Stromal cells as primary drivers of immunopathology: towards targeted disease modification in spondyloarthritis

Project Information

Inflammostrome

Grant agreement ID: 646840

DOI

10.3030/646840

Project closed

EC signature date 2 June 2015

Start date 1 July 2015

End date 31 December 2018

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 599 466,25

EU contribution

€ 1 599 466,25

Coordinated by

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (39)

Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques

Author(s): Sophie J. Bernelot Moens, Sander I. van Leuven, Kang H. Zheng, Stefan R. Havik, Miranda V. Versloot, Leonie M. van Duivenvoorde, Michael Hahne, Erik S. G. Stroes, Dominique L. Baeten, Anouk A. J. Hamers
Published in: PLOS ONE, Issue 11/11, 2016, Page(s) e0164690, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0164690

Effect of Secukinumab on Patient-Reported Outcomes in Patients With Active Ankylosing Spondylitis: A Phase III Randomized Trial (MEASURE 1)

Author(s): Atul A. Deodhar, Maxime Dougados, Dominique L. Baeten, James Cheng-Chung Wei, Piet Geusens, Aimee Readie, Hanno B. Richards, Ruvie Martin, Brian Porter
Published in: Arthritis & Rheumatology, Issue 68/12, 2016, Page(s) 2901-2910, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.39805

Serum inflammatory biomarkers fail to identify early axial spondyloarthritis: results from the SpondyloArthritis Caught Early (SPACE) cohort

Author(s): Maureen C Turina, Nataliya Yeremenko, Floris van Gaalen, Maikel van Oosterhout, Inger J Berg, Ramona Ramonda, Cristina (M C) Lebre, Robert Landewé, Dominique Baeten
Published in: RMD Open, Issue 3/1, 2017, Page(s) e000319, ISSN 2056-5933
Publisher: BMJ
DOI: 10.1136/rmdopen-2016-000319

Residual disease activity and treatment adjustments in psoriatic arthritis in current clinical practice

Author(s): Leonieke J. J. van Mens, Marleen G. H. van de Sande, Inka A. Fluri, Sadaf Atiqi, Arno W. R. van Kuijk, Dominique L. P. Baeten
Published in: Arthritis Research & Therapy, Issue 19/1, 2017, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-017-1424-8

Bone formation in ankylosing spondylitis during anti-tumour necrosis factor therapy imaged by 18F-fluoride positron emission tomography

Author(s): Stefan T G Bruijnen, Nicki J F Verweij, Leonie M van Duivenvoorde, Nathalie Bravenboer, Dominique L P Baeten, Christiaan J van Denderen, Irene E van der Horst-Bruinsma, Alexandre E Voskuyl, Martijn Custers, Peter M van de Ven, Joost C J Bot, Bouke J H Boden, Adriaan A Lammertsma, Otto S H Hoekstra, Pieter G H M Raijmakers, Conny J van der Laken
Published in: Rheumatology, Issue 57/4, 2018, Page(s) 631-638, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kex448

Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort

Author(s): Janneke J. de Winter, Marleen G. van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A. van Gaalen, Torsten Witte, Dominique L. Baeten
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
Publisher: BMJ
DOI: 10.1186/s13075-018-1535-x

Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients

Author(s): Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M. Villiger, Monika Østensen, Frauke Förger
Published in: Arthritis Research & Therapy, Issue 19/1, 2017, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-017-1269-1

Increased arterial wall inflammation in patients with ankylosing spondylitis is reduced by statin therapy

Author(s): Fleur M van der Valk, Sophie J Bernelot Moens, Simone L Verweij, Aart C Strang, Aart J Nederveen, Hein J Verberne, Michael T Nurmohamed, Dominique L Baeten, Erik S G Stroes
Published in: Annals of the Rheumatic Diseases, Issue 75/10, 2016, Page(s) 1848-1851, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2016-209176

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation

Author(s): Sophie Glatt, Dominique Baeten, Terry Baker, Meryn Griffiths, Lucian Ionescu, Alastair D G Lawson, Ash Maroof, Ruth Oliver, Serghei Popa, Foteini Strimenopoulou, Pavan Vajjah, Mark I L Watling, Nataliya Yeremenko, Pierre Miossec, Stevan Shaw
Published in: Annals of the Rheumatic Diseases, Issue 77/4, 2018, Page(s) 523-532, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212127

