction

Auteurs: Yashoda Chandorkar, Arturo Castro Nava, Sjören Schweizerhof, Marcel Van Dongen, Tamás Haraszti, Jens Köhler, Hang Zhang, Reinhard Windoffer, Ahmed Mourran, Martin Möller, Laura De Laporte
Publié dans: Nature Communications, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-11475-4

Synthetic Extracellular Matrices as a Toolbox to Tune Stem CellSecretome

Auteurs: Kaizheng Liu, Tomas Veenendaal, Maury Wiendels, Alejandra M. Ruiz-Zapata, Justin van Laar, Rafail Kyranas, Hilde Enting, Bram van Cranenbroek, Hans J. P. M. Koenen, Silvia M. Mihaila, Egbert Oosterwijk, Paul H. J. Kouwer
Publié dans: ACS Applied Materials and Interfaces, 2020, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.0c16208

Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment

Auteurs: Sitara Vedaraman, Amaury Perez-Tirado, Tamas Haraszti, Jose Gerardo-Nava, Akihiro Nishiguchi, Laura De Laporte
Publié dans: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1002/adhm.202100874

Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids

Auteurs: Paola Torre, Qi Xiao, Irene Buzzacchera, Samuel E. Sherman, Khosrow Rahimi, Nina Yu. Kostina, Cesar Rodriguez-Emmenegger, Martin Möller, Christopher J. Wilson, Michael L. Klein, Matthew C. Good, Virgil Percec
Publié dans: Proceedings of the National Academy of Sciences (PNAS), 2019, ISSN 1091-6490
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1904868116

Responsive polymer networks and brushes for active plasmonics

Auteurs: N. G. Quilis, N. Sharma, S. Fossati, W. Knoll, J. Dostalek
Publié dans: in Polymer and Biopolymer Brushes: Fundamentals and Applications in Materials Science and Biotechnology, 2018, ISBN 1118928903
Éditeur: John Wiley & Sons, Ltd.
DOI: 10.1002/9781119455042.ch24

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