Skip to main content

Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes

Objective

South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden.
We will complete a cluster-randomised clinical trial at 120 locations across India, Pakistan, Sri Lanka and the UK. We will compare family-based intensive lifestyle modification (22 health promotion sessions from a community health worker, active group, N=60 sites) vs usual care (1 session, control group, N=60 sites) for prevention of T2D, amongst 3,600 non-diabetic South Asian men and women with central obesity (waist≥100cm) and/or prediabetes (HbA1c≥6.0%). Participants will be followed annually for 3 years. The primary endpoint will be new-onset T2D (physician diagnosis on treatment or HbA1c≥6.0%, predicted N~734 over 3 years). Secondary endpoints will include waist and weight in the index case and family members. Our study has 80% power to identify a reduction in T2D risk with family-based intervention vs usual care of: 30% in South Asians with central obesity; 24% in South Asians with prediabetes; and 24% overall. Health economic evaluation will determine cost-effectiveness of family based lifestyle modification for prevention of T2D amongst South Asians with central obesity and / or prediabetes. The impact of gender and socio-economic factors on clinical utility and cost-effectiveness will be investigated.
Our results will determine whether screening by waist circumference and/or HbA1c, coupled with intervention by family-based lifestyle modification, is an efficient, effective and equitable strategy for prevention of T2D in South Asians. Our findings will thereby provide a robust evidence base for scalable community-wide approaches to reverse the epidemic of T2D amongst the >1.5 billion South Asians worldwide.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

H2020-HCO-2014
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 386 972,50

Participants (10)

DEVKI DEVI FOUNDATION SOCIETY
India
EU contribution
€ 247 050
Address
Press Enclave Road Saket 2
110017 New Delhi
Activity type
Research Organisations
UNIVERSITY OF COLOMBO
Sri Lanka
EU contribution
€ 155 550
Address
94 Cumaratunga Munidasa Mawatha
00300 Colombo Western Province
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF KELANIYA
Sri Lanka
EU contribution
€ 121 237,50
Address
Dalugama
Kelaniya
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF SURREY
United Kingdom
EU contribution
€ 244 233,75
Address
Stag Hill
GU2 7XH Guildford
Activity type
Higher or Secondary Education Establishments
LONDON NORTH WEST HEALTHCARE NATIONAL HEALTH SERVICE TRUST
United Kingdom
EU contribution
€ 749 537,50
Address
Watford Road
HA1 3UJ Harrow Middlesex
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSTITUTE FOR HEALTH POLICY
Sri Lanka
EU contribution
€ 105 750
Address
72 Park Street
Colombo
Activity type
Research Organisations
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 146 250
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
OULUN YLIOPISTO
Finland
EU contribution
€ 166 990
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
PUNJAB INSTITUTE OF CARDIOLOGY (PIC) LAHORE
Pakistan
EU contribution
€ 113 612,50
Address
Jail Road Ghous Ul Azam
54000 Lahore Punjab
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SERVICES INSTITUTE OF MEDICAL SCIENCES
Pakistan
EU contribution
€ 176 900
Address
Jail Road Opposite Race Course Park
54000 Lahore
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)