Stromal cells as primary drivers of immunopathology: towards targeted disease modification in spondyloarthritis

Información del proyecto

Inflammostrome

Identificador del acuerdo de subvención: 646840

DOI

10.3030/646840

Proyecto cerrado

Fecha de la firma de la CE 2 Junio 2015

Fecha de inicio 1 Julio 2015

Fecha de finalización 31 Diciembre 2018

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 599 466,25

Aportación de la UE

€ 1 599 466,25

Coordinado por

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (39)

Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques

Autores: Sophie J. Bernelot Moens, Sander I. van Leuven, Kang H. Zheng, Stefan R. Havik, Miranda V. Versloot, Leonie M. van Duivenvoorde, Michael Hahne, Erik S. G. Stroes, Dominique L. Baeten, Anouk A. J. Hamers
Publicado en: PLOS ONE, Edición 11/11, 2016, Página(s) e0164690, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0164690

Effect of Secukinumab on Patient-Reported Outcomes in Patients With Active Ankylosing Spondylitis: A Phase III Randomized Trial (MEASURE 1)

Autores: Atul A. Deodhar, Maxime Dougados, Dominique L. Baeten, James Cheng-Chung Wei, Piet Geusens, Aimee Readie, Hanno B. Richards, Ruvie Martin, Brian Porter
Publicado en: Arthritis & Rheumatology, Edición 68/12, 2016, Página(s) 2901-2910, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.39805

Serum inflammatory biomarkers fail to identify early axial spondyloarthritis: results from the SpondyloArthritis Caught Early (SPACE) cohort

Autores: Maureen C Turina, Nataliya Yeremenko, Floris van Gaalen, Maikel van Oosterhout, Inger J Berg, Ramona Ramonda, Cristina (M C) Lebre, Robert Landewé, Dominique Baeten
Publicado en: RMD Open, Edición 3/1, 2017, Página(s) e000319, ISSN 2056-5933
Editor: BMJ
DOI: 10.1136/rmdopen-2016-000319

Residual disease activity and treatment adjustments in psoriatic arthritis in current clinical practice

Autores: Leonieke J. J. van Mens, Marleen G. H. van de Sande, Inka A. Fluri, Sadaf Atiqi, Arno W. R. van Kuijk, Dominique L. P. Baeten
Publicado en: Arthritis Research & Therapy, Edición 19/1, 2017, ISSN 1478-6362
Editor: BMC
DOI: 10.1186/s13075-017-1424-8

Bone formation in ankylosing spondylitis during anti-tumour necrosis factor therapy imaged by 18F-fluoride positron emission tomography

Autores: Stefan T G Bruijnen, Nicki J F Verweij, Leonie M van Duivenvoorde, Nathalie Bravenboer, Dominique L P Baeten, Christiaan J van Denderen, Irene E van der Horst-Bruinsma, Alexandre E Voskuyl, Martijn Custers, Peter M van de Ven, Joost C J Bot, Bouke J H Boden, Adriaan A Lammertsma, Otto S H Hoekstra, Pieter G H M Raijmakers, Conny J van der Laken
Publicado en: Rheumatology, Edición 57/4, 2018, Página(s) 631-638, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/kex448

Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort

Autores: Janneke J. de Winter, Marleen G. van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A. van Gaalen, Torsten Witte, Dominique L. Baeten
Publicado en: Arthritis Research & Therapy, Edición 20/1, 2018, ISSN 1478-6362
Editor: BMJ
DOI: 10.1186/s13075-018-1535-x

Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients

Autores: Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M. Villiger, Monika Østensen, Frauke Förger
Publicado en: Arthritis Research & Therapy, Edición 19/1, 2017, ISSN 1478-6362
Editor: BMC
DOI: 10.1186/s13075-017-1269-1

Increased arterial wall inflammation in patients with ankylosing spondylitis is reduced by statin therapy

Autores: Fleur M van der Valk, Sophie J Bernelot Moens, Simone L Verweij, Aart C Strang, Aart J Nederveen, Hein J Verberne, Michael T Nurmohamed, Dominique L Baeten, Erik S G Stroes
Publicado en: Annals of the Rheumatic Diseases, Edición 75/10, 2016, Página(s) 1848-1851, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2016-209176

