Cancer treatment during pregnancy: from fetal safety to maternal efficacy

Project Information

CRADLE

Grant agreement ID: 647047

DOI 10.3030/647047

Project closed

EC signature date 25 September 2015

Start date 1 October 2015

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

The impact of cancer and chemotherapy during pregnancy on child neurodevelopment: A multimodal neuroimaging analysis

Author(s): J. Blommaert, A. Radwan, C. Sleurs, C. Maggen, M. van Gerwen, V. Wolters, D. Christiaens, R. Peeters, P. Dupont, S. Sunaert, K. Van Calsteren, S. Deprez, F. Amant
Published in: EClinicalMedicine, Issue 28, 2020, Page(s) 100598, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2020.100598

Pregnancy and Cancer: the INCIP Project

Author(s): Charlotte Maggen, Vera E. R. A. Wolters, Elyce Cardonick, Monica Fumagalli, Michael J. Halaska, Christianne A. R. Lok, Jorine de Haan, Katrien Van Tornout, Kristel Van Calsteren, Frédéric Amant
Published in: Current Oncology Reports, Issue 22/2, 2020, ISSN 1523-3790
Publisher: Current Science Inc.
DOI: 10.1007/s11912-020-0862-7

Long-term neurodevelopmental outcome after prenatal exposure to maternal hematological malignancies with or without cytotoxic treatment

Author(s): Mathilde van Gerwen, Evangeline Huis in ‘t Veld, Martine van Grotel, Marry M. van den Heuvel-Eibrink, Kristel Van Calsteren, Charlotte Maggen, Vit Drochytek, Giovanna Scarfone, Camilla Fontana, Robert Fruscio, Elyce Cardonick, Elisabeth M. van Dijk-Lokkart, Frédéric Amant
Published in: Child Neuropsychology, 2021, Page(s) 1-12, ISSN 0929-7049
Publisher: Swets & Zeitlinger
DOI: 10.1080/09297049.2021.1902489

Data describing child development at 6 years after maternal cancer diagnosis and treatment during pregnancy

Author(s): Mathilde van Gerwen, Tineke Vandenbroucke, Magali Verheecke, Kristel Van Calsteren, Michael J. Halaska, Monica Fumagalli, Robert Fruscio, Amarendra Gandhi, Margreet Veening, Lieven Lagae, Petronella B. Ottevanger, Jens-Uwe Voigt, Jorine de Haan, Mina M. Gziri, Charlotte Maggen, Luc Mertens, Gunnar Naulaers, Laurence Claes, Frédéric Amant
Published in: Data in Brief, Issue 32, 2020, Page(s) 106209, ISSN 2352-3409
Publisher: Elsevier BV
DOI: 10.1016/j.dib.2020.106209

Maternal and neonatal outcomes in 80 patients diagnosed with non‐Hodgkin lymphoma during pregnancy: results from the International Network of Cancer, Infertility and Pregnancy

Author(s): Charlotte Maggen, Daan Dierickx, Elyce Cardonick, Mina Mhallem Gziri, Alvaro Cabrera‐Garcia, Roman G. Shmakov, Irit Avivi, Bianca Masturzo, Johannes J. Duvekot, Petronella B. Ottevanger, Andie O’Laughlin, Evgeniya Polushkina, Kristel Van Calsteren, F.J. Sherida H. Woei‐A‐Jin, Frédéric Amant
Published in: British Journal of Haematology, Issue 193/1, 2021, Page(s) 52-62, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17103

Obstetric and maternal outcomes in patients diagnosed with Hodgkin lymphoma during pregnancy: a multicentre, retrospective, cohort study

Author(s): Charlotte Maggen, Daan Dierickx, Pieternella Lugtenburg, Annouschka Laenen, Elyce Cardonick, Roman G Smakov, Mar Bellido, Alvaro Cabrera-Garcia, Mina Mhallem Gziri, Michael J Halaska, Petronella B Ottevanger, Kristel Van Calsteren, Andie O'Laughlin, Evgeniya Polushkina, Laura Van Dam, Irit Avivi, Peter Vandenberghe, F J Sherida H Woei-A-Jin, Frédéric Amant
Published in: The Lancet Haematology, Issue 6/11, 2019, Page(s) e551-e561, ISSN 2352-3026
Publisher: Elsevier Limited
DOI: 10.1016/s2352-3026(19)30195-4

Corrigendum to ‘Genetic and microscopic assessment of the human chemotherapy-exposed placenta reveals possible pathways contributive to fetal growth restriction’[YPLAC 64C (2018) 61–70]

