Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation

Información del proyecto

EXODUS

Identificador del acuerdo de subvención: 647215

DOI

10.3030/647215

Proyecto cerrado

Fecha de la firma de la CE 9 Julio 2015

Fecha de inicio 1 Septiembre 2015

Fecha de finalización 31 Mayo 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 998 063,00

Aportación de la UE

€ 1 998 063,00

Coordinado por

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (21)

Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity

Autores: Meike Mitsdoerffer, Giovanni Di Liberto, Sarah Dötsch, Christopher Sie, Ingrid Wagner, Monika Pfaller, Mario Kreutzfeldt, Simon Fräßle, Lilian Aly, Benjamin Knier, Dirk H Busch, Doron Merkler, Thomas Korn
Publicado en: Brain, Edición 144/6, 2021, Página(s) 1697-1710, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awab093

Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity

Autores: Michael Hiltensperger, Eduardo Beltrán, Ravi Kant, Sofia Tyystjärvi, Gildas Lepennetier, Helena Domínguez Moreno, Isabel J. Bauer, Simon Grassmann, Sebastian Jarosch, Kilian Schober, Veit R. Buchholz, Selin Kenet, Christiane Gasperi, Rupert Öllinger, Roland Rad, Andreas Muschaweckh, Christopher Sie, Lilian Aly, Benjamin Knier, Garima Garg, Ali M. Afzali, Lisa Ann Gerdes, Tania Kümpfel, Sören
Publicado en: Nature Immunology, Edición 22/7, 2021, Página(s) 880-892, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-00948-8

Dendritic cells in central nervous system autoimmunity

Autores: Christopher Sie, Thomas Korn
Publicado en: Seminars in Immunopathology, Edición 39/2, 2017, Página(s) 99-111, ISSN 1863-2297
Editor: Springer Verlag
DOI: 10.1007/s00281-016-0608-7

Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

Autores: Nikolaus Feucht, Mathias Maier, Gildas Lepennetier, Moritz Pettenkofer, Carmen Wetzlmair, Tanja Daltrozzo, Pauline Scherm, Claus Zimmer, Muna-Miriam Hoshi, Bernhard Hemmer, Thomas Korn, Benjamin Knier
Publicado en: Multiple Sclerosis Journal, Edición 25/2, 2019, Página(s) 224-234, ISSN 1352-4585
Editor: SAGE Publications
DOI: 10.1177/1352458517750009

Interleukin-6: designing specific therapeutics for a complex cytokine

Autores: Christoph Garbers, Sylvia Heink, Thomas Korn, Stefan Rose-John
Publicado en: Nature Reviews Drug Discovery, Edición ePub ahead of print, 2018, ISSN 1474-1776
Editor: Nature Publishing Group
DOI: 10.1038/nrd.2018.45

IL-1β and IL-23 Promote Extrathymic Commitment of CD27 + CD122 − γδ T Cells to γδT17 Cells

Autores: Andreas Muschaweckh, Franziska Petermann, Thomas Korn
Publicado en: The Journal of Immunology, Edición 199/8, 2017, Página(s) 2668-2679, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1700287

Deletional tolerance prevents AQP4-directed autoimmunity in mice

Autores: Anna-Lena Vogel, Benjamin Knier, Katja Lammens, Sudhakar Reddy Kalluri, Tanja Kuhlmann, Jeffrey L. Bennett, Thomas Korn
Publicado en: European Journal of Immunology, Edición 47/3, 2017, Página(s) 458-469, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646855

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

Autores: Sylvia Heink, Nir Yogev, Christoph Garbers, Marina Herwerth, Lilian Aly, Christiane Gasperi, Veronika Husterer, Andrew L Croxford, Katja Möller-Hackbarth, Harald S Bartsch, Karl Sotlar, Stefan Krebs, Tommy Regen, Helmut Blum, Bernhard Hemmer, Thomas Misgeld, Thomas F Wunderlich, Juan Hidalgo, Mohamed Oukka, Stefan Rose-John, Marc Schmidt-Supprian, Ari Waisman, Thomas Korn
Publicado en: Nature Immunology, Edición 18/1, 2016, Página(s) 74-85, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/ni.3632

T cell responses in the central nervous system

Autores: Thomas Korn, Axel Kallies
Publicado en: Nature Reviews Immunology, Edición 17/3, 2017, Página(s) 179-194, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/nri.2016.144

Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins

Autores: Christopher Sie, Laura Garcia Perez, Mario Kreutzfeldt, Maria Potthast, Caspar Ohnmacht, Doron Merkler, Samuel Huber, Anne Krug, Thomas Korn
Publicado en: The Journal of Immunology, Edición 203/6, 2019, Página(s) 1417-1427, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1900468

