CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.
I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .
Risultati finali
D2.2: Key findings will be collected in a technical publication or commercial technical note relating new technology capabilities to the dissolution properties of co-crystals / salts / multi-component systems and in metastable solid forms (month 24)
Technical report on approaches to SDI (si apre in una nuova finestra)D21 Production of a technical report on optimal approaches for conducting SDI and interpreting SDI data for compounds susceptible for precipitation month 18
Dissolution testing guidelines for UV/Raman (si apre in una nuova finestra)D1.2: Guideline/application note for performing flow-through dissolution testing with simultaneous UV imaging and Raman spectroscopy including step-by-step instructions for dissolution testing of two drug substances undergoing solid form conversions during dissolution, month 15.
Technical data on nucleation rates (si apre in una nuova finestra)D3.1 Technical data on nucleation rates for a range of molecules in a variety of different media (month 30).
Technical note on new capabilities (si apre in una nuova finestra)D3.2 The key findings will form the basis of a technical note relating new technological capabilities to the precipitation rates of ionisable drugs (month 18).
Literature publications for D2.1-D2.4 (si apre in una nuova finestra)D2.5: At least three literature publications are anticipated for each objective listed above (O2.1-O2.3), with the first of these expected at month 12.
Literature publications for D3.1 & D3.2 (si apre in una nuova finestra)D3.3 At least one publication is anticipated for each objective listed above (O5.1-O5.4) at months 10, 22 and 34.
D16 Establishment of the critical operating parameters defining robustness of UV imaging and between lab variability for flowthrough dissolution data month 27
Prototype light microscopy – UV imaging assay (si apre in una nuova finestra)D1.5: A prototype light microscopy - UV imaging assay will be developed for precipitation studies month 10.
Optimised UV/Raman experiments (si apre in una nuova finestra)D1.1: Optimized experimental setup for performing through dissolution testing with simultaneous UV imaging and Raman spectroscopy, month 12.
UV imaging data validation (si apre in una nuova finestra)D1.7: Validation of UV imaging data by comparison to other microscale dissolution tests and data from Woods apparatus, month 33.
Screening assay for precipitation inhibitors (si apre in una nuova finestra)D2.4: A screening assay will be established for precipitation inhibitors, building on an increased knowledge on mechanisms through which precipitation/re-precipitation can be inhibited (month 30).
ATR-(FTIR) & turbidity studies (si apre in una nuova finestra)D1.4: Feasibility studies on ATR-(FTIR) and turbidity, month 34.
pH-UV imaging method (si apre in una nuova finestra)D1.3: Combined pH - UV imaging method tuned for physiological/ gastrointestinal pH range (pH 1.2, 5.4, 6.8 and 7.4) month 22.
Pubblicazioni
Autori:
Yu Sun, Alex Chapman, Susan W. Larsen, Henrik Jensen, Nickolaj J. Petersen, David M. Goodall, Jesper Østergaard
Pubblicato in:
Analytical Chemistry, Numero 90/11, 2018, Pagina/e 6413-6418, ISSN 0003-2700
Editore:
American Chemical Society
DOI:
10.1021/acs.analchem.8b00587
Autori:
Jesper Østergaard
Pubblicato in:
Journal of Pharmaceutical and Biomedical Analysis, Numero 147, 2018, Pagina/e 140-148, ISSN 0731-7085
Editore:
Elsevier BV
DOI:
10.1016/j.jpba.2017.07.055
Autori:
Maria Doreth, Korbinian Löbmann, Petra Priemel, Holger Grohganz, Robert Taylor, René Holm, Heidi Lopez de Diego, Thomas Rades
Pubblicato in:
European Journal of Pharmaceutics and Biopharmaceutics, Numero 122, 2018, Pagina/e 62-69, ISSN 0939-6411
Editore:
Elsevier BV
DOI:
10.1016/j.ejpb.2017.10.001
Autori:
Peter Madelung, Poul Bertelsen, Jette Jacobsen, Anette Müllertz, Jesper Østergaard
Pubblicato in:
Journal of Drug Delivery Science and Technology, Numero 39, 2017, Pagina/e 516-522, ISSN 1773-2247
Editore:
Editions de Sante
DOI:
10.1016/j.jddst.2017.05.010
Autori:
Yu Sun, Jesper Østergaard
Pubblicato in:
Pharmaceutical Research, Numero 34/5, 2017, Pagina/e 929-940, ISSN 0724-8741
Editore:
Kluwer Academic/Plenum Publishers
DOI:
10.1007/s11095-016-2047-5
Autori:
Sabrine S. Jensen, Henrik Jensen, David M. Goodall, Jesper Østergaard
Pubblicato in:
Journal of Pharmaceutical and Biomedical Analysis, Numero 131, 2016, Pagina/e 113-123, ISSN 0731-7085
Editore:
Elsevier BV
DOI:
10.1016/j.jpba.2016.08.018
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