CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.
Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .
Resultado final
D2.2: Key findings will be collected in a technical publication or commercial technical note relating new technology capabilities to the dissolution properties of co-crystals / salts / multi-component systems and in metastable solid forms (month 24)
Technical report on approaches to SDI (se abrirá en una nueva ventana)D21 Production of a technical report on optimal approaches for conducting SDI and interpreting SDI data for compounds susceptible for precipitation month 18
Dissolution testing guidelines for UV/Raman (se abrirá en una nueva ventana)D1.2: Guideline/application note for performing flow-through dissolution testing with simultaneous UV imaging and Raman spectroscopy including step-by-step instructions for dissolution testing of two drug substances undergoing solid form conversions during dissolution, month 15.
Technical data on nucleation rates (se abrirá en una nueva ventana)D3.1 Technical data on nucleation rates for a range of molecules in a variety of different media (month 30).
Technical note on new capabilities (se abrirá en una nueva ventana)D3.2 The key findings will form the basis of a technical note relating new technological capabilities to the precipitation rates of ionisable drugs (month 18).
Literature publications for D2.1-D2.4 (se abrirá en una nueva ventana)D2.5: At least three literature publications are anticipated for each objective listed above (O2.1-O2.3), with the first of these expected at month 12.
Literature publications for D3.1 & D3.2 (se abrirá en una nueva ventana)D3.3 At least one publication is anticipated for each objective listed above (O5.1-O5.4) at months 10, 22 and 34.
D16 Establishment of the critical operating parameters defining robustness of UV imaging and between lab variability for flowthrough dissolution data month 27
Prototype light microscopy – UV imaging assay (se abrirá en una nueva ventana)D1.5: A prototype light microscopy - UV imaging assay will be developed for precipitation studies month 10.
Optimised UV/Raman experiments (se abrirá en una nueva ventana)D1.1: Optimized experimental setup for performing through dissolution testing with simultaneous UV imaging and Raman spectroscopy, month 12.
UV imaging data validation (se abrirá en una nueva ventana)D1.7: Validation of UV imaging data by comparison to other microscale dissolution tests and data from Woods apparatus, month 33.
Screening assay for precipitation inhibitors (se abrirá en una nueva ventana)D2.4: A screening assay will be established for precipitation inhibitors, building on an increased knowledge on mechanisms through which precipitation/re-precipitation can be inhibited (month 30).
ATR-(FTIR) & turbidity studies (se abrirá en una nueva ventana)D1.4: Feasibility studies on ATR-(FTIR) and turbidity, month 34.
pH-UV imaging method (se abrirá en una nueva ventana)D1.3: Combined pH - UV imaging method tuned for physiological/ gastrointestinal pH range (pH 1.2, 5.4, 6.8 and 7.4) month 22.
Publicaciones
Autores:
Yu Sun, Alex Chapman, Susan W. Larsen, Henrik Jensen, Nickolaj J. Petersen, David M. Goodall, Jesper Østergaard
Publicado en:
Analytical Chemistry, Edición 90/11, 2018, Página(s) 6413-6418, ISSN 0003-2700
Editor:
American Chemical Society
DOI:
10.1021/acs.analchem.8b00587
Autores:
Jesper Østergaard
Publicado en:
Journal of Pharmaceutical and Biomedical Analysis, Edición 147, 2018, Página(s) 140-148, ISSN 0731-7085
Editor:
Elsevier BV
DOI:
10.1016/j.jpba.2017.07.055
Autores:
Maria Doreth, Korbinian Löbmann, Petra Priemel, Holger Grohganz, Robert Taylor, René Holm, Heidi Lopez de Diego, Thomas Rades
Publicado en:
European Journal of Pharmaceutics and Biopharmaceutics, Edición 122, 2018, Página(s) 62-69, ISSN 0939-6411
Editor:
Elsevier BV
DOI:
10.1016/j.ejpb.2017.10.001
Autores:
Peter Madelung, Poul Bertelsen, Jette Jacobsen, Anette Müllertz, Jesper Østergaard
Publicado en:
Journal of Drug Delivery Science and Technology, Edición 39, 2017, Página(s) 516-522, ISSN 1773-2247
Editor:
Editions de Sante
DOI:
10.1016/j.jddst.2017.05.010
Autores:
Yu Sun, Jesper Østergaard
Publicado en:
Pharmaceutical Research, Edición 34/5, 2017, Página(s) 929-940, ISSN 0724-8741
Editor:
Kluwer Academic/Plenum Publishers
DOI:
10.1007/s11095-016-2047-5
Autores:
Sabrine S. Jensen, Henrik Jensen, David M. Goodall, Jesper Østergaard
Publicado en:
Journal of Pharmaceutical and Biomedical Analysis, Edición 131, 2016, Página(s) 113-123, ISSN 0731-7085
Editor:
Elsevier BV
DOI:
10.1016/j.jpba.2016.08.018
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