Protein design from sub-domain sized fragments

Project Information

Protein Lego

Grant agreement ID: 647548

DOI 10.3030/647548

Project closed

EC signature date 31 March 2015

Start date 1 September 2015

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 950 000,00

EU contribution € 1 950 000,00

Coordinated by

UNIVERSITAT BAYREUTH
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach

Author(s): Sergio Romero-Romero, Miguel Costas, Daniel-Adriano Silva Manzano, Sina Kordes, Erendira Rojas-Ortega, Cinthya Tapia, Yasel Guerra, Sooruban Shanmugaratnam, Adela Rodríguez-Romero, David Baker, Birte Höcker, D. Alejandro Fernández-Velasco
Published in: Journal of Molecular Biology, Issue 433/18, 2021, Page(s) 167153, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.167153

ProteinTools: a toolkit to analyze protein structures

Author(s): Noelia Ferruz, Steffen Schmidt, Birte Höcker
Published in: Nucleic Acids Research, Issue 49/W1, 2021, Page(s) W559-W566, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab375

Strategies for designing non-natural enzymes and binders

Author(s): Horst Lechner, Noelia Ferruz, Birte Höcker
Published in: Current Opinion in Chemical Biology, Issue 47, 2018, Page(s) 67-76, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2018.07.022

Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor

Author(s): Saacnicteh Toledo-Patiño, Manish Chaubey, Murray Coles, Birte Höcker
Published in: Biochemistry, Issue 58/48, 2019, Page(s) 4790-4793, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.9b00900

Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design

Author(s): Noelia Ferruz, Francisco Lobos, Dominik Lemm, Saacnicteh Toledo-Patino, José Arcadio Farías-Rico, Steffen Schmidt, Birte Höcker
Published in: Journal of Molecular Biology, 2020, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2020.04.013

Fuzzle 2.0: Ligand Binding in Natural Protein Building Blocks

Author(s): Noelia Ferruz, Florian Michel, Francisco Lobos, Steffen Schmidt, Birte Höcker
Published in: Frontiers in Molecular Biosciences, Issue 8, 2021, ISSN 2296-889X
Publisher: Frontiers Media S.A..
DOI: 10.3389/fmolb.2021.715972

Evolution, folding, and design of TIM barrels and related proteins

Author(s): Sergio Romero-Romero, Sina Kordes, Florian Michel, Birte Höcker
Published in: Current Opinion in Structural Biology, Issue 68, 2021, Page(s) 94-104, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.12.007

Protlego: A Python package for the analysis and design of chimeric proteins

Author(s): Noelia Ferruz; Jakob Noske; Birte Hoecker
Published in: Bioinformatics, 2021, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1101/2020.10.04.325555