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation

Autores: Sophie Glatt, Dominique Baeten, Terry Baker, Meryn Griffiths, Lucian Ionescu, Alastair D G Lawson, Ash Maroof, Ruth Oliver, Serghei Popa, Foteini Strimenopoulou, Pavan Vajjah, Mark I L Watling, Nataliya Yeremenko, Pierre Miossec, Stevan Shaw
Publicado en: Annals of the Rheumatic Diseases, Edición 77/4, 2018, Página(s) 523-532, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212127

Pro-inflammatory CX3CR1 + CD59 + TL1A + IL-23 + monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions

Autores: Francesco Ciccia, Giuliana Guggino, Michael Zeng, Ranjeny Thomas, Vidya Ranganathan, Arifur Rahman, Riccardo Alessandro, Aroldo Rizzo, Laura Saieva, Federica Macaluso, Sergio Peralta, Diana Di Liberto, Francesco Dieli, Paola Cipriani, Roberto Giacomelli, Dominique Baeten, Nigil Haroon
Publicado en: Arthritis & Rheumatology, 2018, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.40582

Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI–TLR Cross-Talk

Autores: Ivo S. Hansen, Willianne Hoepel, Sebastiaan A. J. Zaat, Dominique L. P. Baeten, Jeroen den Dunnen
Publicado en: The Journal of Immunology, Edición 199/12, 2017, Página(s) 4124-4131, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1700883

Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

Autores: Pawel A. Kabala, Chiara Angiolilli, Nataliya Yeremenko, Aleksander M. Grabiec, Barbara Giovannone, Desiree Pots, Timothy R. Radstake, Dominique Baeten, Kris A. Reedquist
Publicado en: Arthritis Research & Therapy, Edición 19/1, 2017, ISSN 1478-6362
Editor: BMC
DOI: 10.1186/s13075-017-1386-x

Ideal target for psoriatic arthritis? Comparison of remission and low disease activity states in a real-life cohort

Autores: Leonieke J J van Mens, Marleen G H van de Sande, Arno W R van Kuijk, Dominique Baeten, Laura C Coates
Publicado en: Annals of the Rheumatic Diseases, Edición 77/2, 2018, Página(s) 251-257, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-211998

Anti-citrullinated protein antibody response after primary EBV infection in kidney transplant patients

Autores: Lianne J. N. Kraal, Marieke L. Nijland, Kristine L. Germar, Dominique L. P. Baeten, Ineke J. M. ten Berge, Cynthia M. Fehres
Publicado en: PLOS ONE, Edición 13/5, 2018, Página(s) e0197219, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0197219

IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses

Autores: Leonieke J. J. van Mens, Marleen G.H van de Sande, Silvia Menegatti, Sija Chen, Iris C. J. Blijdorp, Henriette M. de Jong, Inka A. Fluri, Talia E. Latuhihin, Arno W. R. van Kuijk, Lars Rogge, Nataliya G. Yeremenko, Dominique L. P. Baeten
Publicado en: Arthritis & Rheumatology, 2018, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.40581

Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue

Autores: Oliwia Rysnik, Kirsty McHugh, Leonie van Duivenvoorde, Melissa van Tok, Giuliana Guggino, Joel Taurog, Simon Kollnberger, Francesco Ciccia, Dominique Baeten, Paul Bowness
Publicado en: Journal of Autoimmunity, Edición 70, 2016, Página(s) 12-21, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2016.03.009

Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue

Autores: Oliwia Rysnik, Kirsty McHugh, Leonie van Duivenvoorde, Melissa van Tok, Joel Taurog, Simon Kollnberger, Dominique Baeten, Paul Bowness
Publicado en: Data in Brief, Edición 9, 2016, Página(s) 100-111, ISSN 2352-3409
Editor: Elsevier BV
DOI: 10.1016/j.dib.2016.08.046

Magnetic Resonance Imaging of the Sacroiliac Joints Indicating Sacroiliitis According to the Assessment of SpondyloArthritis international Society Definition in Healthy Individuals, Runners, and Women With Postpartum Back Pain

Autores: Janneke de Winter, Manouk de Hooge, Marleen van de Sande, Henriëtte de Jong, Lonneke van Hoeven, Anoek de Koning, Inger Jorid Berg, Roberta Ramonda, Dominique Baeten, Désirée van der Heijde, Angelique Weel, Robert Landewé
Publicado en: Arthritis & Rheumatology, Edición 70/7, 2018, Página(s) 1042-1048, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.40475

Residual disease activity in psoriatic arthritis: discordance between the rheumatologist’s opinion and minimal disease activity measurement

