Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche

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Publicaciones

It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration

Autores: Andrea Grosso, Maximilian G. Burger, Alexander Lunger, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 5, 2017, Página(s) 68, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2017.00068

Biomimetic click assembled multilayer coatings exhibiting responsive properties

Autores: Maria P. Sousa, Israel Gonzalez de Torre, Mariana B. Oliveira, José C. Rodríguez-Cabello, João F. Mano
Publicado en: Materials Today Chemistry, Edición 4, 2017, Página(s) 150-163, ISSN 2468-5194
Editor: Elsevier Ltd.
DOI: 10.1016/j.mtchem.2017.04.001

Control of angiogenesis and host response by modulating the cell adhesion properties of an Elastin-Like Recombinamer-based hydrogel

Autores: Sebastian Manuel Staubli, Giulia Cerino, Israel Gonzalez De Torre, Matilde Alonso, Daniel Oertli, Friedrich Eckstein, Katharina Glatz, José Carlos Rodríguez Cabello, Anna Marsano
Publicado en: Biomaterials, Edición 135, 2017, Página(s) 30-41, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.04.047

Bioactive scaffolds based on elastin-like materials for wound healing

Autores: J. Carlos Rodríguez-Cabello, I. González de Torre, A. Ibañez-Fonseca, M. Alonso
Publicado en: Advanced Drug Delivery Reviews, Edición 129, 2018, Página(s) 118-133, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2018.03.003

Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation

Autores: Boris L. Gala-Lopez, Daniel Neiman, Tatsuya Kin, Doug O’Gorman, Andrew R. Pepper, Andrew J. Malcolm, Sheina Pianzin, Peter A. Senior, Patricia Campbell, Benjamin Glaser, Yuval Dor, Ruth Shemer, A.M. James Shapiro
Publicado en: Transplantation, Edición 102/6, 2018, Página(s) 978-985, ISSN 0041-1337
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/TP.0000000000002083

Biocompatibility of two model elastin-like recombinamer-based hydrogels formed through physical or chemical cross-linking for various applications in tissue engineering and regenerative medicine

Autores: Arturo Ibáñez-Fonseca, Teresa L. Ramos, Israel González de Torre, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Francisco Javier Arias, María Consuelo del Cañizo, Matilde Alonso, Fermín Sánchez-Guijo, José Carlos Rodríguez-Cabello
Publicado en: Journal of Tissue Engineering and Regenerative Medicine, Edición 12/3, 2018, Página(s) e1450-e1460, ISSN 1932-6254
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/term.2562

Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering

Autores: Israel González de Torre, Arturo Ibáñez-Fonseca, Luis Quintanilla, Matilde Alonso, José-Carlos Rodríguez-Cabello
Publicado en: Acta Biomaterialia, Edición 72, 2018, Página(s) 137-149, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2018.03.027

Islet Encapsulation: Physiological Possibilities and Limitations

Autores: Olle Korsgren
Publicado en: Diabetes, Edición 66/7, 2017, Página(s) 1748-1754, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db17-0065

Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

Autores: Per-Ola Carlsson, Daniel Espes, Amir Sedigh, Avi Rotem, Baruch Zimerman, Helena Grinberg, Tali Goldman, Uriel Barkai, Yuval Avni, Gunilla T. Westermark, Lina Carlbom, Håkan Ahlström, Olof Eriksson, Johan Olerud, Olle Korsgren
Publicado en: American Journal of Transplantation, Edición 18/7, 2018, Página(s) 1735-1744, ISSN 1600-6135
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ajt.14642

Glucose Effectiveness

Autores: Erik Korsgren, Olle Korsgren
Publicado en: Transplantation, Edición 100/1, 2016, Página(s) 111-115, ISSN 0041-1337
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/TP.0000000000000900

Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants

Autores: Jeevan Govindharajulu, Xi Chen, Yuping Li, Jose Rodriguez-Cabello, Mrinal Battacharya, Conrado Aparicio
Publicado en: International Journal of Molecular Sciences, Edición 18/2, 2017, Página(s) 369, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18020369

