CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Deliverables
D2.2: Key findings will be collected in a technical publication or commercial technical note relating new technology capabilities to the dissolution properties of co-crystals / salts / multi-component systems and in metastable solid forms (month 24)
Technical report on approaches to SDI (opens in new window)D21 Production of a technical report on optimal approaches for conducting SDI and interpreting SDI data for compounds susceptible for precipitation month 18
Dissolution testing guidelines for UV/Raman (opens in new window)D1.2: Guideline/application note for performing flow-through dissolution testing with simultaneous UV imaging and Raman spectroscopy including step-by-step instructions for dissolution testing of two drug substances undergoing solid form conversions during dissolution, month 15.
Technical data on nucleation rates (opens in new window)D3.1 Technical data on nucleation rates for a range of molecules in a variety of different media (month 30).
Technical note on new capabilities (opens in new window)D3.2 The key findings will form the basis of a technical note relating new technological capabilities to the precipitation rates of ionisable drugs (month 18).
Literature publications for D2.1-D2.4 (opens in new window)D2.5: At least three literature publications are anticipated for each objective listed above (O2.1-O2.3), with the first of these expected at month 12.
Literature publications for D3.1 & D3.2 (opens in new window)D3.3 At least one publication is anticipated for each objective listed above (O5.1-O5.4) at months 10, 22 and 34.
D16 Establishment of the critical operating parameters defining robustness of UV imaging and between lab variability for flowthrough dissolution data month 27
Prototype light microscopy – UV imaging assay (opens in new window)D1.5: A prototype light microscopy - UV imaging assay will be developed for precipitation studies month 10.
Optimised UV/Raman experiments (opens in new window)D1.1: Optimized experimental setup for performing through dissolution testing with simultaneous UV imaging and Raman spectroscopy, month 12.
UV imaging data validation (opens in new window)D1.7: Validation of UV imaging data by comparison to other microscale dissolution tests and data from Woods apparatus, month 33.
Screening assay for precipitation inhibitors (opens in new window)D2.4: A screening assay will be established for precipitation inhibitors, building on an increased knowledge on mechanisms through which precipitation/re-precipitation can be inhibited (month 30).
ATR-(FTIR) & turbidity studies (opens in new window)D1.4: Feasibility studies on ATR-(FTIR) and turbidity, month 34.
pH-UV imaging method (opens in new window)D1.3: Combined pH - UV imaging method tuned for physiological/ gastrointestinal pH range (pH 1.2, 5.4, 6.8 and 7.4) month 22.
Publications
Author(s):
Yu Sun, Alex Chapman, Susan W. Larsen, Henrik Jensen, Nickolaj J. Petersen, David M. Goodall, Jesper Østergaard
Published in:
Analytical Chemistry, Issue 90/11, 2018, Page(s) 6413-6418, ISSN 0003-2700
Publisher:
American Chemical Society
DOI:
10.1021/acs.analchem.8b00587
Author(s):
Jesper Østergaard
Published in:
Journal of Pharmaceutical and Biomedical Analysis, Issue 147, 2018, Page(s) 140-148, ISSN 0731-7085
Publisher:
Elsevier BV
DOI:
10.1016/j.jpba.2017.07.055
Author(s):
Maria Doreth, Korbinian Löbmann, Petra Priemel, Holger Grohganz, Robert Taylor, René Holm, Heidi Lopez de Diego, Thomas Rades
Published in:
European Journal of Pharmaceutics and Biopharmaceutics, Issue 122, 2018, Page(s) 62-69, ISSN 0939-6411
Publisher:
Elsevier BV
DOI:
10.1016/j.ejpb.2017.10.001
Author(s):
Peter Madelung, Poul Bertelsen, Jette Jacobsen, Anette Müllertz, Jesper Østergaard
Published in:
Journal of Drug Delivery Science and Technology, Issue 39, 2017, Page(s) 516-522, ISSN 1773-2247
Publisher:
Editions de Sante
DOI:
10.1016/j.jddst.2017.05.010
Author(s):
Yu Sun, Jesper Østergaard
Published in:
Pharmaceutical Research, Issue 34/5, 2017, Page(s) 929-940, ISSN 0724-8741
Publisher:
Kluwer Academic/Plenum Publishers
DOI:
10.1007/s11095-016-2047-5
Author(s):
Sabrine S. Jensen, Henrik Jensen, David M. Goodall, Jesper Østergaard
Published in:
Journal of Pharmaceutical and Biomedical Analysis, Issue 131, 2016, Page(s) 113-123, ISSN 0731-7085
Publisher:
Elsevier BV
DOI:
10.1016/j.jpba.2016.08.018
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