Author(s): M. Verheecke, A. Cortès Calabuig, J. Finalet Ferreiro, V. Brys, R. Van Bree, G. Verbist, T. Everaert, L. Leemans, M.M. Gziri, I. Boere, M.J. Halaska, J. Van Houdt, F. Amant, K. Van Calsteren
Published in: Placenta, Issue 69, 2018, Page(s) 117, ISSN 0143-4004
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.placenta.2018.07.008

Executive functioning in 6 year old children exposed to chemotherapy in utero

Author(s): Mathilde van Gerwen, Tineke Vandenbroucke, An-sofie Gorissen, Martine van Grotel, Marry van den Heuvel-Eibrink, Emma Verwaaijen, Madeleine van der Perk, Kristel Van Calsteren, Elisabeth M. van Dijk-Lokkart, Frédéric Amant
Published in: Early Human Development, Issue 151, 2020, Page(s) 105198, ISSN 0378-3782
Publisher: Elsevier BV
DOI: 10.1016/j.earlhumdev.2020.105198

Maternal and obstetrical outcome in 35 cases of well‐differentiated thyroid carcinoma during pregnancy

Author(s): Jan Boucek, Jorine Haan, Michael J. Halaska, Jan Plzak, Kristel Calsteren, Christianne J. M. Groot, Karina Dahl Steffensen, Robert Fruscio, Elske T. Massolt, Philipp Klaritsch, Paolo Zola, Frédéric Amant
Published in: The Laryngoscope, Issue 128/6, 2017, Page(s) 1493-1500, ISSN 0023-852X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1002/lary.26936

Long-term impact of prenatal exposure to chemotherapy on executive functioning: An ERP study

Author(s): Jeroen Blommaert, Rob Zink, Sabine Deprez, Ivan Myatchin, Patrick Dupont, Tineke Vandenbroucke, Charlotte Sleurs, Kristel Van Calsteren, Frédéric Amant, Lieven Lagae
Published in: Clinical Neurophysiology, Issue 130/9, 2019, Page(s) 1655-1664, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2019.06.012

Maternal and Neonatal Outcome after the Use of G-CSF for Cancer Treatment during Pregnancy

Author(s): Claudia Berends, Charlotte Maggen, Christianne A. R. Lok, Mathilde van Gerwen, Ingrid A. Boere, Vera E. R. A. Wolters, Kristel Van Calsteren, Heidi Segers, Marry M. van den Heuvel-Eibrink, Rebecca C. Painter, Mina Mhallem Gziri, Frédéric Amant
Published in: Cancers, Issue 13/6, 2021, Page(s) 1214, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061214

Population Pharmacokinetics of Docetaxel, Paclitaxel, Doxorubicin and Epirubicin in Pregnant Women with Cancer: A Study from the International Network of Cancer, Infertility and Pregnancy (INCIP)

Author(s): Julie M. Janssen, Kristel Van Calsteren, Thomas P. C. Dorlo, Michael J. Halaska, Robert Fruscio, Petronella Ottevanger, Carolien P. Schröder, Ingrid Boere, Petronella O. Witteveen, Rebecca C. Painter, Ruud Bekkers, Vit Drochytek, Jos H. Beijnen, Alwin D. R. Huitema, Frederic C. H. Amant
Published in: Clinical Pharmacokinetics, 2021, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-020-00961-4

Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients

Author(s): Jorine de Haan, Magali Verheecke, Kristel Van Calsteren, Ben Van Calster, Roman G Shmakov, Mina Mhallem Gziri, Michael J Halaska, Robert Fruscio, Christianne A R Lok, Ingrid A Boere, Paolo Zola, Petronella B Ottevanger, Christianne J M de Groot, Fedro A Peccatori, Karina Dahl Steffensen, Elyce H Cardonick, Evgeniya Polushkina, Lukas Rob, Lorenzo Ceppi, Gennady T Sukhikh, Sileny N Han, Frédéric A
Published in: The Lancet Oncology, Issue 19/3, 2018, Page(s) 337-346, ISSN 1470-2045
Publisher: The Lancet Publishing Group
DOI: 10.1016/S1470-2045(18)30059-7

Genetic and microscopic assessment of the human chemotherapy-exposed placenta reveals possible pathways contributive to fetal growth restriction

Author(s): M. Verheecke, A. Cortès Calabuig, J. Finalet Ferreiro, V. Brys, R. Van Bree, G. Verbist, T. Everaert, L. Leemans, M.M. Gziri, I. Boere, M.J. Halaska, J. Vanhoudt, F. Amant, K. Van Calsteren
Published in: Placenta, Issue 64, 2018, Page(s) 61-70, ISSN 0143-4004
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.placenta.2018.03.002

Feasibility of whole-body diffusion-weighted MRI for detection of primary tumour, nodal and distant metastases in women with cancer during pregnancy: a pilot study

