Metabolomics based biomarkers of dietary intake- new tools for nutrition research

Project Information

A-DIET

Grant agreement ID: 647783

DOI 10.3030/647783

Project closed

EC signature date 20 May 2015

Start date 1 August 2015

End date 31 July 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 995 548,00

EU contribution € 1 995 548,00

Coordinated by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

Publications

Peer reviewed articles (33)

Classifying Individuals Into a Dietary Pattern Based on Metabolomic Data

Author(s): Orla Prendiville, Janette Walton, Albert Flynn, Anne P. Nugent, Breige A. McNulty, Lorraine Brennan
Published in: Molecular Nutrition & Food Research, 2021, Page(s) 2001183, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202001183

The Role of Protein Intake and its Timing on Body Composition and Muscle Function in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author(s): Janine Wirth, Elaine Hillesheim, Lorraine Brennan
Published in: The Journal of Nutrition, Issue 150/6, 2020, Page(s) 1443-1460, ISSN 0022-3166
Publisher: American Society for Nutritional Sciences
DOI: 10.1093/jn/nxaa049

Optimisation of a metabotype approach to deliver targeted dietary advice

Author(s): Elaine Hillesheim, Miriam F. Ryan, Eileen Gibney, Helen M. Roche, Lorraine Brennan
Published in: Nutrition & Metabolism, Issue 17/1, 2020, ISSN 1743-7075
Publisher: BioMed Central
DOI: 10.1186/s12986-020-00499-z

The Potential of Multi-Biomarker Panels in Nutrition Research: Total Fruit Intake as an Example

Author(s): Aoife E. McNamara, Janette Walton, Albert Flynn, Anne P. Nugent, Breige A. McNulty, Lorraine Brennan
Published in: Frontiers in Nutrition, Issue 7, 2021, ISSN 2296-861X
Publisher: Frontiers in Nutrition
DOI: 10.3389/fnut.2020.577720

Potential of food intake biomarkers in nutrition research

Author(s): Aoife E. McNamara, Lorraine Brennan
Published in: Proceedings of the Nutrition Society, Issue 79/4, 2020, Page(s) 487-497, ISSN 0029-6651
Publisher: CABI Publishing
DOI: 10.1017/s0029665120007053

Nutrigenomics: lessons learned and future perspectives

Author(s): Brennan, L & de Roos, B
Published in: The American Journal of Clinical Nutrition, Issue 113(3), 2021, Page(s) 503-516, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa366

Metabolomic‐Based Approach to Identify Biomarkers of Apple Intake

Author(s): McNamara, A; Collins, C; Sri Harsha,P.S.C; González‐Peña, D; Gibbons, H; McNulty, B Nugent, A.P; Walton, J; Flynn, A; Brennan, L
Published in: Molecular Nutrition and Food Research, Issue 64(11), 2020, ISSN 1097-0037
Publisher: Wiley
DOI: 10.1002/mnfr.201901158

Dysregulation of Lipid Metabolism Precedes Psychosis…So Is Psychosis a Metabolic Disorder?

Author(s): David Mongan, Xiaofei Yin, Lorraine Brennan, David R. Cotter
Published in: Biological Psychiatry, Issue 89/3, 2021, Page(s) 209-211, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2020.10.017

Metabolomic-based identification of clusters that reflect dietary patterns

Author(s): Helena Gibbons, Eibhlin Carr, Breige A. McNulty, Anne P. Nugent, Janette Walton, Albert Flynn, Michael J. Gibney, Lorraine Brennan
Published in: Molecular Nutrition & Food Research, Issue 61/10, 2017, Page(s) 1601050, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.201601050

Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example

Author(s): Helena Gibbons, Charlotte J. R. Michielsen, Milena Rundle, Gary Frost, Breige A. McNulty, Anne P. Nugent, Janette Walton, Albert Flynn, Michael J. Gibney, Lorraine Brennan
Published in: Molecular Nutrition & Food Research, Issue 61/10, 2017, Page(s) 1700037, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.201700037

