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Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)


First patient treated

First patient treated.

IMP production final

Production of IMP for clinical trial final.

Clinical trial kick-off

Clinical Trial Kick-off meeting with all clinical partners.

Production initiated

Production ready to start.

Clinical databases

IWRS, eCRF and database developed

Training logs

Training logs for personnel complete

Preliminary cost-effectiveness analysis

First preliminary results of health economics: Standard cost-effectiveness analysis of ASC therapy for each country involved, analysis of country differences

All approvals package

All approvals from national ethics committees and national competent authorities of all study sites recieved.

Qualification of production facility

Documentation of proper classification for sterile GMP production.


Establishment of SCIENCE website for public and partner use.

Searching for OpenAIRE data...


Cryopreserved Off-the-Shelf Allogeneic Adipose-Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure-A Safety Study

Author(s): Jens Kastrup, Mandana Haack-Sørensen, Morten Juhl, Rebekka Harary Søndergaard, Bjarke Follin, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Erik Jørgensen, Steffen Helqvist, Jens Jørgen Elberg, Helle Bruunsgaard, Annette Ekblond
Published in: STEM CELLS Translational Medicine, Issue 6/11, 2017, Page(s) 1963-1971, ISSN 2157-6564
DOI: 10.1002/sctm.17-0040

Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies

Author(s): Mariusz Z. Ratajczak, Kamila Bujko, Wojciech Wojakowski
Published in: Polish Archives of Internal Medicine, Issue 126/11, 2016, Page(s) 879-890, ISSN 1897-9483
DOI: 10.20452/pamw.3644

Intracoronary autologous bone marrow cell transfer after acute myocardial infarction: abort and refocus

Author(s): Jozef Bartunek, Wojtek Wojakowski
Published in: European Heart Journal, Issue 38/39, 2017, Page(s) 2944-2947, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehx300

Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phase II Danish Multicentre Study

Author(s): Jens Kastrup, Morten Schou, Ida Gustafsson, Olav W. Nielsen, Rasmus Møgelvang, Klaus F. Kofoed, Charlotte Kragelund, Jens Dahlgaard Hove, Andreas Fabricius-Bjerre, Merete Heitman, Mandana Haack-Sørensen, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Annette Ekblond
Published in: Stem Cells International, Issue 2017, 2017, Page(s) 1-8, ISSN 1687-966X
DOI: 10.1155/2017/8506370

Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies

Published in: ISSN 0009-7330
DOI: 10.1161/circresaha.115.307347

Global position paper on cardiovascular regenerative medicine

Author(s): Francisco Fernández-Avilés, Ricardo Sanz-Ruiz, Andreu M. Climent, Lina Badimon, Roberto Bolli, Dominique Charron, Valentin Fuster, Stefan Janssens, Jens Kastrup, Hyo-Soo Kim, Thomas F. Lüscher, John F. Martin, Philippe Menasché, Robert D. Simari, Gregg W. Stone, Andre Terzic, James T. Willerson, Joseph C. Wu, Francisco Fernández-Avilés, Andre Terzic, Lina Badimon, Kathleen Broughton, Darcy L
Published in: European Heart Journal, Issue 38/33, 2017, Page(s) 2532-2546, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehx248

Rationale and design of the European multicentre study on Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)

Author(s): Christina Paitazoglou, Martin W. Bergmann, Bojan Vrtovec, Steven A.J. Chamuleau, Bas van Klarenbosch, Wojtek Wojakowski, Aleksandra Michalewska-Włudarczyk, Mariann Gyöngyösi, Annette Ekblond, Mandana Haack-Sørensen, Kai Jaquet, Karsten Vrangbaek, Jens Kastrup
Published in: European Journal of Heart Failure, 2019, ISSN 1388-9842
DOI: 10.1002/ejhf.1412

Cryopreservation and Revival of Human Mesenchymal Stromal Cells

Author(s): Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup
Published in: Mesenchymal Stem Cells - Methods and Protocols, Issue 1416, 2016, Page(s) 357-374
DOI: 10.1007/978-1-4939-3584-0_21