Pro-inflammatory CX3CR1 + CD59 + TL1A + IL-23 + monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions

Author(s): Francesco Ciccia, Giuliana Guggino, Michael Zeng, Ranjeny Thomas, Vidya Ranganathan, Arifur Rahman, Riccardo Alessandro, Aroldo Rizzo, Laura Saieva, Federica Macaluso, Sergio Peralta, Diana Di Liberto, Francesco Dieli, Paola Cipriani, Roberto Giacomelli, Dominique Baeten, Nigil Haroon
Published in: Arthritis & Rheumatology, 2018, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.40582

Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI–TLR Cross-Talk

Author(s): Ivo S. Hansen, Willianne Hoepel, Sebastiaan A. J. Zaat, Dominique L. P. Baeten, Jeroen den Dunnen
Published in: The Journal of Immunology, Issue 199/12, 2017, Page(s) 4124-4131, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1700883

Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

Author(s): Pawel A. Kabala, Chiara Angiolilli, Nataliya Yeremenko, Aleksander M. Grabiec, Barbara Giovannone, Desiree Pots, Timothy R. Radstake, Dominique Baeten, Kris A. Reedquist
Published in: Arthritis Research & Therapy, Issue 19/1, 2017, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-017-1386-x

Ideal target for psoriatic arthritis? Comparison of remission and low disease activity states in a real-life cohort

Author(s): Leonieke J J van Mens, Marleen G H van de Sande, Arno W R van Kuijk, Dominique Baeten, Laura C Coates
Published in: Annals of the Rheumatic Diseases, Issue 77/2, 2018, Page(s) 251-257, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-211998

Anti-citrullinated protein antibody response after primary EBV infection in kidney transplant patients

Author(s): Lianne J. N. Kraal, Marieke L. Nijland, Kristine L. Germar, Dominique L. P. Baeten, Ineke J. M. ten Berge, Cynthia M. Fehres
Published in: PLOS ONE, Issue 13/5, 2018, Page(s) e0197219, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0197219

IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses

Author(s): Leonieke J. J. van Mens, Marleen G.H van de Sande, Silvia Menegatti, Sija Chen, Iris C. J. Blijdorp, Henriette M. de Jong, Inka A. Fluri, Talia E. Latuhihin, Arno W. R. van Kuijk, Lars Rogge, Nataliya G. Yeremenko, Dominique L. P. Baeten
Published in: Arthritis & Rheumatology, 2018, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.40581

Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue

Author(s): Oliwia Rysnik, Kirsty McHugh, Leonie van Duivenvoorde, Melissa van Tok, Giuliana Guggino, Joel Taurog, Simon Kollnberger, Francesco Ciccia, Dominique Baeten, Paul Bowness
Published in: Journal of Autoimmunity, Issue 70, 2016, Page(s) 12-21, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2016.03.009

Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue

Author(s): Oliwia Rysnik, Kirsty McHugh, Leonie van Duivenvoorde, Melissa van Tok, Joel Taurog, Simon Kollnberger, Dominique Baeten, Paul Bowness
Published in: Data in Brief, Issue 9, 2016, Page(s) 100-111, ISSN 2352-3409
Publisher: Elsevier BV
DOI: 10.1016/j.dib.2016.08.046

Magnetic Resonance Imaging of the Sacroiliac Joints Indicating Sacroiliitis According to the Assessment of SpondyloArthritis international Society Definition in Healthy Individuals, Runners, and Women With Postpartum Back Pain

Author(s): Janneke de Winter, Manouk de Hooge, Marleen van de Sande, Henriëtte de Jong, Lonneke van Hoeven, Anoek de Koning, Inger Jorid Berg, Roberta Ramonda, Dominique Baeten, Désirée van der Heijde, Angelique Weel, Robert Landewé
Published in: Arthritis & Rheumatology, Issue 70/7, 2018, Page(s) 1042-1048, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.40475

Residual disease activity in psoriatic arthritis: discordance between the rheumatologist’s opinion and minimal disease activity measurement

Author(s): Leonieke J J van Mens, Maureen C Turina, Marleen G H van de Sande, Mike T Nurmohamed, Arno W R van Kuijk, Dominique L P Baeten
Published in: Rheumatology, Issue 57/2, 2017, Page(s) 283-290, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kex183

FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

Author(s): Ivo S. Hansen, Lisette Krabbendam, Jochem H. Bernink, Fabricio Loayza-Puch, Willianne Hoepel, Johan A. van Burgsteden, Elsa C. Kuijper, Christianne J. Buskens, Willem A. Bemelman, Sebastiaan A. J. Zaat, Reuven Agami, Gestur Vidarsson, Gijs R. van den Brink, Esther C. de Jong, Manon E. Wildenberg, Dominique L. P. Baeten, Bart Everts, Jeroen den Dunnen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03318-5

Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study

Author(s): Jürgen Braun, Xenofon Baraliakos, Atul Deodhar, Dominique Baeten, Joachim Sieper, Paul Emery, Aimee Readie, Ruvie Martin, Shephard Mpofu, Hanno B Richards
Published in: Annals of the Rheumatic Diseases, Issue 76/6, 2017, Page(s) 1070-1077, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2016-209730

New treatment paradigms in spondyloarthritis

Author(s): Leonieke J.J. van Mens, Marleen G.H. van de Sande, Dominique L.P. Baeten
Published in: Current Opinion in Rheumatology, Issue 30/1, 2018, Page(s) 79-86, ISSN 1040-8711
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/BOR.0000000000000457

The acetyl code in rheumatoid arthritis and other rheumatic diseases

Author(s): Chiara Angiolilli, Dominique L Baeten, Timothy R Radstake, Kris A Reedquist
Published in: Epigenomics, Issue 9/4, 2017, Page(s) 447-461, ISSN 1750-1911
Publisher: Future Medicine Ltd.
DOI: 10.2217/epi-2016-0136

Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

Author(s): Melissa N. van Tok, Nimman Satumtira, Martha Dorris, Desirée Pots, Gleb Slobodin, Marleen G. van de Sande, Joel D. Taurog, Dominique L. Baeten, Leonie M. van Duivenvoorde
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2017.00920

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

Author(s): Yasunori Omata, Michael Frech, Tatjana Primbs, Sébastien Lucas, Darja Andreev, Carina Scholtysek, Kerstin Sarter, Markus Kindermann, Nataliya Yeremenko, Dominique L. Baeten, Nico Andreas, Thomas Kamradt, Aline Bozec, Andreas Ramming, Gerhard Krönke, Stefan Wirtz, Georg Schett, Mario M. Zaiss
Published in: Cell Reports, Issue 24/1, 2018, Page(s) 169-180, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.06.005

Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes

Author(s): Man Wai Tang, Beatriz Malvar Fernández, Simon P Newsom, Jaap D van Buul, Timothy R D J Radstake, Dominique L Baeten, Paul P Tak, Kris A Reedquist, Samuel García
Published in: Rheumatology, Issue 57/5, 2018, Page(s) 909-920, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kex511

Efficacy and safety of secukinumab in Asian patients with active ankylosing spondylitis: 52-week pooled results from two phase 3 studies

Author(s): James C.-C. Wei, Dominique Baeten, Joachim Sieper, Atul Deodhar, Vaishali Bhosekar, Ruvie Martin, Brian Porter
Published in: International Journal of Rheumatic Diseases, Issue 20/5, 2017, Page(s) 589-596, ISSN 1756-1841
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/1756-185X.13094

Clinical and Imaging Signs of Spondyloarthritis in First-Degree Relatives of HLA-B27-Positive Ankylosing Spondylitis Patients: The Pre-Spondyloarthritis (Pre-SpA) Cohort Study

Author(s): Maureen C. Turina, Janneke J. de Winter, Jacky E. Paramarta, Mihaela Gamala, Nataliya Yeremenko, Marita N. Nabibux, Robert Landewé, Dominique L. Baeten
Published in: Arthritis & Rheumatology, Issue 68/10, 2016, Page(s) 2444-2455, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.39766

A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells

Author(s): Charlotte Hua, Rachel Audo, Nataliya Yeremenko, Dominique Baeten, Michael Hahne, Bernard Combe, Jacques Morel, Claire Daïen
Published in: Journal of Autoimmunity, Issue 73, 2016, Page(s) 64-72, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2016.06.002