Author(s): Sileny N. Han, Frédéric Amant, Katrijn Michielsen, Frederik De Keyzer, Steffen Fieuws, Kristel Van Calsteren, Raphaëla C. Dresen, Mina Mhallem Gziri, Vincent Vandecaveye
Published in: European Radiology, Issue 28/5, 2018, Page(s) 1862-1874, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-017-5126-z

Acute Drug Effects on the Human Placental Tissue: The Development of a Placental Murine Xenograft Model

Author(s): Magali Verheecke, Els Hermans, Sandra Tuyaerts, Erika Souche, Rita Van Bree, Godelieve Verbist, Tina Everaert, Jeroen Van Houdt, Kristel Van Calsteren, Frederic Amant
Published in: Reproductive Sciences, 2018, Page(s) 193371911875677, ISSN 1933-7191
Publisher: SAGE Publications
DOI: 10.1177/1933719118756771

Effects of cancer treatment during pregnancy on fetal and child development

Author(s): Tineke Vandenbroucke, Magali Verheecke, Monica Fumagalli, Christianne Lok, Frédéric Amant
Published in: The Lancet Child & Adolescent Health, Issue 1/4, 2017, Page(s) 302-310, ISSN 2352-4642
Publisher: Elsevier SCI LTD
DOI: 10.1016/S2352-4642(17)30091-3

Integration and validation of the ex vivo human placenta perfusion model

Author(s): Sigrid Conings, Frédéric Amant, Pieter Annaert, Kristel Van Calsteren
Published in: Journal of Pharmacological and Toxicological Methods, Issue 88, 2017, Page(s) 25-31, ISSN 1056-8719
Publisher: Elsevier BV
DOI: 10.1016/j.vascn.2017.05.002

Psychological distress and cognitive coping in pregnant women diagnosed with cancer and their partners

Author(s): Tineke Vandenbroucke, Sileny N. Han, Kristel Van Calsteren, Tom F. Wilderjans, Bea R.H. Van den Bergh, Laurence Claes, Frédéric Amant
Published in: Psycho-Oncology, Issue vol. 26, issue 8, 2016, Page(s) 1215-1221, ISSN 1057-9249
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pon.4301

Postpartum breast cancer: mechanisms underlying its worse prognosis, treatment implications, and fertility preservation

Author(s): Hanne Lefrère, Liesbeth Lenaerts, Virginia F Borges, Pepper Schedin, Patrick Neven, Frédéric Amant
Published in: International Journal of Gynecologic Cancer, Issue 31/3, 2021, Page(s) 412-422, ISSN 1048-891X
Publisher: Blackwell Publishing Inc.
DOI: 10.1136/ijgc-2020-002072

Age‐dependent brain volume and neuropsychological changes after chemotherapy in breast cancer patients

Author(s): Jeroen Blommaert, Gwen Schroyen, Mathieu Vandenbulcke, Ahmed Radwan, Ann Smeets, Ron Peeters, Charlotte Sleurs, Patrick Neven, Hans Wildiers, Frédéric Amant, Stefan Sunaert, Sabine Deprez
Published in: Human Brain Mapping, Issue 40/17, 2019, Page(s) 4994-5010, ISSN 1065-9471
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hbm.24753

Gastric cancer during pregnancy: A report on 13 cases and review of the literature with focus on chemotherapy during pregnancy

Author(s): Charlotte Maggen, Christianne A. Lok, Elyce Cardonick, Mathilde van Gerwen, Petronella B. Ottevanger, Ingrid A. Boere, Martin Koskas, Michael J. Halaska, Robert Fruscio, Mina M. Gziri, Petronella O. Witteveen, Kristel Van Calsteren, Frédéric Amant
Published in: Acta Obstetricia et Gynecologica Scandinavica, Issue 99/1, 2019, Page(s) 79-88, ISSN 0001-6349
Publisher: Wiley-Blackwell
DOI: 10.1111/aogs.13731

Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy

Author(s): Tineke Vandenbroucke, Magali Verheecke, Mathilde van Gerwen, Kristel Van Calsteren, Michael J. Halaska, Monica Fumagalli, Robert Fruscio, Amarendra Gandhi, Margreet Veening, Lieven Lagae, Petronella B. Ottevanger, Jens-Uwe Voigt, Jorine de Haan, Mina M. Gziri, Charlotte Maggen, Luc Mertens, Gunnar Naulaers, Laurence Claes, Frédéric Amant, Jeroen Blommaert, Jana Dekrem, Frederic Goffin, Vincent R
Published in: European Journal of Cancer, Issue 138, 2020, Page(s) 57-67, ISSN 0959-8049
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2020.07.004