REDOX SIGNALING AND METABOLIC STATES IN ANGIOGENESIS IN HEALTH AND DISEASE

Informacje na temat projektu

rEnDOx

Identyfikator umowy o grant: 647057

DOI 10.3030/647057

Projekt został zamknięty

Data podpisania przez KE 9 Grudnia 2015

Data rozpoczęcia 1 Lipca 2016

Data zakończenia 31 Grudnia 2022

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity € 1 999 827,00

Wkład UE € 1 999 827,00

Koordynowany przez

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

Publikacje

Peer reviewed articles (23)

Latrophilin 2 controls vascular morphogenesis and function by inhibiting endothelial cell adhesion and YAP/TAZ mechanosignaling

Autorzy: Camillo, Chiara; Facchinello, Nicola; Gays, Dafne; Villari, Giulia; Gioelli, Noemi; Sandri, Chiara; Arese, Marco; Tamagnone, Luca; Valdembri, Donatella; Santoro, Massimo; Serini, Guido
Opublikowane w: Journal of Cell Biology, Numer 1, 2021, ISSN 1540-8140
Wydawca: Rockefeller
DOI: 10.1101/2020.04.28.065979

ROS signaling and redox biology in endothelial cells

Autorzy: Emiliano Panieri, Massimo M. Santoro
Opublikowane w: Cellular and Molecular Life Sciences, Numer 72/17, 2015, Strona(/y) 3281-3303, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-015-1928-9

Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition

Autorzy: "Nicola Facchinello # 1 , Matteo Astone # 1 , Matteo Audano 2 , Roxana E Oberkersch 1 , Marianna Spizzotin 1 , Enrica Calura 3 , Madalena Marques 4 , Mihaela Crisan 4 , Nico Mitro 2 , Massimo M Santoro 5"
Opublikowane w: Nature Metabolism, Numer 4, 2022, ISSN 2522-5812
Wydawca: Elsevier
DOI: 10.1038/s42255-021-00514-4

Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research

Autorzy: Massimo M. Santoro, Monica Beltrame, Daniela Panáková, Arndt F. Siekmann, Natascia Tiso, Marina Venero Galanternik, Hyun Min Jung, Brant M. Weinstein
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 7, 2019, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2019.00089

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

Autorzy: Massimo M. Santoro
Opublikowane w: Cell Metabolism, Numer 31/1, 2020, Strona(/y) 13-15, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2019.12.007

Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings.

Autorzy: Jacoba J. Louw; Ricardo Nunes Bastos; Xiaowen Chen; Céline Verdood; Anniek Corveleyn; Yaojuan Jia; Jeroen Breckpot; Marc Gewillig; Hilde Peeters; Massimo M. Santoro; Francis Barr; Koenraad Devriendt
Opublikowane w: PLoS Genetics, Numer 3, 2018, ISSN 1553-7390
Wydawca: Public Library of Science
DOI: 10.1371/journal.pgen.1007138

Time to fight: targeting the circadian clock molecular machinery in cancer therapy.

Autorzy: Matteo Astone; Massimo M. Santoro
Opublikowane w: Drug Discov Today ., Numer 1, 2021, ISSN 1359-6446
Wydawca: Elsevier BV
DOI: 10.1016/j.drudis.2021.01.023

Role of amino acid metabolism in angiogenesis

Autorzy: Roxana E. Oberkersch, Massimo M. Santoro
Opublikowane w: Vascular Pharmacology, 2018, ISSN 1537-1891
Wydawca: Elsevier BV
DOI: 10.1016/j.vph.2018.11.001

Before the Pump

Autorzy: Dougall M. Norris, Massimo M. Santoro
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, Numer 38/12, 2018, Strona(/y) 2763-2764, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.311893

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Autorzy: Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-06406-8

Fashioning blood vessels by ROS signalling and metabolism

Autorzy: Massimo Mattia Santoro
Opublikowane w: Seminars in Cell & Developmental Biology, Numer 80, 2018, Strona(/y) 35-42, ISSN 1084-9521
Wydawca: Academic Press
DOI: 10.1016/j.semcdb.2017.08.002

New models to study vascular mural cell embryonic origin: implications in vascular diseases

Autorzy: Sanjay Sinha, Massimo Mattia Santoro
Opublikowane w: Cardiovascular Research, Numer 114/4, 2018, Strona(/y) 481-491, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvy005

“Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior

Autorzy: Raj Sewduth, Massimo M. Santoro
Opublikowane w: Frontiers in Physiology, Numer 7, 2016, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00306

LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation

Autorzy: E. Zulato, F. Ciccarese, V. Agnusdei, M. Pinazza, G. Nardo, E. Iorio, M. Curtarello, M. Silic-Benussi, E. Rossi, C. Venturoli, E. Panieri, M.M. Santoro, V. Di Paolo, L. Quintieri, V. Ciminale, S. Indraccolo
Opublikowane w: Biochemical Pharmacology, Numer 156, 2018, Strona(/y) 479-490, ISSN 0006-2952
Wydawca: Elsevier BV
DOI: 10.1016/j.bcp.2018.09.019

ROS homeostasis and metabolism: a dangerous liason in cancer cells

Autorzy: E Panieri, M M Santoro
Opublikowane w: Cell Death and Disease, Numer 7/6, 2016, Strona(/y) e2253, ISSN 2041-4889
Wydawca: Nature Publishing Group
DOI: 10.1038/cddis.2016.105

Data on metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions

Autorzy: Emiliano Panieri, Massimo M. Santoro
Opublikowane w: Data in Brief, Numer 12, 2017, Strona(/y) 427-432, ISSN 2352-3409
Wydawca: Elsevier BV
DOI: 10.1016/j.dib.2017.04.034

Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues

Autorzy: Emiliano Panieri, Carlo Millia, Massimo M. Santoro
Opublikowane w: Free Radical Biology and Medicine, 2017, ISSN 0891-5849
Wydawca: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.02.022

Blood flow controls bone vascular function and osteogenesis

Autorzy: Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams
Opublikowane w: Nature Communications, Numer 7, 2016, Strona(/y) 13601, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms13601

An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates

Autorzy: Dafne Gays, Christopher Hess, Annalisa Camporeale, Ugo Ala, Paolo Provero, Christian Mosimann, Massimo M. Santoro
Opublikowane w: Development, Numer 144/3, 2017, Strona(/y) 464-478, ISSN 0950-1991
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dev.133926

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

Autorzy: Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Böttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri
Opublikowane w: Nature Communications, Numer 7, 2016, Strona(/y) 13546, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms13546

Cilia Control Vascular Mural Cell Recruitment in Vertebrates

Autorzy: Xiaowen Chen, Dafne Gays, Carlo Milia, Massimo M. Santoro
Opublikowane w: Cell Reports, Numer 18/4, 2017, Strona(/y) 1033-1047, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2016.12.044

Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish

Autorzy: Thomas Dickmeis, Yi Feng, Maria Caterina Mione, Nikolay Ninov, Massimo Santoro, Herman P. Spaink, Philipp Gut
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 7, 2019, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2019.00015

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo

Autorzy: Katia Rupel, Luisa Zupin, Andrea Colliva, Anselmo Kamada, Augusto Poropat, Giulia Ottaviani, Margherita Gobbo, Lidia Fanfoni, Rossella Gratton, Massimo Santoro, Roberto Di Lenarda, Matteo Biasotto, Serena Zacchigna
Opublikowane w: Oxidative Medicine and Cellular Longevity, Numer 2018, 2018, Strona(/y) 1-11, ISSN 1942-0900
Wydawca: Landes Bioscience
DOI: 10.1155/2018/6510159