Förster Resonance Energy Transfer-Paired Hydrogel Forming Silk-Elastin-Like Recombinamers by Recombinant Conjugation of Fluorescent Proteins

Autores: Arturo Ibáñez-Fonseca, Matilde Alonso, Francisco Javier Arias, José Carlos Rodríguez-Cabello
Publicado en: Bioconjugate Chemistry, Edición 28/3, 2017, Página(s) 828-835, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.6b00738

Intrafibrillar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils

Autores: Yuping Li, Jose Carlos Rodriguez-Cabello, Conrado Aparicio
Publicado en: ACS Applied Materials & Interfaces, Edición 9/7, 2017, Página(s) 5838-5846, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.6b15285

Cross-linking of a biopolymer-peptide co-assembling system

Autores: Karla E. Inostroza-Brito, Estelle C. Collin, Anna Majkowska, Sherif Elsharkawy, Alistair Rice, Armando E. del Río Hernández, Xin Xiao, José Rodríguez-Cabello, Alvaro Mata
Publicado en: Acta Biomaterialia, Edición 58, 2017, Página(s) 80-89, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2017.05.043

Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend

Autores: Esen Sayin, Rosti Hama Rashid, José Carlos Rodríguez-Cabello, Ahmed Elsheikh, Erkan Türker Baran, Vasif Hasirci
Publicado en: Bioactive Materials, Edición 2/2, 2017, Página(s) 71-81, ISSN 2452-199X
Editor: Royal Society of Chemistry
DOI: 10.1016/j.bioactmat.2017.04.001

Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

Autores: Mohamed Hamed Misbah, Mercedes Santos, Luis Quintanilla, Christina Günter, Matilde Alonso, Andreas Taubert, José Carlos Rodríguez-Cabello
Publicado en: Beilstein Journal of Nanotechnology, Edición 8, 2017, Página(s) 772-783, ISSN 2190-4286
Editor: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.8.80

Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels

Autores: David Pescador, Arturo Ibáñez-Fonseca, Fermín Sánchez-Guijo, Jesús G. Briñón, Francisco Javier Arias, Sandra Muntión, Cristina Hernández, Alessandra Girotti, Matilde Alonso, María Consuelo del Cañizo, José Carlos Rodríguez-Cabello, Juan Francisco Blanco
Publicado en: Journal of Materials Science: Materials in Medicine, Edición 28/8, 2017, Página(s) 115, ISSN 0957-4530
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10856-017-5928-1

PHBV wet spun scaffold coated with ELR-REDV improves vascularization for bone tissue engineering

Autores: Ayse Selcen Alagoz, Jose Carlos Rodriguez-Cabello, Vasif Hasirci
Publicado en: Biomedical Materials, 2018, ISSN 1748-6041
Editor: Institute of Physics Publishing
DOI: 10.1088/1748-605X/aad139

Protein disorder–order interplay to guide the growth of hierarchical mineralized structures

Autores: Sherif Elsharkawy, Maisoon Al-Jawad, Maria F. Pantano, Esther Tejeda-Montes, Khushbu Mehta, Hasan Jamal, Shweta Agarwal, Kseniya Shuturminska, Alistair Rice, Nadezda V. Tarakina, Rory M. Wilson, Andy J. Bushby, Matilde Alonso, Jose C. Rodriguez-Cabello, Ettore Barbieri, Armando del Río Hernández, Molly M. Stevens, Nicola M. Pugno, Paul Anderson, Alvaro Mata
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04319-0

Tuning the stiffness of surfaces by assembling genetically engineered polypeptides with tailored amino acid sequence

Autores: Rui R. Costa, Miguel González-Pérez, Marcos Herrero-Gutiérrez, Ricardo A. Pires, Matilde Alonso, J. Carlos Rodriguez-Cabello, Rui L. Reis, Iva Pashkuleva
Publicado en: Biomacromolecules, 2018, Página(s) 3401-3411, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.8b00723