The role of metabolomics in determination of new dietary biomarkers

Author(s): A. O'Gorman, L. Brennan
Published in: Proceedings of the Nutrition Society, Issue 76/03, 2017, Page(s) 295-302, ISSN 0029-6651
Publisher: CABI Publishing
DOI: 10.1017/S0029665116002974

Metabolomics in nutrition research-a powerful window into nutritional metabolism

Author(s): L. Brennan
Published in: Essays In Biochemistry, Issue 60/5, 2016, Page(s) 451-458, ISSN 0071-1365
Publisher: Portland Press, Ltd.
DOI: 10.1042/EBC20160029

Metabolomics as a tool in the identification of dietary biomarkers

Author(s): Helena Gibbons, Lorraine Brennan
Published in: Proceedings of the Nutrition Society, Issue 76/01, 2017, Page(s) 42-53, ISSN 0029-6651
Publisher: CABI Publishing
DOI: 10.1017/S002966511600032X

A systematic review of metabolite biomarkers of schizophrenia

Author(s): Jennifer Davison, Aoife O'Gorman, Lorraine Brennan, David R. Cotter
Published in: Schizophrenia Research, 2017, ISSN 0920-9964
Publisher: Elsevier BV
DOI: 10.1016/j.schres.2017.09.021

Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

Author(s): A O'Gorman, T Suvitaival, L Ahonen, M Cannon, S Zammit, G Lewis, H M Roche, I Mattila, T Hyotylainen, M Oresic, L Brennan, D R Cotter
Published in: Translational Psychiatry, Issue 7/9, 2017, Page(s) e1240, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/tp.2017.211

Personalised Interventions—A Precision Approach for the Next Generation of Dietary Intervention Studies

Author(s): Baukje de Roos, Lorraine Brennan
Published in: Nutrients, Issue 9/8, 2017, Page(s) 847, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu9080847

Estimation of Chicken Intake by Adults Using Metabolomics-Derived Markers

Author(s): Xiaofei Yin, Helena Gibbons, Milena Rundle, Gary Frost, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Michael J Gibney, Lorraine Brennan
Published in: The Journal of Nutrition, Issue 147/10, 2017, Page(s) 1850-1857, ISSN 0022-3166
Publisher: American Society for Nutritional Sciences
DOI: 10.3945/jn.117.252197

Uncovering Factors Related to Pancreatic Beta-Cell Function

Author(s): Curran, Aoife M.; Gibney, Eileen R.; Drummond, Elaine; Brennan, Lorraine; Roche, Helen M.; Ryan, Miriam F.; Gibney, Michael J.
Published in: PLoS ONE, Issue 1, 2016, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0161350

Use of metabotyping for optimal nutrition

Author(s): L Brennan
Published in: Curr Opin Biotechnol, Issue 44, 2017, Page(s) 35-38, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2016.10.008

Combining biomarker and self-reported dietary intake data: A review of the state of the art and an exposition of concepts

Author(s): Isobel Claire Gormley, Yuxin Bai, Lorraine Brennan
Published in: Statistical Methods in Medical Research, 2019, Page(s) 096228021983769, ISSN 0962-2802
Publisher: SAGE Publications
DOI: 10.1177/0962280219837698

A scheme for a flexible classification of dietary and health biomarkers

Author(s): Qian Gao, Giulia Praticò, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Lydia A. Afman, David S. Wishart, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens, Lars O. Dragsted
Published in: Genes & Nutrition, Issue 12/1, 2017, ISSN 1555-8932
Publisher: New Century Health Publishers
DOI: 10.1186/s12263-017-0587-x

Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children

Author(s): Francisco Madrid-Gambin, Melanie Föcking, Sophie Sabherwal, Meike Heurich, Jane A. English, Aoife O’Gorman, Tommi Suvitaival, Linda Ahonen, Mary Cannon, Glyn Lewis, Ismo Mattila, Caitriona Scaife, Sean Madden, Tuulia Hyötyläinen, Matej Orešič, Stanley Zammit, Gerard Cagney, David R. Cotter, Lorraine Brennan
Published in: Biological Psychiatry, Issue 86/1, 2019, Page(s) 25-34, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2019.01.018