Human mast cells capture, store, and release bioactive, exogenous IL-17A

Author(s): Troy Noordenbos, Iris Blijdorp, Sijia Chen, Jan Stap, Erik Mul, Juan D. Cañete, Erik Lubberts, Nataliya Yeremenko, Dominique Baeten
Published in: Journal of Leukocyte Biology, Issue 100/3, 2016, Page(s) 453-462, ISSN 0741-5400
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.3HI1215-542R

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B-cell selection

Author(s): Katy A. Lloyd, Johanna Steen, Khaled Amara, Philip J. Titcombe, Lena Israelsson, Susanna L. Lundström, Diana Zhou, Roman A. Zubarev, Evan Reed, Luca Piccoli, Cem Gabay, Antonio Lanzavecchia, Dominique Baeten, Karin Lundberg, Daniel L. Mueller, Lars Klareskog, Vivianne Malmström, Caroline Grönwall
Published in: European Journal of Immunology, Issue 48/6, 2018, Page(s) 1030-1045, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747446

Interleukin-9 Overexpression and Th9 Polarization Characterize the Inflamed Gut, the Synovial Tissue, and the Peripheral Blood of Patients With Psoriatic Arthritis

Author(s): Francesco Ciccia, Giuliana Guggino, Angelo Ferrante, Stefania Raimondo, Rodolfo Bignone, Vito Rodolico, Sergio Peralta, Melissa Van Tok, Alessandra Cannizzaro, Claudia Schinocca, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Riccardo Alessandro, Francesco Dieli, Aroldo Rizzo, Dominique Baeten, Giovanni Triolo
Published in: Arthritis & Rheumatology, Issue 68/8, 2016, Page(s) 1922-1931, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.39649

Long-term efficacy and predictors of remission following adalimumab treatment in peripheral spondyloarthritis: 3-year results from ABILITY-2

Author(s): Filip Van den Bosch, Philip J Mease, Joachim Sieper, Dominique L Baeten, Yinglin Xia, Su Chen, Aileen L Pangan, In-Ho Song
Published in: RMD Open, Issue 4/1, 2018, Page(s) e000566, ISSN 2056-5933
Publisher: BMJ
DOI: 10.1136/rmdopen-2017-000566

A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis

Author(s): Jacqueline E. Paramarta, Maureen C. Turina, Troy Noordenbos, Tanja F. Heijda, Iris C. Blijdorp, Nataliya Yeremenko, Dominique Baeten
Published in: Journal of Translational Medicine, Issue 14/1, 2016, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-016-1050-2

Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis

Author(s): Janneke J. de Winter, Leonieke J. van Mens, Désirée van der Heijde, Robert Landewé, Dominique L. Baeten
Published in: Arthritis Research & Therapy, Issue 18/1, 2016, ISSN 1478-6362
Publisher: Biomedcentral
DOI: 10.1186/s13075-016-1093-z

The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation

Author(s): Maria J. Levels, Melissa N. Van Tok, Tineke Cantaert, Juan D. Cañete, Frans G. M. Kroese, Kristine Germar, Hergen Spits, Dominique L. P. Baeten, Nataliya G. Yeremenko
Published in: Arthritis & Rheumatology, Issue 69/4, 2017, Page(s) 750-762, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.39993

Killer immunoglobulin receptor genes in spondyloarthritis

Author(s): Taco W. Kuijpers, Sanne Vendelbosch, Merlijn van den Berg, Dominique L.P. Baeten
Published in: Current Opinion in Rheumatology, Issue 28/4, 2016, Page(s) 368-375, ISSN 1040-8711
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/BOR.0000000000000302

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

Author(s): Chiara Angiolilli, Pawel A Kabala, Aleksander M Grabiec, Iris M Van Baarsen, Bradley S Ferguson, Samuel García, Beatriz Malvar Fernandez, Timothy A McKinsey, Paul P Tak, Gianluca Fossati, Paolo Mascagni, Dominique L Baeten, Kris A Reedquist
Published in: Annals of the Rheumatic Diseases, Issue 76/1, 2016, Page(s) 277-285, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2015-209064

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

Author(s): Melissa N. van Tok, Nataliya G. Yeremenko, Christine A. Teitsma, Barbara E. Kream, Véronique L. Knaup, Rik J. Lories, Dominique L. Baeten, Leonie M. van Duivenvoorde
Published in: PLOS ONE, Issue 11/10, 2016, Page(s) e0163632, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0163632