Macroporous click-elastin-like hydrogels for tissue engineering applications

Autores: Alicia Fernández-Colino, Frederic Wolf, Hans Keijdener, Stephan Rütten, Thomas Schmitz-Rode, Stefan Jockenhoevel, J. Carlos Rodríguez-Cabello, Petra Mela
Publicado en: Materials Science and Engineering: C, Edición 88, 2018, Página(s) 140-147, ISSN 0928-4931
Editor: Elsevier BV
DOI: 10.1016/j.msec.2018.03.013

Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform

Autores: Filippo Cipriani, Melanie Krüger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, José Carlos Rodriguez-Cabello
Publicado en: Biomacromolecules, Edición 19/11, 2018, Página(s) 4333-4347, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.8b01211

A transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterization

Autores: Constancio Gonzalez-Obeso, Alessandra Girotti, J. Carlos Rodriguez-Cabello
Publicado en: Acta Biomaterialia, Edición 88, 2019, Página(s) 241-250, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2019.02.027

Bicyclic RGD peptides with high integrin α v β 3 and α 5 β 1 affinity promote cell adhesion on elastin-like recombinamers

Autores: Filippo Cipriani, Dominik Bernhagen, Carmen García-Arévalo, Israel González de Torre, Peter Timmerman, José Carlos Rodríguez-Cabello
Publicado en: Biomedical Materials, Edición 14/3, 2019, Página(s) 035009, ISSN 1748-605X
Editor: IOP Publishing
DOI: 10.1088/1748-605x/aafd83

Bioinspired baroplastic glycosaminoglycan sealants for soft tissues

Autores: Rui R. Costa, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva
Publicado en: Acta Biomaterialia, Edición 87, 2019, Página(s) 108-117, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2019.01.040

Spatial control and cell adhesion selectivity on model gold surfaces grafted with elastin-like recombinamers

Autores: Tatjana Flora, I. González de Torre, Luis Quintanilla, M. Alonso, J. Carlos Rodríguez-Cabello
Publicado en: European Polymer Journal, Edición 106, 2018, Página(s) 19-29, ISSN 0014-3057
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.eurpolymj.2018.06.026

A novel lipase-catalyzed method for preparing ELR-based bioconjugates

Autores: Ana M. Testera, Mercedes Santos, Alessandra Girotti, F. Javier Arias, J. Manuel Báñez, Matilde Alonso, J. Carlos Rodríguez-Cabello
Publicado en: International Journal of Biological Macromolecules, Edición 121, 2019, Página(s) 752-759, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/j.ijbiomac.2018.10.028

Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels

Autores: Tatjana Flora, I. González de Torre, M. Alonso, J. Carlos Rodríguez-Cabello
Publicado en: Journal of Materials Science: Materials in Medicine, Edición 30/2, 2019, ISSN 0957-4530
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10856-019-6232-z

Coating Strategies Using Layer-by-layer Deposition for Cell Encapsulation

Autores: Mariana B. Oliveira, Javad Hatami, João F. Mano
Publicado en: Chemistry - An Asian Journal, Edición 11/12, 2016, Página(s) 1753-1764, ISSN 1861-4728
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/asia.201600145

Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system

Autores: Karla E. Inostroza-Brito, Estelle Collin, Orit Siton-Mendelson, Katherine H. Smith, Amàlia Monge-Marcet, Daniela S. Ferreira, Raúl Pérez Rodríguez, Matilde Alonso, José Carlos Rodríguez-Cabello, Rui L. Reis, Francesc Sagués, Lorenzo Botto, Ronit Bitton, Helena S. Azevedo, Alvaro Mata
Publicado en: Nature Chemistry, Edición 7/11, 2015, Página(s) 897-904, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/nchem.2349

Multilayered Films Produced by Layer-by-Layer Assembly of Chitosan and Alginate as a Potential Platform for the Formation of Human Adipose-Derived Stem Cell aggregates