Combining biomarker and food intake data: calibration equations for citrus intake

Author(s): Silvia D'Angelo, Isobel Claire Gormley, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Lorraine Brennan
Published in: The American Journal of Clinical Nutrition, Issue 110/4, 2019, Page(s) 977-983, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqz168

Role of metabolomics in identification of biomarkers related to food intake

Author(s): Cassandra Collins, Aoife E. McNamara, Lorraine Brennan
Published in: Proceedings of the Nutrition Society, Issue 78/02, 2019, Page(s) 189-196, ISSN 0029-6651
Publisher: CABI Publishing
DOI: 10.1017/s002966511900048x

Metabotyping and its role in nutrition research

Author(s): Elaine Hillesheim, Lorraine Brennan
Published in: Nutrition Research Reviews, 2019, Page(s) 1-10, ISSN 0954-4224
Publisher: CABI Publishing
DOI: 10.1017/s0954422419000179

Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions

Author(s): Lorraine Brennan, Helena Gibbons
Published in: Proceedings of the Nutrition Society, 2019, Page(s) 1-5, ISSN 0029-6651
Publisher: CABI Publishing
DOI: 10.1017/s002966511900106x

The Relationship between Fish Intake and Urinary Trimethylamine‐ N ‐Oxide

Author(s): Xiaofei Yin, Helena Gibbons, Milena Rundle, Gary Frost, Breige A. McNulty, Anne P. Nugent, Janette Walton, Albert Flynn, Lorraine Brennan
Published in: Molecular Nutrition & Food Research, Issue 64/3, 2020, Page(s) 1900799, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.201900799

Impact of Sample Storage on the NMR Fecal Water Metabolome

Author(s): Victoria O’Sullivan, Francisco Madrid-Gambin, Taciane Alegra, Helena Gibbons, Lorraine Brennan
Published in: ACS Omega, Issue 3/12, 2018, Page(s) 16585-16590, ISSN 2470-1343
Publisher: ACS publications
DOI: 10.1021/acsomega.8b01761

A Metabolomics Approach to the Identification of Urinary Biomarkers of Pea Intake

Author(s): Pedapati S.C. Sri Harsha, Roshaida Abdul Wahab, Catalina Cuparencu, Lars Dragsted, Lorraine Brennan
Published in: Nutrients, Issue 10/12, 2018, Page(s) 1911, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu10121911

Metabolomics-Based Dietary Biomarkers in Nutritional Epidemiology-Current Status and Future Opportunities

Author(s): Lorraine Brennan, Frank B. Hu
Published in: Molecular Nutrition & Food Research, Issue 63/1, 2019, Page(s) 1701064, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.201701064

Recent Advances in the Application of Metabolomics for Nutrition and Health

Author(s): Diana González-Peña, Lorraine Brennan
Published in: Annual Review of Food Science and Technology, Issue 10/1, 2019, Page(s) 479-519, ISSN 1941-1413
Publisher: Annual Reviews Inc.
DOI: 10.1146/annurev-food-032818-121715

Validation of biomarkers of food intake—critical assessment of candidate biomarkers

Author(s): L. O. Dragsted, Q. Gao, A. Scalbert, G. Vergères, M. Kolehmainen, C. Manach, L. Brennan, L. A. Afman, D. S. Wishart, C. Andres Lacueva, M. Garcia-Aloy, H. Verhagen, E. J. M. Feskens, G. Praticò
Published in: Genes & Nutrition, Issue 13/1, 2018, ISSN 1555-8932
Publisher: New Century Health Publishers
DOI: 10.1186/s12263-018-0603-9

Inferring food intake from multiple biomarkers using a latent variable model

Author(s): Silvia D'Angelo, Lorraine Brennan, Isobel Claire Gormley
Published in: The Annals of Applied Statistics, 2021, ISSN 1932-6157
Publisher: Institute of Mathematical Statistics