Obiettivo South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden. We will complete a cluster-randomised clinical trial at 120 locations across India, Pakistan, Sri Lanka and the UK. We will compare family-based intensive lifestyle modification (22 health promotion sessions from a community health worker, active group, N=60 sites) vs usual care (1 session, control group, N=60 sites) for prevention of T2D, amongst 3,600 non-diabetic South Asian men and women with central obesity (waist≥100cm) and/or prediabetes (HbA1c≥6.0%). Participants will be followed annually for 3 years. The primary endpoint will be new-onset T2D (physician diagnosis on treatment or HbA1c≥6.0%, predicted N~734 over 3 years). Secondary endpoints will include waist and weight in the index case and family members. Our study has 80% power to identify a reduction in T2D risk with family-based intervention vs usual care of: 30% in South Asians with central obesity; 24% in South Asians with prediabetes; and 24% overall. Health economic evaluation will determine cost-effectiveness of family based lifestyle modification for prevention of T2D amongst South Asians with central obesity and / or prediabetes. The impact of gender and socio-economic factors on clinical utility and cost-effectiveness will be investigated.Our results will determine whether screening by waist circumference and/or HbA1c, coupled with intervention by family-based lifestyle modification, is an efficient, effective and equitable strategy for prevention of T2D in South Asians. Our findings will thereby provide a robust evidence base for scalable community-wide approaches to reverse the epidemic of T2D amongst the >1.5 billion South Asians worldwide. Campo scientifico natural sciencescomputer and information sciencesdatabasesmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health scienceshealth sciencesnutritionobesity Parole chiave South Asians Diabetes Obesity Programma(i) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Argomento(i) HCO-05-2014 - Global Alliance for Chronic Diseases: prevention and treatment of type 2 diabetes Invito a presentare proposte H2020-HCO-2014-2015 Vedi altri progetti per questo bando Bando secondario H2020-HCO-2014 Meccanismo di finanziamento RIA - Research and Innovation action Coordinatore IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Contribution nette de l'UE € 1 386 972,50 Indirizzo SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Regno Unito Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 386 972,50 Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto DEVKI DEVI FOUNDATION SOCIETY India Contribution nette de l'UE € 247 050,00 Indirizzo PRESS ENCLAVE ROAD SAKET 2 110017 New Delhi Mostra sulla mappa Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 247 050,00 UNIVERSITY OF COLOMBO Sri Lanka Contribution nette de l'UE € 155 550,00 Indirizzo 94 CUMARATUNGA MUNIDASA MAWATHA 00300 Colombo Western Province Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 155 550,00 UNIVERSITY OF KELANIYA Sri Lanka Contribution nette de l'UE € 121 237,50 Indirizzo DALUGAMA Kelaniya Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 121 237,50 UNIVERSITY OF SURREY Regno Unito Contribution nette de l'UE € 244 233,75 Indirizzo Stag Hill GU2 7XH Guildford Mostra sulla mappa Regione South East (England) Surrey, East and West Sussex West Surrey Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 244 233,75 LONDON NORTH WEST HEALTHCARE NATIONAL HEALTH SERVICE TRUST Regno Unito Contribution nette de l'UE € 749 537,50 Indirizzo WATFORD ROAD HA1 3UJ Harrow Middlesex Mostra sulla mappa Regione London Outer London — West and North West Brent Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 749 537,50 INSTITUTE FOR HEALTH POLICY Sri Lanka Contribution nette de l'UE € 105 750,00 Indirizzo 72 PARK STREET Colombo Mostra sulla mappa Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 105 750,00 ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Paesi Bassi Contribution nette de l'UE € 146 250,00 Indirizzo MEIBERGDREEF 15 1105AZ Amsterdam Mostra sulla mappa Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 146 250,00 OULUN YLIOPISTO Finlandia Contribution nette de l'UE € 166 990,00 Indirizzo PENTTI KAITERAN KATU 1 90014 Oulu Mostra sulla mappa Regione Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 166 990,00 PUNJAB INSTITUTE OF CARDIOLOGY (PIC) LAHORE Pakistan Contribution nette de l'UE € 113 612,50 Indirizzo JAIL ROAD GHOUS UL AZAM 54000 Lahore Punjab Mostra sulla mappa Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 113 612,50 SERVICES INSTITUTE OF MEDICAL SCIENCES Pakistan Contribution nette de l'UE € 176 900,00 Indirizzo JAIL ROAD OPPOSITE RACE COURSE PARK 54000 Lahore Mostra sulla mappa Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 176 900,00