Autores: Javad Hatami, Sandra Silva, Mariana Oliveira, Rui Costa, Rui Reis, João Mano
Publicado en: Polymers, Edición 9/12, 2017, Página(s) 440, ISSN 2073-4360
Editor: MPDI Open Access Publishing
DOI: 10.3390/polym9090440

3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine

Autores: Mercedes Vila, Ana García, Alessandra Girotti, Matilde Alonso, Jose Carlos Rodríguez-Cabello, Arlyng González-Vázquez, Josep A. Planell, Elisabeth Engel, Julia Buján, Natalio García-Honduvilla, María Vallet-Regí
Publicado en: Acta Biomaterialia, Edición 45, 2016, Página(s) 349-356, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2016.09.016

Genetically Engineered Elastin-based Biomaterials for Biomedical Applications

Autores: Mercedes Santos, Sofia Serrano-Ducar, Juan Gonzalez-Valdivieso, Reinaldo Vallejo, Alessandra Girotti, Purificacion Cuadrado, Francisco Javier Arias
Publicado en: Current Medicinal Chemistry, Edición 25, 2018, Página(s) 1-28, ISSN 0929-8673
Editor: Bentham Science Publishers
DOI: 10.2174/0929867325666180508094637

Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

Autores: Hai Zemmour, David Planer, Judith Magenheim, Joshua Moss, Daniel Neiman, Dan Gilon, Amit Korach, Benjamin Glaser, Ruth Shemer, Giora Landesberg, Yuval Dor
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-03961-y

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

Autores: Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor
Publicado en: Nature Communications, Edición 9/1, 2018, Página(s) 1-12, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-07466-6

Self-assembly in Elastin-Like Recombinamers: a Mechanism to Mimic Natural Complexity

Autores: Luis Quintanilla-Sierra, Carmen García-Arévalo, J.C. Rodriguez-Cabello
Publicado en: Materials Today Bio, 2019, Página(s) 100007, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2019.100007

Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA

Autores: Roni Lehmann-Werman, Judith Magenheim, Joshua Moss, Daniel Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, Talya Dor, Markus Grompe, Giora Landesberg, Bao-Li Loza, Abraham Shaked, Kim Olthoff, Benjamin Glaser, Ruth Shemer, Yuval Dor
Publicado en: JCI Insight, Edición 3/12, 2018, ISSN 2379-3708
Editor: JCI Insight
DOI: 10.1172/jci.insight.120687

Hydrophobic Cholesteryl Moieties Trigger Substrate Cell–Membrane Interaction of Elastin–Mimetic Protein Coatings in Vitro

Autores: Leander Poocza, Filippo Cipriani, Matilde Alonso, José Carlos Rodríguez-Cabello
Publicado en: ACS Omega, Edición 4/6, 2019, Página(s) 10818-10827, ISSN 2470-1343
Editor: ACS Publications
DOI: 10.1021/acsomega.9b00548

Use of proteolytic sequences with different cleavage kinetics as a way to generate hydrogels with preprogrammed cell-infiltration patterns imparted over their given 3D spatial structure

Autores: Tatjana Flora, I González de Torre, M Alonso, J Carlos Rodríguez-Cabello
Publicado en: Biofabrication, Edición 11/3, 2019, Página(s) 035008, ISSN 1758-5090
Editor: IOP Publishing
DOI: 10.1088/1758-5090/ab10a5

Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt

Autores: Juan Gonzalez-Valdivieso, Alessandra Girotti, Raquel Muñoz, J. Carlos Rodriguez-Cabello, F. Javier Arias
Publicado en: Biomacromolecules, Edición 20/5, 2019, Página(s) 1996-2007, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.9b00206

Silk-ELR co-recombinamer covered stents obtained by electrospinning

Autores: M Putzu, F Causa, Manuel Parente, Israel González de Torre, J C Rodriguez-Cabello, P A Netti
Publicado en: Regenerative Biomaterials, Edición 6/1, 2018, Página(s) 21-28, ISSN 2056-3418
Editor: ACS Publications
DOI: 10.1093/rb/rby022

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