Autores: Leonieke J J van Mens, Maureen C Turina, Marleen G H van de Sande, Mike T Nurmohamed, Arno W R van Kuijk, Dominique L P Baeten
Publicado en: Rheumatology, Edición 57/2, 2017, Página(s) 283-290, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/kex183

FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

Autores: Ivo S. Hansen, Lisette Krabbendam, Jochem H. Bernink, Fabricio Loayza-Puch, Willianne Hoepel, Johan A. van Burgsteden, Elsa C. Kuijper, Christianne J. Buskens, Willem A. Bemelman, Sebastiaan A. J. Zaat, Reuven Agami, Gestur Vidarsson, Gijs R. van den Brink, Esther C. de Jong, Manon E. Wildenberg, Dominique L. P. Baeten, Bart Everts, Jeroen den Dunnen
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-03318-5

Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study

Autores: Jürgen Braun, Xenofon Baraliakos, Atul Deodhar, Dominique Baeten, Joachim Sieper, Paul Emery, Aimee Readie, Ruvie Martin, Shephard Mpofu, Hanno B Richards
Publicado en: Annals of the Rheumatic Diseases, Edición 76/6, 2017, Página(s) 1070-1077, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2016-209730

New treatment paradigms in spondyloarthritis

Autores: Leonieke J.J. van Mens, Marleen G.H. van de Sande, Dominique L.P. Baeten
Publicado en: Current Opinion in Rheumatology, Edición 30/1, 2018, Página(s) 79-86, ISSN 1040-8711
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/BOR.0000000000000457

The acetyl code in rheumatoid arthritis and other rheumatic diseases

Autores: Chiara Angiolilli, Dominique L Baeten, Timothy R Radstake, Kris A Reedquist
Publicado en: Epigenomics, Edición 9/4, 2017, Página(s) 447-461, ISSN 1750-1911
Editor: Future Medicine Ltd.
DOI: 10.2217/epi-2016-0136

Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

Autores: Melissa N. van Tok, Nimman Satumtira, Martha Dorris, Desirée Pots, Gleb Slobodin, Marleen G. van de Sande, Joel D. Taurog, Dominique L. Baeten, Leonie M. van Duivenvoorde
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2017.00920

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

Autores: Yasunori Omata, Michael Frech, Tatjana Primbs, Sébastien Lucas, Darja Andreev, Carina Scholtysek, Kerstin Sarter, Markus Kindermann, Nataliya Yeremenko, Dominique L. Baeten, Nico Andreas, Thomas Kamradt, Aline Bozec, Andreas Ramming, Gerhard Krönke, Stefan Wirtz, Georg Schett, Mario M. Zaiss
Publicado en: Cell Reports, Edición 24/1, 2018, Página(s) 169-180, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2018.06.005

Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes

Autores: Man Wai Tang, Beatriz Malvar Fernández, Simon P Newsom, Jaap D van Buul, Timothy R D J Radstake, Dominique L Baeten, Paul P Tak, Kris A Reedquist, Samuel García
Publicado en: Rheumatology, Edición 57/5, 2018, Página(s) 909-920, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/kex511

Efficacy and safety of secukinumab in Asian patients with active ankylosing spondylitis: 52-week pooled results from two phase 3 studies

Autores: James C.-C. Wei, Dominique Baeten, Joachim Sieper, Atul Deodhar, Vaishali Bhosekar, Ruvie Martin, Brian Porter
Publicado en: International Journal of Rheumatic Diseases, Edición 20/5, 2017, Página(s) 589-596, ISSN 1756-1841
Editor: Blackwell Publishing Inc.
DOI: 10.1111/1756-185X.13094

Clinical and Imaging Signs of Spondyloarthritis in First-Degree Relatives of HLA-B27-Positive Ankylosing Spondylitis Patients: The Pre-Spondyloarthritis (Pre-SpA) Cohort Study

Autores: Maureen C. Turina, Janneke J. de Winter, Jacky E. Paramarta, Mihaela Gamala, Nataliya Yeremenko, Marita N. Nabibux, Robert Landewé, Dominique L. Baeten
Publicado en: Arthritis & Rheumatology, Edición 68/10, 2016, Página(s) 2444-2455, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.39766

A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells

Autores: Charlotte Hua, Rachel Audo, Nataliya Yeremenko, Dominique Baeten, Michael Hahne, Bernard Combe, Jacques Morel, Claire Daïen
Publicado en: Journal of Autoimmunity, Edición 73, 2016, Página(s) 64-72, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2016.06.002

