REDOX SIGNALING AND METABOLIC STATES IN ANGIOGENESIS IN HEALTH AND DISEASE

Project Information

rEnDOx

Grant agreement ID: 647057

DOI 10.3030/647057

Project closed

EC signature date 9 December 2015

Start date 1 July 2016

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 827,00

EU contribution € 1 999 827,00

Coordinated by

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

Publications

Peer reviewed articles (23)

Latrophilin 2 controls vascular morphogenesis and function by inhibiting endothelial cell adhesion and YAP/TAZ mechanosignaling

Author(s): Camillo, Chiara; Facchinello, Nicola; Gays, Dafne; Villari, Giulia; Gioelli, Noemi; Sandri, Chiara; Arese, Marco; Tamagnone, Luca; Valdembri, Donatella; Santoro, Massimo; Serini, Guido
Published in: Journal of Cell Biology, Issue 1, 2021, ISSN 1540-8140
Publisher: Rockefeller
DOI: 10.1101/2020.04.28.065979

ROS signaling and redox biology in endothelial cells

Author(s): Emiliano Panieri, Massimo M. Santoro
Published in: Cellular and Molecular Life Sciences, Issue 72/17, 2015, Page(s) 3281-3303, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-015-1928-9

Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition

Author(s): "Nicola Facchinello # 1 , Matteo Astone # 1 , Matteo Audano 2 , Roxana E Oberkersch 1 , Marianna Spizzotin 1 , Enrica Calura 3 , Madalena Marques 4 , Mihaela Crisan 4 , Nico Mitro 2 , Massimo M Santoro 5"
Published in: Nature Metabolism, Issue 4, 2022, ISSN 2522-5812
Publisher: Elsevier
DOI: 10.1038/s42255-021-00514-4

Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research

Author(s): Massimo M. Santoro, Monica Beltrame, Daniela Panáková, Arndt F. Siekmann, Natascia Tiso, Marina Venero Galanternik, Hyun Min Jung, Brant M. Weinstein
Published in: Frontiers in Cell and Developmental Biology, Issue 7, 2019, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2019.00089

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

Author(s): Massimo M. Santoro
Published in: Cell Metabolism, Issue 31/1, 2020, Page(s) 13-15, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.12.007

Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings.

Author(s): Jacoba J. Louw; Ricardo Nunes Bastos; Xiaowen Chen; Céline Verdood; Anniek Corveleyn; Yaojuan Jia; Jeroen Breckpot; Marc Gewillig; Hilde Peeters; Massimo M. Santoro; Francis Barr; Koenraad Devriendt
Published in: PLoS Genetics, Issue 3, 2018, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1007138

Time to fight: targeting the circadian clock molecular machinery in cancer therapy.

Author(s): Matteo Astone; Massimo M. Santoro
Published in: Drug Discov Today ., Issue 1, 2021, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2021.01.023

Role of amino acid metabolism in angiogenesis

Author(s): Roxana E. Oberkersch, Massimo M. Santoro
Published in: Vascular Pharmacology, 2018, ISSN 1537-1891
Publisher: Elsevier BV
DOI: 10.1016/j.vph.2018.11.001

Before the Pump

Author(s): Dougall M. Norris, Massimo M. Santoro
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 38/12, 2018, Page(s) 2763-2764, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.311893

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Author(s): Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06406-8

Fashioning blood vessels by ROS signalling and metabolism

Author(s): Massimo Mattia Santoro
Published in: Seminars in Cell & Developmental Biology, Issue 80, 2018, Page(s) 35-42, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2017.08.002

New models to study vascular mural cell embryonic origin: implications in vascular diseases

Author(s): Sanjay Sinha, Massimo Mattia Santoro
Published in: Cardiovascular Research, Issue 114/4, 2018, Page(s) 481-491, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvy005

“Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior

Author(s): Raj Sewduth, Massimo M. Santoro
Published in: Frontiers in Physiology, Issue 7, 2016, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00306

LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation

Author(s): E. Zulato, F. Ciccarese, V. Agnusdei, M. Pinazza, G. Nardo, E. Iorio, M. Curtarello, M. Silic-Benussi, E. Rossi, C. Venturoli, E. Panieri, M.M. Santoro, V. Di Paolo, L. Quintieri, V. Ciminale, S. Indraccolo
Published in: Biochemical Pharmacology, Issue 156, 2018, Page(s) 479-490, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2018.09.019

ROS homeostasis and metabolism: a dangerous liason in cancer cells

Author(s): E Panieri, M M Santoro
Published in: Cell Death and Disease, Issue 7/6, 2016, Page(s) e2253, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/cddis.2016.105

Data on metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions

Author(s): Emiliano Panieri, Massimo M. Santoro
Published in: Data in Brief, Issue 12, 2017, Page(s) 427-432, ISSN 2352-3409
Publisher: Elsevier BV
DOI: 10.1016/j.dib.2017.04.034

Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues

Author(s): Emiliano Panieri, Carlo Millia, Massimo M. Santoro
Published in: Free Radical Biology and Medicine, 2017, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.02.022

Blood flow controls bone vascular function and osteogenesis

Author(s): Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams
Published in: Nature Communications, Issue 7, 2016, Page(s) 13601, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13601

An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates

Author(s): Dafne Gays, Christopher Hess, Annalisa Camporeale, Ugo Ala, Paolo Provero, Christian Mosimann, Massimo M. Santoro
Published in: Development, Issue 144/3, 2017, Page(s) 464-478, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.133926

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

Author(s): Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Böttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri
Published in: Nature Communications, Issue 7, 2016, Page(s) 13546, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13546

Cilia Control Vascular Mural Cell Recruitment in Vertebrates

Author(s): Xiaowen Chen, Dafne Gays, Carlo Milia, Massimo M. Santoro
Published in: Cell Reports, Issue 18/4, 2017, Page(s) 1033-1047, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.12.044

Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish

Author(s): Thomas Dickmeis, Yi Feng, Maria Caterina Mione, Nikolay Ninov, Massimo Santoro, Herman P. Spaink, Philipp Gut
Published in: Frontiers in Cell and Developmental Biology, Issue 7, 2019, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2019.00015

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo

Author(s): Katia Rupel, Luisa Zupin, Andrea Colliva, Anselmo Kamada, Augusto Poropat, Giulia Ottaviani, Margherita Gobbo, Lidia Fanfoni, Rossella Gratton, Massimo Santoro, Roberto Di Lenarda, Matteo Biasotto, Serena Zacchigna
Published in: Oxidative Medicine and Cellular Longevity, Issue 2018, 2018, Page(s) 1-11, ISSN 1942-0900
Publisher: Landes Bioscience
DOI: 10.1155/2018/6510159