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Autores: Garima Garg, Andreas Muschaweckh, Helena Moreno, Ajithkumar Vasanthakumar, Stefan Floess, Gildas Lepennetier, Rupert Oellinger, Yifan Zhan, Tommy Regen, Michael Hiltensperger, Christian Peter, Lilian Aly, Benjamin Knier, Lakshmi Reddy Palam, Reuben Kapur, Mark H. Kaplan, Ari Waisman, Roland Rad, Gunnar Schotta, Jochen Huehn, Axel Kallies, Thomas Korn
Publicado en: Cell Reports, Edición 26/7, 2019, Página(s) 1854-1868.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.01.070

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

Autores: Benjamin Knier, Michael Hiltensperger, Christopher Sie, Lilian Aly, Gildas Lepennetier, Thomas Engleitner, Garima Garg, Andreas Muschaweckh, Meike Mitsdörffer, Uwe Koedel, Bastian Höchst, Percy Knolle, Matthias Gunzer, Bernhard Hemmer, Roland Rad, Doron Merkler, Thomas Korn
Publicado en: Nature Immunology, Edición 19/12, 2018, Página(s) 1341-1351, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-018-0237-5

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

Autores: Tobias Baumann, Andreas Dunkel, Christian Schmid, Sabine Schmitt, Michael Hiltensperger, Kerstin Lohr, Vibor Laketa, Sainitin Donakonda, Uwe Ahting, Bettina Lorenz-Depiereux, Jan E. Heil, Johann Schredelseker, Luca Simeoni, Caroline Fecher, Nina Körber, Tanja Bauer, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Kilian Eyerich, Stefanie Eyerich, Martina Anton, Matthew Streeter, Tina Wang, B
Publicado en: Nature Immunology, Edición 21/5, 2020, Página(s) 555-566, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0666-9

Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

Autores: Ilgiz A. Mufazalov, David Andruszewski, Carsten Schelmbauer, Sylvia Heink, Michaela Blanfeld, Joumana Masri, Yilang Tang, Rebecca Schüler, Christina Eich, F. Thomas Wunderlich, Susanne H. Karbach, Jeffrey A. Bluestone, Thomas Korn, Ari Waisman
Publicado en: The Journal of Immunology, Edición 204/4, 2020, Página(s) 747-751, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1900876

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

Autores: Anna Śledzińska, Maria Vila de Mucha, Katharina Bergerhoff, Alastair Hotblack, Dafne Franz Demane, Ehsan Ghorani, Ayse U. Akarca, Maria A.V. Marzolini, Isabelle Solomon, Frederick Arce Vargas, Martin Pule, Masahiro Ono, Benedict Seddon, George Kassiotis, Charlotte E. Ariyan, Thomas Korn, Teresa Marafioti, Graham M. Lord, Hans Stauss, Richard G. Jenner, Karl S. Peggs, Sergio A. Quezada
Publicado en: Immunity, Edición 52/1, 2020, Página(s) 151-166.e6, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2019.12.007

Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments

Autores: Thomas Korn, Andreas Muschaweckh
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2019.02634

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells

Autores: Andreas Muschaweckh, Veit R. Buchholz, Anne Fellenzer, Christian Hessel, Paul-Albert König, Sha Tao, Ronny Tao, Mathias Heikenwälder, Dirk H. Busch, Thomas Korn, Wolfgang Kastenmüller, Ingo Drexler, Georg Gasteiger
Publicado en: Journal of Experimental Medicine, Edición 213/13, 2016, Página(s) 3075-3086, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20160888

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Autores: Caroline Fecher, Laura Trovò, Stephan A. Müller, Nicolas Snaidero, Jennifer Wettmarshausen, Sylvia Heink, Oskar Ortiz, Ingrid Wagner, Ralf Kühn, Jana Hartmann, Rosa Maria Karl, Arthur Konnerth, Thomas Korn, Wolfgang Wurst, Doron Merkler, Stefan F. Lichtenthaler, Fabiana Perocchi, Thomas Misgeld
Publicado en: Nature Neuroscience, Edición 22/10, 2019, Página(s) 1731-1742, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-019-0479-z

Role of IL-6 in the commitment of T cell subsets

Autores: Thomas Korn, Michael Hiltensperger
Publicado en: Cytokine, Edición 146, 2021, Página(s) 155654, ISSN 1043-4666
Editor: Academic Press
DOI: 10.1016/j.cyto.2021.155654

Inner retinal layer thinning in radiologically isolated syndrome predicts conversion to multiple sclerosis

Autores: L. Aly, J. Havla, G. Lepennetier, T. F. M. Andlauer, C. Sie, E.‐M. Strauß, M.‐M. Hoshi, T. Kümpfel, M. Hiltensperger, M. Mitsdoerffer, M. Mühlau, C. Zimmer, B. Hemmer, T. Korn, B. Knier
Publicado en: European Journal of Neurology, Edición 27/11, 2020, Página(s) 2217-2224, ISSN 1351-5101
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ene.14416

Repositioning TH cell polarization from single cytokines to complex help

Autores: Selma Tuzlak, Anne S. Dejean, Matteo Iannacone, Francisco J. Quintana, Ari Waisman, Florent Ginhoux, Thomas Korn, Burkhard Becher
Publicado en: Nature Immunology, 2021, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-01009-w