Human mast cells capture, store, and release bioactive, exogenous IL-17A

Autores: Troy Noordenbos, Iris Blijdorp, Sijia Chen, Jan Stap, Erik Mul, Juan D. Cañete, Erik Lubberts, Nataliya Yeremenko, Dominique Baeten
Publicado en: Journal of Leukocyte Biology, Edición 100/3, 2016, Página(s) 453-462, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.3HI1215-542R

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B-cell selection

Autores: Katy A. Lloyd, Johanna Steen, Khaled Amara, Philip J. Titcombe, Lena Israelsson, Susanna L. Lundström, Diana Zhou, Roman A. Zubarev, Evan Reed, Luca Piccoli, Cem Gabay, Antonio Lanzavecchia, Dominique Baeten, Karin Lundberg, Daniel L. Mueller, Lars Klareskog, Vivianne Malmström, Caroline Grönwall
Publicado en: European Journal of Immunology, Edición 48/6, 2018, Página(s) 1030-1045, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747446

Interleukin-9 Overexpression and Th9 Polarization Characterize the Inflamed Gut, the Synovial Tissue, and the Peripheral Blood of Patients With Psoriatic Arthritis

Autores: Francesco Ciccia, Giuliana Guggino, Angelo Ferrante, Stefania Raimondo, Rodolfo Bignone, Vito Rodolico, Sergio Peralta, Melissa Van Tok, Alessandra Cannizzaro, Claudia Schinocca, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Riccardo Alessandro, Francesco Dieli, Aroldo Rizzo, Dominique Baeten, Giovanni Triolo
Publicado en: Arthritis & Rheumatology, Edición 68/8, 2016, Página(s) 1922-1931, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.39649

Long-term efficacy and predictors of remission following adalimumab treatment in peripheral spondyloarthritis: 3-year results from ABILITY-2

Autores: Filip Van den Bosch, Philip J Mease, Joachim Sieper, Dominique L Baeten, Yinglin Xia, Su Chen, Aileen L Pangan, In-Ho Song
Publicado en: RMD Open, Edición 4/1, 2018, Página(s) e000566, ISSN 2056-5933
Editor: BMJ
DOI: 10.1136/rmdopen-2017-000566

A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis

Autores: Jacqueline E. Paramarta, Maureen C. Turina, Troy Noordenbos, Tanja F. Heijda, Iris C. Blijdorp, Nataliya Yeremenko, Dominique Baeten
Publicado en: Journal of Translational Medicine, Edición 14/1, 2016, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/s12967-016-1050-2

Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis

Autores: Janneke J. de Winter, Leonieke J. van Mens, Désirée van der Heijde, Robert Landewé, Dominique L. Baeten
Publicado en: Arthritis Research & Therapy, Edición 18/1, 2016, ISSN 1478-6362
Editor: Biomedcentral
DOI: 10.1186/s13075-016-1093-z

The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation

Autores: Maria J. Levels, Melissa N. Van Tok, Tineke Cantaert, Juan D. Cañete, Frans G. M. Kroese, Kristine Germar, Hergen Spits, Dominique L. P. Baeten, Nataliya G. Yeremenko
Publicado en: Arthritis & Rheumatology, Edición 69/4, 2017, Página(s) 750-762, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.39993

Killer immunoglobulin receptor genes in spondyloarthritis

Autores: Taco W. Kuijpers, Sanne Vendelbosch, Merlijn van den Berg, Dominique L.P. Baeten
Publicado en: Current Opinion in Rheumatology, Edición 28/4, 2016, Página(s) 368-375, ISSN 1040-8711
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/BOR.0000000000000302

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

Autores: Chiara Angiolilli, Pawel A Kabala, Aleksander M Grabiec, Iris M Van Baarsen, Bradley S Ferguson, Samuel García, Beatriz Malvar Fernandez, Timothy A McKinsey, Paul P Tak, Gianluca Fossati, Paolo Mascagni, Dominique L Baeten, Kris A Reedquist
Publicado en: Annals of the Rheumatic Diseases, Edición 76/1, 2016, Página(s) 277-285, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2015-209064

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

Autores: Melissa N. van Tok, Nataliya G. Yeremenko, Christine A. Teitsma, Barbara E. Kream, Véronique L. Knaup, Rik J. Lories, Dominique L. Baeten, Leonie M. van Duivenvoorde
Publicado en: PLOS ONE, Edición 11/10, 2016, Página(s) e0163632, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0163632